Molecular Weight(MW): 584.89
ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Cited by 6 Publications
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Rho GTPases were involved in NaAsO2 induced apoptosis in rat CGNs. A. Representative fluorescence images of cells exposed to 0 and 10 μM NaAsO2 for 24 h with or without ZCL278 (an inhibitor of Cdc42), or a Rac1 inhibitor NSC23766. Both ZCL278 and NSC23766 reduced the apoptotic cells. B. The graph indicates TUNEL-positive rat CGNs exposed to NaAsO2 (10 μM) with ZCL278 or NSC23766 groups decreased significantly compared with those of NaAsO2 treatment group. Data are expressed as mean ± SD from at least 5 visual fields. C. Rat CGNs in 96-well plates were treated by 0 and 10 μM NaAsO2 for 24h with or without ZCL278 (an inhibitor of Cdc42) pretreatment for 1 h, or a Rac1 inhibitor NSC23766 pretreatment for 12 h, and assessed by a CCK-8. ZCL278 and NSC23766 increased rat CGNs viability exposed to NaAsO2. All statistical results are expressed as means±SD from at least three independent experiments. ***P<0.001 vs control, # P<0.05, ##P<0.01, ###P<0.001 VS NaAsO2 treatment group.
Cell Physiol Biochem, 2015, 36(4):1613-27.. ZCL278 purchased from Selleck.
(C) Survival rates of shrimp 72 h after ZCL278 injection. Shrimp injected with DMSO were used as controls. (D) WSSV IE1 expression 24 h after ZCL278 injection. Shrimp injected with a corresponding amount of DMSO were used as controls. All results shown are means and SD for experiments repeated at least 3 times; the data were statistically analyzed using the Student t test. *, P < 0.05; **, P < 0.01.
J Virol, 2017, 91(5). ZCL278 purchased from Selleck.
Effects of ZCL278 treatment on the actin polymerization in porcine oocyte. MII oocytes were labeled with phalloidin to visualize actin (green) and counterstained with PI for chromosomes (red). (a) Representative confocal images show actin distribution in control (i) and ZCL278-treated (ii,iii) oocytes. Arrows indicate the defective polymerization of actin. Scale bars, 20 μm. (b) Quantitative analysis of abnormal actin distribution in control (n = 47) and ZCL278‐treated oocytes (n = 52). Each group and data are expressed as means ± SD. *p < 0.05 versus controls. MII: metaphase II; SD: standard deviation.
J Cell Physiol, 2018, doi:10.1002/jcp.27510. ZCL278 purchased from Selleck.
b The graph indicates rat cerebellar astrocytes exposed to NaAsO2 (30 μM) with ZCL278 or NSC23766 groups decreased significantly compared with those of NaAsO2 treatment group. Data are expressed as mean±SD from at least four independent experiments. c Rat cerebellar astrocytes in 96-well plates were treated by 0 and 30 μMNaAsO2 for 24 h with or without ZCL278 (an inhibitor of Cdc42) pretreatment for 1 h, or a Rac1 inhibitor NSC23766 pretreatment for 12 h, and assessed by a CCK-8. ZCL278 and NSC23766 increased rat astrocytes viability exposed to NaAsO2. All statistical results are expressed as means±SD from at least three independent experiments. **P<0.01 for 30 μM NaAsO2 treatment group, NSC23766 and ZCL278 with 0 μM NaAsO2 treatment group compared with control. &&P<0.01 for NSC23766 and ZCL278 with 30 μM NaAsO2 treatment group compared with 30 μM NaAsO2 treatment group.
Biol Trace Elem Res, 2016, 170(1):173-82. ZCL278 purchased from Selleck.
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Choose Selective Rho Inhibitors
|Description||ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.|
ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. 
|In vitro||DMSO||100 mg/mL (170.97 mM)|
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