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CAS No. 24390-14-5
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).
Selleck's Doxycycline Hyclate has been cited by 19 publications
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|Description||Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).|
Doxycycline hyclate 10% (DOXY) has significant toxicity effects on osteoblast cells compared to the control group with a mean cell viability of 84%. Doxycycline hyclate 10% (DOXY) results in a significantly higher alkaline phosphatase activity (approximately 56%) than the control in osteoblasts. Doxycycline hyclate 10% (DOXY) seems to slightly altered the morphology of the osteoblasts. 
|In vivo||Doxycycline hyclate is an effective treatment for acute E. canis infection in dogs.  Doxycycline hyclate (5 mg/kg, orally) decreases the collagenase activity in corneas obtained from rabbits. Doxycycline hyclate (5 mg/kg, orally) promotes corneal reepithelialization in the rabbit alkali-burn model, a result, perhaps, of the drug's ability to inhibit excessive collagenase activity.  Doxycycline hyclate results in 43% of prophylaxis in orally treated mice, in contrast, the sustained-release doxycycline hyclate completely protects mice from infection and resultant pathology.  Doxycycline hyclate results in bioavailability of 70%, Cmin of 1 mg/L, Cmax of 2.3 mg/L and elimination half-life of 7 hours in calves with immature rumen function. |
-  Almazin SM, et al. J Periodontol, 2009, 80(6), 999-1005.
-  Breitschwerdt EB, et al. Antimicrob Agents Chemother, 1998, 42(2), 362-368.
-  Perry HD, et al. Cornea, 1993, 12(5), 379-382.
|In vitro||DMSO||100 mg/mL (194.95 mM)|
|Water||100 mg/mL (194.95 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04686799||Not yet recruiting||Drug: Doxycycline Hyclate 20 MG||Lateral Epicondylitis|Lateral Epicondylitis Left Elbow|Lateral Epicondylitis Right Elbow|Lateral Epicondylitis Unspecified Elbow|Lateral Epicondylitis (Tennis Elbow) Bilateral||Hospital for Special Surgery New York||January 2021||Phase 2|Phase 3|
|NCT04597424||Not yet recruiting||Drug: Experimental: doxycycline|Biological: Bexsero® vaccine||Unsafe Sex|Risk-Taking||French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)||December 2020||Phase 3|
|NCT04269434||Recruiting||Other: No Screening||Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection||Institute of Tropical Medicine Belgium||September 21 2020||Not Applicable|
|NCT03709459||Recruiting||Drug: Doxycycline||STIs Prevention||Kirby Institute|South Australian Health and Medical Research Institute|Monash University||December 17 2019||--|
|NCT03558984||Recruiting||Drug: D-PLEX|Other: Standard of Care||Surgical Site Infection|Sternal Infection|Cardiac Surgery||PolyPid Ltd.||December 17 2019||Phase 3|
|NCT03194204||Completed||Drug: Doxycycline Tablets||Rheumatoid Arthritis||Assiut University||October 1 2019||Not Applicable|
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