Home MAPK -Protein Tyrosine Kinase MEK MEK1/2 Selective Inhibitors

MEK1/2 Selective Inhibitors

  • MEK1
  • MEK1/2
  • MEK2
  • MEK5
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2134 AZD8330 AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. Selective MEK1/2, IC50: 7 nM
S1475 Pimasertib (AS-703026) Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2. Selective MEK1/2 (MM cell line), IC50: 5 nM-2 μM
S1568 PD318088 PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. Selective