MBQ-167

Catalog No.S8749

MBQ-167 Chemical Structure

Molecular Weight(MW): 338.41

MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.

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Biological Activity

Description MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.
Targets
cdc42 [1]
(in metastatic breast cancer cells)
Rac [1]
(in metastatic breast cancer cells)
78 nM 103 nM
In vitro

MBQ-167 inhibits mammary tumor growth and metastasis in immunocompromised mice by ~90%[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: MDA-MB-231 cells
  • Concentrations: 250 or 500 nM
  • Incubation Time: 24 h
  • Method:

    MDA-MB-231 cells are treated with vehicle or MBQ-167 at 250 or 500 nM for 24 h. Cells are fixed, permeabilized, and stained with Rhodamine phalloidin to visualize F-actin, and with p-tyrosine or vinculin to visualize focal adhesions.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female athymic nu/nu mice (4-5wk old) with orthotopic primary tumor establishment
  • Formulation: 12.5% ethanol, 12.5% Cremophor and 75% 1X PBS pH 7.4
  • Dosages: 1 or 10 mg/kg BW
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 68 mg/mL (200.93 mM)
Ethanol 14 mg/mL (41.36 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 338.41
Formula

C22H18N4

CAS No. 2097938-73-1
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Rho Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID