Home GPCR & G Protein Adenosine Receptor agonist 5'-Deoxy-5'-(methylthio)adenosine For research use only.

5'-Deoxy-5'-(methylthio)adenosine

Synonyms: Methylthioadenosine, MTA

5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively.

5'-Deoxy-5'-(methylthio)adenosine Chemical Structure

5'-Deoxy-5'-(methylthio)adenosine Chemical Structure

CAS: 2457-80-9

Purity & Quality Control

Batch: E403201 DMSO] 59 mg/mL] false] Water] 6 mg/mL] false] Ethanol] 3 mg/mL] false Purity: 99.03%
99.03

5'-Deoxy-5'-(methylthio)adenosine Related Products

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Biological Activity

Description 5'-Deoxy-5'-(methylthio)adenosine (Methylthioadenosine, MTA) is a naturally occurring sulfur-containing nucleoside produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors with Ki of 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively.
Targets
A1 [1] A3 [1] A2A [1] A2B [1]
0.15 μM(Ki) 0.68 μM(Ki) 1.13 μM(Ki) 13.9 μM(Ki)

Chemical Information & Solubility

Molecular Weight 297.34 Formula

C11H15N5O3S
CAS No. 2457-80-9 SDF Download 5'-Deoxy-5'-(methylthio)adenosine SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 59 mg/mL ( (198.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 6 mg/mL

Ethanol : 3 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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