Molecular Weight(MW): 584.89
ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
2 Customer Reviews
Rho GTPases were involved in NaAsO2 induced apoptosis in rat CGNs. A. Representative fluorescence images of cells exposed to 0 and 10 μM NaAsO2 for 24 h with or without ZCL278 (an inhibitor of Cdc42), or a Rac1 inhibitor NSC23766. Both ZCL278 and NSC23766 reduced the apoptotic cells. B. The graph indicates TUNEL-positive rat CGNs exposed to NaAsO2 (10 μM) with ZCL278 or NSC23766 groups decreased significantly compared with those of NaAsO2 treatment group. Data are expressed as mean ± SD from at least 5 visual fields. C. Rat CGNs in 96-well plates were treated by 0 and 10 μM NaAsO2 for 24h with or without ZCL278 (an inhibitor of Cdc42) pretreatment for 1 h, or a Rac1 inhibitor NSC23766 pretreatment for 12 h, and assessed by a CCK-8. ZCL278 and NSC23766 increased rat CGNs viability exposed to NaAsO2. All statistical results are expressed as means±SD from at least three independent experiments. ***P<0.001 vs control, # P<0.05, ##P<0.01, ###P<0.001 VS NaAsO2 treatment group.
Cell Physiol Biochem, 2015, 36(4):1613-27.. ZCL278 purchased from Selleck.
b The graph indicates rat cerebellar astrocytes exposed to NaAsO2 (30 μM) with ZCL278 or NSC23766 groups decreased significantly compared with those of NaAsO2 treatment group. Data are expressed as mean±SD from at least four independent experiments. c Rat cerebellar astrocytes in 96-well plates were treated by 0 and 30 μMNaAsO2 for 24 h with or without ZCL278 (an inhibitor of Cdc42) pretreatment for 1 h, or a Rac1 inhibitor NSC23766 pretreatment for 12 h, and assessed by a CCK-8. ZCL278 and NSC23766 increased rat astrocytes viability exposed to NaAsO2. All statistical results are expressed as means±SD from at least three independent experiments. **P<0.01 for 30 μM NaAsO2 treatment group, NSC23766 and ZCL278 with 0 μM NaAsO2 treatment group compared with control. &&P<0.01 for NSC23766 and ZCL278 with 30 μM NaAsO2 treatment group compared with 30 μM NaAsO2 treatment group.
Biol Trace Elem Res, 2016, 170(1):173-82. ZCL278 purchased from Selleck.
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Choose Selective Rho Inhibitors
|Description||ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.|
ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. 
|In vitro||DMSO||100 mg/mL (170.97 mM)|
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