Remodelin hydrobromide

Catalog No.S7641 Synonyms: Remodelin HBr

For research use only.

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

Remodelin hydrobromide Chemical Structure

CAS No. 1622921-15-6

Selleck's Remodelin hydrobromide has been cited by 10 Publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
Targets
NAT10 [1]
In vitro

Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BTI-TN-5B1-4 MlfWSpVv[3Srb36gZZN{[Xl? NWLjXY9oUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDNRW9DKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBDXElvVF6tOWIyNTRiaX7z[YN1KGOnbHzzJIF{e2W|c3XkJIF{KGi7ZILv[4VvKHCncn;4bYRmKHC{b3T1Z5Rqd25iZoLvcUBxNXS7cnHtbY5mKGK7IHHtdIxmgCC{ZXSgZZN{[XluIFnDOVAhRSByLkKyN|g4KM7:TT6= MoSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3N{m4PVAoRjJyNUe5PFkxRC:jPh?=
BTI-TN-5B1-4 MojMSpVv[3Srb36gZZN{[Xl? NHG2UlBKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IF3BU2Ih\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJGJVUS2WTj21RlEuPCCrboPlZ5Qh[2WubIOgZZN{\XO|ZXSgZZMhcHmmcn;n[Y4heGW{b4jp[IUheHKxZIXjeIlwdiCocn;tJJAufHm{YX3pcoUh[nliYX3wcIV5KHKnZDDhd5NigSxiSVO1NEA:KDBwMkKzPFch|ryPLh?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV5OUi5NEc,OjB3N{m4PVA9N2F-
Assay
Methods Test Index PMID
Western blot NAT10 / E-cadherin / Vimentin 31354912

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 363.28
Formula

C15H15BrN4S

CAS No. 1622921-15-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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