MEK1/2 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2134 AZD8330

AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.

Selective MEK1/2, IC50: 7 nM
S1475 Pimasertib (AS-703026)

Pimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.

Selective MEK1/2 (MM cell line), IC50: 5 nM-2 μM
S1568 PD318088

PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.