Home JAK/STAT JAK inhibitor 1,2,3,4,5,6-Hexabromocyclohexane For research use only.

1,2,3,4,5,6-Hexabromocyclohexane

Synonyms: NSC7908

1,2,3,4,5,6-Hexabromocyclohexane (NSC7908) is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range.

1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure

1,2,3,4,5,6-Hexabromocyclohexane Chemical Structure

CAS: 1837-91-8

Selleck's 1,2,3,4,5,6-Hexabromocyclohexane has been cited by 1 publication

Purity & Quality Control

Batch: S590201 DMSO] 5 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99%
99

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Signaling Pathway

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Biological Activity

Description 1,2,3,4,5,6-Hexabromocyclohexane (NSC7908) is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range.
Targets
JAK2 [1]
In vitro
In vitro 1,2,3,4,5,6-Hexabromocyclohexane inhibits Jak2 autophosphorylation in a time- and dose-dependent manner. 1,2,3,4,5,6-Hexabromocyclohexane is noncytotoxic to cells at concentrations that maximally inhibit Jak2 tyrosine autophosphorylation[1].
Cell Research Cell lines BSC-40 cells
Concentrations 50 μM
Incubation Time 0, 1, 4, or 16 h
Method

BSC-40 cells are transfected/infected. Prior to cell lysis, 50 µM 1,2,3,4,5,6-hexabromocyclohexane is applied to the cells for 0, 1, 4, or 16 h. Cellular lysates are then prepared, immunoprecipitated with anti-Jak2 antibody, and immunoblotted with anti-phosphotyrosine antibody to measure tyrosine phosphorylated Jak2 levels.

Chemical Information & Solubility

Molecular Weight 557.54 Formula

C6H6Br6
CAS No. 1837-91-8 SDF --
Smiles C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 5 mg/mL ( (8.96 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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