Catalog No.S7311

Q-VD-Oph Chemical Structure

Molecular Weight(MW): 513.49

Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9.

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Cited by 4 Publications

2 Customer Reviews

  • UA and Q-VD-Oph attenuated TNF-α-induced unclear translocation of NF-κB (C) and P-STAT3(S727) (D) in BEAS-2B cells.

    Mol Nutr Food Res, 2017, 61(12). Q-VD-Oph purchased from Selleck.

    Pre-treatment with Q-VD-OPH inhibits activation of caspase-3 and suppresses inflammasome activation in rats subjected to MCAO/R. a, b Representative immunoblots and quantification demonstrating the effect of increasing concentration (mg/kg) of Q-VDOPH on levels of NLRP3, cleaved caspase-3 and caspase-1 following MCAO (2 h) and reperfusion (24 h) in ipsilateral brain tissues of rats. *P < 0.05. Significant differences between the two groups, N = 3 for each group.

    Neurochem Res, 2018, 43(6):1200-1209. Q-VD-Oph purchased from Selleck.

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Biological Activity

Description Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9.
Caspase-1 [1] Caspase-3 [1] Caspase-8 [1] Caspase-9 [1]
25 nM-400 nM 25 nM-400 nM 25 nM-400 nM 25 nM-400 nM
In vitro

Q-VD-OPh (5-100 μM) potently inhibits Actinomycin D-induced DNA laddering and subsequent apoptosis with minimal toxicity in WEHI 231 cells. Q-VD-OPh prevents caspase mediated cleavage of PARP and activation of the major initiator and effector caspases. [2] Q-VD-OPh protects cardiac myocytes from virus-induced apoptosis in vitro. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
JEG3 cells NEXUblJHfW6ldHnvckBie3OjeR?= M2qyZ|Ux6oDLzszN MmjKZYJzd2ejdHnvckBw\iClYYPwZZNmNThiY3zlZZZi\2ViZoLvcUBqfHNiNUZihKlsTGFicILv[o9zdSC2bzDpeJMhOTkkgJnrSIEh[WO2aY\lJIZz[WevZX70 NGTIR5gzQDF3MUS2Oy=>
MV4-11 cells NGr2V5ZE\WyuII\pZYJqdGm2eTDhd5NigQ>? MUmyOUDPxE1? MVGxJIhwfXJ? M1TLTZBzd3SnY4Tpc44h[2WubIOg[pJwdSClYYPwZZNmNWSncHXu[IVvfCClZXzsJIRm[XSq MV[yO|k2PjN6Nx?=
SH-SY5Y NYjPVXd1S3m2b4TvfIlkcXS7IHHzd4F6 NEPJTpU2KM7:TR?= MYW0PEBp MVvRMXZFNU:SaDDz[Y5{cXSrenXzJHNJNVO\NWmgZ4VtdHNidH:gcoVkem:|aYOgZ4F2e2WmIHL5JIN6eGW{bXX0bJJqdg>? NFrtflEzPzByN{WyOi=>
MEFs MYjGeY5kfGmxbjDhd5NigQ>? NWXyWJpEOjBizszNxsA> M4nwOIV5cGmkaYTl[EBkcGG{YXP0[ZJqe3SrYzDzeJJme3NvaX7keYNm\CCpZX7ldoF1cW:wIHHu[EBzfXC2dYLlJI9nKG63Y3zlZZIh[nWkYnzldy=> NGfnN2wzPTR6MkC2PC=>

... Click to View More Cell Line Experimental Data

In vivo Q-VD-OPh inhibits caspase-1 activity, IL-18 protein expression, and neutrophil infiltration during ischemic ARF in mice. [3] In vivo, caspase inhibition by Q-VD-OPh provides protection from virus-induced myocardial injury, with a significant reduction in caspase-3 activity. [4] In TgCRND8 mice, Q-VD-OPh inhibits caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage. [5]


Cell Research:[2]
+ Expand
  • Cell lines: WEHI-231 cells
  • Concentrations: ~1000 μM
  • Incubation Time: 4 hours
  • Method: Caspase inhibitors are added at the indicated concentrations 30 minutes prior to the addition of apoptotic stimuli. Viability and cell number are determined by trypan blue exclusion from three random fields of greater than 200 cells/field. All experiments are performed a minimum of three times.
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: C57BL/6 mice
  • Formulation: DMSO
  • Dosages: ~120 mg/kg
  • Administration: Intraperitoneal administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (194.74 mM)
Ethanol 100 mg/mL (194.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 513.49
CAS No. 1135695-98-5
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID