Rucaparib (AG-014699,PF-01367338) phosphate

Catalog No.S1098

Rucaparib (AG-014699,PF-01367338) phosphate Chemical Structure

Molecular Weight(MW): 421.36

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.

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6 Customer Reviews

  • For anchorage dependent clonogenic assays, HER2+ breast cancer BT474 cells were seeded at low density in 6-well plates and allowed to adhere overnight. The next day, olaparib and rucaparib were added at the indicated concentrations. Media and drugs were replenished every three days. After 10-15 days, depending on cell proliferation rate, cells were fixed and stained with crystal violet. Images and graphs indicate the results compared to control condition. Data are mean ± S.D. n.s.: non-significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    Total cell extracts of BT-474 cells treated with increasing concentrations of olaparib or rucaparib were subjected to western blot analysis for PARP-1 and poly ADP-ribose (PAR) expression. β-tubulin was used as loading control. Representative images from two separate experiments are shown.

    Eur J Cancer 2014 50(15), 2725-34. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Three sensitive and three resistant cell lines were treated for 24 h with 0.02% DMSO (negative control) or 10 uM rucaparib. Serving as positive control were cells fixed 30 min after exposure to 2 Gy IR. Image acquisition was performed with a confocal microscope (Leica TCS SP2) using the 100X objective and a 2X optical zoom and oil immersion. Red: γH2AX foci. Green: RAD51 foci. *P < 0.05 **P < 0.01 ***P < 0.001. Fluorescence microscopy images of DAPI-stained rucaparib-sensitive (HN4) and rucaparib-resistant (SAS) HNC cell lines treated with DMSO, 2 Gy or 10 uM rucaparib for 24 h.

    Oral Oncol 2014 50(9), 825-31. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    purified PARP-1 and His-XPA were incubated alone ( lane 7 ), with activated PARP-1 (addition of activated DNA and NAD+, lane 8 ), or in the presence of the PARP inhibitor AG-014699 (lane 9 ). Following the various treatments, His-XPA was pulled down ( IP ) from each sample using cobalt-conjugated magnetic beads.

    J Biol Chem 2012 287, 39824-33. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

  • Antitumor effects of transfecting of INPP4B gene combined with PARP inhibitor treatment on PC3 cells. (A) The change of cell number and shape under the microscope. (B) The viability of PC3 cells measured using CCK-8. (C) The cell cycle phase distribution of PC3 detected by flow cytometry. (D) Apoptosis of PC3 cells detected using annexin V-FITC/PI staining. (Asterisks denote statistical significance between Lenti-INPP4B+PARP inhibitor and Lenti-INPP4B and PARP inhibitor treatment, *P<0.05).

    Urol Oncol 2014 32(5), 720-6. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

    in vivo suppression of PAR formation by the PARP inhibitor AG-014699 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor AG-014699 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.


    Dr. David Schrmann from University of Base. Rucaparib (AG-014699,PF-01367338) phosphate purchased from Selleck.

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Description Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.
Features The first PARP inhibitor used in clinical trials combined with temozolomide.
PARP [1]
(Cell-free assay)
1.4 nM(Ki)
In vitro

Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells. Besides, Rucaparib binds detectably to eight other PARP domains, including PARP2, 3, 4, 10, 15, 16, TNKS1 and TNKS2. [1] [2] The radio-sensitization by Rucaparib is due to downstream inhibition of activation of NF-κB, and is independent of SSB repair inhibition. Rucaparib could target NF-κB activated by DNA damage and overcome toxicity observed with classical NF-κB inhibitors without compromising other vital inflammatory functions. [3] Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BT-474 NGrjfHRHfW6ldHnvckBCe3OjeR?= MmDQNE4yNzFxNUCwM|ExODBibl2= MlfNbY5pcWKrdIOgVGFTWCCjY4Tpeol1gSCjdDDzeIFzfGmwZzDjc45k\XKwdILheIlwdiCxZjC1NFAhdk1? M1npXFI2OTJ6NEW1
BT474 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7wd5g2ODBibl2= M4TKV|Ex6oDVMUZCpIQ> MVzy[YR2[2W|IHPlcIwh\3Kxd4ToJIlvKHSqZTDmc5VzKGyrbnXzJIFv\CC|aXfubYZq[2GwdHz5 MoC2NlUyOjh2NUW=
SKBR3 NYrNT5VCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;hOVAxKG6P NIfPS5cyOOLCk{G1xsBl M1PzZ5Jm\HWlZYOgZ4VtdCCpcn;3eIghcW5idHjlJIZwfXJibHnu[ZMh[W6mIIPp[45q\mmlYX70cJk> NXzmZ|lkOjVzMki0OVU>
AU565 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnjVm82ODBibl2= NEDIUGgyOOLCk{G1xsBl M1vtNpJm\HWlZYOgZ4VtdCCpcn;3eIghcW5idHjlJIZwfXJibHnu[ZMh[W6mIIPp[45q\mmlYX70cJk> NITWdnMzPTF{OES1OS=>
EFM192A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjwUWM2ODBibl2= MYCxNQKBmzF3wrDk NUPi[4tKemWmdXPld{Bk\WyuIHfyc5d1cCCrbjD0bIUh\m:3cjDsbY5meyCjbnSgd4lodmmoaXPhcpRtgQ>? MlPTNlUyOjh2NUW=
MDA-MB-231 NGi1T2lCeG:ydH;zbZMhSXO|YYm= M1TDV|ExNzJyL{SwJO69VQ>? NHjiT3IzPCCq M37YTolv\HWlZYOgZZBweHSxc3nzJIRwe2ViZHXw[Y5l\W62bIm= NGTQ[ZAzPDR{MEG1Ni=>
MDA-MB-231 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmyNVAwOjBxNECg{txO M{O1XVI1KGh? MUHicI9kc3NiY3XscEBkgWOuZTDwdo9oemW|c3nvckBqdiCJMj;NJJBp[XOn MUSyOFQzODF3Mh?=
H460 M{DVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPq[Gs1ODBibl2= MmjyNlTDqGh? MnS5bY5kemWjc3XzJINmdGy3bHHyJJJi\Gmxc3Xud4l1cX[rdIm= NGrCV|YzPDRzMU[xNS=>
A549  MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjwOFAxKG6P M370R|I1yqCq NHjFS2lqdmO{ZXHz[ZMh[2WubIXsZZIhemGmaX;z[Y5{cXSrdnn0fS=> Mlf3NlQ1OTF4MUG=
DT40 NEXIepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Tre2lEPTB;MkGgcm0> MmSyNlQ{PTZ6MUO=
DU145 NXftb4d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfLd49KSzVyPUG4JI5O NHfFcGIzPDN3NkixNy=>
COLO704 NGnqWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CzNGlEPTB;Mj61NkDDuSByLk[3JO69VQ>? M{O2PFI{PzJ7NECy
OVMANAb MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLlNWlTUUN3ME2yMlU5KMLzIECuN|gh|ryP NFXxenYzOzd{OUSwNi=>
OAW28 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnJTWM2OD1|Lk[xJOKyKDBwMkig{txO MYiyN|czQTRyMh?=
OVSAHO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrFTWM2OD1|Lk[0JOKyKDBwM{Og{txO NYXZellnOjN5Mkm0NFI>
OVKATE MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2mwbmlEPTB;Mz62OEDDuSBzLke5JO69VQ>? NXrON4RvOjN5Mkm0NFI>
OVCAR3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ja[WlEPTB;Mz63OEDDuSByLkSwJO69VQ>? M1;4dFI{PzJ7NECy
PEO14 M1PJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:5NItKSzVyPUOuPFQhyrFiMD63OkDPxE1? NUK4OHl4OjN5Mkm0NFI>
A2780 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNwOUSgxtEhOC5{NTFOwG0> Moj3NlM4Ojl2MEK=
TOV21G M4HNRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TKdWlEPTB;NT6wO{DDuSBzLkOwJO69VQ>? MlrxNlM4Ojl2MEK=
KK MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfiTJhiUUN3ME22MlE2KMLzIEGuOFIh|ryP M33SR|I{PzJ7NECy
RMUGS NHH2d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHOXndKSzVyPUeuNFMhyrFiMT64N{DPxE1? MnnlNlM4Ojl2MEK=
PEO6 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInrV2xKSzVyPUeuNFYhyrFiMD63OEDPxE1? MUmyN|czQTRyMh?=
OVCA429 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRThwMkmgxtEhOS54NDFOwG0> NYnQNVNZOjN5Mkm0NFI>
OV167 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSwfYhCUUN3ME24MlM{KMLzIEGuNVgh|ryP MVWyN|czQTRyMh?=
RMG1 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTlwM{KgxtEhOi5|NjFOwG0> MnzVNlM4Ojl2MEK=
EFO21 Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO5N5lDUUN3ME25MlkzKMLzIEGuPFch|ryP NGLqTFAzOzd{OUSwNi=>
Tyk-nu M1jHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\MTWM2OD1zMD6yNEDDuSBzLkGyJO69VQ>? Mmf2NlM4Ojl2MEK=
OV207 M2LZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rvSGlEPTB;MUKuNlchyrFiMD6zNkDPxE1? NYLUeIp{OjN5Mkm0NFI>
HEY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j1[GlEPTB;MUOuNFEhyrFiMD63OUDPxE1? NGjBZ2UzOzd{OUSwNi=>
DOV13 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnrTWM2OD5zNTFOwG0> NHflbGozOzd{OUSwNi=>
EFO27 NXr2fWsxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ZRWJKSzVyPkG1JO69VQ>? NUTmU5FqOjN5Mkm0NFI>
HEY C2 MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETQWGJKSzVyPkG1JO69VQ>? MWOyN|czQTRyMh?=
KOC-7cc NEHLRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO0Xmt6UUN3ME6xOUDPxE1? MVyyN|czQTRyMh?=
MCASb NH7lNVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rlWGlEPTB-MUWg{txO MWGyN|czQTRyMh?=
OAW42 NF7xTodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX4TWM2OD5zNTFOwG0> MkDlNlM4Ojl2MEK=
OV2008 NHuzcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH32SGZKSzVyPkG1JO69VQ>? NUixNG1jOjN5Mkm0NFI>
OV90 Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRjF3IN88US=> NHrZSY8zOzd{OUSwNi=>
OVCA420b MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITLcIRKSzVyPkG1JO69VQ>? M33WXVI{PzJ7NECy
OVCA432 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRjF3IN88US=> NIj2cHUzOzd{OUSwNi=>
PEA2 NEK0SXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NED6eWRKSzVyPkG1JO69VQ>? MWCyN|czQTRyMh?=
SKOV3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TFUWlEPTB-MUWg{txO M2n4TFI{PzJ7NECy
TOV112D M{XvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;kXVNIOC1|IN88US=> NXXNPGRmUUN3ME6xOUDPxE1? NVm1clNvOjN5Mkm0NFI>
C4-2 Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWGzSpY2OC1|IN88US=> MlnDNVQh\A>? NHzpbIVFVVOR MlHp[IVkemWjc3XzJINwdG:weTDueY1j\XJiZH;z[UBl\XCnbnTlcpRtgQ>? MWCyN|U3PTJ2NB?=
PC3 NHnqXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPrNE0{KM7:TR?= M3HmbFE1KGR? M1H2OGROW09? MVPk[YNz\WG|ZYOgZ49td267IH71cYJmeiCmb4PlJIRmeGWwZHXueIx6 MmPwNlM2PjV{NES=
DU145 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjpNE0{KM7:TR?= NXfVWIU{OTRiZB?= NWTvO3l2TE2VTx?= MULk[YNz\WG|ZYOgZ49td267IH71cYJmeiCmb4PlJIRmeGWwZHXueIx6 MnzHNlM2PjV{NES=
VCaP  NUDSbZlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;ETVA4OC1|IN88US=> NGH1fGoyPCCm Mlq3SG1UVw>? MX3k[YNz\WG|ZYOgZ49td267IH71cYJmeiCmb4PlJIRmeGWwZHXueIx6 M3XYe|I{PTZ3MkS0
LNCaP  M3m0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjQd5kxNTNizszN MXGxOEBl MVLEUXNQ NWrET4Ux\GWlcnXhd4V{KGOxbH;ufUBvfW2kZYKg[I9{\SCmZYDlcoRmdnSueR?= NI\5b4czOzV4NUK0OC=>
MDA-MB-468 NV\MV2MzS2WubDDWbYFjcWyrdImgRZN{[Xl? MXXJR|UxRTlwNzFOwG0> MofFNlI3PzhzNkG=
Cal-51 MmfMR4VtdCCYaXHibYxqfHliQYPzZZk> MlrmTWM2OD16Lk[g{txO NFXwbHYzOjZ5OEG2NS=>

... Click to View More Cell Line Experimental Data

In vivo Rucaparib is not toxic but significantly enhances temozolomide-induced TGD in the DNA repair protein-competent D384Med xenografts. Pharmacokinetics studies also show that Rucaparib is detected in the brain tissue, which indicates that Rucaparib has potential in intra-cranial malignancy therapy. [4] Rucaparib significantly potentiates the cytotoxicity of topotecan and temozolomide in NB-1691, SH-SY-5Y, and SKNBE (2c) cells. Rucaparib enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts. [5]


Kinase Assay:[1]
+ Expand

Ki Determination:

Inhibition of human full-length recombinant PARP-1 by [32P]NAD+ incorporation is measured. The [32P]ADP-ribose incorporated into acid insoluble material is quantified using a PhosphorImager. Ki is calculated by nonlinear regression analysis.
Cell Research:[4]
+ Expand
  • Cell lines: D425Med, D283Med and D384Med cells
  • Concentrations: 0.4 μM
  • Incubation Time: 3 or 5 days
  • Method: Medulloblastoma cell lines are seeded in 96-well plates at a density of 1 × 103, 3 × 103 and 3 × 103, respectively. At 24 hours (D384Med) or 48 hours (D283Med and D425Med) after seeding, the cells are exposed to various concentrations of temozolomide in the presence or absence of 0.4 μM Rucaparib. After 3 days (D425Med and D384Med) or 5 days (D283Med) of culture, cell viability is evaluated by a XTT cell proliferation kit assay. Cell growth is expressed as a percentage in relation to DMSO or 0.4 μM Rucaparib-alone controls. The concentration of temozolomide, alone or in combination with Rucaparib that inhibited growth by 50% (GI50) is calculated. The potentiation factor 50 (PF50) is defined as the ratio of the GI50 of temozolomide in the presence of Rucaparib to the GI50 of temozolomide alone.
    (Only for Reference)
Animal Research:[4]
+ Expand
  • Animal Models: CD-1 nude mice bearing established D283Med xenografts
  • Formulation: Normal saline
  • Dosages: 1 mg/kg
  • Administration: One or four daily by i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (199.35 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.36


CAS No. 459868-92-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03694262 Not yet recruiting Endometrial Cancer Medical College of Wisconsin February 1 2019 Phase 2
NCT03559049 Not yet recruiting Stage IV Non-small Cell Lung Cancer University of Michigan Cancer Center|Merck Sharp & Dohme Corp.|Clovis Oncology Inc. January 2019 Phase 1|Phase 2
NCT03617679 Not yet recruiting Metastatic Endometrial Cancer University of Colorado Denver|Clovis Oncology Inc. December 2018 Phase 2
NCT03639935 Not yet recruiting Biliary Tract Cancer University of Michigan Cancer Center|Dana-Farber Cancer Institute|Vanderbilt University Medical Center November 2018 Phase 2
NCT03654833 Not yet recruiting Mesothelioma Malignant University of Leicester|British Lung Foundation|Clovis Oncology Inc.|Eli Lilly and Company|Merck Sharp & Dohme Corp.|BerGenBio ASA|Roche Pharma AG|University Hospitals Leicester|The Christie NHS Foundation Trust October 1 2018 Phase 2
NCT03413995 Recruiting Prostate Cancer Metastatic Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins September 10 2018 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID