Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MVXBdI9xfG:|aYOgRZN{[Xl? MlTuOVDPxE1? Mo[1NlRp M1fXcIlv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm MluyNlYyPjlyN{W=
HGL5 MX;BdI9xfG:|aYOgRZN{[Xl? MnrnOVDPxE1? NYXh[VBQOjSq NWDSbVdwcW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? NIT1V4kzPjF4OUC3OS=>
HepG2 MoLjRZBweHSxc3nzJGF{e2G7 NUD5dnNpOjEQvF2= Mm\lNYg> NHv3RoxifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh M3;C[lI3OTZ2N{m1
BEL-7402 MoP1RZBweHSxc3nzJGF{e2G7 MlnLNlDPxE1? MmnBNYg> NVPu[lAz[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? MojzNlYyPjR5OUW=
CEF NET1dJNMcW6jc3WgRZN{[Xl? NVzmZm5KOCx|Mzy2O{wyODEQvF2= NV\JTIJMOTWvaX6= Ml:y[I94di2{ZXf1cIF1\XNiUGKg[Y57gW2nIHHjeIl3cXS7IITvJFQx97zHIHH0JFExOM7:TR?= NXHKU4w2OjZzMEKzN|k>
SP2/0 NVjzUZRkSXCxcITvd4l{KEG|c3H5 NXLwdYRvOTByzszN MonKNYg> MojVSG1UVw>? NF32c3djdG:la4OgeIhmKGGyb4D0c5NqeyCxZjDTVFIwOCClZXzsdy=> M4PCWlI3ODd2N{Oy
HUVEC-2c MkjyRZBweHSxc3nzJGF{e2G7 MYO1NO69VQ>? MojoOog> MlP1[IVkemWjc3XkJJRp\SCxeD3MSGwucW6mdXPl[EBifXSxcHjh[5k> M4Hye|I3ODJzN{K5
U1 NIHGboxCeG:ydH;zbZMhSXO|YYm= MnSyNE0yODEQvF2= Mn32Nog> MnrsdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MlPvNlU6QDB7NEK=
ACH-2 MYLBdI9xfG:|aYOgRZN{[Xl? MVmwMVIxOM7:TR?= NYfzVZQxOmh? NHrDS3Rz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NHu5UlUzPTl6MEm0Ni=>
U1 NX63UG9NU2mwYYPlJGF{e2G7 M4rMRlExOM7:TR?= NFq2e40zcA>? MoDnbY5pcWKrdIOgZ4F{eGG|ZT2z MoK1NlU6QDB7NEK=
A549/V16 NXrabIVDSXCxcITvd4l{KEG|c3H5 MU[1NO69VQ>? NIK4XFAycA>? MX\y[ZBz\XO|ZYOgWGcwXE1vaX7keYNm\CCjcH;weI9{cXN? M2H1VFI2QTR4MEOz
SGN NWPaeWVRSXCxcITvd4l{KEG|c3H5 NWPTW3Y2OjCvTR?= Ml64OFhp M2XkTIhieyCwbzDpcoZtfWWwY3Wgc44hSUmILDDjZYxx[WmwIHX4dJJme3Orb36gc5Ih[2WubDDhdI9xfG:|aYO= NHv1engzPTh5NE[zNy=>
HCT116  NF3RflhCeG:ydH;zbZMhSXO|YYm= NYrwN2ViPTEQvF2= NH\zVnczcA>? NWP2[ZVicW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S M3qxVlI2QDZ6OEG4
DTK-SME M4jYTmFxd3C2b4Ppd{BCe3OjeR?= MmLZOVDPxE1? MV2ybC=> MlHPSG1UVw>? MUfwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHL1dIl3[WOjaX7l NGeyT|MzPTh2M{i5Oy=>
HL-60 NH\iZZJCeG:ydH;zbZMhSXO|YYm= M4nDVlUx|ryP NGW5W|Q1QGh? NXGzU|ZVemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? NYCw[Vh6OjV6MkSwOFM>
U937 NX3LTYFkSXCxcITvd4l{KEG|c3H5 MnKzOVDPxE1? NGHGWWY1QGh? MYDy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> NWLOdGFrOjV6MkSwOFM>
A549 MVjBdI9xfG:|aYOgRZN{[Xl? MVyyNEDPxE1? NGPBTG0zPGh? NFnTNXlz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KEiIQ2CgeJJm[XSvZX70 NGXuXmQzPTd7NEG0PS=>
HeLa MlPTRZBweHSxc3nzJGF{e2G7 NY\VbGJIOTEQvF2= MXq0PIg> MWLk[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 MVuyOVc4OjV2NR?=
SGC-7901 MYPBdI9xfG:|aYOgRZN{[Xl? MVeyNOKh|ryP MmK4NYg> MWDpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IH;4ZYxqeGyjdHnu NGfH[XgzPTd4N{C3Oi=>
MCF-7 M1PSUmFxd3C2b4Ppd{BCe3OjeR?= MUmxNO69VQ>? NXewToNxOmh? NIPlO2dqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JFND MXyyOVczOjFzNB?=
A549 MYnBdI9xfG:|aYOgRZN{[Xl? NELDR5YyOCEQvF2= MXGyOIg> NXfYTpZTTE2VTx?= Ml7GdJJwdW:2ZYOgTGJENXS{ZXH0[YQhSTV2OTDj[YxtKHO3co\peoFtKCZiYYT0[Y52[XSnczD0bIUh[2ynYY\l[EBRSVKSIHX4dJJme3Orb36= MYCyOVY5OzV4OB?=
U87 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmPI1zPTEQvF2= NGfwfWQycA>? M17yUJJm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? MWqyOVY5OTZ4OB?=
Neocortical Neuron MXTO[ZVzd3SxeHnjbZR6KEG|c3H5 NIXlV3AyODEQvF2= NXvD[4VrOWh? MoToZY51[Wexbnn6[ZMhUG:rYX3p[IUhSS2LbnT1Z4VlKE6ndYLveI95cWOrdIm= NUDqTWxrOjV4N{WwNFE>
Primary human placental cytotrophoblasts MVXBdI9xfG:|aYOgRZN{[Xl? NFu1W48{OM7:TR?= MXyyOIg> M4jCZWROW09? M3XQVZJmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= NYC4OXV7OjV4NEK1PVI>
MM NU\HN3BFSXCxcITvd4l{KEG|c3H5 M{DuRlUx|ryP M4K0bVIxdWmw NXLVTHpoeGG{dHz5JIlvcGmkaYTzJHNJUy2rbnT1Z4VlKCClZXzsJIRm[XSq NHPQXlczPTV|MEC5PC=>
DLD1 M2fmV2Fxd3C2b4Ppd{BCe3OjeR?= Moj5NlDDqM7:TR?= MVSxbC=> MUDwZZJ1dHlicnX2[ZJ{\XNiY3XscEBieG:ydH;zbZMh[2G3c3XkJIJ6KFeVUEG= MnvqNlU2OjR{NE[=
MDA-MB-231 NITkdVJEgXSxdH;4bYNqfHliQYPzZZk> MlToNVDPxE1? MmL1NYg> MUTheYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 M3GyZ|I2PTJzNUCx
MKN28 NIjCU5pCeG:ydH;zbZMhSXO|YYm= M1frRlEx|ryP NWnnUoF4OzCvaX6= MU\EUXNQ NWTnZ21ScW6qaXLpeJMhXE6ILd8xJJBtfXNiQ1jYMYlv\HWlZXSgZZBweHSxc3nz M3K1WlI2PTF|OU[w
HL-60 NVTTNGFIS3m2b4TvfIlkcXS7IFHzd4F6 NXfnS2FQOTByzszN NInGdFYycA>? M1HGNWROW09? NYjycI1IyqCrbYDyc5ZmeyC4aXHibYxqfHlib3[gWGNPSXNvdILlZZRm\CClZXzsdy=> MYmyOVUxOjl|Mh?=
AGS M2fDbWFxd3C2b4Ppd{BCe3OjeR?= NFTQdI4yOM7:TR?= M1vjSVFp NVHH[WlVeHKndnXueJMh[3W{Y4XtbY4ucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID24MEBidmRiLUmgdJJwfGWrboO= NELFN3MzPTR7MkKxOC=>
A549  M1\ZOWFxd3C2b4Ppd{BCe3OjeR?= NH[1NWQyOM7:TR?= Mn7xNlRp M{XJUYJtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? Ml7DNlU1OzR7OEm=
INS-1 MUjBdI9xfG:|aYOgRZN{[Xl? MXm1NO69VQ>? NHP1OJA3cA>? MUDEUXNQ NXLmbnJL\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGWjcnz5JIFxd3C2b4TpZ{Bk\Wyuc9Mg MVyyOVQ{ODh7Nx?=
Primary hepatocytes  M3fjO2Fxd3C2b4Ppd{BCe3OjeR?= MoHqOVDPxE1? MUCxPIg> NG\qT2ZqdmirYnn0d{BieG:ydH;zbZMhd2ZiaHXwZZRw[3m2ZYOgbY5lfWOnZDDifUBC[3RiRDDhcoQhXE6ILd8x MYiyOVQxPzV|OB?=
L929-A  NGXXSmZEgXSxdH;4bYNqfHliQYPzZZk> M4rFWlIxyqEQvF2= NIDUc5czPGh? MUTpcohq[mm2czDUUmbPuS2rbnT1Z4VlKGOnbHyg[IVifGh? NVnqWmttOjV|OUi1OFA>
L929-N M4H5[GN6fG:2b4jpZ4l1gSCDc4PhfS=> NFe0cFUzOMLizszN M4r5PVI1cA>? NYjtfIVm\W6qYX7j[ZMh\GWjdHigeoliKGG3dH;jdolv\SCWTldOtUBxem:mdXP0bY9v Ml\yNlU{QTh3NEC=
Cytotoxicity Assay MXnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NH\FeHQzOM7:TR?= NIjJdWw1QGh? M13PSZBz\X[nboSgUWhOTC2rbnT1Z4VlKGOnbHyg[IVifGh? MUiyOVM6OjFzNh?=
COS7 NHzhS4ZMcW6jc3WgRZN{[Xl? NUfmVYdzOTEQvF2= M3jCV|I1cA>? MWrpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? MX[yOVM5PDB{NR?=
COS7 MVLBdI9xfG:|aYOgRZN{[Xl? MXmxNO69VQ>? NIXTdZY1QGh? MoPMdIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= NITtO|MzPTN6NECyOS=>
A375 NGHqXYVCeG:ydH;zbZMhSXO|YYm= MUizNO69VQ>? NXrPc2tFOmh? MnjVdJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm NFTBbJozPTN5NkGxOS=>
A549 Moi1RZBweHSxc3nzJGF{e2G7 MYG1NO69VQ>? NHqwUI4zPGh? MXfy[ZZmenOnczDybYJwe2:vZTDibY9o\W6nc3nzJIFv\CCjcH;weI9{cXNiY3H1d4VlKGK7IDDDbIlrd26pZHHu NH\aNmozPTN2OUe4NS=>
A549 MYPBdI9xfG:|aYOgRZN{[Xl? MmT2Nk42NTJ3zszN MkXxNYg> NYLX[5VR\GWlcnXhd4V{KHSqZTDwc5B2dGG2aX;uJI9nKGGyb4D0c5Rq[yClZXzsd{Bl\XCnbnSgc44h[2:wY3XueJJifGmxboO= NHH3XpgzPTN2MkSyOy=>
 NBL-W-S  M1\MO2Fxd3C2b4Ppd{BCe3OjeR?= MkSyOVDPxE1? MlG1NYg> MYjmeYxtgSC{ZYPjeYV{KGOnbHygeoli[mmuaYT5JIFnfGW{IFfBUnQuPjFidILlZZRu\W62 NV24[llsOjV|MkOyNlI>
Caki-1  NXrkZnBxSXCxcITvd4l{KEG|c3H5 MYm0NO69VQ>? M1;ZdlQ5cA>? NFrEWG1z\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ MkP4NlUzPzlzOUG=
769-P MmfpRZBweHSxc3nzJGF{e2G7 M1HGXVQx|ryP M1jtZ|Q5cA>? Mmm5doVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> M2nGOFI2Ojd7MUmx
H9c2 M4ezTGFxd3C2b4Ppd{BCe3OjeR?= NGfLXHI2OM7:TR?= MmXrNYg> MlW4bY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? NV36cYF3OjV{OEO4NVk>
K562 NV3lSW96SXCxcITvd4l{KEG|c3H5 M1nrV|Ux|ryP M4DUUlRp NYnCclRtcW6qaXLpeJMhUmGlLVGtbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? MkXLNlUzPDF4MUm=
L929 NUnEeGpRSXCxcITvd4l{KEG|c3H5 MkjQNVDPxE1? M17mWlZp MX3pcoR2[2W|IH7lZ5JweHSxc3nzJJdqfGhiVF7G M1uxbVI2OTl3Nk[w
A549 NX3NSHJKSXCxcITvd4l{KEG|c3H5 NX70e3NjOTEQvF2= M3TMT|Np MWny[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= MWOyOVE3OTZ7OR?=
MCF-7 NFH4OGRCeG:ydH;zbZMhSXO|YYm= M33WUlIx|ryP MmnuNog> MV3k[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz Mkf1NlUyQDJ{NEC=
OS NI\EOGxCeG:ydH;zbZMhSXO|YYm= NV;pU|ZWOjBxNEFOwG0> M{[1TVczcA>? NGTwNXhqdmirYnn0d{BQWyClZXzsJJZq[WKrbHn0fUBz\WS3Y4Tpc44h[nliQ{[gZ4Vz[W2rZHW= NGLFSZUzPTF3MkO5PS=>
HUVECs M1rpN2Fxd3C2b4Ppd{BCe3OjeR?= NWXxVllOOTEQvF2= MlziNog> NGXVWW7DqGmwaHnibZR{KGGyb4D0c5NqeyCjbnSg[oFkcWyrdHH0[ZMh[XW2b4DoZYd6KGmwIFTFUnYzNWmwZnXjeIVlKEiXVlXDdy=> NUjUZoFZOjVzM{i3NFM>
EA.hy926 MYjBdI9xfG:|aYOgRZN{[Xl? NF7PTm0yOM7:TR?= M1zWPFJp NXiyTG84yqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? M1joNVI2OTN6N{Cz
Ebs Mlv1RZBweHSxc3nzJGF{e2G7 M3nLOVExNTFyMN88US=> MVKyOIg> MYVCpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl Mmf6NlUyOzR6MUe=
Jurkat NIjGVZpCeG:ydH;zbZMhSXO|YYm= MnLwNlDPxE1? NXjkdVdmOjSq NELjXVJFVVOR NHizOZhx[XK2aXHscJkhcW6qaXLpeEBk\WyuIHTlZZRpKG:oIFr1dotifCClZXzsd{BqdmS3Y3XkJIJ6KDFyMEW4MWY1KGOxbXLpcoVlKHerdHigWnBCyqB? M1vJTVI2OTJyN{Kz
K562 NGfJS5BCeG:ydH;zbZMhSXO|YYm= NITlVI0xNjFvMd88US=> MVyxbC=> NGnkZ2tqdmirYnn0d{BkdGWjdnHn[UBw\iCKU2C5NEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NEHXfngzPTFzOUG4PC=>
IMR-32 MWPBdI9xfG:|aYOgRZN{[Xl? M{LJb|QxyqEQvF5CpC=> NYL0OJlvOmh? M1\x[oRm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? MkS5NlUxQDR5NUW=
RPMI 8226 M2HPc2Fxd3C2b4Ppd{BCe3OjeR?= M{WxNVExOM7:TR?= MmG1NYg> MUfhcI1we3RiY3;tdIxmfGWueTDicI9kc3NiY3XscEBl\WG2aDDjZZV{\WRiYomgcoVkem:|dHH0bY4uOQ>? MnnUNlUxOzd6NUG=
U266  Mn7iRZBweHSxc3nzJGF{e2G7 M{f2VVExOM7:TR?= MVmxbC=> M4\ENZBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= MUCyOVA{Pzh3MR?=
H929  M134UmFxd3C2b4Ppd{BCe3OjeR?= NHHrWWkyODEQvF2= MYexbC=> MWrwZZJ1cWGubImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? Mk\SNlUxOzd6NUG=
MM.1S  NF;zXYtCeG:ydH;zbZMhSXO|YYm= MWqxNFDPxE1? Mn;ENYg> NX;We5F2\W[oaXPp[Y51dHlicILleoVvfHNic3;yZYZmdmmkLXnu[JVk\WRiY3XscEBl\WG2aDDjc41jcW6nIIfpeIghdmWlcn;zeIF1cW5vMR?= MXiyOVA{Pzh3MR?=
C6 MkPqRZBweHSxc3nzJGF{e2G7 NWTWRWduPTEQvF2= MV[0PIg> M2Ds[JBz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? NInDTZozPTBzM{S3PS=>
AGS NV;RR3dMSXCxcITvd4l{KEG|c3H5 NGTYUZA2OM7:TR?= NHnGfIkzPGh? MmTxZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= NHzVWnozPTByOU[5PC=>
HeLa  Mn\kRZBweHSxc3nzJGF{e2G7 NV3TdWR5PDEQvF2= MXKyOIg> NE\EPIZqdmirYnn0d{B1cGViaX7jdoVie2WmIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNqWk6IMUKx MYWyOFkzQDZ6NR?=
THP-1  M1Xle2Fxd3C2b4Ppd{BCe3OjeR?= NIPjPXcyOM7:TR?= NWDSSGxYOWh? Mlv5doVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> NEPVT3YzPDl{M{[1Ny=>
P815  NXvoUZRVSXCxcITvd4l{KEG|c3H5 M4nqVVExOCEEtV2= MkfUNVJp MmLOSG1UVw>? M2TjfYlvcGmkaYTzJJZqenW|LXnu[JVk\WRiYYDvdJRwe2m| M1vqcVI1QTJ|Mkez
HCT116 M1SwVGFxd3C2b4Ppd{BCe3OjeR?= NXK4SGtmOjEQvF2= M1;we|I1cA>? MVThZpJw\2G2ZYOgc4YhXFFvaX7keYNm\CCjcH;weI9{cQ>? MkG0NlQ5QTB2NEm=
SW1116  M3nrNGFxd3C2b4Ppd{BCe3OjeR?= NHvnV5UyOCEEtV2= NX6w[HptOWh? MkPxSG1UVw>? NXzzOGZmemW|dILhbY5{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkh\2WoaYTpcoljKHCudYOg[IVkcXSjYnnu[S=> NFTnco8zPDh5NEK4Oi=>
LOVO NInh[G5CeG:ydH;zbZMhSXO|YYm= M4n2bFExKML3TR?= NV;s[HRpOWh? NHHiUVJFVVOR M3jObJJme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= MV6yOFg4PDJ6Nh?=
SNU449  M1nmOmFxd3C2b4Ppd{BCe3OjeR?= NWX4S|N4OjEQvF2= MVi0PIg> NGHiOVVFVVOR MnXE[IVkemWjc3XzJI1qWi12NUGtbY5lfWOnZDDhdI9xfG:2aXO= M3XUZ|I1QDRzNkO4
Caco-2 Mn7RRZBweHSxc3nzJGF{e2G7 M{HuTFQx6oDLzszN NVy2NpRLPGh? M2DwXpBz\X[nboTzJHNVNTdvaX7keYNm\CCcTz2xJINp[W6pZYOgZY5lKFSHUjDkdo9x NGPEdIYzPDh{MkG4Ny=>
macrophage M2TkOWNmdGxiVnnhZoltcXS7IFHzd4F6 NVXHRWVmOC1{MEFOwG0> MWKyOIg> M2nFdolv\HWlZYOgWG5HNSCjbnSgVolxOy2mZYDlcoRmdnRibnXjdo9xfG:|aYOgbY4hdWGlcn;wbIFo\Q>? NH\4NZMzPDd7OUW2OS=>
AGS  NFLhU5VCeG:ydH;zbZMhSXO|YYm= MVmyNO69VQ>? NYHHO|YzOTKq MXjEUXNQ MXfy[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MVyyOFc5QTdyMx?=
LCC9  MlPtR4VtdCCYaXHibYxqfHliQYPzZZk> NGP3b2syODEQvF2= NIe3VHQ2\A>? M2H0ToJtd2OtczDj[YxtKGSnYYToJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25iTEG3JIFv\CClaHzvdo9yfWmwZR?= NUHpdGNHOjR5OEWyOVY>
U937  MkP1coVkem:ydH;zbZMhSXO|YYm= MWOxNOKh|ryP NX;kVIZoOzEEoH3pci=> MnrFbY5lfWOnczDu[YNzd3C2b4Ppd{Bkd22kaX7lJJdqfGhiVF7G MYGyOFc4Ozd3Nh?=
T cell MWXD[YxtKHC{b3zp[oVz[XSrb36gZZN{[Xl? NVe3RZZjOC1zMEFOwG0> NGHRRWc4Omh? NVPNb3U3UUN3ME23NEDPxE1uIHnubIljcXS|IHHueIkuS0R|LXnu[JVk\WRiVDDj[YxtKHC{b3zp[oVz[XSrb36gbY4hWEKPQ4O= MYWyOFc3QDdyNx?=
HeLa  NGLPfplCeG:ydH;zbZMhSXO|YYm= MVO1NO69VQ>? NH34b2U4Omh? M2rSZWROW09? MUTwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkd22yb4Xu[JPDqDIkgKO1 NWX1XI5xOjR5NUS3PFY>
HeLa  NWnjfGkzSXCxcITvd4l{KEG|c3H5 MorBNVAx|ryP MYmyOIg> NVvLWFFWe3WycILld5NmeyC{YYTlJI9nKGOnbHyg[IVifGhiaX7keYNm\CCkeTDveoVz\XiycnXzd4lwdiCxZjDHOVlUKG:{IFe3NXIheDF3MHfseYVlyqB? MmLVNlQ4OjJ2Nki=
IEC-6  MX\BdI9xfG:|aYOgRZN{[Xl? M{D2XVEx|ryP MljnNlRp MV3wdoV3\W62czDUZ4RCNWmwZIXj[YQh[2G|cHHz[U0{KGOuZXH2ZYdmKGGwZDFOtk1k[XSnbnnuJIRm\3KjZHH0bY9v NUnvZYVjOjR5MUG1O|E>
HCT116 NFHKdmpCeG:ydH;zbZMhSXO|YYm= M2rzXFIx|ryP NU\HSI1kOjSq MXLpcohq[mm2czD0bIUh[2WubDDhdI9xfG:2aXOgbY5lfWOnZDDifUB[VFR{MEW= MlLWNlQ4OTN6MUK=
L02 NVewemhJSXCxcITvd4l{KEG|c3H5 MnfONlDPxE1? Mm\SNYg> MV7wdoV3\W62czD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBOTUiS MUeyOFcxPjR4MR?=
A375 MmrPRZBweHSxc3nzJGF{e2G7 MnHKNlDPxE1? MXiyOIg> M{Lt[JJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? MnnRNlQ3QTlzMUG=
HDPC NXv2PIVCSXCxcITvd4l{KEG|c3H5 NUTG[odKPTEEtV2= MkDKNlRp NFfubJlqdmirYnn0d{BPVy2rbnT1Z4VlKGGyb4D0c5Nqew>? M{jmdlI1PjN2NUmz
A549 NGqwZYNCeG:ydH;zbZMhSXO|YYm= MnH3OVDDvU1? NV\TdYQ5Omh? MYHEUXNQ MYHwdoV3\W62czD0bIUhcHmyb3TpdIxwcWRiRF7BJINwdnSnboSgdIhie2ViaX7keYNm\CCkeTDj[ZBp[WyxY3jyc41qdg>? MkPzNlQ2QDhzM{W=
 BV-2 NVTnSZd[SXCxcITvd4l{KEG|c3H5 MXOyNO69VQ>? NH7kS|QzcA>? MV;zeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? MkDkNlQ2PThzMUi=
HT-29  NWX2eFhSSXCxcITvd4l{KEG|c3H5 M{PwOVUx|ryP M4DFVFQ5cA>? MoPSZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u NVrzZWZiOjR3NEmxO|U>
A549 MVzBdI9xfG:|aYOgRZN{[Xl? MWK1{txO MnHlNlRp NXK2R49ne3WycILld5NmeyB4ZdMgLGJMOTByNECpMYlv\HWlZXSgZZBweHSxc3nzxsA> MUOyOFUzQTh5MR?=
MIA-PaCa-2 NHTQdGZCeG:ydH;zbZMhSXO|YYm= MUOyOIg> MWficI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? MXWyOFUyODl7Mh?=
Caki-1 M2PobWFxd3C2b4Ppd{BCe3OjeR?= NU[ydFBUOjEQvF2= NXvsW4Q1OWh? NUDWUlFwcW6qaXLpeJMhW0OSLXnu[JVk\WRiYYDvdJRwe2m| M2KxeFI1PTB2Nkix
CLL M4nHOWFxd3C2b4Ppd{BCe3OjeR?= MX[yOe69VQ>? NUDHRmZ7OWh? NVTPSY1teGG{dHnhcIx6KGKub3Prd{BOVE5{MkO4MYlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? MYeyOFQ3PzZ|NB?=
SGC-7901 MnPjRZBweHSxc3nzJGF{e2G7 M3rEcVEx|ryP NHfyVVAzPGh? MVzwdo9ud3SnczD0bIUhS0eLST3pcohq[mm2ZXSgZ4VtdCCpcn;3eIghcW5iU1fDMVc6ODFiY3XscJM> MVmyOFQ2PDR6OB?=
k1735 MnLnRZBweHSxc3nzJGF{e2G7 M13q[lIx6oDLzszt NEfsb5Q1cA>? NUWyXJFOcW6qaXLpeJPDqFOjbH3vcoVtdGFvaX7keYNm\CCjcH;weI9{cXN? NXjLU|hzOjR2NUGxNVY>
HaCaT  NFnEXI1CeG:ydH;zbZMhSXO|YYm= MnjrNVAx|ryP NWLH[VJJOWh? NUjRdphD[my3boTzJHVXSi2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDIZWNiXCClZXzsdy=> NXHZfWl6OjR|NU[5PVc>
podocytes MmHHRZBweHSxc3nzJGF{e2G7 MmXHNlAx|ryP MYW2bC=> NFfzNFJqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSB|LEStSGdG NUm3clNKOjR|M{e3O|c>
 KB NHn0e3FCeG:ydH;zbZMhSXO|YYm= MV[1NO69VQ>? MlO3NlRp NYLpfZBzcW6qaXLpeJMhVGmlbz3BMYlv\HWlZXSgZ4F{eGG|ZT2zJIFv\CCSQWLQJIFkfGm4YYTpc44> MlLMNlQ{Ozd2OUK=
 HepG2  NGjDSWpCeG:ydH;zbZMhSXO|YYm= NWrwb4NuOTEQvF2= M1zZdVI1cA>? MWny[YR2[2W|II\pcYVvfGmwIHPs[YF3[WenIHPheZNm\CCkeTDMVHM> MnfHNlQ{OjV6MU[=
fetal rat lung fibroblasts  NV7LWoxHU2mwYYPlJGF{e2G7 MUK4NO69VcLi NYjtTlZvOWh? Ml\jbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> MoLXNlQ{OTRzM{W=
PDL fibroblasts MVfLbY5ie2ViQYPzZZk> Mly4PFDPxE4EoB?= M{K0WVFp M1rOcYlvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh M2DsUlI1OzF2MUO1
MB49 NVHkUYtJSXCxcITvd4l{KEG|c3H5 M{n5fFIx|ryP NXrt[2Q2OWh? NI\oOWpz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? NFjjfGgzPDJ6MkSzNy=>
5637 Ml25RZBweHSxc3nzJGF{e2G7 M4P6SFIx|ryP MmTFNYg> MYHy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> NYniS4ZKOjR{OEK0N|M>
A549  M3zzXmFxd3C2b4Ppd{BCe3OjeR?= M4GyWFExOM7:TR?= MXm0PIg> M13BWpN2eHC{ZYPz[ZMhfGinIHHwc5B1d3OrczDjZZV{\WRiYomgdIlx\XKrbnZCpC=> NEL2ZYwzPDJ5MkKwNS=>
MCC-2 NFe4e2xCeG:ydH;zbZMhSXO|YYm= NIHzSG0zOCEQvF2= NELqS4o3cA>? NFLDfHhFVVOR MmnEZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= M1SxWVI1OjZ{NkW4
ADF MUXBdI9xfG:|aYOgRZN{[Xl? MXG0NO69VQ>? M{nGXVZp MVTpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MmHqNlQzOjh{M{K=
 U373  MWTBdI9xfG:|aYOgRZN{[Xl? NITiNXE1OM7:TR?= NEnpW4w3cA>? NFTkPGdqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> MYeyOFIzQDJ|Mh?=
RKO-HIPK2i NWnEWYJKSXCxcITvd4l{KEG|c3H5 MXi0NO69VQ>? Ml3DOog> Mk\vbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MWCyOFIzQDJ|Mh?=
HEC-1B MlqwRZBweHSxc3nzJGF{e2G7 MkfGNlDPxE1? NF\wb4oycA>? MXjy[YR2[2W|IGTQMYlv\HWlZXSgZZBweHSxc3nzxsBk[XOyYYPlMVMh[W6mIHPhd5Bie2VvOR?= M3rBT|I1OjF|M{W4
4T1 NX;rRXlLS2WubDDWbYFjcWyrdImgRZN{[Xl? MnT0Nk42NTFyzszN NUDkbnNCPGh? MVrEUXNQ NUHxZ5M{emW|Y4Xld{B1cGViY4n0c5RwgGmlaYT5JI9nKDSWMTDj[YxteyCrbnT1Z4VlKGK7IGPQSHQhcW5iYTDjc45k\W62cnH0bY9vKGSncHXu[IVvfCCvYX7u[ZI> NILPUnAzPDJyNkG2NS=>
OS  NInONHVCeG:ydH;zbZMhSXO|YYm= MlrrNlDPxE1? NXnD[oVyPGh? M4juUolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDQSHQ> MmrhNlQzODR7M{e=
RPE MUjBdI9xfG:|aYOgRZN{[Xl? M{G0b|ExOM7:TR?= NFvy[HE1QGh? M4j0[ZBienSrYXzsfUBqdmirYnn0d{B1cGViY3HsdIFqdi1zIHHu[EAuOiCjY4TpeoF1cW:wIHHzJJdmdGxiYYOgeIhmKGOjc4Dhd4Uh[WO2aY\heIlwdg>? NH3xWnQzPDJyMkC1Ni=>
UD29a NVH5WGFHSXCxcITvd4l{KEG|c3H5 MWW1NO69VQ>? Ml3TNlRp M{DvOolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDOWXQ{ NF3wcIczPDF7MEW3OC=>
SH-SY5Y  MVHBdI9xfG:|aYOgRZN{[Xl? MWCxNO69VQ>? NHu5N5YzPGh? M3jEV4F1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> MnviNlQyPDV2NkO=
HeLa  MXnBdI9xfG:|aYOgRZN{[Xl? NFTIXGcyOC9{MN88US=> NGjKfpAzPGh? NYrkTmF7cW6qaXLpeJMhfGinIHHjeIl3cXS7IH;mJJRp\SCvYXrvdol1gSCxZjD0bIUhdWWvYnXyd{Bw\iC2aHWgZ4F{eGG|ZT3mZY1qdHl? NGnaUZgzPDF|N{K2Oi=>
SCCVII  NIjqelJCeG:ydH;zbZMhSXO|YYm= NGjnWZUzPc7:TR?= NGG1PXIycA>? NXW1fWRLcW6qaXLpeJMhfGinIHPlcIwhc2mubHnu[{Bi\nSncjDkZZNifGmwaXK= MWSyOFEzPjR4NB?=
RAW 264.7 M4XsTWFxd3C2b4Ppd{BCe3OjeR?= MVGyNO69VQ>? MnnzNVhp NGPSNWJqdmO{ZXHz[ZMhVEN|LVnJM:6zNWGldHnuJJJifGmxIHPvcZBiemWmIITvJGVEXFZvTV;TJJRz\WG2bXXueEBwdmy7 Mk[xNlQyOTZ5MEe=
A549  NGX6W29CeG:ydH;zbZMhSXO|YYm= NI\ZVoMzNjYQvF2= MWqyOIg> MV;k[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> NULSb3R7OjRzMEK1NlI>
UM-SCC-10A  MkDTRZBweHSxc3nzJGF{e2G7 MlW1OVDDvU1? NXvEe5hWOmh? MUPy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JIhq\2hvZH;z[UBqe2:jbHHueI9t[WO2b37l MYqyOFA6QDd3Mx?=
BGC-823 NVLSTo9wSXCxcITvd4l{KEG|c3H5 MlzZNVAh|ryP MnzCNlRp M4TCeZJm\HWlZYOgeIV1emGwZILpcoUucW6mdXPl[EBieG:ydH;zbZPDqA>? NXi4UJhbOjRyOUi1NVE>
Nalm-6  M3jXOWFxd3C2b4Ppd{BCe3OjeR?= MXeyNO69VQ>? NUjxUpJ7PGh? M1KzRYlvcGmkaYTzJINie3Cjc3WtPEBidmRiY3HzdIF{\S1|IHHjeIl3[XSrb36gZY5lKFCDUmCtNUBkdGWjdnHn[S=> NEH1XHUzPDB|OUm2Oy=>
KHOS  NFnJPFBCeG:ydH;zbZMhSXO|YYm= MnrZOFDPxE1? NFfuXIIzPGh? M{[3eIJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MnH0NlQxOjV|NkG=
G292 MnvhRZBweHSxc3nzJGF{e2G7 NVq4[otEPDEQvF2= NYTzU|ZROjSq MXzicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li MYKyOFAzPTN4MR?=
MG-63 NUX4R|RzSXCxcITvd4l{KEG|c3H5 NFrafmo1OM7:TR?= M2i5cVI1cA>? Mn7pZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= M2X6W|I1ODJ3M{[x
EBV-transformed B cells MY\BdI9xfG:|aYOgRZN{[Xl? NYXx[|VbOjEQvF2= NUDkW2M3Omh? MlPTSG1UVw>? MXricI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> MV:yOFAxQDZ{OB?=
IM-9 B MoHKRZBweHSxc3nzJGF{e2G7 M3jOWVIx|ryP M{XmZVJp MXfEUXNQ MV7icI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> Mn3tNlQxODh4Mki=
CNE1 Mmr5RZBweHSxc3nzJGF{e2G7 MmnSNlDPxE1? NIrZe2E1QGh? NFrWUIxjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? NF20[GczOzl6NUCyPS=>
CNE2 MWXBdI9xfG:|aYOgRZN{[Xl? NEH3bXgzOM7:TR?= NUf1W4JoPDiq NX3HT3hH[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? MVKyN|k5PTB{OR?=
HL-60 MmjmRZBweHSxc3nzJGF{e2G7 NHraclU2OML3TR?= M1H6[VFp MmXTSG1UVw>? NHHtdVhqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCEQUG0OS=> M37aeVI{QTR6N{Wx
L929 MYHBdI9xfG:|aYOgRZN{[Xl? NGrkSlAyNjJ34pETOeKh|ryPwrC= NFvmXZQzPGh? M4CxUoF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? MlHlNlM6PDF5Nkm=
Jurkat MlywR4VtdCCYaXHibYxqfHliQYPzZZk> M37Y[VLPxE1? NGLFWWs1cA>? NYfuWWo3emW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB NWTHWGhTOjN6OU[wOlE>
RAW264.7  MWfBdI9xfG:|aYOgRZN{[Xl? Mn32NVAh|ryP NE\oZ3MzPGh? NHKzVFRl\WO{ZXHz[ZMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JGdC M4ewfVI{QDJyMkCz
A431  MYTLbY5ie2ViQYPzZZk> NYHPdHB5PDEQvF2= NYPWXHZxOmh? MX3icI9kc3NiZnnz[ZRqdi2rbnT1Z4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2W|IHHu[EBRSVKS Ml\WNlM5ODByNUi=
Jurkat M1rkTmNmdGxiVnnhZoltcXS7IFHzd4F6 NH\lW5IzPS1zMEFOwG0> MnzwOog> MlXUbY5pcWKrdIOgfk1HSS2FTVutbY5lfWOnZDDj[YxtKGSnYYTo NXHKNZJLOjN7M{O1N|I>
COS-7  MXPGeY5kfGmxbjDBd5NigQ>? NXTONoFrPTEEtV2= NHzXWm0zPGh? NEXm[2xi\m[nY4TzJJRp\SCycn;j[ZN{cW6pIH;mJGFVVjG|IIfpeIgheG:ueWGgeJJi[3S| MknBNlM6OzN{MEi=
CAL27 MVzBdI9xfG:|aYOgRZN{[Xl? MlX4NVAh|ryP NGfER3MzcA>? MYnzeZBxemW|c3XzJGN2ei2QUIOtdoVlfWOnZDD2bYFjcWyrdImgZpkhfXBidH:gPVAm NGC0[5kzOzlzN{O5Oi=>
THP-1  MXLBdI9xfG:|aYOgRZN{[Xl? NHHrd4EyOC13MN88US=> NVXy[mdROmh? NX;TTopucW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= NGXES|YzOzlyMEK5PS=>
K562 NH7EOmNCeG:ydH;zbZMhSXO|YYm= MlzpNlDPxE1? NVywSllqPDiq MX\pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X MXWyN|g4Pjh{Nh?=
HL-60 NI\nN4FCeG:ydH;zbZMhSXO|YYm= NXXTVFlWOTByzszN M3vUV|I1cA>? MVnpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBi[mmndHHu[UBlcXSncoDlcoV{yqB? NYHVe5dnOjN6NkW3O|g>
HeLa  NEPGXYhCeG:ydH;zbZMhSXO|YYm= M3XROlIx|ryP NHi3SJkzcA>? NYjjb4tEcW6qaXLpeJMhTE2PUDDpcoR2[2WmIHHwc5B1d3Orcx?= NVXHfWdPOjN6NkO5OlY>
U251 Mn;aRZBweHSxc3nzJGF{e2G7 NHjhfmMzOM7:TR?= MUOyOIg> NXK4eZZ2cW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| NHXUTFUzOzhzNkixOi=>
HL-60 MWjBdI9xfG:|aYOgRZN{[Xl? NX3aUlh4PTEEtV2= NHznZXU1cA>? NHT3UGVjdG:la4OgeIhmKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzygMVktKGGwZDDQRXJRKGmwZIXj[YQh[nliNoO= Ml7YNlM5ODR5ME[=
Ec-109 MVHBdI9xfG:|aYOgRZN{[Xl? Mn[1NVAh|ryP NYPFSHRjPDiq Mny2doVxemW|c3XzJHBGNW2nZHnheIVlKEWlLUGwPUBk\WyuIHHwc5B1d3Orcx?= NVjOUmZxOjN5OEK2OFE>
RKO MW\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NXPEd5VFOTBizszN NVm5bY9KOjSq NGmwblFqdmirYnn0d{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliY3H1d4VlKGK7IFTBRi=> MlLZNlM4PThyNkS=
T98G MWLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NEmyS|EyNTFyMN88US=> NV;jc|hQOjSq NVfYRo9VcW2ycn;2[ZMh[2WubDD2bYFjcWyrdImgZ491emWjdH3lcpQhf2m2aDDUVy=> NYTzXJdHOjN5NkmyO|U>
Jurkat Mki1R4VtdCCYaXHibYxqfHliQYPzZZk> MorQNVAxNTJyMN88US=> M374clI1cA>? NHvoS5dqdmirYnn0d{BJ[UF2IHnu[JVk\XNiYYDvdJRwe2m|IHTldIVv\GWwdDDv[kBkd26lZX70doF1cW:wwrC= MmXmNlM4OzJ2OEG=
Molt-3  NIn0XIdCeG:ydH;zbZMhSXO|YYm= M1L5PFUx|ryP NHXRSHczcA>? M{jxS5Jm\HWlZYOgcYVt[XSxbnnuMYlv\HWlZXSgZZBweHSxc3nz MoPXNlM4OjVyMUO=
hMSC12 NGjN[o5CeG:ydH;zbZMhSXO|YYm= MVmxNFDPxE1? M3zPNVRl MnvlbY5pcWKrdIOgc5N1\W:pZX7pZ{BkfWy2dYLlMYlv\HWlZXSgZ4VtdCCmZXH0bEBidmRiY3HsZ4lncWOjdHnvci=> NYDW[4lwOjN4NUe4NlI>
HM7  MX;BdI9xfG:|aYOgRZN{[Xl? NFvHWGszOM7:TdMg NGrwXmEycA>? NHPXbIpjdG:la4OgZZBq[3WuYYLlckBCKGGlZYTheIUucW6mdXPl[EBk[XOyYYPlMVMh[WO2aY\heIlwdiCjbnSgVGFTWCClbHXheoFo\Q>? NEf1ZWszOzV6M{SxNi=>
Hep-2  MUnBdI9xfG:|aYOgRZN{[Xl? MofCNlDPxE4EoB?= NEXt[nEzPGh? M{\4OmROW09? NFroOndidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> MX:yN|U5ODB|Mh?=
HSCs NGnFWpFCeG:ydH;zbZMhSXO|YYm= NHy5cW82OM7:TR?= NFvoNI0zPGh? MlfXSG1UVw>? MX;pcohq[mm2czDubYxwfGmwaXKtbY5lfWOnZDDEUmEh\GGvYXflJIlv\GmlYYTl[EBjgSCSQWLQJINt\WG4YXfl MmfFNlM1QTl6N{S=
HL-60  NHHBbFhEgXSxdH;4bYNqfHliQYPzZZk> MY[yNO69VcLi NHnWPHkzPGh? MlnBdoVlfWOnczD0bIUh[3m2b4TvfIlkKGWoZnXjeEBw\iCHcom1 NFLS[nAzOzR7NES4NC=>
HA MkPvRZBweHSxc3nzJGF{e2G7 MWm1NO69VQ>? Mn\xNlRp NUHQOHFKe3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD MmXnNlM1PzV7NU[=
C666-1 M{K3d2Fxd3C2b4Ppd{BCe3OjeR?= MX61NO69VQ>? M1v5e|I1cA>? NHnvb2V{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? NHO3c3AzOzR5NUm1Oi=>
Hepa1-6 MoTnRZBweHSxc3nzJGF{e2G7 MX21NO69VQ>? MnHoNog> NFnnUHVqdmirYnn0d{BkfXKldX3pckBidmRicnXzeoVz[XS{b3ytbY5lfWOnZDDhdI9xfG:|aYO= MYeyN|Q1Pjd3Mx?=
PLC/PRF/5c NInCNXlCeG:ydH;zbZMhSXO|YYm= NXnPeo9vPTEQvF2= NE\Fe4EycA>? MULwdoV3\W62czDhdI9xfG:|aYOgeJJq\2encnXkJIJ6KEOLTh?= MoDaNlM1Ozh6MkS=
HCT116 NYrUXXNUSXCxcITvd4l{KEG|c3H5 MlnTNVAx|ryP Moq1NU42cA>? MlTLbY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp MnHUNlM4PDR|NUO=
HCEC NXX5UmhKTnWwY4Tpc44hSXO|YYm= NEHiR3Y2OM7:TR?= M4i0R|czcA>? M{LTXGROW09? M3[xSpJme3SxcnXzJI9nKHSqZTDuc5Ju[WxiSFPFR{BxcGWwb4T5dIU> NE\0W40zOzd2MkCxNS=>
Primary rat cerebral cortical neurons MX3BdI9xfG:|aYOgRZN{[Xl? MofONVAx|ryP NVvRZW5uOWh? M4TzOpBz\X[nboTzJGNlNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDj[YxtKGSnYYTo Mlz2NlM4PDF|MUe=
MDA-MB-231  M2f0S2Fxd3C2b4Ppd{BCe3OjeR?= MV[yOe69VQ>? NXvFNog3OjSq NXLDc2Nx[WK{b3fheIV{KGO7dH;0c5hq[2m2eTDhcoQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgVoc{ NFfKdGYzPTN|N{W0OC=>
NLRP3-Tet-on-MC/9  MYPBdI9xfG:|aYOgRZN{[Xl? NH:xN3EyOC12MN88US=> M3\0VFEzcA>? NIjxT25ifHSnboXheIV{KHSqZTDj[YxtKGSnYYToJINifXOnZDDifUBESVCVLXHzd49kcWG2ZXSgUmxTWDNibYX0ZY51eyCrbjD0bIUhXGW2LX;uJJN6e3SnbR?= NG[zO2QzOzdyM{O4PS=>
KNS42  M3vENmFxd3C2b4Ppd{BCe3OjeR?= MUG1NO69VQ>? M3PhR|Fp NXz5NoZZemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDjc41xdGW2ZXz5JIFjd2yrc3jl[EBk[XOyYYPlJFMwPyCjY4Tpeol1gSCrbjDy[ZNxd26|ZTD0c{BCSlRvMk[zM|JFTy:vZYTmc5JucW5iY3;tZolv[XSrb36= M2Lud|I{PjlzMUS1
MCF-7  NW\QWlhPSXCxcITvd4l{KEG|c3H5 NVGybXc3OjEQvF5CpC=> MYq3Nog> MY\pcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= M1rGRlI{Pjd3NkSz
hCMEC/D3  MYTBdI9xfG:|aYOgRZN{[Xl? M4rFSFI2|ryP MWO3Nog> MmDwdoVlfWOnczDMeJhCKGmwZIXj[YQh[XCxcITvd4l{ NUL0bIZsOjN4NkWxPVg>
Jurkat NVrM[Yg1SXCxcITvd4l{KEG|c3H5 NHW3bFMyOi53LUWw{txO M2HZb|Fp MVPkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> NUXvNph[OjN2NEK5O|Y>
CNE-1 MUXBdI9xfG:|aYOgRZN{[Xl? MnOxNlDPxE4EoB?= NV;kZ5Q1OjSq NYW3TY93cW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M3\xd|I{PDJ4OEWw
HONE-1 MXfBdI9xfG:|aYOgRZN{[Xl? M1L0OlIx|ryPwrC= NVjNd2NGOjSq MoG0bY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NUC0fYV{OjN2Mk[4OVA>
astrocytes cell NFXx[VhCeG:ydH;zbZMhSXO|YYm= NIn1WIQ1OM7:TR?= MUS2bC=> M{XySpJm\HWlZYOg[YFzdHliYYDvdJRwe2m|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\Q>? MU[yN|QyOTd5OB?=
U-937 NILPN2FCeG:ydH;zbZMhSXO|YYm= MojuNVDPxE1? NGPuXZk{OG2rbh?= MmTpdJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? M2rNWVI{PDFyN{S4
MDA-MB-231 M3HmOGFxd3C2b4Ppd{BCe3OjeR?= MYixNFDPxE1? MYSxbC=> MX;pcohq[mm2czDz[Y5{cXSrenH0bY9vKHSxIGTSRWlNKHWyb36gUXRFUCCmb4fuMZJm\3WuYYTpc44> MVmyN|QxQDR{OR?=
HeLa  MlX3RZBweHSxc3nzJGF{e2G7 M4LLTlExOM7:TR?= NH;ONIczcA>? M2LFbIJtd2OtczDKVnMuOTViSX7keYNmeyCDcH;weI91cWNiQ3XscEBF\WG2aB?= MWSyN|M1PDB2NR?=
Ec109 M{T1OmFxd3C2b4Ppd{BCe3OjeR?= MUixNO69VQ>? NE[1dmI3cA>? MUPicI9kc3NiYYDvdJRwfGmlIHPvcYJqdmG2aX;uJI9nKFSjdD3TcYFkVjdiYX7kJJJi\GmjdHnvci=> NYi3cWJyOjN|M{i1Olg>
H460  NHfzZVhCeG:ydH;zbZMhSXO|YYm= M33qXlEx|ryP Mkf0Oog> M4LUOoJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v MViyN|M{QDV4OB?=
HeLa  NGHwVlJCeG:ydH;zbZMhSXO|YYm= MYi1NO69VQ>? NELzR5UyNjWq NIfEXpVi[nKxZ3H0[ZPDqEOqbHHtfYRq[S2rbnT1Z4VlKGGyb4D0c5Nqew>? MknuNlM{ODN6MES=
SK-HEP1 NIfrb|FCeG:ydH;zbZMhSXO|YYm= M2H3SVExOM7:TR?= MmDmNYg> NIrnSo1qdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= NVnPWow1OjN|MEK2OVA>
QGY7701 NVrvflJySXCxcITvd4l{KEG|c3H5 MkHzNlXPxE1? MnP2NU42cA>? MXTpcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu M2LqPVI{OjRyME[x
HepG2 NWfHT3BFSXCxcITvd4l{KEG|c3H5 NUnEfYxvOjEQvF2= NIPOclI{OG2rbh?= MmHFbY5pcWKrdIOgeIhmKGWwaHHuZ4VlKGOnbHyg[IVifGhiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKGGyaXflcolvKGGwZDDUVmFKVA>? M{n1XVI{OjJ2MkO5
U87  NFvTZ4ZCeG:ydH;zbZMhSXO|YYm= MVOyOe69VQ>? NGPlfHEzcA>? MVLk[YNz\WG|ZYOgbZNwdGmzdXnybZRq\2WwaX6gLGlUVClvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aDygZpV1KG6xdDDu[YNzd3SrYzDj[YxtKGSnYYTo NUDPPGU5OjN{Mkm2NlY>
HSC-2 NFS3cHhCeG:ydH;zbZMhSXO|YYm= M3zqbVI2NzVyzszN NUfmfJNXOWh? NVv5eWtDcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> MXuyN|E2PTJ2OB?=
HSC-4 NXHINolHSXCxcITvd4l{KEG|c3H5 M{T0W|I2NzVyzszN NFXo[FYycA>? MUPpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NU\wcFNnOjNzNUWyOFg>
CL-1 M4n5bGFxd3C2b4Ppd{BCe3OjeR?= NIXpUI8zOM7:TR?= Ml\YNYg> NYLL[GdX[myxY3vzJG9RPDR7IHnu[JVk\WRiY3XscEBl\WG2aB?= MVyyN|E{OTd6Mh?=
MEL NVOxcGN6SXCxcITvd4l{KEG|c3H5 NWr4VWdYOjEQvF2= MnX6NlRp MkG2SG1UVw>? NE[5e5ZqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NILJV5gzOzBzNEi4Oy=>
Bel-7402  NGPjWmdE[XOyYYPlJGFkfGm4YYTpc44hSXO|YYm= MUe1NO69VQ>? NIHsVVkzcA>? NHXx[ohqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ M{XjXlI{ODB6N{Sy
Eca-109 NHqyOmxCeG:ydH;zbZMhSXO|YYm= M1r4[lI2|ryP NGfBcmg{OG2rbh?= MljxbY5pcWKrdIOgRmouSjFzLXnu[JVk\WRiY3XscEBl\WG2aB?= MWqyN|A4Pjl4Nx?=
MEL M4\5eGFxd3C2b4Ppd{BCe3OjeR?= MnrYNlDPxE1? MUexbC=> NWjyb5diTE2VTx?= Mn2ybY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NXuy[lhyOjNyMUS4PFc>
Bel-7402  M2TRZ2Fxd3C2b4Ppd{BCe3OjeR?= MoHzOVDPxE1? MV2ybC=> NIm1TZpqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ M4HOTVI{ODB6N{Sy
L929 Mm\hSpVv[3Srb36gRZN{[Xl? NITWSXYzNjYQvF2= NXm4WoxJOWh? NYPjbHhKcW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? Ml;aNlMxODB3MUi=
RCC  M1y3SGNmdGxiVnnhZoltcXS7IFHzd4F6 M4HGd|ExOM7:TR?= MkK2NlRp MXPy[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ MVKyNlk6OTR7NB?=
NB2a/d1 Mlu1RZBweHSxc3nzJGF{e2G7 Mn\JNVAx|ryP NFz6W|A4Omh? M4fmVIF1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> MWKyNlk5QDV2MR?=
T cell MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSyOU0yODEQvF2= MYmyOIg> Ml\n[I9{\S2mZYDlcoRmdnSueTDpcohq[mm2ZXSgWEBk\WyuIIDyc4xq\mW{YYTpc44hdWWmaXH0[YQhfGi{b4XnbEB1cGViY3:td5RqdXWuYYTpc44hf2m2aDDhcpRqNUOGMzDhcoQh[W62aT3DSFI5 NFfjNnUzOjl6MkWzPC=>
K562 NV\je3pwSXCxcITvd4l{KEG|c3H5 M3r0Z|ExOM7:TR?= MXyxbC=> MnHjZoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? MlrBNlI6PzJ|N{K=
Jurkat  NYLudZBjSXCxcITvd4l{KEG|c3H5 NULHWZdRPDEQvF2= MVGxbC=> MWPhZo9tcXOqZYOgSoF{VC2rbnT1Z4VlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=> MlzwNlI6PDJ5M{i=
BGC-823 MV\BdI9xfG:|aYOgRZN{[Xl? MnnONVAx|ryP MXyxbC=> NGHWR2Rx[XK2aXHscJkhemW|Y4Xld{Bk\WyuczDh[4FqdnO2IHThcYFo\SCxZjDkZYllgmWrbh?= MWeyNlkzPjV2NR?=
Hep3B NVO5NW1zSXCxcITvd4l{KEG|c3H5 NX7DbWpEPTEQvF2= NX;HUphwOWh? MnTPZoxw[2u|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGhGT0O| MnexNlI6OjNzNUS=
LLC-PK1 NYPLXGtLSXCxcITvd4l{KEG|c3H5 NHXHUo8zOM7:TR?= NVvET|YzOWh? NVP1ZmVjeHKndnXueJMh[2m|cHzheIlvNWmwZIXj[YQh\GWpcnHkZZRqd25ib3[gRZRoPSxiYnXjcIlvNTFuIHHu[EBCfGdzMjDwdo91\Wmwcx?= NWfCSXp5OjJ6OU[wN|c>
A549 M{TIR2Fxd3C2b4Ppd{BCe3OjeR?= NHPDdXQ2OM7:TR?= M4[wRlFp M3P5coJtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= MV6yNlg5PzJzNR?=
SGC-7901  MWHBdI9xfG:|aYOgRZN{[Xl? MYexNO69VQ>? MmK1NlRp NFLpTIdqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? M17BRVIzQDR6NUm3
DM6 Mn2yRZBweHSxc3nzJGF{e2G7 MnT2NVAx|ryP MmXKO|Jp NIiyNHBjdG:la4OgZo91cCCHMl[tNUBidmRiRULGeJIudWWmaXH0[YQh[3m2b4TvfIlkcXS7 M{PFdlIzQDJ3M{K4
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Ishikawa  Mnr3RZBweHSxc3nzJGF{e2G7 NEn0S5EzPc7:TR?= NGr4c2MzPGh? NUK2bIZtemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[WZiQUG= MVSyNlA5QDlzOB?=
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MDA-MB-468 NWO5T2J{SXCxcITvd4l{KEG|c3H5 NHy2T2g2OMLizszN MV2ybC=> NHXWN4ZjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> MoLiNlE6ODF|OE[=

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
Synonyms N/A

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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