All New Products Listed Chronologically

Cat.No. Product Name Information Added
S9896 JNJ-67856633

JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.

Sep 23 2021
S9782 Sulfopin

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.

Sep 23 2021
S6385 Prexasertib (LY2606368)

Prexasertib (LY2606368, ACR 368) is a selective ATP competitor inhibitor of Chk1 and Chk2 with IC50s of 1 nM and 8 nM in cell-free assays, respectively. Prexasertib also inhibits RSK1 with an IC50 of 9 nM in cell-free assay.

Sep 23 2021
S8912 Eribulin Mesylate (E7389)

Eribulin Mesylate (E7389, B-1939, ER-086526), an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

Sep 23 2021
S0167 RO8994 RO8994 is a potent and selective small-molecule MDM2 inhibitor with IC50 values of 5 nM in HTRF binding assays and 20 nM in MTT proliferation assays, respectively. Sep 18 2021
S6971 Ervogastat Ervogastat (PF-06865571, DGAT2i) is a potent diacylglycerol acyltransferase 2 (DGAT2) inhibitor that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). Sep 18 2021
S0793 ML188 ML188 is a non-covalent SARS-CoV 3CLpro inhibitor with IC50 of 1.5 μM. ML188 has antiviral activity. Sep 16 2021
S9706 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively. Sep 16 2021
S5989 SKI-178 SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines. Sep 16 2021
S0430 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. Sep 16 2021

CITCO is a potent and selective constitutive androstane receptor (CAR) agonist with EC50 of 49 nM. CITCO displays >50-fold selectivity for CAR over PXR in the transient transfection assay.

Sep 16 2021
S6386 MRT67307

MRT67307 (IKKε/TBK1 Inhibitor II) inhibits IKKε and TBK1 with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potent ULK1 and ULK2 inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can blocks autophagy in cells.

Sep 16 2021
S9926 ML-SA1

ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. ML-SA1 also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of ML-SA1 against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.

Sep 16 2021
S9606 Galloflavin Galloflavin (NSC 107022) is a novel inhibitor of lactate dehydrogenasee (LDH) with Ki values of 5.46 μM and 15.06 μM for LDH-A and LDH-B, respectively. Sep 16 2021
S0822 TLR4-IN-C34 TLR4-IN-C34 (TLR4-C34, C34, TLR4-C34-IN) is a potent and selective antagonist of Toll-like receptor 4 (TLR4). TLR4-IN-C34 reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. Sep 10 2021
S3584 Luzindole Luzindole (N-0774, N-acetyl-2-benzyltryptamine) is a selective melatonin receptor antagonist with Kis of 179 nM for MT1 and 7.3 nM for MT2, respectively. Sep 10 2021
E0029 Hexa-D-arginine

Hexa-D-arginine is a potent and specific furin inhibitor with Ki values of 106 nM, 580 nM, and 13.2 μm for furin, PACE4, and PC1, respectively.

Sep 10 2021
S9876 Dac51 Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation. Sep 10 2021
E0031 RN-1747

RN-1747 is a selective TRPV4 agonist with EC50s of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 also antagonizes TRPM8 with IC50 of 4 μM.

Sep 10 2021
E0016 Tertiapin-Q

Tertiapin-Q (TPNQ) is a derivative of tertiapin and inhibits BK-type K+ channels in a use- and concentration-dependent manner. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with Ki values of 1.3 nM and 13.3 nM respectively.

Sep 10 2021