All New Products Listed Chronologically

Cat.No. Product Name Information Added
S5770 Pizotifen Pizotifen (Pizotyline, BC-105) is a potent antagonist of 5-Hydroxytryptamine (5-HT, Serotonin) 5-HT2 receptor with a high affinity for 5-HT1C binding site. Apr 27 2021
S5785 Norethindrone acetate Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Apr 27 2021
S5960 Dabigatran etexilate mesylate Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM. Apr 27 2021
S5969 Dicloxacillin Sodium hydrate Dicloxacillin Sodium hydrate (DLX, Dycill, Dynapen, Pathocil), a narrow-spectrum β-Lactam antibiotic of the penicillin class, induces drug-metabolizing CYP enzymes to a clinically relevant extent. Apr 27 2021
S5972 Hydrocortisone hemisuccinate Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid with anti-inflammatory properties, is an inhibitor of proinflammatory cytokine with IC50 of 6.7 μM and 21.4 μM for Interleukin-6 (IL-6) and IL-3, respectively. Apr 27 2021
S5977 3-Amino-1,2,4-triazole 3-Amino-1,2,4-triazole (1,2,4-Triazol-3-amine, 3-AT, Aminotriazole, Amitrol, 3-Amino-1H-1,2,4-triazole, Trapidil impurity B) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities. Apr 27 2021
S5979 2',3'-Dideoxyadenosine 2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication. Apr 27 2021
S5981 S(-)-Propranolol hydrochloride (S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. Apr 27 2021
S9724 SZL P1-41 SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells. Apr 27 2021
S9864 Elimusertib (BAY-1895344) Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM. Apr 27 2021
S4513 RGD peptide (GRGDNP) RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3. Apr 27 2021
S5330 Amikacin Sulfate Salt Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Apr 27 2021
S5786 Bromfenac sodium hydrate Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively. Apr 27 2021
S6997 CHAPS CHAPS is a zwitterionic surfactant that decreases the sequence specificity of the nucleosome. Apr 27 2021
S5608 Pantoprazole sodium hydrate Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM. Apr 27 2021
S5975 Calcein Calcein (Fluorexon) is a fluorescent fluid phase marker used to track and visualize cellular processes such as synaptic vesicle fusion. Calcein is also the fluorophore for live cells in the commonly used Live/Dead viability assay. Apr 27 2021
S5974 Alizarin Red S Alizarin Red S sodium (Alizarin red S mono sodiumsalt, ARS sodium, C.I. Mordant Red 3, C.I 58005, Alizarin Carmine, Alizarin Red, Alizarin sodium monosulfonate, Alizarin sulfonate sodium, Alizarinsulfonic acid sodium salt, Sodium alizarinsulfonate) is an anthraquinone dye that has been used to evaluate calcium-rich deposits by cells in culture. Apr 27 2021
S5978 Gallein Gallein (Pyrogallol phthalein) is an inhibitor of G protein βγ (G beta-gamma complex, Gβγ) subunit interaction with PI3 kinase. Gallein inhibits β-ionone effects and exhibits anti-tumor activity. Gallein can be used as a biological stain. Apr 27 2021
S5961 Prednisolone disodium phosphate Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells. Apr 27 2021
S9789 JHU37152 JHU37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively. Apr 27 2021
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