All New Products Listed Chronologically

Cat.No. Product Name Information Added
S6174 NS8593 Hydrochloride NS8593 is a potent negative gating inhibitor of small conductance Ca2+ -activated K+ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM. Jul 15 2021
S6930 MK2 Inhibitor III MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. Jul 15 2021
S9907 Syrosingopine (Su-3118) Syrosingopine (Su-3118) is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively. Jul 15 2021
S6875 CASIN CASIN (Pirl1-related Compound 2) directly inhibits activation of Cdc42/RhoGDI with IC50 of 2 μM. Jul 06 2021
S6895 TCPOBOP TCPOBOP is a constitutive androstane receptor (CAR) agonist. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Jul 06 2021
S9886 Biocytin Biocytin ((+)-Biocytin, Biotinyl-L-lysine) is a conjugate of D-biotin and L-lysine. Biocytin is an attractive neuronal tracer. It labels neurons fast over long distances, and it can be used in conjunction with calcium dyes to report on neuronal activity in retrogradely labeled live neurons. Jul 06 2021
S9887 P110 P110 is a dynamin-related protein 1 (Drp1)-specific inhibitor that binds directly to Drp1. Jul 06 2021
S6387 Cilengitide Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively. Jul 06 2021
S6391 Sephin-1 Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A. Jul 06 2021
S6947 MK6-83 MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients. Jul 06 2021
S6987 Iron Dextran Iron dextran (Fero Gradumet, Conferon, Fe dextran, INFeD) is an anti-anemia drug that can be used in the study of iron-deficiency anemia in animals. Jul 06 2021
S0292 MSX-127 MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist. Jul 06 2021
S0293 MSX-130 MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4). Jul 06 2021
S9779 Emavusertib (CA-4948) Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity. Jul 06 2021
S0778 LC3-mHTT-IN-AN1 LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. Jul 06 2021
S0326 Olodanrigan (EMA401) Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. Jul 06 2021
S8911 BOS172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM. Jul 06 2021
S6036 ER-000444793 ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM. Jul 06 2021
S2846 ML359 ML359 is a small molecule inhibitor of protein disulfide isomerase (PDI). Jul 06 2021
S2881 Homo-PROTAC cereblon degrader 1 Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3. Jul 06 2021
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