Itacitinib (INCB39110)

Catalog No.S7812

Itacitinib (INCB39110) Chemical Structure

Molecular Weight(MW): 553.51

Itacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.

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Biological Activity

Description Itacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
Targets
JAK1 [1]
()
In vitro

INCB039110 is a potent and selective inhibitor of JAK1, with >20 and >200-fold selectivity over JAK2 and JAK3, respectively. The activity against JAK1, 2, 3, and TYK2 are 2, 63, >2000, and 795 nM, respectively[1].

In vivo INCB039110 blocks tumor growth in human pancreatic xenograft models in mice at clinically relevant doses, both as monotherapy and in combination with cytotoxic agents such as gemcitabine[2].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (180.66 mM)
Ethanol 100 mg/mL (180.66 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 553.51
Formula

C26H23F4N9O

CAS No. 1334298-90-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070781 Not yet recruiting Drug: Itacitinib|Drug: Tocilizumab Steroid Refractory GVHD|Graft Vs Host Disease Columbia University|Incyte Corporation October 2019 Phase 1
NCT03978637 Recruiting Drug: Itacitinib Bronchiolitis Obliterans Syndrome Incyte Corporation September 9 2019 Phase 1|Phase 2
NCT03721965 Recruiting Drug: Itacitinib|Drug: Corticosteroids Acute Graft-versus-host Disease Incyte Corporation April 16 2019 Phase 1|Phase 2
NCT03697408 Recruiting Drug: Itacitinib|Drug: Everolimus Classical Hodgkin Lymphoma University of Pennsylvania February 11 2019 Phase 1|Phase 2
NCT03627052 Recruiting Drug: Itacitinib|Drug: Placebo Moderate to Severe Ulcerative Colitis Incyte Corporation September 20 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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JAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID