For research use only. Not for use in humans.
Molecular Weight(MW): 454.75
CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
Selleck's CCG-1423 has been cited by 10 publications
5 Customer Reviews
Cells were treated with CCG-1423 for 48 h. CCG-1423 blocked the nuclear translocation of MRTF-A.
Cell Signal, 2017, 31:87-95. CCG-1423 purchased from Selleck.
The expression of type I collagen was decreased by a selective MRTF-A inhibitor CCG-1423. (A, C and E) CCG-1423 inhibited the synthesis COL1A1 mRNA in MCF-7, T47D and MDA-MB-231 cells. (B, D and F) CCG-1423 inhibited the synthesis of type I collagen in MCF-7, T47D and MDA-MB-231 cells. From A to F, breast cancer cells were treated with 10 μM of CCG-1423 for 24 h. mRNAs and proteins were examined with RT-qPCR or Western-blot. (G) CCG-1423 inhibited COL1A1 promoter activity in MCF-7 breast cancer cells. Data are shown as mean ± S.E.M, based on three to six independent experiments. **, p < 0.01.
Biomed Pharmacother, 2018, 104:718-728. CCG-1423 purchased from Selleck.
Daam1 and RhoA participates in the rearrangement of stress fibers in glioblastoma cells. Daam1 siRNA and CCG-1423 disrupted the formation of actin stress fibers in U251 cells. U251 cells were grown on coverslips, then transiently transfected with Daam1 siRNA or pre-treated with 10 ng/ml CCG-1423 for 1 h. U251 cells were then incubated in culture medium containing 20 ng/ml recombinant Wnt5a (rWnt5a) for 4 h. Subsequently, the cells were fixed and F-actin organization was analyzed by phalloidin staining. Magnification, ×400.
Oncol Rep, 2018, 39(2):465-472. CCG-1423 purchased from Selleck.
QKI-silenced CAKI-1 cells were cultured in medium with/without 1.5 μM CCG-1423 (RhoA inhibitor) for 24 h. Levels of YAP and pYAP expression were detected by western blot analysis. The relative protein band intensity was quantified by densitometry and normalized to β-actin using Image J analysis software. Each experiment was repeated three times and data are presented as the mean ± SD. *P < 0.05 for inhibitor− vs. inhibitor+.
Acta Biochim Biophys Sin, 2018, doi:10.1093/abbs/gmy142. CCG-1423 purchased from Selleck.
Purity & Quality Control
Choose Selective Rho Inhibitors
|Description||CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.|
CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells.  CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.  In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity.  CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts. 
|In vitro||DMSO||90 mg/mL (197.91 mM)|
|Ethanol||4 mg/mL warmed (8.79 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.