Rucaparib (AG-014699,PF-01367338) phosphate

Catalog No.S1098

Rucaparib (AG-014699,PF-01367338) phosphate Chemical Structure

Molecular Weight(MW): 421.36

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.

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In DMSO USD 134 In stock
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6 Customer Reviews

  • For anchorage dependent clonogenic assays, HER2+ breast cancer BT474 cells were seeded at low density in 6-well plates and allowed to adhere overnight. The next day, olaparib and rucaparib were added at the indicated concentrations. Media and drugs were replenished every three days. After 10-15 days, depending on cell proliferation rate, cells were fixed and stained with crystal violet. Images and graphs indicate the results compared to control condition. Data are mean ± S.D. n.s.: non-significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    Total cell extracts of BT-474 cells treated with increasing concentrations of olaparib or rucaparib were subjected to western blot analysis for PARP-1 and poly ADP-ribose (PAR) expression. β-tubulin was used as loading control. Representative images from two separate experiments are shown.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Three sensitive and three resistant cell lines were treated for 24 h with 0.02% DMSO (negative control) or 10 uM rucaparib. Serving as positive control were cells fixed 30 min after exposure to 2 Gy IR. Image acquisition was performed with a confocal microscope (Leica TCS SP2) using the 100X objective and a 2X optical zoom and oil immersion. Red: γH2AX foci. Green: RAD51 foci. *P < 0.05 **P < 0.01 ***P < 0.001. Fluorescence microscopy images of DAPI-stained rucaparib-sensitive (HN4) and rucaparib-resistant (SAS) HNC cell lines treated with DMSO, 2 Gy or 10 uM rucaparib for 24 h.

    Oral Oncol 2014 50(9), 825-31. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    purified PARP-1 and His-XPA were incubated alone ( lane 7 ), with activated PARP-1 (addition of activated DNA and NAD+, lane 8 ), or in the presence of the PARP inhibitor AG-014699 (lane 9 ). Following the various treatments, His-XPA was pulled down ( IP ) from each sample using cobalt-conjugated magnetic beads.

    J Biol Chem 2012 287, 39824-33. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Antitumor effects of transfecting of INPP4B gene combined with PARP inhibitor treatment on PC3 cells. (A) The change of cell number and shape under the microscope. (B) The viability of PC3 cells measured using CCK-8. (C) The cell cycle phase distribution of PC3 detected by flow cytometry. (D) Apoptosis of PC3 cells detected using annexin V-FITC/PI staining. (Asterisks denote statistical significance between Lenti-INPP4B+PARP inhibitor and Lenti-INPP4B and PARP inhibitor treatment, *P<0.05).

    Urol Oncol 2014 32(5), 720-6. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    in vivo suppression of PAR formation by the PARP inhibitor AG-014699 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor AG-014699 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.
     
     

     

    Dr. David Schrmann from University of Base. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

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Biological Activity

Description Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.
Features The first PARP inhibitor used in clinical trials combined with temozolomide.
Targets
PARP [1]
(Cell-free assay)
1.4 nM(Ki)
In vitro

Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. Besides, Rucaparib binds detectably to eight other PARP domains, including PARP2, 3, 4, 10, 15, 16, TNKS1 and TNKS2. [1] [2] The radio-sensitization by Rucaparib is due to downstream inhibition of activation of NF-κB, and is independent of SSB repair inhibition. Rucaparib could target NF-κB activated by DNA damage and overcome toxicity observed with classical NF-κB inhibitors without compromising other vital inflammatory functions. [3] Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BT-474 NYfkRY55TnWwY4Tpc44hSXO|YYm= NVfYbYlwOC5zL{GvOVAxNzFyMECgcm0> NYLQNlFlcW6qaXLpeJMhWEGUUDDhZ5Rqfmm2eTDheEB{fGG{dHnu[{Bkd26lZYLueJJifGmxbjDv[kA2ODBibl2= NE\wfmwzPTF{OES1OS=>
BT474 NXfDbW9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e3O|UxOCCwTR?= NH\mfm4yOOLCk{G1xsBl Mne3doVlfWOnczDj[YxtKGe{b4f0bEBqdiC2aHWg[o92eiCuaX7ld{BidmRic3nncolncWOjboTsfS=> NY\SRm9LOjVzMki0OVU>
SKBR3 NVLBZopJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LHPVUxOCCwTR?= MWOxNQKBmzF3wrDk M1zBe5Jm\HWlZYOgZ4VtdCCpcn;3eIghcW5idHjlJIZwfXJibHnu[ZMh[W6mIIPp[45q\mmlYX70cJk> M3na[VI2OTJ6NEW1
AU565 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHnPIJYPTByIH7N NHvwOY0yOOLCk{G1xsBl MXTy[YR2[2W|IHPlcIwh\3Kxd4ToJIlvKHSqZTDmc5VzKGyrbnXzJIFv\CC|aXfubYZq[2GwdHz5 MVOyOVEzQDR3NR?=
EFM192A NHLsWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz6dHQ4PTByIH7N NGnU[4kyOOLCk{G1xsBl NE\uPWVz\WS3Y3XzJINmdGxiZ4Lve5RpKGmwIITo[UBnd3W{IHzpcoV{KGGwZDDzbYdvcW[rY3HueIx6 MXeyOVEzQDR3NR?=
MDA-MB-231 NV7JPW9KTnWwY4Tpc44hSXO|YYm= MV:xNE8zOC92MDFOwG0> MWOyOEBp NF3OWVdqdmO{ZXHz[ZMheC2DS2SgcIV3\Wy|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NInUd5QzPDR{MEG1Ni=>
MDA-MB-231 NFSyT2xE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYDY[|g6OC5zLUSwJO69VQ>? M2C1ZVI1KGh? MnTPTWM2OOLCiU5ihKkyPy55N9Mg{txO MVSyOFQzODF3Mh?=
MDA-MB-231 MnzQRZBweHSxc3nzJGF{e2G7 M{\QUVExNzJyL{SwJO69VQ>? M2TWR|I1KGh? M4nHcolv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NFi4bZkzPDR{MEG1Ni=>
MDA-MB-231 NGTSOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm2VZUyOC9{MD:0NEDPxE1? NVXrXHB3OjRiaB?= MYTicI9kc3NiY3XscEBkgWOuZTDwdo9oemW|c3nvckBqdiCJMj;NJJBp[XOn NWnmUIhCOjR2MkCxOVI>
H460 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzTdVR3PDByIH7N MlfNNlTDqGh? MWHpcoNz\WG|ZYOgZ4VtdHWuYYKgdoFlcW:|ZX7zbZRqfmm2eR?= MWOyOFQyOTZzMR?=
A549  MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlniOFAxKG6P MYiyOOKhcA>? NHjOUWtqdmO{ZXHz[ZMh[2WubIXsZZIhemGmaX;z[Y5{cXSrdnn0fS=> NY[0VFBNOjR2MUG2NVE>
DT40 NYLpRVBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;nNnRVUUN3ME2yNUBvVQ>? MlizNlQ{PTZ6MUO=
DU145 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF6IH7N MX6yOFM2PjhzMx?=
COLO704 NWq2WFRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD1{LkWyJOKyKDBwNkeg{txO NVfHSYxLOjN5Mkm0NFI>
OVMANAb MnTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwNUigxtEhOC5|ODFOwG0> M{DWTVI{PzJ7NECy
OV177 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofnTWM2OD1{Lke4JOKyKDBwN{Gg{txO NYW0TlA2OjN5Mkm0NFI>
OAW28 M3PHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTNwNkGgxtEhOC5{ODFOwG0> NFzxfXkzOzd{OUSwNi=>
OVSAHO MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNwNkSgxtEhOC5|MzFOwG0> NGnjfIYzOzd{OUSwNi=>
OVKATE NEXkWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHSTWM2OD1|Lk[0JOKyKDFwN{mg{txO NVHRcGNrOjN5Mkm0NFI>
OVCAR3 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT4TWM2OD1|Lke0JOKyKDBwNECg{txO NEn6U5kzOzd{OUSwNi=>
PEO14 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLFRYFKSzVyPUOuPFQhyrFiMD63OkDPxE1? M2PGXFI{PzJ7NECy
A2780 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC2TWM2OD1|Lkm0JOKyKDBwMkWg{txO NEHFfWgzOzd{OUSwNi=>
OVTOKO Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXleYFKSzVyPUSuNVQhyrFiMT61N{DPxE1? MYCyN|czQTRyMh?=
KURAMOCHIb M2rLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDWTWM2OD12LkO0JOKyKDBwMkmg{txO MkjJNlM4Ojl2MEK=
TOV21G MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHuTWM2OD13LkC3JOKyKDFwM{Cg{txO NV3HRYl1OjN5Mkm0NFI>
OVISE NFnxNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTVwNkigxtEhOC5{MzFOwG0> M1LKTVI{PzJ7NECy
KK Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTZwMUWgxtEhOS52MjFOwG0> NV\LemFLOjN5Mkm0NFI>
RMUGS M{LXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\DfYJKSzVyPUeuNFMhyrFiMT64N{DPxE1? MWqyN|czQTRyMh?=
PEO6 NWfOe|dET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[zZXU2UUN3ME23MlA3KMLzIECuO|Qh|ryP NEDGPZMzOzd{OUSwNi=>
OVCA429 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[xfWNKSzVyPUiuNlkhyrFiMT62OEDPxE1? MWCyN|czQTRyMh?=
OV167 MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\BTWM2OD16LkOzJOKyKDFwMUig{txO MV2yN|czQTRyMh?=
RMG1 M{LHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOwRXBKSzVyPUmuN|IhyrFiMj6zOkDPxE1? NEmxR5YzOzd{OUSwNi=>
OVCAR5 NHf6T49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTlwNUCgxtEhOi53OTFOwG0> NU\Hb3l[OjN5Mkm0NFI>
EFO21 NY[2bo5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfyU4VzUUN3ME25MlkzKMLzIEGuPFch|ryP MV:yN|czQTRyMh?=
ES2 NGjHVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrlTWM2OD1zMD6xNkDDuSBzLkKzJO69VQ>? MUmyN|czQTRyMh?=
Tyk-nu NGL2WItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFyLkKwJOKyKDFwMUKg{txO M{LMdFI{PzJ7NECy
CAOV3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFyLkO3JOKyKDBwOEeg{txO MojUNlM4Ojl2MEK=
OV207 M3fpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzITWM2OD1zMj6yO{DDuSByLkOyJO69VQ>? M1fybVI{PzJ7NECy
HEY MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\Z[GlEPTB;MUOuNFEhyrFiMD63OUDPxE1? M13HcFI{PzJ7NECy
DOV13 M3\nT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf4O5NKSzVyPkG1JO69VQ>? NY\nfpVnOjN5Mkm0NFI>
EFO27 NVK5THBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq3ZW1oUUN3ME6xOUDPxE1? MUiyN|czQTRyMh?=
HEY C2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fsRWlEPTB-MUWg{txO NUPNfGxxOjN5Mkm0NFI>
KOC-7cc NXH5SZV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j3bWlEPTB-MUWg{txO NXvFU4htOjN5Mkm0NFI>
MCASb MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfrZpFOUUN3ME6xOUDPxE1? MUSyN|czQTRyMh?=
OAW42 M2LGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jJeGlEPTB-MUWg{txO Mn7CNlM4Ojl2MEK=
OV2008 NWfOcFhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPlXXBFUUN3ME6xOUDPxE1? Mmr3NlM4Ojl2MEK=
OV90 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\MTWM2OD5zNTFOwG0> MXGyN|czQTRyMh?=
OVCA420b Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XNNmlEPTB-MUWg{txO NYfkWHFlOjN5Mkm0NFI>
OVCA432 NGTTTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rwemlEPTB-MUWg{txO NVzvdHdNOjN5Mkm0NFI>
PEA2 NEnSSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f1fGlEPTB-MUWg{txO M3TvSVI{PzJ7NECy
SKOV3 M1HDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrY[ZVzUUN3ME6xOUDPxE1? MWmyN|czQTRyMh?=
TOV112D NHW4cGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzONE0{KM7:TR?= M4XSdGlEPTB-MUWg{txO MnfHNlM4Ojl2MEK=
C4-2 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ny[FAuOyEQvF2= M17CT|E1KGR? MkLySG1UVw>? NVfhRlhO\GWlcnXhd4V{KGOxbH;ufUBvfW2kZYKg[I9{\SCmZYDlcoRmdnSueR?= MlvNNlM2PjV{NES=
PC3 NH7nXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;Ce3cxNTNizszN NUnafHJkOTRiZB?= NV7hTW9ITE2VTx?= MlL1[IVkemWjc3XzJINwdG:weTDueY1j\XJiZH;z[UBl\XCnbnTlcpRtgQ>? MkjUNlM2PjV{NES=
DU145 NELwcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVewMVMh|ryP M1XuelE1KGR? MVzEUXNQ NF3JT2Nl\WO{ZXHz[ZMh[2:ub375JI52dWKncjDkc5NmKGSncHXu[IVvfGy7 M{W1cVI{PTZ3MkS0
VCaP  MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TIW|AuOyEQvF2= MmnUNVQh\A>? M4XkfGROW09? Mn\S[IVkemWjc3XzJINwdG:weTDueY1j\XJiZH;z[UBl\XCnbnTlcpRtgQ>? M3zNclI{PTZ3MkS0
LNCaP  MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HIUVAuOyEQvF2= NGfRfncyPCCm NVqyc4lXTE2VTx?= MWjk[YNz\WG|ZYOgZ49td267IH71cYJmeiCmb4PlJIRmeGWwZHXueIx6 NX\pRZg2OjN3NkWyOFQ>
MDA-MB-468 NUnJZXhkS2WubDDWbYFjcWyrdImgRZN{[Xl? M2T6c2lEPTB;OT63JO69VQ>? NI\ZPJgzOjZ5OEG2NS=>
MDA-MB-231 NVjRUHN4S2WubDDWbYFjcWyrdImgRZN{[Xl? NWn6RnljUUN3ME2xN{DPxE1? NH23VIMzOjZ5OEG2NS=>
Cal-51 M3\xSGNmdGxiVnnhZoltcXS7IFHzd4F6 MXTJR|UxRThwNjFOwG0> NEL1e2wzOjZ5OEG2NS=>

... Click to View More Cell Line Experimental Data

In vivo Rucaparib is not toxic but significantly enhances temozolomide-induced TGD in the DNA repair protein-competent D384Med xenografts. Pharmacokinetics studies also show that Rucaparib is detected in the brain tissue, which indicates that Rucaparib has potential in intra-cranial malignancy therapy. [4] Rucaparib significantly potentiates the cytotoxicity of topotecan and temozolomide in NB-1691, SH-SY-5Y, and SKNBE (2c) cells. Rucaparib enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts. [5]

Protocol

Kinase Assay:[1]
+ Expand

Ki Determination:

Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis.
Cell Research:[4]
+ Expand
  • Cell lines: D425Med, D283Med and D384Med cells
  • Concentrations: 0.4 μM
  • Incubation Time: 3 or 5 days
  • Method: Medulloblastoma cell lines are seeded in 96-well plates at a density of 1 × 103, 3 × 103 and 3 × 103, respectively. At 24 hours (D384Med) or 48 hours (D283Med and D425Med) after seeding, the cells are exposed to various concentrations of temozolomide in the presence or absence of 0.4 μM Rucaparib. After 3 days (D425Med and D384Med) or 5 days (D283Med) of culture, cell viability is evaluated by a XTT cell proliferation kit assay. Cell growth is expressed as a percentage in relation to DMSO or 0.4 μM Rucaparib-alone controls. The concentration of temozolomide, alone or in combination with Rucaparib that inhibited growth by 50% (GI50) is calculated. The potentiation factor 50 (PF50) is defined as the ratio of the GI50 of temozolomide in the presence of Rucaparib to the GI50 of temozolomide alone.
    (Only for Reference)
Animal Research:[4]
+ Expand
  • Animal Models: CD-1 nude mice bearing established D283Med xenografts
  • Formulation: Normal saline
  • Dosages: 1 mg/kg
  • Administration: One or four daily by i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (199.35 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.36
Formula

C19H18FN3O.H3PO4

CAS No. 459868-92-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03694262 Not yet recruiting Endometrial Cancer Medical College of Wisconsin February 1 2019 Phase 2
NCT03559049 Not yet recruiting Stage IV Non-small Cell Lung Cancer University of Michigan Cancer Center|Merck Sharp & Dohme Corp.|Clovis Oncology Inc. January 2019 Phase 1|Phase 2
NCT03617679 Not yet recruiting Metastatic Endometrial Cancer University of Colorado Denver|Clovis Oncology Inc. December 2018 Phase 2
NCT03639935 Not yet recruiting Biliary Tract Cancer University of Michigan Cancer Center|Dana-Farber Cancer Institute|Vanderbilt University Medical Center November 2018 Phase 2
NCT03654833 Not yet recruiting Mesothelioma Malignant University of Leicester|British Lung Foundation|Clovis Oncology Inc.|Eli Lilly and Company|Merck Sharp & Dohme Corp.|BerGenBio ASA|Roche Pharma AG|University Hospitals Leicester|The Christie NHS Foundation Trust October 1 2018 Phase 2
NCT03413995 Recruiting Prostate Cancer Metastatic Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins September 10 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID