Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NWXkR|l[SXCxcITvd4l{KEG|c3H5 NH3KcWk2OM7:TR?= MWKyOIg> M3[0cYlv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm M4fsNFI3OTZ7MEe1
HGL5 MlXFRZBweHSxc3nzJGF{e2G7 M3yxRlUx|ryP MVWyOIg> MmDnbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NUPkPZNtOjZzNkmwO|U>
HepG2 MYXBdI9xfG:|aYOgRZN{[Xl? M3zxeVIx|ryP MmXJNYg> Mo\4ZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MXSyOlE3PDd7NR?=
BEL-7402 M{TtVWFxd3C2b4Ppd{BCe3OjeR?= MXWyNO69VQ>? MnTxNYg> MlXOZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> NV25cGF6OjZzNkS3PVU>
CEF Mm[4T4lv[XOnIFHzd4F6 M3\G[FAtOzNuNkesNVAx|ryP M1LhZlE2dWmw NGTH[|Vld3ewLYLl[5Vt[XSnczDQVkBmdnq7bXWgZYN1cX[rdImgeI8hPDExvJWgZZQhOTByzszN MorWNlYyODJ|M{m=
SP2/0 NIPr[4xCeG:ydH;zbZMhSXO|YYm= NWnteZFvOTByzszN M4WzdlFp MojLSG1UVw>? MXjicI9kc3NidHjlJIFxd3C2b4Ppd{Bw\iCVUEKvNEBk\Wyucx?= MmexNlYxPzR5M{K=
HUVEC-2c MX7BdI9xfG:|aYOgRZN{[Xl? Mn\WOVDPxE1? M32zOlZp NISzNmNl\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? NXnNdpdEOjZyMkG3Nlk>
U1 NYrF[oxESXCxcITvd4l{KEG|c3H5 MV6wMVExOM7:TR?= NF7SVJozcA>? MWDy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MXqyOVk5ODl2Mh?=
ACH-2 M{HU[WFxd3C2b4Ppd{BCe3OjeR?= MW[wMVIxOM7:TR?= MWKybC=> MWHy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NU\2NZVOOjV7OEC5OFI>
U1 MoPIT4lv[XOnIFHzd4F6 MUKxNFDPxE1? M1WyOVJp MYXpcohq[mm2czDjZZNx[XOnLUO= MmezNlU6QDB7NEK=
A549/V16 NYjJXYVZSXCxcITvd4l{KEG|c3H5 NIjVd2M2OM7:TR?= NYXiU3VPOWh? NWP3WGxZemWycnXzd4V{KFSJL2TNMYlv\HWlZXSgZZBweHSxc3nz M1vzXFI2QTR4MEOz
SGN MWjBdI9xfG:|aYOgRZN{[Xl? MljqNlBuVQ>? MkLGOFhp MYLoZZMhdm9iaX7mcJVmdmOnIH;uJGFKTixiY3HsdIFqdiCneIDy[ZN{cW:wIH;yJINmdGxiYYDvdJRwe2m| NEK4NIgzPTh5NE[zNy=>
HCT116  MWXBdI9xfG:|aYOgRZN{[Xl? Mm\COVDPxE1? M13sVlJp NWTiXVd7cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S NGDDdWMzPTh4OEixPC=>
DTK-SME NEnqdFJCeG:ydH;zbZMhSXO|YYm= MVq1NO69VQ>? NY\6SYNqOmh? NVfn[2N4TE2VTx?= NXHO[pdCeGG{dHnhcIx6KGmwaHnibZR{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBjfXCrdnHjZYlv\Q>? MX2yOVg1Ozh7Nx?=
HL-60 NW\pSVNqSXCxcITvd4l{KEG|c3H5 NVS2V|dRPTEQvF2= NXLHWmVyPDiq NEDQOplz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? MW[yOVgzPDB2Mx?=
U937 MnzXRZBweHSxc3nzJGF{e2G7 Mn\TOVDPxE1? M2T3fFQ5cA>? MnXVdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MkP2NlU5OjRyNEO=
A549 MnjLRZBweHSxc3nzJGF{e2G7 M2PGeVIxKM7:TR?= M2[z[VI1cA>? NWjERXRKemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCKRlPQJJRz\WG2bXXueC=> M134SlI2Pzl2MUS5
HeLa NFvXfIRCeG:ydH;zbZMhSXO|YYm= MmXXNVDPxE1? M{X5XlQ5cA>? MnTQ[IVkdGmwZYOgeIhmKHKjdHWgc4Yh[XCxcITvd4l{KGS{YX3heIlk[WyueR?= NGT5NJUzPTd5MkW0OS=>
SGC-7901 NUnMUnR7SXCxcITvd4l{KEG|c3H5 MoHBNlDDqM7:TR?= MXSxbC=> NWr2UFNKcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBwgGGuaYDsZZRqdg>? NIPwOpczPTd4N{C3Oi=>
MCF-7 Mk\SRZBweHSxc3nzJGF{e2G7 MUOxNO69VQ>? MWqybC=> NE\tSZlqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JFND NFPnRnczPTd{MkGxOC=>
A549 MlqwRZBweHSxc3nzJGF{e2G7 M3q3d|ExKM7:TR?= NVr4NJlFOjSq M{HNfWROW09? M1yyc5Bzd22xdHXzJGhDSy22cnXheIVlKEF3NEmgZ4VtdCC|dYL2bZZidCBoIHH0eIVvfWG2ZYOgeIhmKGOuZXH2[YQhWEGUUDDlfJBz\XO|aX;u MnSyNlU3QDN3Nki=
U87 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLkOVDPxE1? M4r4NFFp MlrPdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 NYHFXYo6OjV4OEG2Olg>
Neocortical Neuron Mo\HUoV2em:2b4jpZ4l1gSCDc4PhfS=> MoHMNVAx|ryP NYD5NHZzOWh? Mne2ZY51[Wexbnn6[ZMhUG:rYX3p[IUhSS2LbnT1Z4VlKE6ndYLveI95cWOrdIm= NFfKU5MzPTZ5NUCwNS=>
Primary human placental cytotrophoblasts MkDoRZBweHSxc3nzJGF{e2G7 MlHIN|DPxE1? M4LhWFI1cA>? NELNVYNFVVOR MknidoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi NF31c3UzPTZ2MkW5Ni=>
MM MoXSRZBweHSxc3nzJGF{e2G7 MmTsOVDPxE1? M4DWUFIxdWmw NIj4WmRx[XK2bImgbY5pcWKrdIOgV2hMNWmwZIXj[YQhKGOnbHyg[IVifGh? MmTiNlU2OzByOUi=
DLD1 MVTBdI9xfG:|aYOgRZN{[Xl? M2HtVlIxyqEQvF2= MWqxbC=> MVjwZZJ1dHlicnX2[ZJ{\XNiY3XscEBieG:ydH;zbZMh[2G3c3XkJIJ6KFeVUEG= NWn4e3BiOjV3MkSyOFY>
MDA-MB-231 NX\WNZJPS3m2b4TvfIlkcXS7IFHzd4F6 M4K5clEx|ryP NGDNNmMycA>? MmLlZZVodWWwdIOgZ4VtdCCmZXH0bEBi\nSncjDDTHVCKHS{ZXH0cYVvfA>? NFThUJEzPTV{MUWwNS=>
MKN28 Ml31RZBweHSxc3nzJGF{e2G7 NIC4S2syOM7:TR?= MoniN|BucW5? M{nocWROW09? NF7HXW1qdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= NHq0WGEzPTVzM{m2NC=>
HL-60 NVHMWmZoS3m2b4TvfIlkcXS7IFHzd4F6 M2\s[|ExOM7:TR?= MXKxbC=> M1P4c2ROW09? MVNCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| M3vWSVI2PTB{OUOy
AGS Mo\YRZBweHSxc3nzJGF{e2G7 M{HxXFEx|ryP M3qzPFFp NUKzcJBVeHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= MU[yOVQ6OjJzNB?=
A549  MYXBdI9xfG:|aYOgRZN{[Xl? MmHZNVDPxE1? NGC3SlgzPGh? Ml\4Zoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp MmLhNlU1OzR7OEm=
INS-1 NFrySVJCeG:ydH;zbZMhSXO|YYm= NFG0VHU2OM7:TR?= MnnIOog> NEXHT5ZFVVOR MkfC[IVkemWjc3XzJJRp\SCycn;wc5J1cW:wIH;mJIViemy7IHHwc5B1d3SrYzDj[Yxte8Li MlG2NlU1OzB6OUe=
Primary hepatocytes  NWK4WZc{SXCxcITvd4l{KEG|c3H5 M4jSVFUx|ryP M4HVZlE5cA>? NGXXdmRqdmirYnn0d{BieG:ydH;zbZMhd2ZiaHXwZZRw[3m2ZYOgbY5lfWOnZDDifUBC[3RiRDDhcoQhXE6ILd8x M4rlXFI2PDB5NUO4
L929-A  NFq3Z4pEgXSxdH;4bYNqfHliQYPzZZk> MVeyNOKh|ryP NUjWOHdlOjSq M1e3U4lvcGmkaYTzJHRPTs7zLXnu[JVk\WRiY3XscEBl\WG2aB?= NH2y[lIzPTN7OEW0NC=>
L929-N NFHDO|ZEgXSxdH;4bYNqfHliQYPzZZk> NWDn[WlLOjEEoN88US=> M1LlfFI1cA>? NWHsO5N3\W6qYX7j[ZMh\GWjdHigeoliKGG3dH;jdolv\SCWTldOtUBxem:mdXP0bY9v NXrweXlPOjV|OUi1OFA>
Cytotoxicity Assay MVPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> Mn;uNlDPxE1? MWS0PIg> NYTNd457eHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= Ml:zNlU{QTJzMU[=
COS7 NIjRW3BMcW6jc3WgRZN{[Xl? NV32cXZCOTEQvF2= NIq3XFMzPGh? NG\CeJRqdmO{ZXHz[ZMh[2G|cHHz[UA{NzdiYXP0bZZqfGmncx?= Ml;pNlU{QDRyMkW=
COS7 NF3lSFVCeG:ydH;zbZMhSXO|YYm= MXuxNO69VQ>? NXjy[HprPDiq NHnuXZBx[XK2aXHscJkheHKndnXueIVlKE[FMUCxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MnjVNlU{QDRyMkW=
A375 M4CzRWFxd3C2b4Ppd{BCe3OjeR?= MVezNO69VQ>? NX3KTYR1Omh? MoHzdJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm MWOyOVM4PjFzNR?=
A549 MVnBdI9xfG:|aYOgRZN{[Xl? M1vBdVUx|ryP MXqyOIg> MUXy[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu MlzmNlU{PDl5OEG=
A549 MoXpRZBweHSxc3nzJGF{e2G7 MYmyMlUuOjYQvF2= M3Lrb|Fp MVTk[YNz\WG|ZYOgeIhmKHCxcIXsZZRqd25ib3[gZZBweHSxdHnjJINmdGy|IHTldIVv\CCxbjDjc45k\W62cnH0bY9vew>? MkmwNlU{PDJ2Mke=
 NBL-W-S  NGmyO4lCeG:ydH;zbZMhSXO|YYm= MXm1NO69VQ>? MXexbC=> NYrHZoNu\nWubImgdoV{[3WnczDj[YxtKH[rYXLpcIl1gSCjZoTldkBISU6WLU[xJJRz\WG2bXXueC=> NVfibmtJOjV|MkOyNlI>
Caki-1  NFTIU3ZCeG:ydH;zbZMhSXO|YYm= M{H1Z|Qx|ryP NYTvblZ2PDiq MWHy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz MWeyOVI4QTF7MR?=
769-P NG\XdWtCeG:ydH;zbZMhSXO|YYm= M3XWb|Qx|ryP NFvFSo01QGh? M3ewbJJm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> Ml\uNlUzPzlzOUG=
H9c2 NFzRRm5CeG:ydH;zbZMhSXO|YYm= Mmj6OVDPxE1? MYexbC=> NH3uSlVqdmirYnn0d{BFV1hvaX7keYNm\CClYYPwZZNmKDNiYXP0bZZifGmxbjDieZQhdm:2IITo[UBtd3O|IH;mJINmdGy| M1PxOlI2Ojh|OEG5
K562 NV\DVlF2SXCxcITvd4l{KEG|c3H5 MnPUOVDPxE1? M4P2NFRp MXzpcohq[mm2czDKZYMuSS2rbnT1Z4VlKGOnbHygZZBweHSxc3nz NHyzcZczPTJ2MU[xPS=>
L929 NYTzOFFKSXCxcITvd4l{KEG|c3H5 MX2xNO69VQ>? M1nLNlZp NEPVSJBqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H M{\jflI2OTl3Nk[w
A549 M4PpZmFxd3C2b4Ppd{BCe3OjeR?= M{G4PFEx|ryP MlTFN4g> M3jLOZJm\HWlZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGDRVS=> MUOyOVE3OTZ7OR?=
MCF-7 M3rHOGFxd3C2b4Ppd{BCe3OjeR?= MlHiNlDPxE1? NFjmUoMzcA>? NIfwfVVl\WO{ZXHz[ZMhU0SULYPpVm5CNWmwZIXj[YQh[XCxcITvd4l{ NEX0SoczPTF6MkK0NC=>
OS MnzURZBweHSxc3nzJGF{e2G7 NInkWGEzOC92MN88US=> NIfGTlQ4Omh? NFfCdY5qdmirYnn0d{BQWyClZXzsJJZq[WKrbHn0fUBz\WS3Y4Tpc44h[nliQ{[gZ4Vz[W2rZHW= NHX3S5ozPTF3MkO5PS=>
HUVECs NX:1ZWlHSXCxcITvd4l{KEG|c3H5 NFTDNGEyOM7:TR?= MViybC=> M4K2ReKhcW6qaXLpeJMh[XCxcITvd4l{KGGwZDDmZYNqdGm2YYTld{BifXSxcHjh[5khcW5iRFXOWlIucW6oZXP0[YQhUFWYRVPz MnjmNlUyOzh5MEO=
EA.hy926 NEK4O|VCeG:ydH;zbZMhSXO|YYm= NILUR5cyOM7:TR?= MonVNog> MmjlxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBGSS6qeUmyOi=> NVvsWIdDOjVzM{i3NFM>
Ebs NVTydZZqSXCxcITvd4l{KEG|c3H5 MVmxNE0yODEQvF2= M4TD[VI1cA>? MWZCpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl NHzSfnYzPTF|NEixOy=>
Jurkat M2O5RmFxd3C2b4Ppd{BCe3OjeR?= NFrxN3AzOM7:TR?= M{f5NlI1cA>? M1fNd2ROW09? M2rsVJBienSrYXzsfUBqdmirYnn0JINmdGxiZHXheIghd2ZiSoXyb4F1KGOnbHzzJIlv\HWlZXSgZpkhOTByNUitSlQh[2:vYnnu[YQhf2m2aDDWVGHDqA>? M{j3OlI2OTJyN{Kz
K562 NVLvTWtiSXCxcITvd4l{KEG|c3H5 MVOwMlEuOc7:TR?= M3XRVVFp NITTR3hqdmirYnn0d{BkdGWjdnHn[UBw\iCKU2C5NEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NGDrXYQzPTFzOUG4PC=>
IMR-32 NWK3cGs5SXCxcITvd4l{KEG|c3H5 M1jYTFQxyqEQvF5CpC=> MViybC=> MmK2[IVkemWjc3WgbY4h[XCxcITveIlkKGOnbHzzJINwdXCjcnXkJJRwKFRvMjD0c5hqdg>? M1LSc|I2ODh2N{W1
RPMI 8226 MVHBdI9xfG:|aYOgRZN{[Xl? NF;t[HoyODEQvF2= NFrieYgycA>? NFzHfXlidG2xc4SgZ49ueGyndHXsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= M3na[VI2ODN5OEWx
U266  MVLBdI9xfG:|aYOgRZN{[Xl? M2HEUVExOM7:TR?= MWOxbC=> NHzXbopx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= MWiyOVA{Pzh3MR?=
H929  MYnBdI9xfG:|aYOgRZN{[Xl? M{XFNVExOM7:TR?= NVi2O214OWh? M4nUOJBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= NE\jdJozPTB|N{i1NS=>
MM.1S  M1vwXWFxd3C2b4Ppd{BCe3OjeR?= MUSxNFDPxE1? NFTCeFQycA>? MYjl[oZq[2mnboTsfUBxemW4ZX70d{B{d3KjZnXubYIucW6mdXPl[EBk\WyuIHTlZZRpKGOxbXLpcoUhf2m2aDDu[YNzd3O2YYTpck0y Ml3iNlUxOzd6NUG=
C6 M1TydmFxd3C2b4Ppd{BCe3OjeR?= NWO3NGlGPTEQvF2= MXi0PIg> MkTXdJJmfmWwdIOgeIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZ4F2e2WmIHL5JJBz\WewZX7vcI9v\Q>? M4rHNVI2ODF|NEe5
AGS MXHBdI9xfG:|aYOgRZN{[Xl? M3i5SVUx|ryP M3vJUlI1cA>? NIOyeW5i[m:uaYPod{DPui2uYYDhZ4hwdmVvaX7keYNm\CClZXzsJIRm[XSqIHHu[EBqdmirYnn0[YQh\3Kxd4To MXKyOVAxQTZ7OB?=
HeLa  M1m2ZmFxd3C2b4Ppd{BCe3OjeR?= NGLPbFM1OM7:TR?= MluzNlRp M4HG[olvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= MX2yOFkzQDZ6NR?=
THP-1  M2DvPGFxd3C2b4Ppd{BCe3OjeR?= NIns[WMyOM7:TR?= MlriNYg> NXPYRXdLemWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCDTFGtV2RVyqB? NV7ndpZzOjR7MkO2OVM>
P815  MVLBdI9xfG:|aYOgRZN{[Xl? M1;uUlExOCEEtV2= MnrlNVJp MVjEUXNQ MmrPbY5pcWKrdIOgeolzfXNvaX7keYNm\CCjcH;weI9{cXN? NGPIRYwzPDl{M{K3Ny=>
HCT116 MULBdI9xfG:|aYOgRZN{[Xl? M2jpOlIx|ryP MkLCNlRp MojBZYJzd2ejdHXzJI9nKFSTLXnu[JVk\WRiYYDvdJRwe2l? MY[yOFg6ODR2OR?=
SW1116  NGXGZlVCeG:ydH;zbZMhSXO|YYm= MWKxNEDDvU1? MYCxbC=> M4PEdWROW09? MV3y[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n M{n1ZVI1QDd2Mki2
LOVO NHjRXFZCeG:ydH;zbZMhSXO|YYm= NGruXZgyOCEEtV2= MX6xbC=> NW\OeGFiTE2VTx?= MljQdoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= MlPsNlQ5PzR{OE[=
SNU449  NHr0UoVCeG:ydH;zbZMhSXO|YYm= MkjlNlDPxE1? M3vlcVQ5cA>? MWrEUXNQ M3nJfoRm[3KnYYPld{BucVJvNEWxMYlv\HWlZXSgZZBweHSxdHnj NF;3[IQzPDh2MU[zPC=>
Caco-2 M{TaemFxd3C2b4Ppd{BCe3OjeR?= MUO0NQKBkc7:TR?= NWnKSI9iPGh? M3T2V5Bz\X[nboTzJHNVNTdvaX7keYNm\CCcTz2xJINp[W6pZYOgZY5lKFSHUjDkdo9x MWSyOFgzOjF6Mx?=
macrophage NVK3UWJ3S2WubDDWbYFjcWyrdImgRZN{[Xl? MVewMVIxOM7:TR?= MUSyOIg> MnHqbY5lfWOnczDUUmYuKGGwZDDSbZA{NWSncHXu[IVvfCCwZXPyc5B1d3OrczDpckBu[WO{b4DoZYdm MXWyOFc6QTV4NR?=
AGS  NV;lToFySXCxcITvd4l{KEG|c3H5 MWKyNO69VQ>? NI\NRmkyOmh? MorUSG1UVw>? NVvNfnN6emWmdXPld{B1cGViaX7keYN1cW:wIH;mJIFxd3C2b4Ppd{BqdiC{ZYPwc45{\SC2bzD0bIUhTXSRQXOg[pJi[3Srb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NYPCN5dOOjR5OEm3NFM>
LCC9  NYmyPFd[S2WubDDWbYFjcWyrdImgRZN{[Xl? NE\PN4MyODEQvF2= MlLNOYQ> M37ycYJtd2OtczDj[YxtKGSnYYToJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25iTEG3JIFv\CClaHzvdo9yfWmwZR?= M3H1fVI1Pzh3MkW2
U937  MoC1coVkem:ydH;zbZMhSXO|YYm= MnzwNVDDqM7:TR?= MXizNOKhdWmw NXPBeYtNcW6mdXPld{Bv\WO{b4D0c5NqeyClb33ibY5mKHerdHigWG5H MoTLNlQ4PzN5NU[=
T cell MlXPR4VtdCCycn;sbYZmemG2aX;uJIF{e2G7 NXrtdWdJOC1zMEFOwG0> NHvWS5k4Omh? Mn;TTWM2OD15MDFOwG0tKGmwaHnibZR{KGGwdHmtR2Q{NWmwZIXj[YQhXCClZXzsJJBzd2yrZnXyZZRqd25iaX6gVGJOS3N? NHv5VZYzPDd4OEewOy=>
HeLa  NFPzXFRCeG:ydH;zbZMhSXO|YYm= NUP4eo9RPTEQvF2= NVjnS4ZvPzKq NVHBepkyTE2VTx?= M1\1RZBz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOxbYDveY5le8LiMfMAl|U> MUeyOFc2PDd6Nh?=
HeLa  NWT6fo01SXCxcITvd4l{KEG|c3H5 NFrDd5YyODEQvF2= NFzRVpEzPGh? MVnzeZBxemW|c3XzJJJifGVib3[gZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KG:4ZYLlfJBz\XO|aX;uJI9nKEd3OWOgc5IhTzdzUjDwNVUx\2y3ZXVCpC=> MUiyOFczOjR4OB?=
IEC-6  MWDBdI9xfG:|aYOgRZN{[Xl? M3LaS|Ex|ryP NInneoQzPGh? NIK1W3hxemW4ZX70d{BV[2SDLXnu[JVk\WRiY3HzdIF{\S1|IHPs[YF3[WenIHHu[EDPui2lYYTlcolvKGSnZ4Lh[IF1cW:w MVSyOFcyOTV5MR?=
HCT116 NX3JZ2U6SXCxcITvd4l{KEG|c3H5 NUDTeHZ6OjEQvF2= NWO4WYdiOjSq NYDpN413cW6qaXLpeJMhfGinIHPlcIwh[XCxcITveIlkKGmwZIXj[YQh[nliWVzUNlA2 NX[3Z2lLOjR5MUO4NVI>
L02 MVLBdI9xfG:|aYOgRZN{[Xl? NV;uPVN5OjEQvF2= NWjaVVZSOWh? MX;wdoV3\W62czD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBOTUiS NF;5O3MzPDdyNkS2NS=>
A375 NYHBOplVSXCxcITvd4l{KEG|c3H5 M3;SWlIx|ryP M2[zTVI1cA>? NIDzcJJz\X[ncoPld{BlcWOrdILpco9v\SCELXnu[JVk\WRiYYDvdJRwe2m| MVSyOFY6QTFzMR?=
HDPC M{DLcWFxd3C2b4Ppd{BCe3OjeR?= M2XrdVUxyrWP MXyyOIg> MVHpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> NWLFfFVJOjR4M{S1PVM>
A549 NWnZOpFnSXCxcITvd4l{KEG|c3H5 MUS1NOK2VQ>? NIjDWVgzcA>? NVzlZ3JpTE2VTx?= NHX4U5lxemW4ZX70d{B1cGViaInwc4RqeGyxaXSgSG5CKGOxboTlcpQheGijc3WgbY5lfWOnZDDifUBk\XCqYXzvZ4hzd22rbh?= NV3lUo1[OjR3OEixN|U>
 BV-2 M17WN2Fxd3C2b4Ppd{BCe3OjeR?= NILZepQzOM7:TR?= MXuybC=> NEn1WIx{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= NISyWokzPDV3OEGxPC=>
HT-29  MlrCRZBweHSxc3nzJGF{e2G7 NFnicXc2OM7:TR?= MlfyOFhp MWjicI9kc3NidHjlJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGujZX3w[oVzd2x? MkPCNlQ2PDlzN{W=
A549 NULJe2M2SXCxcITvd4l{KEG|c3H5 M3HkOVXPxE1? NUTMN5dsOjSq MkfQd5VxeHKnc4Pld{A3\cLiKFLLNVAxPDBrLXnu[JVk\WRiYYDvdJRwe2m|wrC= NVqyfoJpOjR3Mkm4O|E>
MIA-PaCa-2 NULvU2J6SXCxcITvd4l{KEG|c3H5 MlPJNlRp MnvEZoxw[2u|IHPs[YF3[WenIH;mJINie3Cjc3WtN{BqdmS3Y3XkJIJ6KGKxdHigRU01PDN4NUSgZY5lKHCjY3zpeIF5\Wx? NEftXWczPDVzMEm5Ni=>
Caki-1 NXPKeY1nSXCxcITvd4l{KEG|c3H5 M4fOXFIx|ryP MmHJNYg> M3LsfIlvcGmkaYTzJHNEWC2rbnT1Z4VlKGGyb4D0c5Nqew>? MYeyOFUxPDZ6MR?=
CLL Mnm2RZBweHSxc3nzJGF{e2G7 MnjuNlXPxE1? MUOxbC=> M1m4dJBienSrYXzsfUBjdG:la4OgUWxPOjJ|OD3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ Mn3lNlQ1Pjd4M{S=
SGC-7901 NY\lelJuSXCxcITvd4l{KEG|c3H5 NHfLU2QyOM7:TR?= NI[3R3QzPGh? M3P1NpBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? NUPYXIxDOjR2NUS0PFg>
k1735 MXPBdI9xfG:|aYOgRZN{[Xl? MmjTNlDjiIoQvH2= NXvxe49xPGh? M{TSRolvcGmkaYTzxsBU[Wyvb37lcIxiNWmwZIXj[YQh[XCxcITvd4l{ M4q4[FI1PDVzMUG2
HaCaT  MYDBdI9xfG:|aYOgRZN{[Xl? M{fNdlExOM7:TR?= NWq5SlNNOWh? NYXZS45z[my3boTzJHVXSi2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDIZWNiXCClZXzsdy=> MY[yOFM2Pjl7Nx?=
podocytes NVnUSWpLSXCxcITvd4l{KEG|c3H5 MUOyNFDPxE1? NXLkZop5Pmh? M1jDfolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> MVqyOFM{Pzd5Nx?=
 KB MkW3RZBweHSxc3nzJGF{e2G7 M1X1SFUx|ryP Ml\ONlRp M3S4UYlvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u NYrRbZlROjR|M{e0PVI>
 HepG2  NVfPfZd3SXCxcITvd4l{KEG|c3H5 NEexU3UyOM7:TR?= MVqyOIg> NVzKPZh6emWmdXPld{B3cW2nboTpckBkdGWjdnHn[UBk[XW|ZXSgZpkhVFCV MUKyOFMzPThzNh?=
fetal rat lung fibroblasts  M{Xpc2tqdmG|ZTDBd5NigQ>? NHfON4k5OM7:TdMg NXHkSZF1OWh? NFvw[2dqdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? M1jBTlI1OzF2MUO1
PDL fibroblasts Mo\OT4lv[XOnIFHzd4F6 NGf4TZc5OM7:TdMg M1ziV|Fp MUPpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> NWfRfG9FOjR|MUSxN|U>
MB49 M2j3RmFxd3C2b4Ppd{BCe3OjeR?= M3rGW|Ix|ryP NUDJWHJEOWh? MYry[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> M{PWdVI1Ojh{NEOz
5637 MmrZRZBweHSxc3nzJGF{e2G7 MX2yNO69VQ>? NWL5T|ZjOWh? M2LhRZJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MWOyOFI5OjR|Mx?=
A549  M2XrT2Fxd3C2b4Ppd{BCe3OjeR?= M1fmfVExOM7:TR?= NFrsNGo1QGh? NWHKTJlLe3WycILld5NmeyC2aHWgZZBweHSxc3nzJINifXOnZDDifUBxcXCncnnu[eKh M4PYdFI1Ojd{MkCx
MCC-2 MV3BdI9xfG:|aYOgRZN{[Xl? NXOzd2lsOjBizszN NFHwe5Y3cA>? M{[4T2ROW09? MUTicI9kc3NiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5mKGGyb4D0c5NqeyClZXzsJIRm[XSq MlzUNlQzPjJ4NUi=
ADF NI\vRpFCeG:ydH;zbZMhSXO|YYm= NWnVZpRxPDEQvF2= MofLOog> M2LKbYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy NX76UGF[OjR{MkiyN|I>
 U373  MYjBdI9xfG:|aYOgRZN{[Xl? MoXMOFDPxE1? Ml;YOog> MkfhbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NWKxbXdTOjR{MkiyN|I>
RKO-HIPK2i MUXBdI9xfG:|aYOgRZN{[Xl? MlvNOFDPxE1? MlHXOog> M2K3fIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy MmCwNlQzOjh{M{K=
HEC-1B MXfBdI9xfG:|aYOgRZN{[Xl? NGPLdmczOM7:TR?= NFTIO2YycA>? M2\MNJJm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 M13hPFI1OjF|M{W4
4T1 NH7OW|JE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M4LrZ|IvPS1zMN88US=> M3\3S|Rp Mn22SG1UVw>? MmDadoV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= M4S1T|I1OjB4MU[x
OS  MWDBdI9xfG:|aYOgRZN{[Xl? NET5cFczOM7:TR?= Mk\NOIg> NEPLZpJqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgVGRV NV3HZmJHOjR{MES5N|c>
RPE MnGzRZBweHSxc3nzJGF{e2G7 MUmxNFDPxE1? NVrESYtOPDiq Mmr1dIFzfGmjbHz5JIlvcGmkaYTzJJRp\SClYXzwZYlvNTFiYX7kJE0zKGGldHn2ZZRqd25iYYOge4VtdCCjczD0bIUh[2G|cHHz[UBi[3SrdnH0bY9v MYiyOFIxOjB3Mh?=
UD29a M{nrUmFxd3C2b4Ppd{BCe3OjeR?= M{HEflUx|ryP NX3tT2o1OjSq NFK2cllqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgUnVVOw>? NWLFd3FSOjRzOUC1O|Q>
SH-SY5Y  MWDBdI9xfG:|aYOgRZN{[Xl? NF3ORVUyOM7:TR?= M{nVR|I1cA>? MlLVZZR1\W63YYTld{Bk[XOyYYPlJIFkfGm4YYTpc44h[W6mIHPlcIwh\GWjdHigbY5lfWOnZDDifUBJVkVvMlTH Ml\VNlQyPDV2NkO=
HeLa  MkXFRZBweHSxc3nzJGF{e2G7 M3\MNVExNzJyzszN NX7WV5F{OjSq M4L1WYlvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjD0bIUhdWGsb4LpeJkhd2ZidHjlJI1mdWKncoOgc4YhfGinIHPhd5Bie2VvZnHtbYx6 M1[5RVI1OTN5Mk[2
SCCVII  NFrCXlZCeG:ydH;zbZMhSXO|YYm= NGfsbmYzPc7:TR?= Mmj4NYg> MUHpcohq[mm2czD0bIUh[2WubDDrbYxtcW6pIHHmeIVzKGSjc3H0bY5q[g>? M{jXNVI1OTJ4NE[0
RAW 264.7 MVTBdI9xfG:|aYOgRZN{[Xl? NUDt[ZZ2OjEQvF2= MlX5NVhp M4jvS4lv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? MWqyOFEyPjdyNx?=
A549  NETneG5CeG:ydH;zbZMhSXO|YYm= NGGzWmIzNjYQvF2= NFTORpczPGh? NH3sbYxl\WO{ZXHz[ZMhd3KrZH;ubY4ucW6mdXPl[EBifXSxcHjh[5kh[XNid3XscEBidmRiTH;zd{Bw\iEQlN-IcUBidHOxIH;jZ5VzemWmIHT1dolv\yCjdYTvdIhi\2mlIIDyc4Nme3N? NFrrTnMzPDFyMkWyNi=>
UM-SCC-10A  MVTBdI9xfG:|aYOgRZN{[Xl? NX:3THNKPTEEtV2= M3TleFJp Mn7XdoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBpcWeqLXTvd4UhcXOxYXzhcpRwdGGldH;u[S=> NHLMNYQzPDB7OEe1Ny=>
BGC-823 NH;JflBCeG:ydH;zbZMhSXO|YYm= M{n2WFExKM7:TR?= M4izeVI1cA>? M4jmO5Jm\HWlZYOgeIV1emGwZILpcoUucW6mdXPl[EBieG:ydH;zbZPDqA>? NW\qOVg1OjRyOUi1NVE>
Nalm-6  M13mW2Fxd3C2b4Ppd{BCe3OjeR?= M{PYWVIx|ryP NWm0RldLPGh? MWjpcohq[mm2czDjZZNx[XOnLUigZY5lKGOjc4Dhd4UuOyCjY4TpeoF1cW:wIHHu[EBRSVKSLUGgZ4xm[X[jZ3W= MUCyOFA{QTl4Nx?=
KHOS  MkjmRZBweHSxc3nzJGF{e2G7 NF\rXFM1OM7:TR?= M2f2WFI1cA>? M1vDPYJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= M1rWblI1ODJ3M{[x
G292 M1vFV2Fxd3C2b4Ppd{BCe3OjeR?= M1PsdlQx|ryP NFnvXIMzPGh? MljmZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= M2HOXFI1ODJ3M{[x
MG-63 MUPBdI9xfG:|aYOgRZN{[Xl? MVq0NO69VQ>? NULHWpBbOjSq NHnO[HpjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg NGnFPJQzPDB{NUO2NS=>
EBV-transformed B cells NFrSfG5CeG:ydH;zbZMhSXO|YYm= MUeyNO69VQ>? MU[ybC=> M{fs[2ROW09? NIXrdFRjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? NXT5T4JTOjRyMEi2Nlg>
IM-9 B MWnBdI9xfG:|aYOgRZN{[Xl? MXqyNO69VQ>? NWjmRYsyOmh? M2L0PGROW09? MVricI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> Ml:yNlQxODh4Mki=
CNE1 M1nhOWFxd3C2b4Ppd{BCe3OjeR?= MUSyNO69VQ>? NYrKeosyPDiq MWjicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NF;wbJczOzl6NUCyPS=>
CNE2 NGfjbJNCeG:ydH;zbZMhSXO|YYm= M2\OflIx|ryP NHrwN5M1QGh? MknQZoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> M4ewTlI{QTh3MEK5
HL-60 MU\BdI9xfG:|aYOgRZN{[Xl? NVGzemlDPTEEtV2= MUmxbC=> MX3EUXNQ M1HNbIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKDMUS1 NX74epNkOjN7NEi3OVE>
L929 NETRb3VCeG:ydH;zbZMhSXO|YYm= NYG1SpFmOS5{NfMAl|XDqM7:TdMg NXywTHExOjSq M2jIUIF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? NHe2b4EzOzl2MUe2PS=>
Jurkat MnHNR4VtdCCYaXHibYxqfHliQYPzZZk> MnLrNu69VQ>? NHfHb|M1cA>? MYHy[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? NEC2UHYzOzh7NkC2NS=>
RAW264.7  Mon4RZBweHSxc3nzJGF{e2G7 M33JSlExKM7:TR?= MUOyOIg> MkLQ[IVkemWjc3XzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDHRS=> NFHn[W0zOzh{MEKwNy=>
A431  M4riVmtqdmG|ZTDBd5NigQ>? M1TjeVQx|ryP M2LkfFJp NX;6b|R{[myxY3vzJIZqe2W2aX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPld{BidmRiUFHSVC=> NXLKT3p7OjN6MECwOVg>
Jurkat NG\XU5pE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NX;tSI1OOjVvMUCw{txO NW\wVIU{Pmh? NGPkO3hqdmirYnn0d{B7NU[DLVPNT{1qdmS3Y3XkJINmdGxiZHXheIg> MmHsNlM6OzN3M{K=
COS-7  MkLwSpVv[3Srb36gRZN{[Xl? NG\OO4Y2OML3TR?= NVfaeXBNOjSq M4K1XYFn\mWldIOgeIhmKHC{b3Pld5Nqdmdib3[gRXRPOXNid3n0bEBxd2y7UTD0doFkfHN? MX2yN|k{OzJyOB?=
CAL27 MoO5RZBweHSxc3nzJGF{e2G7 MV6xNEDPxE1? MmmyNog> MVvzeZBxemW|c3XzJGN2ei2QUIOtdoVlfWOnZDD2bYFjcWyrdImgZpkhfXBidH:gPVAm NHu5XXAzOzlzN{O5Oi=>
THP-1  NXPHcFN[SXCxcITvd4l{KEG|c3H5 NGD6TW4yOC13MN88US=> M2K4dlJp MYLpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1emmydH;sbYRm NYixNFNFOjN7MECyPVk>
K562 Ml70RZBweHSxc3nzJGF{e2G7 NGnSXpczOM7:TR?= MnG5OFhp MXXpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X MWqyN|g4Pjh{Nh?=
HL-60 NYS0cG02SXCxcITvd4l{KEG|c3H5 M1;xOFExOM7:TR?= MnnZNlRp NF7oT2RqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= MX:yN|g3PTd5OB?=
HeLa  MmPwRZBweHSxc3nzJGF{e2G7 NIH0cZkzOM7:TR?= MUmybC=> NGPWT3RqdmirYnn0d{BFVU2SIHnu[JVk\WRiYYDvdJRwe2m| M3XoNFI{QDZ|OU[2
U251 NWLpc2JUSXCxcITvd4l{KEG|c3H5 MW[yNO69VQ>? MkT1NlRp MlvRbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ NXzUUHk2OjN6MU[4NVY>
HL-60 M2WwWWFxd3C2b4Ppd{BCe3OjeR?= M2jUeFUxyrWP NF7mV2w1cA>? MlTNZoxw[2u|IITo[UBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID25MEBidmRiUFHSVEBqdmS3Y3XkJIJ6KD[| M3TRbFI{QDB2N{C2
Ec-109 NIr4bFNCeG:ydH;zbZMhSXO|YYm= MoS5NVAh|ryP MYO0PIg> MlnWdoVxemW|c3XzJHBGNW2nZHnheIVlKEWlLUGwPUBk\WyuIHHwc5B1d3Orcx?= M3HBVFI{Pzh{NkSx
RKO MmXFR4VtdCCYaXHibYxqfHliQYPzZZk> MVSxNEDPxE1? MX2yOIg> MXHpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= NY\Id|AxOjN5NUiwOlQ>
T98G NF\HbItE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M2f0SlEuOTByzszN MVGyOIg> M1;LPIlueHKxdnXzJINmdGxidnnhZoltcXS7IHPveJJm[XSvZX70JJdqfGhiVGO= M3z2TlI{PzZ7Mke1
Jurkat NVzVdoVJS2WubDDWbYFjcWyrdImgRZN{[Xl? MWCxNFAuOjByzszN NIPsfVQzPGh? MUnpcohq[mm2czDIZWE1KGmwZIXj[ZMh[XCxcITvd4l{KGSncHXu[IVvfCCxZjDjc45k\W62cnH0bY9vyqB? MWCyN|c{OjR6MR?=
Molt-3  NXO1cJhUSXCxcITvd4l{KEG|c3H5 Ml3yOVDPxE1? MkTQNog> NEfq[pZz\WS3Y3XzJI1mdGG2b37pck1qdmS3Y3XkJIFxd3C2b4Ppdy=> MkXRNlM4OjVyMUO=
hMSC12 M{K0[2Fxd3C2b4Ppd{BCe3OjeR?= NEHafG4yODEQvF2= MnnFOIQ> MnTsbY5pcWKrdIOgc5N1\W:pZX7pZ{BkfWy2dYLlMYlv\HWlZXSgZ4VtdCCmZXH0bEBidmRiY3HsZ4lncWOjdHnvci=> M2D0Z|I{PjV5OEKy
HM7  MnzqRZBweHSxc3nzJGF{e2G7 M3v0OVIx|ryPwrC= NYH5WnJMOWh? MUTicI9kc3NiYYDpZ5Vt[XKnbjDBJIFk\XSjdHWtbY5lfWOnZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVEBkdGWjdnHn[S=> MXuyN|U5OzRzMh?=
Hep-2  M2XON2Fxd3C2b4Ppd{BCe3OjeR?= NVXnOYJ2OjEQvF5CpC=> M1nsdFI1cA>? MnSxSG1UVw>? M37BZ4FtdGW4aXH0[ZMhfGinIHTlZ5Jm[XOnIH;mJINmdGxidnnhZoltcXS7IHnu[JVk\WRiYomgd4ltcWKrbnnu M4TIb|I{PThyMEOy
HSCs MXfBdI9xfG:|aYOgRZN{[Xl? NF33SYs2OM7:TR?= M{TkXFI1cA>? Mof4SG1UVw>? NE[w[nFqdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm MlLhNlM1QTl6N{S=
HL-60  NHy2[G1EgXSxdH;4bYNqfHliQYPzZZk> NEXWSowzOM7:TdMg MlHzNlRp NULnT3ozemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 NUPzOm1lOjN2OUS0PFA>
HA M1zqO2Fxd3C2b4Ppd{BCe3OjeR?= NHToRXQ2OM7:TR?= MkPkNlRp NETicJh{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? Mn;wNlM1PzV7NU[=
C666-1 M2nrTmFxd3C2b4Ppd{BCe3OjeR?= NWL1SWpYPTEQvF2= Ml7NNlRp NITNWVl{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? MVqyN|Q4PTl3Nh?=
Hepa1-6 M4PVfGFxd3C2b4Ppd{BCe3OjeR?= MkLaOVDPxE1? NFvSXIozcA>? NYnUVZR4cW6qaXLpeJMh[3W{Y4XtbY4h[W6mIILld5ZmemG2cn;sMYlv\HWlZXSgZZBweHSxc3nz NHuwcIEzOzR2Nke1Ny=>
PLC/PRF/5c M3\USGFxd3C2b4Ppd{BCe3OjeR?= M2jSWFUx|ryP MUSxbC=> M4nXcpBz\X[nboTzJIFxd3C2b4Ppd{B1emmpZ3Xy[YQh[nliQ1nO M4HDRVI{PDN6OEK0
HCT116 NFTze|hCeG:ydH;zbZMhSXO|YYm= MmDBNVAx|ryP NV\lOoRrOS53aB?= MnvMbY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp M2HNN|I{PzR2M{Wz
HCEC M4S5TWZ2dmO2aX;uJGF{e2G7 NWjGdGFOPTEQvF2= MoHHO|Jp MWTEUXNQ M{L0O5Jme3SxcnXzJI9nKHSqZTDuc5Ju[WxiSFPFR{BxcGWwb4T5dIU> NVHVNFlrOjN5NEKwNVE>
Primary rat cerebral cortical neurons NWDDXFFVSXCxcITvd4l{KEG|c3H5 MYixNFDPxE1? NF7IUXkycA>? NYHIRok{eHKndnXueJMhS2RvaX7keYNm\CCjcH;weI9{cXNiYX7kJINmdGxiZHXheIg> Mkf5NlM4PDF|MUe=
MDA-MB-231  MV;BdI9xfG:|aYOgRZN{[Xl? Mm\5NlXPxE1? NXXsXmRuOjSq NUG0eJZD[WK{b3fheIV{KGO7dH;0c5hq[2m2eTDhcoQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgVoc{ NFLOSmMzPTN|N{W0OC=>
NLRP3-Tet-on-MC/9  NHPzOIZCeG:ydH;zbZMhSXO|YYm= NEjkTXcyOC12MN88US=> MkfxNVJp NILvTWNifHSnboXheIV{KHSqZTDj[YxtKGSnYYToJINifXOnZDDifUBESVCVLXHzd49kcWG2ZXSgUmxTWDNibYX0ZY51eyCrbjD0bIUhXGW2LX;uJJN6e3SnbR?= MoPVNlM4ODN|OEm=
KNS42  NWjnNnpRSXCxcITvd4l{KEG|c3H5 NUDvVHdsPTEQvF2= NGC1R40ycA>? MUXy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGOxbYDs[ZRmdHliYXLvcIl{cGWmIHPhd5Bie2ViMz:3JIFkfGm4aYT5JIlvKHKnc4DvcpNmKHSxIFHCWE0zPjNxMlTHM41mfG[xcn3pckBkd22kaX7heIlwdg>? NFS0flYzOzZ7MUG0OS=>
MCF-7  NUnPcIRRSXCxcITvd4l{KEG|c3H5 MU[yNO69VcLi NVWweldZPzKq MYHpcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= M1;XNFI{Pjd3NkSz
hCMEC/D3  NGPZ[YdCeG:ydH;zbZMhSXO|YYm= NXWye4t3OjYQvF2= MnvNO|Jp MX7y[YR2[2W|IFz0fGEhcW6mdXPl[EBieG:ydH;zbZM> M1TlOlI{PjZ3MUm4
Jurkat M17qWGFxd3C2b4Ppd{BCe3OjeR?= NFTQZ4MyOi53LUWw{txO MnzrNYg> M1q0TIRwe2ViZHXw[Y5l\W62bImgd5VxeHKnc4Pld{BUWEhvaX7keYNm\CCSYYKtOEBkdGWjdnHn[UwhWEGUUDDjcIVifmGpZTygSG5CKG[{YXft[Y51[XSrb36sJIFv\CCub4PzJI9nKH[rYXLpcIl1gQ>? M4nNXFI{PDR{OUe2
CNE-1 MXjBdI9xfG:|aYOgRZN{[Xl? MUCyNO69VcLi M3G5clI1cA>? MWLpcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq M1nmTVI{PDJ4OEWw
HONE-1 NG[wN|hCeG:ydH;zbZMhSXO|YYm= NILXU2czOM7:TdMg NILseGIzPGh? MYLpcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq M2XKe|I{PDJ4OEWw
astrocytes cell NESyUIhCeG:ydH;zbZMhSXO|YYm= MV[0NO69VQ>? MWC2bC=> NIHZeGpz\WS3Y3XzJIViemy7IHHwc5B1d3OrczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmV? NEP0cIgzOzRzMUe3PC=>
U-937 NFfGR29CeG:ydH;zbZMhSXO|YYm= MkLzNVDPxE1? NYrWeHJXOzCvaX6= MmjXdJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? MmKzNlM1OTB5NEi=
MDA-MB-231 NVrnTZFISXCxcITvd4l{KEG|c3H5 NUn4TJVSOTByzszN MnTiNYg> MlzibY5pcWKrdIOgd4Vve2m2aYrheIlwdiC2bzDUVmFKVCC3cH;uJG1VTEhiZH;3ck1z\We3bHH0bY9v NWXv[XljOjN2MEi0Nlk>
HeLa  MoGzRZBweHSxc3nzJGF{e2G7 NGHVZ5IyODEQvF2= MVeybC=> NXS1dldX[myxY3vzJGpTWy1zNTDJcoR2[2W|IFHwc5B1d3SrYzDD[YxtKESnYYTo Mn\UNlM{PDRyNEW=
Ec109 MXXBdI9xfG:|aYOgRZN{[Xl? NXnzU49zOTEQvF2= M2\ie|Zp NEPBRXJjdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? MX:yN|M{QDV4OB?=
H460  M3TPVGFxd3C2b4Ppd{BCe3OjeR?= MmroNVDPxE1? NX7uOIVDPmh? M4flWYJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v NEnreWMzOzN|OEW2PC=>
HeLa  MXPBdI9xfG:|aYOgRZN{[Xl? NY[wZXZbPTEQvF2= M3nyTFEvPWh? MUjhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NHTJRlQzOzNyM{iwOC=>
SK-HEP1 NFPlc2ZCeG:ydH;zbZMhSXO|YYm= MUKxNFDPxE1? MXGxbC=> M4D6N4lvcGmkaYTzJGNzXDFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVctKC16LDCtPUwh[W6mIIDvcJkpSUSSLYLpZo9{\SlicH;sfY1memG|ZR?= Mlz0NlM{ODJ4NUC=
QGY7701 M1TyfGFxd3C2b4Ppd{BCe3OjeR?= NHW5[|kzPc7:TR?= MoXnNU42cA>? NEfoZ45qdmirYnn0d{Bi[2O3bYXsZZRqd25ib3[gd5VjNUdzIIDoZZNmKGmwZIXj[YQh[nliRF;YJEsheXWncnPleIlv M1G5fVI{OjRyME[x
HepG2 NULUSVB4SXCxcITvd4l{KEG|c3H5 MVSyNO69VQ>? M3uxTlMxdWmw NVfxOog4cW6qaXLpeJMhfGinIHXubIFv[2WmIHPlcIwh\GWjdHigZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIHHwbYdmdmmwIHHu[EBVWkGLTB?= MUSyN|IzPDJ|OR?=
U87  M1[2dWFxd3C2b4Ppd{BCe3OjeR?= NHju[48zPc7:TR?= M4TSe|Jp MUnk[YNz\WG|ZYOgbZNwdGmzdXnybZRq\2WwaX6gLGlUVClvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aDygZpV1KG6xdDDu[YNzd3SrYzDj[YxtKGSnYYTo NV25TmJMOjN{Mkm2NlY>
HSC-2 Mm\VRZBweHSxc3nzJGF{e2G7 NEXoSoMzPS93MN88US=> M{nlPFFp MnfLbY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= MoHnNlMyPTV{NEi=
HSC-4 NYjyfFl{SXCxcITvd4l{KEG|c3H5 MUiyOU82OM7:TR?= NV\oboZrOWh? MlvrbY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= NWDr[HljOjNzNUWyOFg>
CL-1 MWHBdI9xfG:|aYOgRZN{[Xl? MVSyNO69VQ>? NXHSPW9WOWh? MmnBZoxw[2u|IF;QOFQ6KGmwZIXj[YQh[2WubDDk[YF1cA>? NGW4bZAzOzF|MUe4Ni=>
MEL NFXvdXFCeG:ydH;zbZMhSXO|YYm= NWDBSlZpOjEQvF2= NHy5[W0zPGh? NVTWcJpYTE2VTx?= NWrRW|A{cW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= MWSyN|AyPDh6Nx?=
Bel-7402  NVrue|ZRS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 NHPtO5c2OM7:TR?= MYGybC=> MnnBbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NHGwe40zOzByOEe0Ni=>
Eca-109 MVvBdI9xfG:|aYOgRZN{[Xl? MUGyOe69VQ>? M3vqSlMxdWmw MU\pcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq MojyNlMxPzZ7Nke=
MEL MoDGRZBweHSxc3nzJGF{e2G7 MkHNNlDPxE1? M4LFe|Fp MV3EUXNQ NGTsS5lqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| Mn7VNlMxOTR6OEe=
Bel-7402  NWPXT2dXSXCxcITvd4l{KEG|c3H5 NYrJPZZJPTEQvF2= NVvnO2Z3Omh? M3:yfolvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NFPKcI0zOzByOEe0Ni=>
L929 MWLGeY5kfGmxbjDBd5NigQ>? M4GzUlIvPc7:TR?= MYexbC=> NV\Nd3p[cW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? M3\4SlI{ODByNUG4
RCC  M1WwbmNmdGxiVnnhZoltcXS7IFHzd4F6 MorHNVAx|ryP NH3tfHAzPGh? MYHy[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ NUftVlZuOjJ7OUG0PVQ>
NB2a/d1 MkP5RZBweHSxc3nzJGF{e2G7 NFnoN3EyODEQvF2= NFXpflY4Omh? M3XPWYF1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> NXHU[nA6OjJ7OEi1OFE>
T cell NVz5cYp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qyTVI2NTFyMN88US=> NX\KSWxzOjSq MXnkc5NmNWSncHXu[IVvfGy7IHnubIljcXSnZDDUJINmdGxicILvcIln\XKjdHnvckBu\WSrYYTl[EB1cHKxdXfoJJRp\SClbz3zeIlufWyjdHnvckB4cXSqIHHueIkuS0R|IHHu[EBidnSrLVPENlg> M4DDcFIzQTh{NUO4
K562 NI\zWmtCeG:ydH;zbZMhSXO|YYm= MYOxNFDPxE1? MnXkNYg> NIKxdoxjdG:la4OgRYJvd2KjdnnzZ5VuyqCILXnu[JVk\WRiYYDvdJRwe2m| NHf4dmczOjl5MkO3Ni=>
Jurkat  MmG4RZBweHSxc3nzJGF{e2G7 MnLzOFDPxE1? MmP6NYg> M1fpbYFjd2yrc3jld{BH[XOOLXnu[JVk\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp MlvCNlI6PDJ5M{i=
BGC-823 NH31UFVCeG:ydH;zbZMhSXO|YYm= M17PdFExOM7:TR?= NY\YVlQ3OWh? MkD2dIFzfGmjbHz5JJJme2O3ZYOgZ4VtdHNiYXfhbY5{fCCmYX3h[4Uhd2ZiZHHp[JpmcW5? M{TEfFIzQTJ4NUS1
Hep3B NGHCbm9CeG:ydH;zbZMhSXO|YYm= NUfofFRSPTEQvF2= M{GxV|Fp MVjicI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? NEm3TVAzOjl{M{G1OC=>
LLC-PK1 NGnDd3NCeG:ydH;zbZMhSXO|YYm= NF;zVJEzOM7:TR?= NX:1[2JNOWh? NHr3R2txemW4ZX70d{BkcXOybHH0bY4ucW6mdXPl[EBl\We{YXTheIlwdiCxZjDBeIc2NCCkZXPsbY4uOSxiYX7kJGF1\zF{IIDyc5RmcW6| Mo\VNlI5QTZyM{e=
A549 M13Cc2Fxd3C2b4Ppd{BCe3OjeR?= NXru[o11PTEQvF2= MXmxbC=> MYLicI9kc3NidHjlJGJCUS2rbnT1Z4VlKGGyb4D0c5Nqe8Li MnfONlI5QDd{MUW=
SGC-7901  NXTDbFVQSXCxcITvd4l{KEG|c3H5 NEnTUI0yOM7:TR?= MX6yOIg> M2\SOIlvcGmkaYTzJO6zNM7{LXTpcYV1cHmuYXPyfYx{cGmtb37pck1qdmS3Y3XkJIFxd3C2b4Ppd:Kh MXOyNlg1QDV7Nx?=
DM6 MoDCRZBweHSxc3nzJGF{e2G7 NFLiRlMyODEQvF2= M2P6flczcA>? MVPicI9kc3NiYn;0bEBGOkZvMTDhcoQhTTKIdIKtcYVlcWG2ZXSgZ5l1d3SxeHnjbZR6 MVSyNlgzPTN{OB?=
MCF-7, MDA-MB-468, Caco-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XMbVUx|ryP MUS0PIg> NETQVW5qdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBqdmS3Y3XkJIJ6KHOjcH;ubY4> MXGyNlgxODl4OB?=
A2750  NHrtToRCeG:ydH;zbZMhSXO|YYm= MofFNlDPxE1? MmjiNog> NFHG[HhFVVOR M1jH[4Jtd2OtczDjZZNx[XOnIHPs[YF3[WenIHT1dolv\yCqZXzlcoFtcW5idILlZZRu\W62IHHu[EBz\WS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? NGSzfXYzOjd6NEO2Ny=>
U87  MUDBdI9xfG:|aYOgRZN{[Xl? M33mdVIx|ryP NUfke5BQOjSq NYew[HFKemWmdXPld{B1cGViYYDvdJRwe2m|IILheIUhcW6mdXPl[EBjgSCSTFHC NHm0No0zOjd5OEe4NC=>
HT1080 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[xU|Ux|ryP MmewO4Q> MoDKbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZ4F2e2WmIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCGQ1GgZY5lKE:PUB?= Mn;4NlI4PDB7OES=
A549  NYDjNYVYSXCxcITvd4l{KEG|c3H5 Mnr6OVDPxE1? MnvENog> NWXxN49jeGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> MXOyNlczOThyNB?=
Primary OPC Mo\wRZBweHSxc3nzJGF{e2G7 MnHtNe69VQ>? NGTmPIE3cC9{NHi= MljidoVlfWOnczD0bIUheGW{Y3XueIFo\SCxZjDj[YxteyCrbjDlZZJtgS1iYX7kJIxifGVvYYDvdJRwe2m|L37lZ5Jwe2m| NX\IT5FjOjJ5MEezPFU>
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A549  Mn;GRZBweHSxc3nzJGF{e2G7 M{P3cVUx|ryP MWmxbC=> MoL3dJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSmGxaIXvd4ll\SCL MWOyNlY5PzZ|NR?=
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shC9  MniyRZBweHSxc3nzJGF{e2G7 MknYNVDPxE1? M120N|E3cA>? NUf1dJV2[my3boTzJHNJUCCneIDy[ZN{cW:wIHnuJJNpSzliY3XscJMh\Xiyb4Pl[EB1dyCnaYTo[ZIhWEFib4KgUHBE NHHEOGczOjZ2MUC5OC=>
primary MEFs Moe2SpVv[3Srb36gRZN{[Xl? M2Tze|EzcA>? NX;sN4hJyqCrbnPy[YF{\XNiZYTvdI9{cWSnLXnu[JVk\WRibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBl\XCxbHHybZpifGmxbh?= M3PYR|IzPjF|N{[3
3T9 MEFs NXLLelFqTnWwY4Tpc44hSXO|YYm= MV:xOog> NWj0[Gg1cW6lcnXhd4V{KGO7dH;jbJJwdWViYzDy[Yxm[XOnIHHmeIVzKGW2b4Dvd4ll\S22cnXheI1mdnR? MlzCNlI3OTN5Nke=
3T9 MEFs NELSeVlHfW6ldHnvckBCe3OjeR?= NXzs[JpIOTiq NEX3fI92eHKnZ4XsZZRmeyCrbnn0bYF1d3JiY3HzdIF{\S17IHL1eEBld3ewcnXneYxifGW|IHXm[oVkfG:{IHPhd5Bie2W|IHHmeIVzKGW2b4Dvd4ll\SC2cnXheI1mdnR? NYXSOlZsOjJ4MUO3Olc>
MDA-MB-231  MkL0RZBweHSxc3nzJGF{e2G7 M1LoO|Ix|ryP NUXIb2YyPGR? Mk\jdoVlfWOnczD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBu\XSob4LtbY4hfHKnYYTt[Y51KHejczDzbYdvcW[rY3HueIx6 NH3tNlIzOjV7M{S0NS=>
C6  M2[4eGFxd3C2b4Ppd{BCe3OjeR?= NF;KNFIyOM7:TR?= NXH6e3BsOjSq MlfHZoxw[2u|IITo[UB{fXCycnXzd4l3\SCnZn\lZ5Qhd2ZidHjlJJBmeHSrZHWgc44hfmmjYnnsbZR6 NIDa[VYzOjV6OEm4NC=>
HL-60  NIfqNIpCeG:ydH;zbZMhSXO|YYm= NVrad2lPOTByzszN MofDNlRp NXPzPVJVcW6qaXLpeJMhfGinIHPlcIwh[XCxcITvd4l{KHOnbHXjeIVlKChtKT3t[Y51cHmuIN8yMUgy6obUNjmt[IlodHWlb4D5doFvd3OrZHZCpFU> NWPreHMyOjJ3NE[2Olk>
HL-60 M4rKcGFxd3C2b4Ppd{BCe3OjeR?= M1rxSFExNThyzszN Mlr5OIg> NYHzVHlKcW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? NYXRN3F2OjJ3MkOyNlk>
BCC NH7Qc3FCeG:ydH;zbZMhSXO|YYm= NFXvZmk2OM7:TR?= M3TDPVFp M{HwSYlvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? NXG0UJB2OjJ3MUm0N|Y>
RAW 264.7 NFHPOIRCeG:ydH;zbZMhSXO|YYm= MY[1NE8yODEQvF2= NVzYXZI5OWh? Ml\BZ49v[2WwdILheIlwdi2mZYDlcoRmdnRiaX7obYJqfHNiRF;OMYlv\HWlZXSgdnJPSSClbHXheoFo\Q>? NIjiT24zOjR7MUSyOi=>
K562 NG\Sc5JCeG:ydH;zbZMhSXO|YYm= MUGyOe69VQ>? MWCybC=> MYfwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkdy22cnXheI1mdnRid3n0bEBidXW{ZX7zbY4hTyCjbnSgWHJCUUx? M3PwOFIzPDh|N{e3
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PC3 M4DlVWFxd3C2b4Ppd{BCe3OjeR?= M{\EUVEx|ryP M33HdlRp M4XtcYNwfW62ZYLzJIZt[X[xY3;4bYQucW6mdXPl[EBk[XOyYYPlMZJmdGG2ZXSgZZBweHSxc3nz M3vqbFIzPDdzOUe0
SMMC-7721 NYLmS|l3SXCxcITvd4l{KEG|c3H5 NXfSfIlUPTEQvF2= Mm\1OFhp MorDZZR1\W63YYTld{BwXFJvaX7keYNm\CCjcH;weI9{cXN? MWiyNlQ3PTh|Mx?=
HeLa  MWnBdI9xfG:|aYOgRZN{[Xl? M1Xkd|UxyqEQvF2= MVG0M|hp MXrpcohq[mm2czDTWHMucW6mdXPl[EBt[XSnLYDoZZNmKGGyb4D0c5Rq[yCndnXueJM> M3TaVFIzPDZyNUC0
HeLa  MoraRZBweHSxc3nzJGF{e2G7 M1jnXVUxyqEQvF2= NWTTUFJWOWh? MVrzeZBxemW|c3XzJJRp\SCIUlHQMYlv\HWlZXSgZYNkfW23bHH0bY9vKG:oIHHucoV5cW5iVjDwc5NqfGm4ZTDj[Yxtew>? Mnr3NlI1PDl2NEC=
T47D  MVzBdI9xfG:|aYOgRZN{[Xl? MYmxNFDPxE1? NH;WZYkycA>? MWHicI9kc3NidHjlJIdmdmW{YYTpc44hd2ZiRT3jZYQwS1SIMjDifUBUXFN? MkXXNlI1ODFzNki=
HeLa  M4LVZmFxd3C2b4Ppd{BCe3OjeR?= NYLPT4Y4OzEQvF2= NH;4cY01cA>? MXNCpIlv[3KnYYPld{B1cGViZ3Xu[ZJidCClZXzsJJZq[WKrbHn0fUA1QCCqIHHmeIVzKHCqb4Tv[Jlv[W2rYzD0doVifG2nboVCpC=> NYftb4c2OjJ|OUSyOFg>
HCC MWHBdI9xfG:|aYOgRZN{[Xl? NGrsOFUzOCEQvF5CpC=> MYSybC=> MlvNZZR1\W63YYTld{B1cGViRFjBJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCSQWLQ NGK4[GgzOjN2MkezNi=>
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EMT-6  M4PiRmN6fG:2b4jpZ4l1gSCDc4PhfS=> NEjtdnUyODEQvF2= NVfHbmZKOWh? NG\iVFVx[XK2aXHscJkh[myxY3vl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nlic3nyZY1me2mwZR?= NYXSSJU3OjJ{NUG5NlE>
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Molt4-hyg M3fLUmFxd3C2b4Ppd{BCe3OjeR?= NW\pbJFtOTEQvF2= M3zERlAvPWh? NUmzfGx6[myxY3vzJIZiem6nc3;sMYlv\HWlZXSgZ4F{eGG|ZT2zMYxqc2ViYXP0bZZqfHl? NVe5UFVUOjZ{N{W4NVE>
HeLa NWLYcJQ1SXCxcITvd4l{KEG|c3H5 NGXtfmsyOM7:TR?= NY\P[lRoOC53aB?= NGjGN4tqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2aHWgZ49u[mmwZXSgeJJm[XSvZX70JJdqfGhiZ3;tbZNqdiCQIHHu[EBVWkGLTB?= NVPLR3NOOjJzN{m2OlE>
Jurkat T NHLDOpdCeG:ydH;zbZMhSXO|YYm= MoHSN|DPxE1? MW[wMlVp NV:3fIN2TE2VTx?= MWficI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| NGTNfoMzOjF3OUi5PC=>
Neutrophil M4DCcmFxd3C2b4Ppd{BCe3OjeR?= MX6yNO69VQ>? M2LLNFAvPWh? MojjZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= NEToXJUzPjF7Nki0OC=>
HCT116 MkXVRZBweHSxc3nzJGF{e2G7 MmjSOVDDqM7:TR?= MmLaNog> MlzsdoV3\XK|ZYOgd5lv\XKpaYP0bYMh[XCxcITvd4l{KGWoZnXjeJMhd2ZiY3Xs[YNwgGmkIHHu[EBPWENvMUdCpC=> NE\WUnIzOjF3OUe1Ni=>
MDA-MB-231  MnjSRZBweHSxc3nzJGF{e2G7 NWjSXIZKOi53LUeuOe69VQ>? NG\CUVIzcA>? NYDhZVJucW6qaXLpeJMhfGinIHPlcIwh\GWjdHigc4YhVUSDLV3CMVI{OSClZXzsd{BqdmS3Y3XkJIJ6KFOGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= NF7JW5YzOjFzNUWyOi=>
LNCaP M3HiSmFxd3C2b4Ppd{BCe3OjeR?= NVjPeW46PDEQvF2= NYXtNpc3Omh? NF;Ud3FqdmirYnn0d{BjfXSnaX6gbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NX72WXhxOjJzMUS3OlQ>
MB231 NIPJS5JCeG:ydH;zbZMhSXO|YYm= NEnmXFYyODEQvF2= NEnpeI8ycA>? MVfEUXNQ M1TESIFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? MXqyNlEyOjl2MB?=
HCC38  NFG0cZlCeG:ydH;zbZMhSXO|YYm= MVmxNFDPxE1? Mn[xNYg> MUDEUXNQ M3WxbIFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? NGfVeFczOjFzMkm0NC=>
MDA-MB231 NHHtZVZCeG:ydH;zbZMhSXO|YYm= M2n5UVUxyqEQvF2= NHzFU4wzPGh? M{Do[mROW09? MX7hZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M2\BTFIzOTBzM{O1
LNCaP MWDBdI9xfG:|aYOgRZN{[Xl? MWK1NOKh|ryP NXyxPHZvOjSq Mo[3SG1UVw>? MlPBZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MoLjNlIyODF|M{W=
HCT116 NHzhPIdCeG:ydH;zbZMhSXO|YYm= MlT3OVDDqM7:TR?= M{e2WFI1cA>? NVPqcmdoTE2VTx?= MWPhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NInIWJIzOjFyMUOzOS=>
Ishikawa  MXvBdI9xfG:|aYOgRZN{[Xl? M3jIdVI2|ryP NVK0cndEOjSq NXTTN41EemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[WZiQUG= NGK0PVEzOjB6OEmxPC=>
 YD-8  NILZZYJCeG:ydH;zbZMhSXO|YYm= NYrHeY5XOTByzszN M4fnUFFp M2\OR4lvcGmkaYTzJHBNTU9vaX7keYNm\CCjcH;weI9{cXN? NFTwS4kzOjB6NkG4Ny=>
eosinophil  NFTUdnRCeG:ydH;zbZMhSXO|YYm= MXe5NO69VQ>? Mk[2NlRp M4HlbYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE[jczDhcpRq[m:medMg M3rGZlIzODd7M{O0
L929 NHe5XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjwempDOi53zszN NWPmUJd2OjSq MXHpcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDwMZA{QCCjbnSgUmYu|rqEIITvJIF2\22nboSgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 MXWyNlAzPzB7Nx?=
YD-8  NVOxcoVESXCxcITvd4l{KEG|c3H5 MXKxNFDPxE1? M3O5T|Fp MkmzZoxw[2u|IITo[UBIWy2KQ3ytbY5lfWOnZDDhdI9xfG:|aYO= MVmyNlAzODB5OB?=
HBx MXrBdI9xfG:|aYOgRZN{[Xl? MnnSNlXPxE1? NUTtUZFJPDiq NEHye|NFVVOR NHm2S29z\WS3Y3XkJINmdGxiZHXheIghcW6mdXPl[EBjgSB|LV3B M4TtWlIzODJyMEe4
U937  MoXPRZBweHSxc3nzJGF{e2G7 M3vtO|UxyqEQvF2= NGO4cpUycA>? MX7pcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh Ml3GNlE6QTh5M{G=
HL60 MUXBdI9xfG:|aYOgRZN{[Xl? MWi0NO69VQ>? MWO0NI1qdg>? NHOyXVZFVVOR NWfsTWVv[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MYGyNVk5OzJ7Nh?=
M-14 MVvBdI9xfG:|aYOgRZN{[Xl? M{DzOFI2|ryP NFT5dIExNjWq NW\SPZhKyqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? MYKyNVk2PDl3OR?=
SK-BR-3 NVXYUo9vSXCxcITvd4l{KEG|c3H5 M2DGN|UxyqEQvF2= M2r0WFJp M1PlR4Jtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> MWCyNVkxOTN6Nh?=
MDA-MB-468 M1i1d2Fxd3C2b4Ppd{BCe3OjeR?= NHrLRVA2OMLizszN M3XISlJp NFPINmhjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> MYeyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
Synonyms N/A

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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