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PLX-4720

Name: PLX-4720
Brand: Selleck Chemicals
SKU: S1152
Rating: 5 (167 reviews)

Catalog No.S1152

For research use only.

PLX4720 is a potent and selective inhibitor of B-Raf^V600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

CAS No. 918505-84-7

Selleck's PLX-4720 has been cited by 167 publications

Purity & Quality Control

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Raf Signaling Pathway Map

Biological Activity

Description

Targets

C-Raf-1 (Y340D/Y341D) ^[1] (Cell-free assay)	B-Raf (V600E) ^[1] (Cell-free assay)	BRK ^[1] (Cell-free assay)	B-Raf ^[1] (Cell-free assay)
6.7 nM	13 nM	130 nM	160 nM

In vitro

PLX-4720 displays >10 times selectivity against wild type B-Raf, and >100 times selectivity over other kinases such as Frk, Src, Fak, FGFR, and Aurora A with IC50 of 1.3-3.4 μM. PLX-4720 significantly inhibits the ERK phosphorylation in cell lines bearing B-Raf^V600E with IC50 of 14-46 nM, but not the cells with wild-type B-Raf. PLX-4720 significantly inhibits the growth of tumor cell lines bearing the B-Raf^V600E oncogene, such as COLO205, A375, WM2664, and COLO829 with GI50 of 0.31 μM, 0.50 μM, 1.5 μM, and 1.7 μM, respectively. In addition, PLX-4720 treatment at 1 μM induces cell cycle arrest and apoptosis exclusively in the B-Raf^V600E-positive 1205Lu cells, but not in the B-Raf wild-type C8161 cells. ^[1] PLX-4720 treatment (10 μM) significantly induces >14-fold expression of BIM in the PTEN⁺ cells, compared with the PTEN- cell lines (4-fold), giving an explanation of the resistance of PTEN^- cells to PLX-4720-induced apoptosis. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

DU-4475	M2fNPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoCwTWM2OD1yLkC3OFU4KM7:TR?=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
EoL-1-cell	NIPGXWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MofFTWM2OD1yLkG0NVY3KM7:TR?=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
C32	NF3kXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Ml;PTWM2OD1yLkG1NVMyKM7:TR?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
M14	NGjKWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXvlOVZ3UUN3ME2wMlIyPzV5IN88US=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
CP50-MEL-B	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MYrJR\|UxRTBwMkm3PFQh\|ryP	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
A101D	M{WyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MXzJR\|UxRTBwM{K1PFkh\|ryP	M2nXPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
G-361	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHfLT45KSzVyPUCuN\|Q3OzdizszN	MoO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
HT-144	M1jkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYjJR\|UxRTBwM{[zNlkh\|ryP	NYfSTGF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
ACN	NYnrPYVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MUPJR\|UxRTBwM{i0O\|ch\|ryP	MmWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
COLO-829	MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4HiTmlEPTB;MD6zPFk3QCEQvF2=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
MEL-HO	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M2LoZmlEPTB;MD60NVE4QSEQvF2=	MkP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
SH-4	MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NV25TY9OUUN3ME2wMlQyPDJ{IN88US=>	M3LT[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
SK-MEL-3	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3K0bmlEPTB;MD61NVU3QCEQvF2=	NXyxU2ZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
A375	NF3FeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MYXJR\|UxRTBwNkezOVkh\|ryP	MkPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
MMAC-SF	MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MnLaTWM2OD1yLk[4OlE1KM7:TR?=	NHTEUo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
BHT-101	NV;3PWFRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVjJR\|UxRTBwN{C3NFIh\|ryP	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
K5	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVjVTHQ1UUN3ME2wMlc3OTR6IN88US=>	NX73NGhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
BV-173	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MnjFTWM2OD1yLke5OlQ1KM7:TR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
RVH-421	M2Dpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1jRcWlEPTB;MD64Olc6PiEQvF2=	NV;CbmdjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
HCC2218	Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVfJR\|UxRTBwOEe4OFQh\|ryP	NG\lTZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
WM-115	MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NXThR\|BIUUN3ME2wMlg5Pjl{IN88US=>	NXWyWXBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
SK-MEL-28	Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NXPh[ZlnUUN3ME2xMlA1PTZ7IN88US=>	MoHoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
COLO-679	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUf1Z2Z6UUN3ME2xMlExPDZ2IN88US=>	M{m5elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
MZ7-mel	M{jGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M2Hae2lEPTB;MT6xOFk3OyEQvF2=	M1\qUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
SK-MEL-30	M3GzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MULJR\|UxRTFwM{OzPFYh\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
NCI-H209	Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYrncpBxUUN3ME2xMlYxQDZizszN	NV7oSFZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
HTC-C3	NX\xTnJbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHHtfphKSzVyPUGuOlYzQTRizszN	NGLy[Hk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
KARPAS-45	Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mny4TWM2OD1{LkC0PVc5KM7:TR?=	NEnNXpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
NCI-SNU-5	M4\EPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NHLpSJhKSzVyPUKuNVE6PjlizszN	NVPUVmFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
KP-4	NUDSSYpXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NEjCU2pKSzVyPUKuN\|A4QDdizszN	MlnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
PA-1	NV3sSnJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGHWT4pKSzVyPUKuO\|I3PzNizszN	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
HuO-3N1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3HYbWlEPTB;Mj64O\|k1PiEQvF2=	MkfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
NCI-H358	M4DzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MXzJR\|UxRTJwOUKyN\|Ih\|ryP	M3zVSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
CTB-1	MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MlPWTWM2OD1\|LkSwNVc3KM7:TR?=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
697	MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MmDrTWM2OD1\|LkW1NlY3KM7:TR?=	MnjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
CP66-MEL	MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MYLJR\|UxRTRwMUW5Nlch\|ryP	MlTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
NB13	NW\JbIJWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		Mn3WTWM2OD12LkS5NVc6KM7:TR?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
DBTRG-05MG	NFnaWVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MkjqTWM2OD12LkWzN\|I2KM7:TR?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
A2058	NH:xW\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVvDeHNXUUN3ME20MlczOTZ2IN88US=>	NHLqRmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
KG-1	NX7NXm1kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NFz2elRKSzVyPUSuO\|M6ODhizszN	NXvuPZAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
8305C	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFrlcJlKSzVyPUWuNVg4OyEQvF2=	Mo\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
RPMI-7951	MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MmXYTWM2OD13LkiwNlg{KM7:TR?=	NWTPSWpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
CHL-1	MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MYnJR\|UxRTVwOUe2NFMh\|ryP	MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
TI-73	NVvScFBvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYPJR\|UxRTZwMEC5NFIh\|ryP	M1PBdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
HT-1080	NFjzUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MX7JR\|UxRTZwMUC5OFYh\|ryP	M1LmPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
ES5	NIjYPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVWyfYY3UUN3ME22MlE1QTJ2IN88US=>	NHnqWWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
8-MG-BA	NInYWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NX7L[lQ2UUN3ME22MlE5OTJ7IN88US=>	NUK5U2lyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
NB7	M{Ltemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUX1d4VtUUN3ME22MlIyOzd\|IN88US=>	NYW3V4o4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
H4	NVfGcWptT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MkP1TWM2OD14LkKyOFk{KM7:TR?=	M2fwdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
CAL-72	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M1fQPWlEPTB;Nj60OVQzOyEQvF2=	Mlz5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
HCC1806	M3LwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYTJR\|UxRTZwOEG5N\|Eh\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
BCPAP	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NIrSZ4dKSzVyPUeuNlE4PjRizszN	NFjndZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
LB2241-RCC	NEm5R4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NEXtfYxKSzVyPUeuN\|Y6ODdizszN	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
COLO-741	NYT3NGNTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MnTFTWM2OD16LkCxOlc6KM7:TR?=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
HSC-3	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NG\qZVhKSzVyPUiuNFcxPjhizszN	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
SW982	NF7RW\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVzsRVRsUUN3ME24MlQyPTF4IN88US=>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
GCT	M3XpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MX;JR\|UxRThwN{WzNVQh\|ryP	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
KY821	NFSyT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MUTJR\|UxRTlwMEWxO\|gh\|ryP	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
JVM-3	NXL3OXJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYThSGV3UUN3ME25MlU3QTl7IN88US=>	Mlr4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
RS4-11	M13K[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M2n1cGlEPTB;OT62NFQ5KM7:TR?=	MmK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
VA-ES-BJ	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVP1OWtuUUN3ME2xNE4xOTR7IN88US=>	M1fRR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
A431	MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MljnTWM2OD1zMD60NlEzKM7:TR?=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
LXF-289	M3zzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MX;JR\|UxRTFyLkS1PEDPxE1?	NXTZZWtwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
SK-MEL-24	MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NH3ZW45KSzVyPUGwMlgzPzRizszN	NYi3SGpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
NOS-1	NVniXZh{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXLJR\|UxRTFyLki0O\|Ih\|ryP	M1Xm[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
KNS-62	Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NUjuTWg6UUN3ME2xNU4zPDB2IN88US=>	NXTpdo4yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
SK-HEP-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NGqyRWJKSzVyPUGxMlM2OjdizszN	MkTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
A3-KAW	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVHiboVjUUN3ME2xNU44OTd6IN88US=>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
SK-LU-1	M{n5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NXSyXFgyUUN3ME2xNk4zPjV3IN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
TYK-nu	M2K1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MkHTTWM2OD1zMj6zPVMzKM7:TR?=	NWqydoh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
NMC-G1	M1e3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVPmPVlOUUN3ME2xNk43ODZ{IN88US=>	NXKyN\|llRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
BB65-RCC	NELkUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M{njW2lEPTB;MUKuO\|E3QSEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
QIMR-WIL	M2nhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		Mln3TWM2OD1zMj64PFM{KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
D-566MG	NIjjV\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1fsbGlEPTB;MUOuPVU4PiEQvF2=	NUL6c3Z6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
KYSE-140	M2X3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		Mle0TWM2OD1zND6wO\|U{KM7:TR?=	Mn3qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
SCC-4	M4i4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEXxTI9KSzVyPUG0MlM{PTlizszN	NX\yUm9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
U251	MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MkjFTWM2OD1zND64OFkzKM7:TR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
D-542MG	MoTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mn3yTWM2OD1zND65NlIzKM7:TR?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
LAMA-84	MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHzJdXdKSzVyPUG0Mlk6OzJizszN	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
NCI-H720	M3vFTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVTPXYZuUUN3ME2xOU4zPjh2IN88US=>	M{\3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
DEL	MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M2DtU2lEPTB;MUWuOFI6OyEQvF2=	NH7TS289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
SBC-1	NYTKXYdkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NI\jc3FKSzVyPUG1MlQ{ODVizszN	NVP5OJBURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
ECC10	NVPyPYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MWPJR\|UxRTF3LkS0OVgh\|ryP	NHzwc4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
Daoy	MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4j0[2lEPTB;MUWuO\|YyPiEQvF2=	M4fnXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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HOP-62	NFSxW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MVHJR\|UxRTJ6LkexN{DPxE1?	MmfBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
EGI-1	M4\QOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MnrZTWM2OD1{OD64PFQ2KM7:TR?=	M{XqV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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LB996-RCC	NXHYOFRnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NITJNoJKSzVyPUK5MlU3QDJizszN	MnzzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
LCLC-97TM1	NFHIfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NXPZboJUUUN3ME2zNk4yQTZ2IN88US=>	M1q4blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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ChaGo-K-1	Mm\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYfvOHpPUUN3ME2zN{44OjN4IN88US=>	M4fYRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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U031	NXi2OIhjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M2HzZmlEPTB;M{WuPFE{OiEQvF2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
HMV-II	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NWj3T2VmUUN3ME2zOk4xPzd2IN88US=>	M3jSVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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NCI-H1155	NEDtdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MV7JR\|UxRTN6LkCwNVUh\|ryP	MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
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AN3-CA	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVPJR\|UxRTN6LkG2NVUh\|ryP	NYjGNYxlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
UACC-257	M4CybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NEH6T5NKSzVyPUO4Mlc6KM7:TR?=	M4C2OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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KP-N-YN	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NVPQV4REUUN3ME20NE41Ojh3IN88US=>	M{G1eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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HGC-27	NVK3eHZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGSyTWFKSzVyPUSzMlI4PCEQvF2=	NUjrO3RORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
NCI-H1092	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NEXSc5ZKSzVyPUSzMlI5QTVizszN	NX7CVHFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
KARPAS-299	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MmDrTWM2OD12Mz6zNFcyKM7:TR?=	M{\rdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
LB1047-RCC	M2TvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MYTJR\|UxRTR2Lkm5OVkh\|ryP	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
786-0	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NG\LNJNKSzVyPUS1MlY2KM7:TR?=	MlPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
HCC2157	Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVfJR\|UxRTR4LkCzOVkh\|ryP	M134cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
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EFM-19	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MWfJR\|UxRTR4Lke1N\|Mh\|ryP	Ml7pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
EW-16	NEjwNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2\RRmlEPTB;NE[uO\|gxPiEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxNlMxODJyLze+V2FPT0WUPD;hQi=>
UM-UC-3	NHziVVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2DWOmlEPTB;NE[uPFA2QSEQvF2=	NX23cHdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
HT-29	M1uyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NFnLV3VKSzVyPUS3Mlg4QTJizszN	M1fMUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOzByMkCvK\|5USU6JRWK8M4E,
LN-405	M4rrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUnO[XFMUUN3ME20PE4xQDJ5IN88US=>	MkjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVI{ODB{MD:nQnNCVkeHUkyvZV4>
NCI-H727	NFK5cmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M2rqO2lEPTB;NEiuO\|czPiEQvF2=	NU\3eWJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
D-502MG	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NEe4T2RKSzVyPUS4Mlk3PzZizszN	NUjYPY1iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
GMS-10	Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NH[zenZKSzVyPUS5MlI6PzRizszN	NH;acHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyOjNyMEKwM{c,W0GQR1XSQE9iRg>?
MEL-JUSO	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXnJR\|UxRTR7LkO0O{DPxE1?	NW\rcWtvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTJ\|MECyNE8oRlODTlfFVlww[T5?
insect cells	MnzBSpVv[3Srb36gZZN{[Xl?		M{LFNGlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMufGGpZ3XkJGJTSUZiVk[wNGUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER\|M4KHW\|aX7nJIJqd3SrbonsZZRm\C2PRVugZZMhe3Wkc4TyZZRmKGK7IFHsdIhiW2O{ZXXuJIF{e2G7LDDJR\|UxKD1iMD6wNVMh\|ryPLh?=	M3u5WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NE[xPFI4Lz5{OUS2NVgzPzxxYU6=
A375	NFTWUmFHfW6ldHnvckBie3OjeR?=		NWfpOVFzUW6qaXLpeIlwdiCxZjDCVmFHKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDBN\|c2KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDFVmsheGixc4Doc5J6dGG2aX;uJIJ6KEGucHjhV4Nz\WWwIHHzd4F6NCCLQ{WwJF0hOC5yNESg{txONg>?	NVHkXXRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0OlE5OjdpPkK5OFYyQDJ5PD;hQi=>
A375	M4qyVWZ2dmO2aX;uJIF{e2G7		NI\n[4ZKdmirYnn0bY9vKG:oIHKtVoFnKGmwIHj1cYFvKEF\|N{WgZ4VtdHNiYYPz[ZN{\WRicHjvd5Bpd3K7bHH0bY9vKG:oIFXST{whUUN3MDC9JFAvODR4IN88UU4>	NVzxNmJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFg6OTFpPkKyPFA5QTFzPD;hQi=>
A375	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NF3tSppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGzO\|Uh[2WubIOg[ZhxemW\|c3nu[{BDNVKjZjDWOlAxTSCvdYThcpQh[W6mIIfpcIQhfHmyZTDSZZMtKEmFNUCgQUAxNjVizszNMi=>	MofjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MEi5NVEoRjJ{OEC4PVEyRC:jPh?=
A375	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=	MlLDO\|IhcHK\|	MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBN\|c2KGOnbHzzJIhiemKxcnnu[{BDWkGIIG[2NFBGKG23dHHueEBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u	M4HLdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NE[xPFI4Lz5{OUS2NVgzPzxxYU6=
HCT116	NUnZdVAxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M4XxZ2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKGJvUnHmJIFv\CCNUlHTJI12fGGwdDygTWM2OCB;IEK3JO69VS5?	NWLNW2hSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4NFg6OTFpPkKyPFA5QTFzPD;hQi=>
A673	MVjxTHRUKGG\|c3H5		NVGzO3Z7eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IFG2O\|Mh[2WubIO=	NIL0eJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
Saos-2	MWPxTHRUKGG\|c3H5		NYrqSIJ3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=>	MnrmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN\|koRjJ7NEO1NVM6RC:jPh?=
RD	MUjxTHRUKGG\|c3H5		MlzkdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-
SK-N-SH	MljpdWhVWyCjc4PhfS=>		MUHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?=	NF7LVpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N\|UyOzl:L3G+
NB1643	MnTQdWhVWyCjc4PhfS=>		NUTmUY9neUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=>	M1fUd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
OHS-50	M{PVVpFJXFNiYYPzZZk>		Mn\LdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKE:KUz21NEBk\Wyucx?=	M1HtUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2	NF;yV2tyUFSVIHHzd4F6		MUfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?=	M4nxNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC	Mkm4dWhVWyCjc4PhfS=>		MoTmdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[\|ohWHKrbXHyfUB{[3KnZX6g[o9zKFONLV6tUWMh[2WubIO=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR\|NUGzPUc,Ojl2M{WxN\|k9N2F-

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	p-MEK / MEK / p-ERK / ERK / p-FAK(S910) ; p-EGFR 1173 / EGFR / p-Akt / Akt ; p27 / Cyclin D1 / pRb ; pAkt(Ser473) / pAkt(Thr308)	23076151 26023796 21828154
Immunofluorescence	LAMP1 ; ZKSCAN3 / TFEB	30979895
Growth inhibition assay	Cell viability	27848137
ELISA	mIFN-γ	23204132

In vivo

Oral administration of PLX-4720 at 20 mg/kg/day induces significant tumor growth delays and regressions in B-Raf^V600E-dependent COLO205 tumor xenografts, without obvious adverse effects in mice even at dose of 1 g/kg. PLX-4720 at 100 mg/kg twice daily almost completely eliminates the 1205Lu xenografts bearing B-Raf^V600E, while has no activity against C8161 xenografts bearing wild-type B-Raf. The anti-tumor effects of PLX-4720 correlate with the blockade of MAPK pathway in those cells harboring the V600E mutation. ^[1] PLX-4720 treatment at 30 mg/kg/day significant inhibits the tumor growth of 8505c xenografts by >90%, and dramatically decreases distant lung metastases. ^[3]

Protocol (from reference)

Kinase Assay:^[1]	In vitro Raf kinase activities: The in vitro kinase activities of wild type Raf and mutants are determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer's AlphaScreen Technology. For each enzyme (0.1 ng), 20-μL reactions are carried out in 20 mM Hepes (pH 7.0), 10 mM MgCl₂, 1 mM DTT, 0.01% Tween-20, 100 nM biotin-MEK protein, various ATP concentrations, and increasing concentrations of PLX-4720 at room temperature. Reactions are stopped at 2, 5, 8, 10, 20, and 30 minutes with 5 μL of a solution containing 20 mM Hepes (pH 7.0), 200 mM NaCl, 80 mM EDTA, and 0.3% BSA. The stop solution also includes phospho-MEK Antibody, Streptavidin-coated Donor beads and Protein A Acceptor beads from the AlphaScreen Protein A Detection Kit. The antibody and beads are preincubated in stop solution in the dark at room temperature for 30 minutes. The final dilution of antibody is 1/2,000, and the final concentration of each bead is 10 μg/mL. The assay plates are incubated at room temperature for one hour then are read on a PerkinElmer AlphaQuest reader.
Cell Research:^[1]	Cell lines: COLO205, A375, WM2664, COLO829, HT716, SW620, H460, Calu-6, HCT116, SK-MEL2, SK-MEL3, Lovo, H1299, 1205Lu, and C8161 cells Concentrations: Dissolved in DMSO, final concentrations ~1 mM Incubation Time: 24, 48, and 72 hours Method: Cells are treated with various concentrations PLX-4720 for 24, 48, and 72 hours. Cell proliferation is measured by using the CellTiter-Glo Luminescent Cell Viability Assay or MTT assay. For cell cycle analysis, supernatant and cells are collected, pelleted, and fixed with 70% ethanol. Before staining with propidium iodide (10 μg/mL), cells are incubated for 1 hour at 37 °C in 0.5 mg/mL RNase I to rid samples of residual RNA contamination. Samples are then analyzed by using the EPICS XL apparatus. For the assessment of apoptosis, media and cells are harvested and pelleted before staining with annexin-FITC and propidium iodide. Samples are subsequently analyzed by using the EPICS XL apparatus.
Animal Research:^[1]	Animal Models: Female athymic mice (NCr nu/nu) implanted s.c. with COLO205 cells, and SCID mice with 1205Lu or C8161 cells Dosages: 5, 20, or 100 mg/kg Administration: Oral gavage once or twice daily

References

Solubility (25°C)

In vitro


In vivo	Add solvents to the product individually and in order (Data is from Selleck tests instead of citations): 2% DMSO+50% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing. Click to purchase: PEG300 Tween 80	5mg/mL

Chemical Information

Molecular Weight	413.83
Formula	C₁₇H₁₄ClF₂N₃O₃S
CAS No.	918505-84-7
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F

Download PLX-4720 SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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Frequently Asked Questions

Question 1:
What would you recommend to make working solution for intraperitoneal injection into mice?

Answer:
PLX4720 has very limited solubility in aqueous solution and for this reason, we recommend oral gavage to administer this compound as not fully dissolved suspension can be used in oral gavage feeding.

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