• Cdc42-subclass
  • Rac
  • Rho-subclass

Cdc42-subclass Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7686 ML141 ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis. Selective cdc42, IC50: 200 nM
S6000 CID44216842 CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively. Selective Cdc42 WT, EC50: 1.0 μM; Cdc42 Q61L, IC50: 1.2 μM
S5996 MLS-573151 MLS-573151 is a selective cell division cycle 42 (Cdc42) inhibitor with an EC50 of 2 μM, which acts by blocking the binding of GTP to Cdc42. Selective Cdc42, EC50: 2 μM
S7293 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. Selective Cdc42 GTPase, Kd: 11.4 μM
S8749 MBQ-167 MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells. Pan cdc42, IC50: 78 nM