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Catalog No.S9321

15 publications

Topotecan Chemical Structure

CAS No. 123948-87-8

Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

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Selleck's Topotecan has been cited by 15 publications

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Biological Activity

Description Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
Topo I [1]


Solubility (25°C)

In vitro DMSO 84 mg/mL (199.31 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.45


CAS No. 123948-87-8
Storage powder
in solvent
Synonyms N/A
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04428879 Recruiting Drug: Topotecan Episcleral Plaque Retinoblastoma The Hospital for Sick Children June 16 2020 Phase 1
NCT04156347 Not yet recruiting Drug: Episcleral Topotecan Retinoblastoma Targeted Therapy Technologies LLC April 1 2020 Phase 1
NCT03927274 Recruiting Drug: Topotecan Glioma of Brain H. Lee Moffitt Cancer Center and Research Institute June 20 2019 Early Phase 1
NCT02298348 Active not recruiting Drug: Sorafenib|Drug: Cyclophosphamide|Drug: Topotecan Neuroblastoma New Approaches to Neuroblastoma Therapy Consortium|University of California San Francisco|Children''s Hospital Los Angeles|Lucile Packard Children''s Hospital|Children''s Hospital Medical Center Cincinnati|University of Michigan|Seattle Children''s Hospital|Dana-Farber Cancer Institute|The Hospital for Sick Children|Children''s Healthcare of Atlanta|University of Chicago|Cook Children''s Health Care System|Children''s Hospital Colorado April 2015 Phase 1
NCT02303028 Active not recruiting Drug: Topotecan and Pazopanib Solid Tumors The Hospital for Sick Children|C17 Council March 2015 Phase 1|Phase 2

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID