Molecular Weight(MW): 454.75
CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
Cited by 7 Publications
5 Customer Reviews
Cells were treated with CCG-1423 for 48 h. CCG-1423 blocked the nuclear translocation of MRTF-A.
Cell Signal, 2017, 31:87-95. CCG-1423 purchased from Selleck.
The expression of type I collagen was decreased by a selective MRTF-A inhibitor CCG-1423. (A, C and E) CCG-1423 inhibited the synthesis COL1A1 mRNA in MCF-7, T47D and MDA-MB-231 cells. (B, D and F) CCG-1423 inhibited the synthesis of type I collagen in MCF-7, T47D and MDA-MB-231 cells. From A to F, breast cancer cells were treated with 10 μM of CCG-1423 for 24 h. mRNAs and proteins were examined with RT-qPCR or Western-blot. (G) CCG-1423 inhibited COL1A1 promoter activity in MCF-7 breast cancer cells. Data are shown as mean ± S.E.M, based on three to six independent experiments. **, p < 0.01.
Biomed Pharmacother, 2018, 104:718-728. CCG-1423 purchased from Selleck.
Daam1 and RhoA participates in the rearrangement of stress fibers in glioblastoma cells. Daam1 siRNA and CCG-1423 disrupted the formation of actin stress fibers in U251 cells. U251 cells were grown on coverslips, then transiently transfected with Daam1 siRNA or pre-treated with 10 ng/ml CCG-1423 for 1 h. U251 cells were then incubated in culture medium containing 20 ng/ml recombinant Wnt5a (rWnt5a) for 4 h. Subsequently, the cells were fixed and F-actin organization was analyzed by phalloidin staining. Magnification, ×400.
Oncol Rep, 2018, 39(2):465-472. CCG-1423 purchased from Selleck.
QKI-silenced CAKI-1 cells were cultured in medium with/without 1.5 μM CCG-1423 (RhoA inhibitor) for 24 h. Levels of YAP and pYAP expression were detected by western blot analysis. The relative protein band intensity was quantified by densitometry and normalized to β-actin using Image J analysis software. Each experiment was repeated three times and data are presented as the mean ± SD. *P < 0.05 for inhibitor− vs. inhibitor+.
Acta Biochim Biophys Sin, 2018, doi:10.1093/abbs/gmy142. CCG-1423 purchased from Selleck.
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Choose Selective Rho Inhibitors
|Description||CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.|
CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells.  CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.  In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity.  CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts. 
|In vitro||DMSO||90 mg/mL (197.91 mM)|
|Ethanol||4 mg/mL warmed (8.79 mM)|
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