Irinotecan hydrochloride

Catalog No.S5026 Synonyms: CPT-11, (+)-Irinotecan

For research use only.

Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Irinotecan hydrochloride Chemical Structure

CAS No. 100286-90-6

Selleck's Irinotecan hydrochloride has been cited by 12 Publications

Purity & Quality Control

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Biological Activity

Description Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.
Targets
Topo I [1] cytotoxicity in HT-29 cells [1]
(Cell-based assay)
cytotoxicity in LoVo cells [1]
(Cell-based assay)
5.17 μM 15.8 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 623.14
Formula

C33H39ClN4O6

CAS No. 100286-90-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05095064 Recruiting Drug: Onivyde® + 5-FULV Metastatic Pancreatic Ductal Adenocarcinoma University Hospital Antwerp|Universitair Ziekenhuis Brussel|AZ Nikolaas|General Hospital Groeninge|University Hospital St Luc Brussels|ASZ Aalst|Erasme University Hospital|Centre Hospitalier Universitaire de Liege September 27 2021 --
NCT04901702 Active not recruiting Drug: Onivyde|Drug: Talazoparib|Drug: Temozolomide Recurrent Solid Tumor|Recurrent Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Solid Neoplasm|Recurrent Neuroblastoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent Wilms Tumor|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Malignant Germ Cell Tumor|Refractory Malignant Solid Neoplasm|Refractory Neuroblastoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma St. Jude Children''s Research Hospital|Pfizer|Ipsen June 9 2021 Phase 1|Phase 2
NCT04825288 Recruiting Biological: XB2001 or Placebo Pancreatic Cancer XBiotech Inc. May 27 2021 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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