Doxycycline Hyclate

Catalog No.S4163

Doxycycline Hyclate Chemical Structure

Molecular Weight(MW): 512.94

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).

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Biological Activity

Description Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).
Targets
MMP [6]
In vitro

Doxycycline hyclate 10% (DOXY) has significant toxicity effects on osteoblast cells compared to the control group with a mean cell viability of 84%. Doxycycline hyclate 10% (DOXY) results in a significantly higher alkaline phosphatase activity (approximately 56%) than the control in osteoblasts. Doxycycline hyclate 10% (DOXY) seems to slightly altered the morphology of the osteoblasts. [1]

In vivo Doxycycline hyclate is an effective treatment for acute E. canis infection in dogs. [2] Doxycycline hyclate (5 mg/kg, orally) decreases the collagenase activity in corneas obtained from rabbits. Doxycycline hyclate (5 mg/kg, orally) promotes corneal reepithelialization in the rabbit alkali-burn model, a result, perhaps, of the drug's ability to inhibit excessive collagenase activity. [3] Doxycycline hyclate results in 43% of prophylaxis in orally treated mice, in contrast, the sustained-release doxycycline hyclate completely protects mice from infection and resultant pathology. [4] Doxycycline hyclate results in bioavailability of 70%, Cmin of 1 mg/L, Cmax of 2.3 mg/L and elimination half-life of 7 hours in calves with immature rumen function. [5]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (194.95 mM)
Water 100 mg/mL (194.95 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 512.94
Formula

C22H24N2O8.1/2C2H6O.HCl.1/2H2O

CAS No. 24390-14-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709459 Not yet recruiting STIs Prevention Kirby Institute|Sydney Sexual Health Centre|Melbourne Sexual Health Centre|Kirketon Road Centre|South Australian Health and Medical Research Institute|Monash University February 2019 --
NCT03709459 Not yet recruiting STIs Prevention Kirby Institute|Sydney Sexual Health Centre|Melbourne Sexual Health Centre|Kirketon Road Centre|South Australian Health and Medical Research Institute|Monash University February 2019 --
NCT03824340 Not yet recruiting Infertility Aljazeera Hospital January 30 2019 Not Applicable
NCT03824340 Not yet recruiting Infertility Aljazeera Hospital January 30 2019 Not Applicable
NCT02929121 Recruiting Lymphedema|Lymphatic Filariasis|Filariasis The Task Force for Global Health|United States Agency for International Development (USAID) January 15 2019 Phase 3
NCT02929121 Recruiting Lymphedema|Lymphatic Filariasis|Filariasis The Task Force for Global Health|United States Agency for International Development (USAID) January 15 2019 Phase 3

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MMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID