ZCL278

Catalog No.S7293

For research use only.

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

ZCL278 Chemical Structure

CAS No. 587841-73-4

Selleck's ZCL278 has been cited by 12 Publications

5 Customer Reviews

Purity & Quality Control

Choose Selective Rho Inhibitors

Biological Activity

Description ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
Targets
Cdc42 GTPase [1]
()
11.4 μM(Kd)
In vitro

ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(170.97 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 584.89
Formula

C21H19BrClN5O4S2

CAS No. 587841-73-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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