All New Products Listed Chronologically

Cat.No. Product Name Information Added
S2963 WS-12 WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM. Nov 10 2021
E0140 PRL-3 Inhibitor (Compound 5e)

PRL-3 Inhibitor (Compound 5e) is a potent PRL-3 inhibitor with an IC50 of 0.9 μM.

Nov 10 2021
E0133 NNMTi

NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM.

Nov 10 2021
S0502 SR8278 SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα. Nov 04 2021
S6996 LC-2 LC-2 is a first PROTAC capable of degrading endogenous KRASG12C with DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling. Nov 04 2021
S9615 PF-06928215 PF-06928215 is a high affinity inhibitor of cyclic GMP-AMP synthase (cGAS) with an IC50 of 4.9 μM. Nov 04 2021
S0186 TA-01 TA-01 is a potent inhibitor of CK1δ/ε and p38 MAPK with IC50 of 6.4 nM, 6.8 nM and 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. Nov 04 2021
E0026 ML-SI3

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

Nov 04 2021
S8224 PF-3644022

PF-3644022 is a potent freely reversible ATP-competitive inhibitor of MAPKAPK2 (MK2) with an Ki of 3 nM. PF-3644022 also potently inhibits TNFα production with an IC50 of 160 nM.

Nov 04 2021
S9980 DAPI Dihydrochloride DAPI Dihydrochloride (DAPI 2HCl) is a fluorescent dye that binds strongly to adenine–thymine-rich regions in DNA. Nov 04 2021
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

Nov 04 2021
E0131 Luteolin-7-O-glucuronide

Luteolin-7-O-glucuronide (Luteolin 7-glucuronide) is a flavone glycoside found in plants. Luteolin-7-O-glucuronide possesses anti-microbial, antioxidant, anti-mutagenic, anti-genotoxic, anti-inflammatory, and anti-arthritic activities.

Nov 04 2021
S6384 Smoothened Agonist (SAG)

Smoothened Agonist (SAG) is potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.

Nov 04 2021
S9921 PF-06424439

PF-06424439 is a first orally bioavailable small-molecule inhibitor of DGAT2 with an IC50 of 14 nM.

Nov 04 2021
E0147 Simethicone

Simethicone (Simeticone) is a nonabsorbable, surface-active, antifoaming agent.

Nov 04 2021
S6984 Dianhydrogalactitol (VAL-083) Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity. Oct 26 2021
S0036 PF-06869206 PF-06869206 is a selective inhibitor of NPT2a (also referred to as NaPi2a or SLC34A1) with an IC50 of 380 nM. Oct 26 2021
S0947 Cafestol Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60. Oct 26 2021
E0118 BDP-13176 BDP-13176 is a potent fascin 1 inhibitor with an IC50 of 240 nM. Oct 26 2021
S6764 Pamufetinib (TAS-115) Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively. Oct 26 2021
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