Remodelin hydrobromide

For research use only.

Catalog No.S7641 Synonyms: Remodelin HBr

7 publications

Remodelin hydrobromide Chemical Structure

CAS No. 1622921-15-6

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 97 In stock
USD 97 In stock
USD 357 In stock
USD 947 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Remodelin hydrobromide has been cited by 7 publications

Purity & Quality Control

Choose Selective Histone Acetyltransferase Inhibitors

Biological Activity

Description Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
Targets
NAT10 [1]
()
In vitro

Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BTI-TN-5B1-4 NX;uNoJNTnWwY4Tpc44h[XO|YYm= Mk\1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCPQV;CJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDCWGkuXE5vNVKxMVQhcW6|ZXP0JINmdGy|IHHzd4V{e2WmIHHzJIh6\HKxZ3XuJJBmem:6aXTlJJBzd2S3Y4Tpc44h\nKxbTDwMZR6emGvaX7lJIJ6KGGvcHzlfEBz\WRiYYPzZZktKEmFNUCgQUAxNjJ{M{i3JO69VS5? M1HadlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUe5PFkxLz5{MEW3PVg6ODxxYU6=
BTI-TN-5B1-4 MofZSpVv[3Srb36gZZN{[Xl? NFLMclVKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IF3BU2Ih\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJGJVUS2WTj21RlEuPCCrboPlZ5Qh[2WubIOgZZN{\XO|ZXSgZZMhcHmmcn;n[Y4heGW{b4jp[IUheHKxZIXjeIlwdiCocn;tJJAufHm{YX3pcoUh[nliYX3wcIV5KHKnZDDhd5NigSxiSVO1NEA:KDBwMkKzPFch|ryPLh?= M3PMV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUe5PFkxLz5{MEW3PVg6ODxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
NAT10 / E-cadherin / Vimentin ; 

PubMed: 31354912     


Inhibition of NAT10 using remodelin reverses the EMT in HCC cell lines. (a) Western blotting of NAT10, E-cadherin, and vimentin expression.

31354912

Protocol

Solubility (25°C)

In vitro DMSO 72 mg/mL warmed (198.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 363.28
Formula

C15H15BrN4S

CAS No. 1622921-15-6
Storage powder
in solvent
Synonyms Remodelin HBr
Smiles C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Histone Acetyltransferase Signaling Pathway Map

Tags: buy Remodelin hydrobromide | Remodelin hydrobromide supplier | purchase Remodelin hydrobromide | Remodelin hydrobromide cost | Remodelin hydrobromide manufacturer | order Remodelin hydrobromide | Remodelin hydrobromide distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID