Topo I Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1231 Topotecan HCl

Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.

Selective Topo I (DU-145 Luc cells), IC50: 2 nM; Topo I (MCF-7 Luc cells), IC50: 13 nM
S1288 Camptothecin

Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2.

Selective Topo I, IC50: 0.68 μM
S3603 Betulinic acid

Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.

Selective Eukaryotic topoisomerase I, IC50: 5 μM
S2423 (S)-10-Hydroxycamptothecin

10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.

S2217 Irinotecan HCl Trihydrate

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.

S4908 SN-38

SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

S7261 Beta-Lapachone

Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.

S1198 Irinotecan

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

S1327 Ellagic acid

Ellagic acid has antiproliferative and antioxidant property.