Remodelin hydrobromide

For research use only.

Catalog No.S7641 Synonyms: Remodelin HBr

7 publications

Remodelin hydrobromide Chemical Structure

CAS No. 1622921-15-6

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

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10mM (1mL in DMSO) USD 97 In stock
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Selleck's Remodelin hydrobromide has been cited by 7 publications

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Biological Activity

Description Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
NAT10 [1]
In vitro

Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BTI-TN-5B1-4 NX;uNoJNTnWwY4Tpc44h[XO|YYm= Mk\1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCPQV;CJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDCWGkuXE5vNVKxMVQhcW6|ZXP0JINmdGy|IHHzd4V{e2WmIHHzJIh6\HKxZ3XuJJBmem:6aXTlJJBzd2S3Y4Tpc44h\nKxbTDwMZR6emGvaX7lJIJ6KGGvcHzlfEBz\WRiYYPzZZktKEmFNUCgQUAxNjJ{M{i3JO69VS5? M1HadlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUe5PFkxLz5{MEW3PVg6ODxxYU6=
BTI-TN-5B1-4 MofZSpVv[3Srb36gZZN{[Xl? NFLMclVKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IF3BU2Ih\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJGJVUS2WTj21RlEuPCCrboPlZ5Qh[2WubIOgZZN{\XO|ZXSgZZMhcHmmcn;n[Y4heGW{b4jp[IUheHKxZIXjeIlwdiCocn;tJJAufHm{YX3pcoUh[nliYX3wcIV5KHKnZDDhd5NigSxiSVO1NEA:KDBwMkKzPFch|ryPLh?= M3PMV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUe5PFkxLz5{MEW3PVg6ODxxYU6=

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
NAT10 / E-cadherin / Vimentin ; 

PubMed: 31354912     

Inhibition of NAT10 using remodelin reverses the EMT in HCC cell lines. (a) Western blotting of NAT10, E-cadherin, and vimentin expression.



Solubility (25°C)

In vitro DMSO 72 mg/mL warmed (198.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 363.28


CAS No. 1622921-15-6
Storage powder
in solvent
Synonyms Remodelin HBr
Smiles C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Histone Acetyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID