Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

Size Price Stock Quantity  
USD 117 In stock
USD 470 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

3 Customer Reviews

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MY\BdI9xfG:|aYOgRZN{[Xl? NGHJb3Y2OM7:TR?= MVeyOIg> MVvpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> NFHzVIszPjF4OUC3OS=>
HGL5 NVr4OopISXCxcITvd4l{KEG|c3H5 M4nPXlUx|ryP NVu2fmlUOjSq M{nVdYlv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm NVH1VIpMOjZzNkmwO|U>
HepG2 M1XUPWFxd3C2b4Ppd{BCe3OjeR?= NH7RfIkzOM7:TR?= M2jzVFFp M3nwe4F1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MnXYNlYyPjR5OUW=
BEL-7402 NV:xdWt1SXCxcITvd4l{KEG|c3H5 MoeyNlDPxE1? M{fmU|Fp M4fZeoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MY[yOlE3PDd7NR?=
CEF MWXLbY5ie2ViQYPzZZk> NHLiRnQxNDN|LE[3MFExOM7:TR?= M2rNb|E2dWmw M{DGUYRwf25vcnXneYxifGW|IGDSJIVvgnmvZTDhZ5Rqfmm2eTD0c{A1OO,:hTDheEAyODEQvF2= MWmyOlExOjN|OR?=
SP2/0 NXWzfIRlSXCxcITvd4l{KEG|c3H5 MVqxNFDPxE1? MkHBNYg> MnjxSG1UVw>? NVq5cZRw[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> MYCyOlA4PDd|Mh?=
HUVEC-2c MXvBdI9xfG:|aYOgRZN{[Xl? M1XvOVUx|ryP MmfOOog> MkfC[IVkemWjc3XkJJRp\SCxeD3MSGwucW6mdXPl[EBifXSxcHjh[5k> M4m0[VI3ODJzN{K5
U1 MYTBdI9xfG:|aYOgRZN{[Xl? Mn62NE0yODEQvF2= M2HlUlJp MkXLdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NXTHPW1pOjV7OEC5OFI>
ACH-2 NVzCdJI5SXCxcITvd4l{KEG|c3H5 MVOwMVIxOM7:TR?= NWP2NVlkOmh? NX[5bYg3emWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MVyyOVk5ODl2Mh?=
U1 NGjRV|lMcW6jc3WgRZN{[Xl? M2fQdlExOM7:TR?= MWmybC=> M3XU[4lvcGmkaYTzJINie3Cjc3WtNy=> NI\GN20zPTl6MEm0Ni=>
A549/V16 MlmwRZBweHSxc3nzJGF{e2G7 NFzMV3o2OM7:TR?= MXOxbC=> M2\pTZJmeHKnc4Pld{BVTy:WTT3pcoR2[2WmIHHwc5B1d3Orcx?= Mm\iNlU6PDZyM{O=
SGN NHnz[mRCeG:ydH;zbZMhSXO|YYm= NF\EN5QzOG2P M1PTd|Q5cA>? NXLnOJhVcGG|IH7vJIlv\my3ZX7j[UBwdiCDSV[sJINidHCjaX6g[ZhxemW|c3nvckBweiClZXzsJIFxd3C2b4Ppdy=> MoHJNlU5PzR4M{O=
HCT116  MYfBdI9xfG:|aYOgRZN{[Xl? MWq1NO69VQ>? NF7ndGEzcA>? M4j2XolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgSGRXWA>? MWqyOVg3QDhzOB?=
DTK-SME NHjXVXJCeG:ydH;zbZMhSXO|YYm= M1\IR|Ux|ryP MnrDNog> M3vzc2ROW09? MWnwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHL1dIl3[WOjaX7l M{TQelI2QDR|OEm3
HL-60 MkSyRZBweHSxc3nzJGF{e2G7 MVe1NO69VQ>? NHzhNXY1QGh? NUHXWXNzemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? NYDldYYxOjV6MkSwOFM>
U937 NFrjSZRCeG:ydH;zbZMhSXO|YYm= NGi4U|U2OM7:TR?= MYW0PIg> NYTDWZVOemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? MYSyOVgzPDB2Mx?=
A549 MXPBdI9xfG:|aYOgRZN{[Xl? M2HtW|IxKM7:TR?= NH74T|IzPGh? MYry[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JGhHS1BidILlZZRu\W62 NVH2Slh{OjV5OUSxOFk>
HeLa NFzHOZVCeG:ydH;zbZMhSXO|YYm= MlznNVDPxE1? MkLaOFhp NFPUWXNl\WOuaX7ld{B1cGVicnH0[UBw\iCjcH;weI9{cXNiZILhcYF1cWOjbHz5 MWSyOVc4OjV2NR?=
SGC-7901 NIPuW2FCeG:ydH;zbZMhSXO|YYm= MoTqNlDDqM7:TR?= MnvLNYg> M4\VVYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgc5hidGmybHH0bY4> MUOyOVc3PzB5Nh?=
MCF-7 MmjHRZBweHSxc3nzJGF{e2G7 Mle1NVDPxE1? NFHabJYzcA>? NFWxO5dqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JFND NHPIWGczPTd{MkGxOC=>
A549 MkLQRZBweHSxc3nzJGF{e2G7 M{TzRlExKM7:TR?= MlzzNlRp NF\uW29FVVOR MofvdJJwdW:2ZYOgTGJENXS{ZXH0[YQhSTV2OTDj[YxtKHO3co\peoFtKCZiYYT0[Y52[XSnczD0bIUh[2ynYY\l[EBRSVKSIHX4dJJme3Orb36= MYWyOVY5OzV4OB?=
U87 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fiPFUx|ryP MmPuNYg> NH3zbldz\WOxdnXyd{Bk\WyuIHfyc5d1cCCocn;tJHROYiC2cnXheI1mdnR? M{DW[lI2PjhzNk[4
Neocortical Neuron M1zNWW5mfXKxdH;4bYNqfHliQYPzZZk> MUKxNFDPxE1? MWSxbC=> NEC4S2VidnSjZ3;ubZpmeyCKb3nhcYll\SCDLVnu[JVk\WRiTnX1do91d3irY3n0fS=> M3u0TlI2Pjd3MECx
Primary human placental cytotrophoblasts NIG0UZNCeG:ydH;zbZMhSXO|YYm= M13kSVMx|ryP M1HkO|I1cA>? M2XONGROW09? M3;TVZJmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= M{XHPFI2PjR{NUmy
MM Ml6zRZBweHSxc3nzJGF{e2G7 M2i1XFUx|ryP MXuyNI1qdg>? M1THXpBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? NFOyeo8zPTV|MEC5PC=>
DLD1 Mor5RZBweHSxc3nzJGF{e2G7 MWqyNOKh|ryP MX2xbC=> MVnwZZJ1dHlicnX2[ZJ{\XNiY3XscEBieG:ydH;zbZMh[2G3c3XkJIJ6KFeVUEG= MoP3NlU2OjR{NE[=
MDA-MB-231 MnH2R5l1d3SxeHnjbZR6KEG|c3H5 M3LpW|Ex|ryP M{\hOlFp NG[yUZlifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 NXftfYJuOjV3MkG1NFE>
MKN28 MUPBdI9xfG:|aYOgRZN{[Xl? NF73UlgyOM7:TR?= M4S1O|MxdWmw M1vvXmROW09? NVvEWZE{cW6qaXLpeJMhXE6ILd8xJJBtfXNiQ1jYMYlv\HWlZXSgZZBweHSxc3nz M33IUFI2PTF|OU[w
HL-60 NWX6S3VXS3m2b4TvfIlkcXS7IFHzd4F6 NH7Y[nkyODEQvF2= M3PZRlFp MmH1SG1UVw>? M3Phd:KhcW2ycn;2[ZMhfmmjYnnsbZR6KG:oIGTDUmF{NXS{ZXH0[YQh[2WubIO= NVfKZYRsOjV3MEK5N|I>
AGS NFz2OFNCeG:ydH;zbZMhSXO|YYm= NIO5OJcyOM7:TR?= MofpNYg> MUHwdoV3\W62czDjeZJkfW2rbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3WtN{whNThuIHHu[EAuQSCycn;0[Ylvew>? NW\NUYFwOjV2OUKyNVQ>
A549  NV;rPYlOSXCxcITvd4l{KEG|c3H5 NFzjRVkyOM7:TR?= MXuyOIg> NXfhbXhb[myxY3vzJGROSVNvaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgZY5lKGGyb4D0c5Rq[yClZXzsJIRm[XSq M1;nb|I2PDN2OUi5
INS-1 MXvBdI9xfG:|aYOgRZN{[Xl? M2rNSlUx|ryP NV30e2ROPmh? M4\kN2ROW09? MV\k[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[g[YFzdHliYYDvdJRwfGmlIHPlcIx{yqB? M3Pkd|I2PDNyOEm3
Primary hepatocytes  M2X6bWFxd3C2b4Ppd{BCe3OjeR?= MWG1NO69VQ>? M{npNVE5cA>? MmjRbY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= MnLONlU1ODd3M{i=
L929-A  Mk\vR5l1d3SxeHnjbZR6KEG|c3H5 MX2yNOKh|ryP Moe0NlRp NUjIbnF[cW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo MmjPNlU{QTh3NEC=
L929-N NWP3S2F2S3m2b4TvfIlkcXS7IFHzd4F6 M3P5flIxyqEQvF2= NHvCN4czPGh? MVHlcohidmOnczDk[YF1cCC4aXGgZZV1d2O{aX7lJHRPTs7zIIDyc4R2[3Srb36= NX\xdYxiOjV|OUi1OFA>
Cytotoxicity Assay M3zSS2NmdGxiVnnhZoltcXS7IFHzd4F6 Mn:2NlDPxE1? MYK0PIg> NYnHd4t{eHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= NFvubVIzPTN7MkGxOi=>
COS7 MlrMT4lv[XOnIFHzd4F6 MoDFNVDPxE1? NFrXd3kzPGh? NUTMcVFicW6lcnXhd4V{KGOjc4Dhd4UhOy95IHHjeIl3cXSrZYO= NWT0TGE{OjV|OESwNlU>
COS7 Ml\oRZBweHSxc3nzJGF{e2G7 MkfVNVDPxE1? NXX3RWlUPDiq Mom2dIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= M1nBTFI2Ozh2MEK1
A375 NF3t[GZCeG:ydH;zbZMhSXO|YYm= Mk\pN|DPxE1? NFj4VmMzcA>? MYnwdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> MVWyOVM4PjFzNR?=
A549 NHTP[HJCeG:ydH;zbZMhSXO|YYm= MofPOVDPxE1? MXyyOIg> M4HXfpJmfmW{c3XzJJJq[m:|b33lJIJqd2enbnXzbZMh[W6mIHHwc5B1d3OrczDjZZV{\WRiYomgJGNpcWqxbnfkZY4> M2X2R|I2OzR7N{ix
A549 NXK5eng1SXCxcITvd4l{KEG|c3H5 NWXJco1lOi53LUK1{txO NGjhXWYycA>? M3\tXIRm[3KnYYPld{B1cGVicH;weYxifGmxbjDv[kBieG:ydH;0bYMh[2WubIOg[IVx\W6mIH;uJINwdmOnboTyZZRqd26| NV7rTIVXOjV|NEK0Nlc>
 NBL-W-S  NV;vTIg{SXCxcITvd4l{KEG|c3H5 NY\h[GY2PTEQvF2= MXGxbC=> MWDmeYxtgSC{ZYPjeYV{KGOnbHygeoli[mmuaYT5JIFnfGW{IFfBUnQuPjFidILlZZRu\W62 MkXwNlU{OjN{MkK=
Caki-1  Ml3sRZBweHSxc3nzJGF{e2G7 NVXPbWw4PDEQvF2= MVu0PIg> NXT1O2I3emWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? M4jmUVI2Ojd7MUmx
769-P NIW3bpZCeG:ydH;zbZMhSXO|YYm= M1PRNVQx|ryP NVHKU5hIPDiq MkLwdoVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> NEDJOWszPTJ5OUG5NS=>
H9c2 MYHBdI9xfG:|aYOgRZN{[Xl? MnXDOVDPxE1? MkD5NYg> MXvpcohq[mm2czDEU3gucW6mdXPl[EBk[XOyYYPlJFMh[WO2aY\heIlwdiCkdYSgco91KHSqZTDsc5N{KG:oIHPlcIx{ MY[yOVI5OzhzOR?=
K562 MXvBdI9xfG:|aYOgRZN{[Xl? Mn7YOVDPxE1? MWS0bC=> NHPYSJFqdmirYnn0d{BL[WNvQT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ NEHQbo4zPTJ2MU[xPS=>
L929 MnPRRZBweHSxc3nzJGF{e2G7 Mnr1NVDPxE1? NUTRdHVCPmh? NWT0SVNtcW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? NY\WNZhFOjVzOUW2OlA>
A549 NFT4e5dCeG:ydH;zbZMhSXO|YYm= NX\pTGVtOTEQvF2= NVrWW3gyO2h? MUHy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= NWLzTWhROjVzNkG2PVk>
MCF-7 M13KNmFxd3C2b4Ppd{BCe3OjeR?= MXWyNO69VQ>? NYnrZ4t[Omh? M{flcoRm[3KnYYPld{BMTFJvc3nSUmEucW6mdXPl[EBieG:ydH;zbZM> MUGyOVE5OjJ2MB?=
OS NGDqd5pCeG:ydH;zbZMhSXO|YYm= NXzpZ5BrOjBxNEFOwG0> MmDuO|Jp MYXpcohq[mm2czDPV{Bk\WyuII\pZYJqdGm2eTDy[YR2[3Srb36gZpkhSzZiY3XyZY1q\GV? M1;BbVI2OTV{M{m5
HUVECs NVfFToE4SXCxcITvd4l{KEG|c3H5 MYWxNO69VQ>? NHezeZMzcA>? MUpCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGhWXkWFcx?= MXyyOVE{QDdyMx?=
EA.hy926 MlqzRZBweHSxc3nzJGF{e2G7 NEjiUmwyOM7:TR?= MljBNog> MoLsxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBGSS6qeUmyOi=> MVGyOVE{QDdyMx?=
Ebs NVG2NVN6SXCxcITvd4l{KEG|c3H5 MkPONVAuOTByzszN NYHFTJFuOjSq MoLRxsBOVVSVIHflcoVz[XSrb36gdoF1\SCmZXPy[YF{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36gc4Yhgi2YQVSu[o1sKGmwY4LlZZNm\A>? NW\admd5OjVzM{S4NVc>
Jurkat NEC2fIRCeG:ydH;zbZMhSXO|YYm= M2LGWlIx|ryP Mn\hNlRp NHO5WnpFVVOR NV3pPYQ{eGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi M3PzZ|I2OTJyN{Kz
K562 M2PoRWFxd3C2b4Ppd{BCe3OjeR?= MWqwMlEuOc7:TR?= NFXGbWYycA>? MoHJbY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MV[yOVEyQTF6OB?=
IMR-32 NWLxUIpPSXCxcITvd4l{KEG|c3H5 NGTXdmU1OMLizszNxsA> MmjqNog> M2\NWoRm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? MXqyOVA5PDd3NR?=
RPMI 8226 MoLhRZBweHSxc3nzJGF{e2G7 Mn3ZNVAx|ryP NF3CXHoycA>? NF;4Xm9idG2xc4SgZ49ueGyndHXsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= MX2yOVA{Pzh3MR?=
U266  MV\BdI9xfG:|aYOgRZN{[Xl? NWPTOph3OTByzszN NFXaXowycA>? NIP3SpNx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NEixTpMzPTB|N{i1NS=>
H929  NGnrVmtCeG:ydH;zbZMhSXO|YYm= NIHUc3gyODEQvF2= NFrQN3YycA>? MkfndIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NVKw[W1qOjVyM{e4OVE>
MM.1S  NGDybo1CeG:ydH;zbZMhSXO|YYm= NVe5fFU4OTByzszN NWHwdXdvOWh? NUfSV4Nl\W[oaXPp[Y51dHlicILleoVvfHNic3;yZYZmdmmkLXnu[JVk\WRiY3XscEBl\WG2aDDjc41jcW6nIIfpeIghdmWlcn;zeIF1cW5vMR?= NYiwSItNOjVyM{e4OVE>
C6 NGXRfXNCeG:ydH;zbZMhSXO|YYm= Mo\SOVDPxE1? M{focFQ5cA>? NEPvPWZxemW4ZX70d{B1cGVibH;zd{Bw\iClZXzsJJZq[WKrbHn0fUBk[XW|ZXSgZpkheHKnZ37lco9td26n MXuyOVAyOzR5OR?=
AGS MVvBdI9xfG:|aYOgRZN{[Xl? Mn34OVDPxE1? M4\yc|I1cA>? NGe1VY5i[m:uaYPod{DPui2uYYDhZ4hwdmVvaX7keYNm\CClZXzsJIRm[XSqIHHu[EBqdmirYnn0[YQh\3Kxd4To NEHXUXYzPTByOU[5PC=>
HeLa  Mo\iRZBweHSxc3nzJGF{e2G7 MX[0NO69VQ>? NF\JWnozPGh? M2iybYlvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= NYHNR2FmOjR7Mki2PFU>
THP-1  NYXHRVZTSXCxcITvd4l{KEG|c3H5 M2nW[VEx|ryP MlLVNYg> MnXYdoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> MXOyOFkzOzZ3Mx?=
P815  Mn;NRZBweHSxc3nzJGF{e2G7 MmHONVAxKML3TR?= NVj2dGdXOTKq M{X3V2ROW09? MmXvbY5pcWKrdIOgeolzfXNvaX7keYNm\CCjcH;weI9{cXN? MmXhNlQ6OjN{N{O=
HCT116 M2Kx[mFxd3C2b4Ppd{BCe3OjeR?= NYPZcmVqOjEQvF2= NET4fG8zPGh? NFP2cWpi[nKxZ3H0[ZMhd2ZiVGGtbY5lfWOnZDDhdI9xfG:|aR?= M3\SZlI1QDlyNES5
SW1116  MWXBdI9xfG:|aYOgRZN{[Xl? NIT4XWQyOCEEtV2= M3jwbVFp MlzGSG1UVw>? MkHHdoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= Ml6xNlQ5PzR{OE[=
LOVO NVzLW5dMSXCxcITvd4l{KEG|c3H5 NHrQ[mkyOCEEtV2= Mo\RNYg> NWLSem56TE2VTx?= NX\ZW3BvemW|dILhbY5{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkh\2WoaYTpcoljKHCudYOg[IVkcXSjYnnu[S=> Mn3xNlQ5PzR{OE[=
SNU449  MnrkRZBweHSxc3nzJGF{e2G7 MlnENlDPxE1? MnvlOFhp Mn3ZSG1UVw>? M1[1eIRm[3KnYYPld{BucVJvNEWxMYlv\HWlZXSgZZBweHSxdHnj M{ToWFI1QDRzNkO4
Caco-2 MojBRZBweHSxc3nzJGF{e2G7 MYi0NQKBkc7:TR?= NWThUFE5PGh? NFu5TnVxemW4ZX70d{BUXC15LXnu[JVk\WRiWl:tNUBkcGGwZ3XzJIFv\CCWRWKg[JJweA>? MX2yOFgzOjF6Mx?=
macrophage M2TUeGNmdGxiVnnhZoltcXS7IFHzd4F6 NWnUUlgzOC1{MEFOwG0> MUKyOIg> M{\mRYlv\HWlZYOgWG5HNSCjbnSgVolxOy2mZYDlcoRmdnRibnXjdo9xfG:|aYOgbY4hdWGlcn;wbIFo\Q>? M{jnW|I1Pzl7NU[1
AGS  MWHBdI9xfG:|aYOgRZN{[Xl? NIDTUIMzOM7:TR?= NIPnfIgyOmh? MnLkSG1UVw>? M1LVRpJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ M4HUUFI1Pzh7N{Cz
LCC9  NGX0cnVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1T0XlExOM7:TR?= M2HwO|Vl NIXvT2VjdG:la4OgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIFyxO{BidmRiY3jsc5JweXWrbnW= NFfBeW8zPDd6NUK1Oi=>
U937  M2TRTY5m[3KxcITvd4l{KEG|c3H5 M{LiXFExyqEQvF2= Mni4N|DDqG2rbh?= NHnZRWlqdmS3Y3XzJI5m[3KxcITvd4l{KGOxbXLpcoUhf2m2aDDUUmY> M{fs[FI1Pzd|N{W2
T cell MnzyR4VtdCCycn;sbYZmemG2aX;uJIF{e2G7 NUn0PJd4OC1zMEFOwG0> MoTUO|Jp MWXJR|UxRTdyIN88UUwhcW6qaXLpeJMh[W62aT3DSFMucW6mdXPl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCrbjDQRm1Eew>? M17NUlI1PzZ6N{C3
HeLa  MYHBdI9xfG:|aYOgRZN{[Xl? MnzHOVDPxE1? NWS2TJlnPzKq MkPwSG1UVw>? NUKwcFlweHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3;tdI92dmS|wrCx5qCUPQ>? MnfxNlQ4PTR5OE[=
HeLa  MY\BdI9xfG:|aYOgRZN{[Xl? Mn;qNVAx|ryP NUn0eIZiOjSq MU\zeZBxemW|c3XzJJJifGVib3[gZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KG:4ZYLlfJBz\XO|aX;uJI9nKEd3OWOgc5IhTzdzUjDwNVUx\2y3ZXVCpC=> MlmyNlQ4OjJ2Nki=
IEC-6  MWLBdI9xfG:|aYOgRZN{[Xl? NVTpeYdMOTEQvF2= NW[4eYVwOjSq M17ae5Bz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NFHEdnYzPDdzMUW3NS=>
HCT116 NUTVRXk6SXCxcITvd4l{KEG|c3H5 M4LKPVIx|ryP Mmj0NlRp MUTpcohq[mm2czD0bIUh[2WubDDhdI9xfG:2aXOgbY5lfWOnZDDifUB[VFR{MEW= MnzxNlQ4OTN6MUK=
L02 M3zGNWFxd3C2b4Ppd{BCe3OjeR?= MWmyNO69VQ>? NVrqfGpUOWh? NXXaNWp4eHKndnXueJMhfGinIHPlcIwh[XCxcITvd4l{KGmwZIXj[YQh[nliTVXIVC=> Mnu3NlQ4ODZ2NkG=
A375 NXTSU5ZySXCxcITvd4l{KEG|c3H5 NEDYOVkzOM7:TR?= Ml[5NlRp MkXndoV3\XK|ZYOg[IlkcXS{aX7vcoUhSi2rbnT1Z4VlKGGyb4D0c5Nqew>? NWPzNFduOjR4OUmxNVE>
HDPC MluzRZBweHSxc3nzJGF{e2G7 MWK1NOK2VQ>? MoX5NlRp MlL0bY5pcWKrdIOgUm8ucW6mdXPl[EBieG:ydH;zbZM> MlrSNlQ3OzR3OUO=
A549 MlL2RZBweHSxc3nzJGF{e2G7 M4XwU|UxyrWP MUGybC=> NHvIfWFFVVOR M3TnSZBz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw M2DkN|I1PTh6MUO1
 BV-2 M4jaVWFxd3C2b4Ppd{BCe3OjeR?= MnPkNlDPxE1? NY[ze2EzOmh? MmOxd5VxeHKnc4Pld{BWXi2rbnT1Z4VlKGOqcn;tZZRqdiCneITyeZNqd25iYX7kJIRqdGG2aX;uJI9nKHSqZTDueYNt\WG{IHXueoVtd3Cn M3\Hb|I1PTV6MUG4
HT-29  M1\iN2Fxd3C2b4Ppd{BCe3OjeR?= M1K4d|Ux|ryP NX;2UY03PDiq MkLDZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u NYnCPWtuOjR3NEmxO|U>
A549 NFT2VlBCeG:ydH;zbZMhSXO|YYm= MYC1{txO NVTpemNvOjSq NUC5VXQ6e3WycILld5NmeyB4ZdMgLGJMOTByNECpMYlv\HWlZXSgZZBweHSxc3nzxsA> M1OxOlI1PTJ7OEex
MIA-PaCa-2 MoLzRZBweHSxc3nzJGF{e2G7 NVTFT3dqOjSq NHnyRpNjdG:la4OgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGmwZIXj[YQh[nliYn;0bEBCNTR2M{[1OEBidmRicHHjcIl1[XinbB?= M3O5UlI1PTFyOUmy
Caki-1 MXLBdI9xfG:|aYOgRZN{[Xl? MkjqNlDPxE1? MlXFNYg> MkXEbY5pcWKrdIOgV2NRNWmwZIXj[YQh[XCxcITvd4l{ NXXj[JdTOjR3MES2PFE>
CLL NGfYR|RCeG:ydH;zbZMhSXO|YYm= Ml3vNlXPxE1? NG\RSlEycA>? NELEcJlx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NXT0SHhsOjR2Nke2N|Q>
SGC-7901 MoXPRZBweHSxc3nzJGF{e2G7 NHTpVXkyOM7:TR?= MnPQNlRp NVnUTGFMeHKxbX;0[ZMhfGinIFPHTWkucW6qaXLpeIVlKGOnbHyg[5Jwf3SqIHnuJHNISy15OUCxJINmdGy| NIHSOnEzPDR3NES4PC=>
k1735 NXztUYI3SXCxcITvd4l{KEG|c3H5 M2e4RlIx6oDLzszt MXW0bC=> M3r0R4lvcGmkaYTzxsBU[Wyvb37lcIxiNWmwZIXj[YQh[XCxcITvd4l{ NWDEV5hmOjR2NUGxNVY>
HaCaT  Mm\iRZBweHSxc3nzJGF{e2G7 NHjIOJQyODEQvF2= NG\MSGYycA>? M4DKc4JtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= M1P6NVI1OzV4OUm3
podocytes NULvW2FuSXCxcITvd4l{KEG|c3H5 Mle3NlAx|ryP M4[zXVZp NFTOdFlqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSB|LEStSGdG Mo[xNlQ{Ozd5N{e=
 KB NWT5fmY6SXCxcITvd4l{KEG|c3H5 NXrCc24{PTEQvF2= MXOyOIg> M{\sVolvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u NYPsPJUzOjR|M{e0PVI>
 HepG2  MX3BdI9xfG:|aYOgRZN{[Xl? NEH6PHMyOM7:TR?= Mmf0NlRp MnLndoVlfWOnczD2bY1mdnSrbjDjcIVifmGpZTDjZZV{\WRiYomgUHBU NH7aVnYzPDN{NUixOi=>
fetal rat lung fibroblasts  NV;OXmFzU2mwYYPlJGF{e2G7 NX6xWJRPQDEQvF5CpC=> M1;HelFp MmjMbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> NULDbo9OOjR|MUSxN|U>
PDL fibroblasts MljJT4lv[XOnIFHzd4F6 NEjYWWI5OM7:TdMg MUSxbC=> MYHpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> NIrUZWczPDNzNEGzOS=>
MB49 NUXMPFQ{SXCxcITvd4l{KEG|c3H5 M4jwelIx|ryP MmGyNYg> NH[0cVdz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? NHWwXWwzPDJ6MkSzNy=>
5637 MnLpRZBweHSxc3nzJGF{e2G7 MXSyNO69VQ>? MmjINYg> NGqzSJlz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? MmXRNlQzQDJ2M{O=
A549  MkfVRZBweHSxc3nzJGF{e2G7 NIjxTIsyODEQvF2= M3rMRVQ5cA>? Mlvtd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg NYXkcGtIOjR{N{KyNFE>
MCC-2 M{LzO2Fxd3C2b4Ppd{BCe3OjeR?= M{nBT|IxKM7:TR?= MUC2bC=> MUXEUXNQ MoTjZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= NFX0U2YzPDJ4Mk[1PC=>
ADF NYrkSGFsSXCxcITvd4l{KEG|c3H5 MkHVOFDPxE1? M4jCe|Zp MXnpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NXjF[IVLOjR{MkiyN|I>
 U373  M1XiNmFxd3C2b4Ppd{BCe3OjeR?= M2exSFQx|ryP M17RS|Zp MUPpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MnvINlQzOjh{M{K=
RKO-HIPK2i M1rybWFxd3C2b4Ppd{BCe3OjeR?= NYP4PVk5PDEQvF2= M2Ps[lZp MlLzbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NELl[4gzPDJ{OEKzNi=>
HEC-1B Ml\kRZBweHSxc3nzJGF{e2G7 MmDXNlDPxE1? MnfBNYg> NHvkXIRz\WS3Y3XzJHRRNWmwZIXj[YQh[XCxcITvd4l{yqClYYPwZZNmNTNiYX7kJINie3Cjc3WtPS=> MlrkNlQzOTN|NUi=
4T1 NF;2OnRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MlzYNk42NTFyzszN MWe0bC=> MYPEUXNQ NXXlZlRpemW|Y4Xld{B1cGViY4n0c5RwgGmlaYT5JI9nKDSWMTDj[YxteyCrbnT1Z4VlKGK7IGPQSHQhcW5iYTDjc45k\W62cnH0bY9vKGSncHXu[IVvfCCvYX7u[ZI> M1i3RVI1OjB4MU[x
OS  NVH0OpFQSXCxcITvd4l{KEG|c3H5 NGLyeGgzOM7:TR?= M2W2XlRp MVXpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliUFTU NX7hZZIzOjR{MES5N|c>
RPE M3TnWGFxd3C2b4Ppd{BCe3OjeR?= M{HSTlExOM7:TR?= M1T0T|Q5cA>? MVPwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> Mo[3NlQzODJyNUK=
UD29a NF:2XnpCeG:ydH;zbZMhSXO|YYm= M1K3OFUx|ryP MlfNNlRp M4rLZolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDOWXQ{ M2jMWVI1OTlyNUe0
SH-SY5Y  MnPxRZBweHSxc3nzJGF{e2G7 MoLLNVDPxE1? NU\x[VZuOjSq NGTMWmZifHSnboXheIV{KGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KEiQRT2ySGc> NVXOSnhuOjRzNEW0OlM>
HeLa  MXnBdI9xfG:|aYOgRZN{[Xl? MlK3NVAwOjEQvF2= NGXYcXEzPGh? NUHEVll1cW6qaXLpeJMhfGinIHHjeIl3cXS7IH;mJJRp\SCvYXrvdol1gSCxZjD0bIUhdWWvYnXyd{Bw\iC2aHWgZ4F{eGG|ZT3mZY1qdHl? NEH6PHEzPDF|N{K2Oi=>
SCCVII  NFfo[ZlCeG:ydH;zbZMhSXO|YYm= NUjsbGpEOjYQvF2= MV[xbC=> MUDpcohq[mm2czD0bIUh[2WubDDrbYxtcW6pIHHmeIVzKGSjc3H0bY5q[g>? M3rZUFI1OTJ4NE[0
RAW 264.7 MnPmRZBweHSxc3nzJGF{e2G7 M1L6PVIx|ryP NFjmWHkyQGh? NX63dZJFcW6lcnXhd4V{KEyFMz3JTU/Pui2jY4TpckBz[XSrbzDjc41x[XKnZDD0c{BGS1SYLV3PV{B1emWjdH3lcpQhd26ueR?= MofqNlQyOTZ5MEe=
A549  MWHBdI9xfG:|aYOgRZN{[Xl? MV6yMlXPxE1? Mn3xNlRp MVPk[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> NHHJe24zPDFyMkWyNi=>
UM-SCC-10A  M3rhNmFxd3C2b4Ppd{BCe3OjeR?= NEL0bW82OML3TR?= NYDPfJBWOmh? NH;XfWVz\WS3Y3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGirZ3it[I9{\SCrc3;hcIFvfG:uYXP0c45m MknqNlQxQTh5NUO=
BGC-823 MUXBdI9xfG:|aYOgRZN{[Xl? NU\HVnVSOTBizszN MVSyOIg> Mn6zdoVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh M{n4XFI1ODl6NUGx
Nalm-6  M1XpNmFxd3C2b4Ppd{BCe3OjeR?= NVnWSHhuOjEQvF2= M2XPZlRp NVm5d5hzcW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm M4T6U|I1ODN7OU[3
KHOS  M3PoPGFxd3C2b4Ppd{BCe3OjeR?= NEHKfFg1OM7:TR?= MUmyOIg> NULteldG[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NH36UpEzPDB{NUO2NS=>
G292 NX3GNIJ3SXCxcITvd4l{KEG|c3H5 MmHUOFDPxE1? MUOyOIg> M4j1ZoJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= NVfVfm1XOjRyMkWzOlE>
MG-63 MonaRZBweHSxc3nzJGF{e2G7 Mm\3OFDPxE1? M1XzSFI1cA>? MlfqZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MkPqNlQxOjV|NkG=
EBV-transformed B cells MnzSRZBweHSxc3nzJGF{e2G7 NF62OJIzOM7:TR?= NITEd4kzcA>? M3HZ[mROW09? Mn;pZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ NHjSfpMzPDByOE[yPC=>
IM-9 B MWHBdI9xfG:|aYOgRZN{[Xl? MWiyNO69VQ>? MWiybC=> M4\kdmROW09? M325RoJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? NWHBWWhXOjRyMEi2Nlg>
CNE1 NUXtZ4N[SXCxcITvd4l{KEG|c3H5 NHXpNZQzOM7:TR?= NXO0T3JUPDiq NGHIXWpjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? NEnWc|YzOzl6NUCyPS=>
CNE2 NV7wWYJ[SXCxcITvd4l{KEG|c3H5 NEnRS4szOM7:TR?= M4n3N|Q5cA>? NFrnd2pjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MoTpNlM6QDVyMkm=
HL-60 MUjBdI9xfG:|aYOgRZN{[Xl? Mn33OVDDvU1? NIjOdFEycA>? NGXp[VFFVVOR MWHpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBDSTF2NR?= M1;V[lI{QTR6N{Wx
L929 NFzF[Y1CeG:ydH;zbZMhSXO|YYm= MWixMlI26oDVNdMg{txOyqB? NF36bHczPGh? NVO0eGFS[XWpbXXueJMhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 MlzQNlM6PDF5Nkm=
Jurkat NEP2[WFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3K1TlLPxE1? NWftWHN6PGh? MVHy[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? NFmwSo4zOzh7NkC2NS=>
RAW264.7  M3ixNWFxd3C2b4Ppd{BCe3OjeR?= Mn3QNVAh|ryP NFr3NXAzPGh? MVLk[YNz\WG|ZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFfB NEPT[IMzOzh{MEKwNy=>
A431  NF7meY5McW6jc3WgRZN{[Xl? M1v0dlQx|ryP MVeybC=> MlvDZoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= M2HVfFI{QDByMEW4
Jurkat Mk\TR4VtdCCYaXHibYxqfHliQYPzZZk> MlOzNlUuOTByzszN NITMe3c3cA>? MXvpcohq[mm2czD6MWZCNUOPSz3pcoR2[2WmIHPlcIwh\GWjdHi= MmmwNlM6OzN3M{K=
COS-7  M1j3e2Z2dmO2aX;uJGF{e2G7 MX:1NOK2VQ>? M4L6PVI1cA>? M1jZcYFn\mWldIOgeIhmKHC{b3Pld5Nqdmdib3[gRXRPOXNid3n0bEBxd2y7UTD0doFkfHN? NEnDW|gzOzl|M{KwPC=>
CAL27 NGHteJJCeG:ydH;zbZMhSXO|YYm= M4[wWFExKM7:TR?= MmjVNog> MnGxd5VxeHKnc4Pld{BEfXJvTmDzMZJm\HWlZXSgeoli[mmuaYT5JIJ6KHWyIITvJFkxLQ>? MV6yN|kyPzN7Nh?=
THP-1  NFr1Z4JCeG:ydH;zbZMhSXO|YYm= M17heFExNTVyzszN NXPjOYh3Omh? NYP5NJRncW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= M4[zcVI{QTByMkm5
K562 Mo\sRZBweHSxc3nzJGF{e2G7 NV;FenlHOjEQvF2= MXu0PIg> NXTveGZmcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliND3NWS=> M1\aXVI{QDd4OEK2
HL-60 Ml:1RZBweHSxc3nzJGF{e2G7 M1Lp[VExOM7:TR?= NVjHeIF4OjSq M3ruT4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGGkaXX0ZY5mKGSrdHXydIVv\XQEoB?= M1W2e|I{QDZ3N{e4
HeLa  MXnBdI9xfG:|aYOgRZN{[Xl? M4SwclIx|ryP NH30fGYzcA>? NITqUGZqdmirYnn0d{BFVU2SIHnu[JVk\WRiYYDvdJRwe2m| MUSyN|g3Ozl4Nh?=
U251 MW\BdI9xfG:|aYOgRZN{[Xl? NV73eJViOjEQvF2= MXiyOIg> NGjHT4tqdmirYnn0d{Bk[XO2aXPpckBqdmS3Y3XkJGczN01icHjhd4Uh[XK{ZYP0JIFv\CCjcH;weI9{cXN? MYiyN|gyPjhzNh?=
HL-60 NUn5SlJTSXCxcITvd4l{KEG|c3H5 MmPaOVDDvU1? NVHZ[oZrPGh? NVvFWHA4[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z M2[wVVI{QDB2N{C2
Ec-109 MVHBdI9xfG:|aYOgRZN{[Xl? MmXtNVAh|ryP MnjVOFhp MX7y[ZBz\XO|ZYOgVGUudWWmaXH0[YQhTWNvMUC5JINmdGxiYYDvdJRwe2m| NYr1PZhpOjN5OEK2OFE>
RKO MYPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> Mlf2NVAh|ryP NH;XWXQzPGh? M4HScIlvcGmkaYTzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSClYYXz[YQh[nliRFHC MX[yN|c2QDB4NB?=
T98G MkHTR4VtdCCYaXHibYxqfHliQYPzZZk> NH\wdpkyNTFyMN88US=> MnrYNlRp NETlZmxqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT NGjaZVgzOzd4OUK3OS=>
Jurkat NX3RPW9IS2WubDDWbYFjcWyrdImgRZN{[Xl? MoPYNVAxNTJyMN88US=> M4X5UVI1cA>? MVzpcohq[mm2czDIZWE1KGmwZIXj[ZMh[XCxcITvd4l{KGSncHXu[IVvfCCxZjDjc45k\W62cnH0bY9vyqB? NUD6bolPOjN5M{K0PFE>
Molt-3  MX\BdI9xfG:|aYOgRZN{[Xl? NGjWe2c2OM7:TR?= NFrOTlczcA>? NHvt[mdz\WS3Y3XzJI1mdGG2b37pck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NV\JcY1ROjN5MkWwNVM>
hMSC12 MUHBdI9xfG:|aYOgRZN{[Xl? NFn0NZAyODEQvF2= NVf4TJFuPGR? MXnpcohq[mm2czDvd5Rmd2enbnnjJIN2dHS3cnWtbY5lfWOnZDDj[YxtKGSnYYToJIFv\CClYXzjbYZq[2G2aX;u MlnpNlM3PTd6MkK=
HM7  NHKyfG1CeG:ydH;zbZMhSXO|YYm= NFLmRmszOM7:TdMg NYXrV5NMOWh? NH;wSotjdG:la4OgZZBq[3WuYYLlckBCKGGlZYTheIUucW6mdXPl[EBk[XOyYYPlMVMh[WO2aY\heIlwdiCjbnSgVGFTWCClbHXheoFo\Q>? Mn7rNlM2QDN2MUK=
Hep-2  MoPPRZBweHSxc3nzJGF{e2G7 NH;kfFczOM7:TdMg MVWyOIg> MnO5SG1UVw>? MnTDZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= M3LKOVI{PThyMEOy
HSCs MX;BdI9xfG:|aYOgRZN{[Xl? M1TFXVUx|ryP MYiyOIg> NFLUcGlFVVOR Mo\YbY5pcWKrdIOgcoltd3SrbnniMYlv\HWlZXSgSG5CKGSjbXHn[UBqdmSrY3H0[YQh[nliUFHSVEBkdGWjdnHn[S=> NFHaR2MzOzR7OUi3OC=>
HL-60  MVPDfZRwfG:6aXPpeJkhSXO|YYm= MVeyNO69VcLi MX[yOIg> MU\y[YR2[2W|IITo[UBkgXSxdH;4bYMh\W[oZXP0JI9nKEW{eUW= MorxNlM1QTR2OEC=
HA M3fMNmFxd3C2b4Ppd{BCe3OjeR?= NIDEWW02OM7:TR?= MXOyOIg> NG\EWW1{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? M1X1VVI{PDd3OUW2
C666-1 MXTBdI9xfG:|aYOgRZN{[Xl? M4\Jb|Ux|ryP NIrRUlQzPGh? NWW3SmxCe3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD NXrw[HFGOjN2N{W5OVY>
Hepa1-6 NG\BUoRCeG:ydH;zbZMhSXO|YYm= M2\wN|Ux|ryP NWXERYtkOmh? NFLQe2tqdmirYnn0d{BkfXKldX3pckBidmRicnXzeoVz[XS{b3ytbY5lfWOnZDDhdI9xfG:|aYO= MmOzNlM1PDZ5NUO=
PLC/PRF/5c NV7DOpMxSXCxcITvd4l{KEG|c3H5 NWnld2pxPTEQvF2= MoLpNYg> M1:xSJBz\X[nboTzJIFxd3C2b4Ppd{B1emmpZ3Xy[YQh[nliQ1nO M{D4blI{PDN6OEK0
HCT116 MWDBdI9xfG:|aYOgRZN{[Xl? M3rGSFExOM7:TR?= NYGxUpJ1OS53aB?= MX7pcohq[mm2czDPd{1qdmS3Y3XkJINmdGxiZHXheIg> NFfXVFczOzd2NEO1Ny=>
HCEC MnftSpVv[3Srb36gRZN{[Xl? M{DGW|Ux|ryP NXPYSYlHPzKq NGixSZRFVVOR MY\y[ZN1d3KnczDv[kB1cGVibn;ycYFtKEiFRVOgdIhmdm:2eYDl MVKyN|c1OjBzMR?=
Primary rat cerebral cortical neurons NUPvNGI3SXCxcITvd4l{KEG|c3H5 NFvkPG0yODEQvF2= MlS5NYg> NHTGNoNxemW4ZX70d{BE\C2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgZ4VtdCCmZXH0bC=> NWHvdGdCOjN5NEGzNVc>
MDA-MB-231  MV;BdI9xfG:|aYOgRZN{[Xl? Mnm3NlXPxE1? NYm2cVFsOjSq MkXoZYJzd2ejdHXzJIN6fG:2b4jpZ4l1gSCjbnSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGGwZDDQRXJRKGmwZIXj[YQh[nliUnez MXiyOVM{PzV2NB?=
NLRP3-Tet-on-MC/9  Mo\nRZBweHSxc3nzJGF{e2G7 NFPZRZUyOC12MN88US=> M{j2dFEzcA>? NHS3WlVifHSnboXheIV{KHSqZTDj[YxtKGSnYYToJINifXOnZDDifUBESVCVLXHzd49kcWG2ZXSgUmxTWDNibYX0ZY51eyCrbjD0bIUhXGW2LX;uJJN6e3SnbR?= MlPGNlM4ODN|OEm=
KNS42  MYfBdI9xfG:|aYOgRZN{[Xl? NWXpU4l5PTEQvF2= Mn\5NYg> MUPy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGOxbYDs[ZRmdHliYXLvcIl{cGWmIHPhd5Bie2ViMz:3JIFkfGm4aYT5JIlvKHKnc4DvcpNmKHSxIFHCWE0zPjNxMlTHM41mfG[xcn3pckBkd22kaX7heIlwdg>? MoGzNlM3QTFzNEW=
MCF-7  M2jCbGFxd3C2b4Ppd{BCe3OjeR?= NH7WWZczOM7:TdMg NV\WZYhbPzKq M2DTSYlvcGmkaYTzJIVyfW:uLTDhcoQhPC2RSGStcYVlcWG2ZXSgZZBweHSxc3nz MmOzNlM3PzV4NEO=
hCMEC/D3  MXvBdI9xfG:|aYOgRZN{[Xl? M4jnWFI2|ryP M2DpTlczcA>? NH[yS4pz\WS3Y3XzJGx1gEFiaX7keYNm\CCjcH;weI9{cXN? MXiyN|Y3PTF7OB?=
Jurkat NHnTfJRCeG:ydH;zbZMhSXO|YYm= MlXMNVIvPS13MN88US=> NHnzfIwycA>? NHfxUVVld3OnIHTldIVv\GWwdHz5JJN2eHC{ZYPz[ZMhW1CKLXnu[JVk\WRiUHHyMVQh[2ynYY\h[4UtKFCDUmCgZ4xm[X[jZ3WsJGRPSSCocnHncYVvfGG2aX;uMEBidmRibH;zd{Bw\iC4aXHibYxqfHl? NHnUPWkzOzR2Mkm3Oi=>
CNE-1 MnfYRZBweHSxc3nzJGF{e2G7 NYixT3g2OjEQvF5CpC=> MmnLNlRp NG\qbmpqdmirYnn0d{BTSURyMEGtbY5lfWOnZDDj[YxtKGSnYYTo NX\0UVU1OjN2Mk[4OVA>
HONE-1 Ml\nRZBweHSxc3nzJGF{e2G7 MY[yNO69VcLi MVSyOIg> M3PqdIlvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= NWThS4ZsOjN2Mk[4OVA>
astrocytes cell NY\DOJpJSXCxcITvd4l{KEG|c3H5 MW[0NO69VQ>? NIe2fGE3cA>? Mmi2doVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m M{Gzd|I{PDFzN{e4
U-937 NH7EUY5CeG:ydH;zbZMhSXO|YYm= MXqxNO69VQ>? NX74cXVlOzCvaX6= NXrVbFhWeHKndnXueJMhXE6ILXnu[JVk\WRibnXjdo9xfG:|aYO= MX2yN|QyODd2OB?=
MDA-MB-231 NXz2N2FtSXCxcITvd4l{KEG|c3H5 Mn36NVAx|ryP NFzwcHIycA>? NXX0[JFMcW6qaXLpeJMhe2Wwc3n0bZpifGmxbjD0c{BVWkGLTDD1dI9vKE2WRFig[I94di2{ZXf1cIF1cW:w MWWyN|QxQDR{OR?=
HeLa  MYLBdI9xfG:|aYOgRZN{[Xl? MV[xNFDPxE1? NFizb44zcA>? MVricI9kc3NiSmLTMVE2KEmwZIXj[ZMhSXCxcITveIlkKEOnbHygSIVifGh? NWL4dFJ5OjN|NESwOFU>
Ec109 MVLBdI9xfG:|aYOgRZN{[Xl? MX:xNO69VQ>? MlfQOog> M{DoPIJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v M2XqSFI{OzN6NU[4
H460  NVvle5dpSXCxcITvd4l{KEG|c3H5 MYSxNO69VQ>? NHfzb4I3cA>? M4mwe4Jtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v MmXTNlM{Ozh3Nki=
HeLa  NFPKXWJCeG:ydH;zbZMhSXO|YYm= M1jt[|Ux|ryP MX2xMlVp M1X4TYFjem:pYYTld:KhS2iuYX35[IliNWmwZIXj[YQh[XCxcITvd4l{ NUe5bVBtOjN|MEO4NFQ>
SK-HEP1 MWjBdI9xfG:|aYOgRZN{[Xl? MVexNFDPxE1? NX\KfJRmOWh? NF7FXGJqdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= M2LTclI{OzB{NkWw
QGY7701 M1Oxc2Fxd3C2b4Ppd{BCe3OjeR?= NFLCfHIzPc7:TR?= MmjPNU42cA>? NYjORWwycW6qaXLpeJMh[WOldX31cIF1cW:wIH;mJJN2[i2JMTDwbIF{\SCrbnT1Z4VlKGK7IFTPXEAsKHG3ZYLj[ZRqdg>? NGfsNlMzOzJ2MEC2NS=>
HepG2 Ml31RZBweHSxc3nzJGF{e2G7 MkjkNlDPxE1? MUSzNI1qdg>? M33hWolvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? M{DsTFI{OjJ2MkO5
U87  M2jqdmFxd3C2b4Ppd{BCe3OjeR?= M{D2eFI2|ryP NFzycYkzcA>? NFLUXFZl\WO{ZXHz[ZMhcXOxbHnxeYlzcXSrZ3XubY4hMEmVTDmtbY5lfWOnZDDhdI9xfG:2aXOgZ4VtdCCmZXH0bEwh[nW2IH7veEBv\WO{b4TpZ{Bk\WyuIHTlZZRp MXGyN|IzQTZ{Nh?=
HSC-2 MV;BdI9xfG:|aYOgRZN{[Xl? M3j5OFI2NzVyzszN M2fGSFFp MYHpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NVW3[pdnOjNzNUWyOFg>
HSC-4 M17POmFxd3C2b4Ppd{BCe3OjeR?= NGnHN2UzPS93MN88US=> NFzuclYycA>? MXHpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= MoTpNlMyPTV{NEi=
CL-1 MXXBdI9xfG:|aYOgRZN{[Xl? NVTuNHBIOjEQvF2= NIr0ZWUycA>? MXjicI9kc3NiT2C0OFkhcW6mdXPl[EBk\WyuIHTlZZRp M1fWXVI{OTNzN{iy
MEL MXjBdI9xfG:|aYOgRZN{[Xl? MkHDNlDPxE1? M{f4OlI1cA>? MmHTSG1UVw>? MY\pcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ MlO5NlMxOTR6OEe=
Bel-7402  NX7ud49uS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 NXuzZ2dYPTEQvF2= Mn;pNog> M1HPW4lvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NWjNOlBHOjNyMEi3OFI>
Eca-109 NX;KR29vSXCxcITvd4l{KEG|c3H5 M1LDcVI2|ryP M33oVlMxdWmw NF\ENHpqdmirYnn0d{BDUi2EMUGtbY5lfWOnZDDj[YxtKGSnYYTo NUfoPJVKOjNyN{[5Olc>
MEL MmnERZBweHSxc3nzJGF{e2G7 MoSyNlDPxE1? MnrLNYg> MYLEUXNQ M3m2PIlueGGrcnXzJHAzYDdvaX7keYNm\CCPRVygZ4VtdCCjcH;weI9{cXN? M2PkbVI{ODF2OEi3
Bel-7402  Mm\uRZBweHSxc3nzJGF{e2G7 MlLxOVDPxE1? MXeybC=> NIPHUIJqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ NEnldmwzOzByOEe0Ni=>
L929 MUXGeY5kfGmxbjDBd5NigQ>? NEG2NXIzNjYQvF2= MYCxbC=> MmjYbY5kemWjc3XzJHJKWDFiZYjwdoV{e2mxbjDhcoQh\XijY3XyZoF1\WRiVF7G{tEucW6mdXPl[EBucXSxY3jvcoRzcWGuIHT5d4Z2dmO2aX;uJIFv\CCUT2OgdJJw\HWldHnvci=> MmTPNlMxODB3MUi=
RCC  NIC1cVdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MYWxNFDPxE1? NIPocXozPGh? MVXy[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ NYf5UYdnOjJ7OUG0PVQ>
NB2a/d1 MknJRZBweHSxc3nzJGF{e2G7 MmT4NVAx|ryP NXfrcnZsPzKq M1nYSIF1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> M3nDT|IzQTh6NUSx
T cell M4rjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Dub|I2NTFyMN88US=> NVrybVh{OjSq MY\kc5NmNWSncHXu[IVvfGy7IHnubIljcXSnZDDUJINmdGxicILvcIln\XKjdHnvckBu\WSrYYTl[EB1cHKxdXfoJJRp\SClbz3zeIlufWyjdHnvckB4cXSqIHHueIkuS0R|IHHu[EBidnSrLVPENlg> NGrMXFczOjl6MkWzPC=>
K562 MVPBdI9xfG:|aYOgRZN{[Xl? MXWxNFDPxE1? NHi4bZMycA>? NUjPV|V{[myxY3vzJGFjdm:kYY\pd4N2dcLiRj3pcoR2[2WmIHHwc5B1d3Orcx?= MXeyNlk4OjN5Mh?=
Jurkat  NUfI[oVXSXCxcITvd4l{KEG|c3H5 M3LRPVQx|ryP M1zy[FFp NVrmc5pO[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? Ml3ZNlI6PDJ5M{i=
BGC-823 NX\sfmVJSXCxcITvd4l{KEG|c3H5 NVztPW1rOTByzszN NXS3Vpc1OWh? NHzqN4hx[XK2aXHscJkhemW|Y4Xld{Bk\WyuczDh[4FqdnO2IHThcYFo\SCxZjDkZYllgmWrbh?= MX2yNlkzPjV2NR?=
Hep3B MVTBdI9xfG:|aYOgRZN{[Xl? NWHLXJV7PTEQvF2= NVvXVpZiOWh? MVTicI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? MlTNNlI6OjNzNUS=
LLC-PK1 NWK2bVR5SXCxcITvd4l{KEG|c3H5 Mn;SNlDPxE1? NYrQWJE{OWh? Ml7rdJJmfmWwdIOgZ4l{eGyjdHnuMYlv\HWlZXSg[IVoemGmYYTpc44hd2ZiQYTnOUwh[mWlbHnuMVEtKGGwZDDBeIcyOiCycn;0[Ylvew>? NH3lRoczOjh7NkCzOy=>
A549 MoK4RZBweHSxc3nzJGF{e2G7 M2LFNlUx|ryP NV7neHNxOWh? MmW5Zoxw[2u|IITo[UBDSUlvaX7keYNm\CCjcH;weI9{cXQEoB?= NV3LUJY4OjJ6OEeyNVU>
SGC-7901  MmX1RZBweHSxc3nzJGF{e2G7 NIiwZ2cyOM7:TR?= NV3LcFJyOjSq MYTpcohq[mm2czFOtkzPui2maX3leIh6dGGlconsd4hqc2:waX6tbY5lfWOnZDDhdI9xfG:|aYRCpC=> M2HTO|IzQDR6NUm3
DM6 M2C2ZmFxd3C2b4Ppd{BCe3OjeR?= NX:zPIh6OTByzszN MWi3Nog> MlLGZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? M4HuVFIzQDJ3M{K4
MCF-7, MDA-MB-468, Caco-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jpZ|Ux|ryP M1PVSVQ5cA>? NETI[IFqdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBqdmS3Y3XkJIJ6KHOjcH;ubY4> NHnub2EzOjhyMEm2PC=>
A2750  M4f4W2Fxd3C2b4Ppd{BCe3OjeR?= NIC2U5kzOM7:TR?= Ml7CNog> MV3EUXNQ MnnHZoxw[2u|IHPhd5Bie2ViY3zlZZZi\2ViZIXybY5oKGinbHXuZYxqdiC2cnXheI1mdnRiYX7kJJJm\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp NXrBdZJ7OjJ5OESzOlM>
U87  MWfBdI9xfG:|aYOgRZN{[Xl? MojyNlDPxE1? NGrWPWozPGh? NYP6dGs2emWmdXPld{B1cGViYYDvdJRwe2m|IILheIUhcW6mdXPl[EBjgSCSTFHC NFz2U3IzOjd5OEe4NC=>
HT1080 M1zYXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVO1NO69VQ>? NELicZY4\A>? MYfpcohq[mm2czD0bIUh[2WubDDndo94fGhiaX7obYJqfGmxbjDjZZV{\WRiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKESFQTDhcoQhV02S MmTLNlI4PDB7OES=
A549  Ml3KRZBweHSxc3nzJGF{e2G7 MUW1NO69VQ>? MUCybC=> M{HRZpBienSrYXzsfUBl\WO{ZXHz[ZMhe2:maYXtJJNmdGWwaYTlMYlv\HWlZXSgZZBweHSxc3nz NFzJSXIzOjd{MUiwOC=>
Primary OPC MmrjRZBweHSxc3nzJGF{e2G7 MUex{txO M3vCOlZpNzJ2aB?= M{\tcpJm\HWlZYOgeIhmKHCncnPlcpRi\2Vib3[gZ4VtdHNiaX6g[YFzdHlvIHHu[EBt[XSnLXHwc5B1d3Orcz;u[YNzd3Orcx?= M1nDelIzPzB5M{i1
PMNs M1fGVmFxd3C2b4Ppd{BCe3OjeR?= MnnZOFDPxE1? NF3iTXQ3cA>? M4rm[mROW09? M{TVNZJmfmW{c3XkJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CClYYPwZZNmNTNidH:gcoVieiC4ZXjpZ4xmKGyndnXsdy=> MUOyNlY6OjV5Nx?=
A549  MYnBdI9xfG:|aYOgRZN{[Xl? MknHOVDPxE1? Mnv3NYg> M3nISJBz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKjb3j1c5Nq\GViSR?= NYK2RnRIOjJ4OEe2N|U>
AGS MUHBdI9xfG:|aYOgRZN{[Xl? MmXJNlDPxE1? M4jlO|EzcA>? MkTvbY5pcWKrdIOgeIhmKGGldHn2ZZRqd25ib3[gdJJwNWOjc4Dhd4UuOyCrbjDy[ZNxd26|ZTD0c{B1cGViRYTPRYMh\nKjY4Tpc44> NUe3e5g{OjJ4OEezPVg>
shC9  M{\r[WFxd3C2b4Ppd{BCe3OjeR?= MnrGNVDPxE1? NH[zSXgyPmh? M{fYVIJtfW62czDTTGgh\XiycnXzd4lwdiCrbjDzbGM6KGOnbHzzJIV5eG:|ZXSgeI8h\Wm2aHXyJHBCKG:{IFzQRy=> MV6yNlY1OTB7NB?=
primary MEFs M4C2PGZ2dmO2aX;uJGF{e2G7 NISwOHUyOmh? MoHkxsBqdmO{ZXHz[ZMh\XSxcH;zbYRmNWmwZIXj[YQhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDk[ZBwdGG{aYrheIlwdg>? MVOyNlYyOzd4Nx?=
3T9 MEFs NFzlc4tHfW6ldHnvckBCe3OjeR?= MWSxOog> Mnf6bY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> M2rxcVIzPjF|N{[3
3T9 MEFs M4fjZ2Z2dmO2aX;uJGF{e2G7 M3vIT|E5cA>? MYT1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> NHPHOYMzOjZzM{e2Oy=>
MDA-MB-231  NW\iUZA3SXCxcITvd4l{KEG|c3H5 MlHpNlDPxE1? M3LlXFRl NYK0e5dPemWmdXPld{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCvZYTmc5JucW5idILlZZRu\W62IIfhd{B{cWewaX\pZ4FvfGy7 NVrLbo1uOjJ3OUO0OFE>
C6  M1;TVmFxd3C2b4Ppd{BCe3OjeR?= MWSxNO69VQ>? MYqyOIg> MlLtZoxw[2u|IITo[UB{fXCycnXzd4l3\SCnZn\lZ5Qhd2ZidHjlJJBmeHSrZHWgc44hfmmjYnnsbZR6 NXHkV2ZbOjJ3OEi5PFA>
HL-60  MmGxRZBweHSxc3nzJGF{e2G7 MVKxNFDPxE1? M1iyb|I1cA>? MWPpcohq[mm2czD0bIUh[2WubDDhdI9xfG:|aYOgd4Vt\WO2ZXSgLEsqNW2nboTofYwh|rJvKEJiirI3MS2maXfseYNweHm{YX7vd4ll\cLiNR?= NFHvenIzOjV2Nk[2PS=>
HL-60 M4nCdWFxd3C2b4Ppd{BCe3OjeR?= MX2xNE05OM7:TR?= NE\CNpc1cA>? MX;pcohq[mm2czDUS2hSNWmwZIXj[YQh[2WubDDhdI9xfG:|aYRCpC=> NYnwRlNoOjJ3MkOyNlk>
BCC MVzBdI9xfG:|aYOgRZN{[Xl? M4fvPVUx|ryP Ml7LNYg> NYLhNXl6cW6qaXLpeJMhTEGWUz3t[YRq[XSnZDDndo94fGhiaX7obYJqfGmxbh?= Mn7wNlI2OTl2M{[=
RAW 264.7 MYTBdI9xfG:|aYOgRZN{[Xl? MlLSOVAwOTByzszN NYfhdpNxOWh? MX7jc45k\W62cnH0bY9vNWSncHXu[IVvfCCrbnjpZol1eyCGT16tbY5lfWOnZDDyVm5CKGOuZXH2ZYdm MkjjNlI1QTF2Mk[=
K562 MoHnRZBweHSxc3nzJGF{e2G7 M1i3V|I2|ryP M{jZblJp MofJdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[29vdILlZZRu\W62IIfpeIgh[W23cnXud4lvKEdiYX7kJHRTSUmO M4LwbVIzPDh|N{e3
SGC-7901 NVu0WHA2SXCxcITvd4l{KEG|c3H5 NEDE[ZAzOCEQvF5CpC=> MoLsNog> NXjtboJi[XS2ZX71ZZRmeyCKMl:yxsBweiCWTl[g{tEucW6mdXPl[EBk\WyuIHHwc5B1d3OrczDhd{B4\WyuIHHzJINie3Cjc3WtN{Bi[3Srdnn0feKh M4LTc|IzPDdzNUi5
PC3 MnzRRZBweHSxc3nzJGF{e2G7 NHnYSWUyOM7:TR?= NIjVPJQ1cA>? NHLhR4Fkd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> M1PKXFIzPDdzOUe0
SMMC-7721 Ml7SRZBweHSxc3nzJGF{e2G7 M4[5Z|Ux|ryP MUK0PIg> NV;mfINz[XS2ZX71ZZRmeyCxVGKtbY5lfWOnZDDhdI9xfG:|aYO= NEDOW4MzOjR4NUizNy=>
HeLa  NGXLNFZCeG:ydH;zbZMhSXO|YYm= MXW1NOKh|ryP NV;GdpF3PC96aB?= MWXpcohq[mm2czDTWHMucW6mdXPl[EBt[XSnLYDoZZNmKGGyb4D0c5Rq[yCndnXueJM> M{T3S|IzPDZyNUC0
HeLa  MlzkRZBweHSxc3nzJGF{e2G7 MXm1NOKh|ryP NUTQXGdvOWh? NGnSVY1{fXCycnXzd4V{KHSqZTDGVmFRNWmwZIXj[YQh[WOldX31cIF1cW:wIH;mJIFvdmW6aX6gWkBxd3OrdHn2[UBk\Wyucx?= NH7ZR2czOjR2OUS0NC=>
T47D  MWfBdI9xfG:|aYOgRZN{[Xl? MXSxNFDPxE1? MkLuNYg> M{La[4Jtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NV;WNItzOjJ2MEGxOlg>
HeLa  MnHMRZBweHSxc3nzJGF{e2G7 Ml\4N|DPxE1? M1HGNFRp NWLLSlJWyqCrbnPy[YF{\XNidHjlJIdmdmW{YXygZ4VtdCC4aXHibYxqfHliNEigbEBi\nSncjDwbI91d2S7bnHtbYMhfHKnYYTt[Y51yqB? M{DnSVIzOzl2MkS4
HCC NFP0cIRCeG:ydH;zbZMhSXO|YYm= NXL1NWZzOjBizszNxsA> MXSybC=> MnPFZZR1\W63YYTld{B1cGViRFjBJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCSQWLQ MYWyNlM1Ojd|Mh?=
mESCs M4fkNmFxd3C2b4Ppd{BCe3OjeR?= MVmyMlXPxE1? MlmzNog> M2fDeIlvcGmkaYTzJJRp\SCQYV[tcYVlcWG2ZXSgZ4F{eGG|ZTDhZ5RqfmG2aX;u NHvFfXozOjJ6NUK3OC=>
EMT-6  M4TKRmN6fG:2b4jpZ4l1gSCDc4PhfS=> MonzNVAx|ryP NV3adIt3OWh? NF;ae3Nx[XK2aXHscJkh[myxY3vl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nlic3nyZY1me2mwZR?= NXu5d3ZUOjJ{NUG5NlE>
MCF7 NFPMcoxCeG:ydH;zbZMhSXO|YYm= MnXJOVDDqM7:TR?= NXzMWpF5OWh? NHzDSlZqdmirYnn0d{BRSSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtPUwh[W6mIIDvcJkpSUSSLYLpZo9{\SlicH;sfY1memG|ZR?= NUHrRmhFOjJ{MkOzOFU>
K562 NWLxcHZlSXCxcITvd4l{KEG|c3H5 M2jpblIxKM7:TdMg MYW0PIg> MYfEUXNQ MYXicI9kc3NibHHwZZRqdmmkLXnu[JVk\WRiaX7obYJqfGmxbjDv[kB3cWGkaXzpeJkh[W6mIHHwc5B1d3OrczDpcoR2[3Srb36= NHXq[mgzOjJzNkG1PC=>
Molt4-hyg NV;oTFR5SXCxcITvd4l{KEG|c3H5 Mn[2NVDPxE1? NGXvSJoxNjWq NYPSNog3[myxY3vzJIZiem6nc3;sMYlv\HWlZXSgZ4F{eGG|ZT2zMYxqc2ViYXP0bZZqfHl? MX[yOlI4PThzMR?=
HeLa NHjRcHZCeG:ydH;zbZMhSXO|YYm= Ml3mNVDPxE1? M{SxblAvPWh? NHv3V4pqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2aHWgZ49u[mmwZXSgeJJm[XSvZX70JJdqfGhiZ3;tbZNqdiCQIHHu[EBVWkGLTB?= MXiyNlE4QTZ4MR?=
Jurkat T NXT0b4ZFSXCxcITvd4l{KEG|c3H5 MkjkN|DPxE1? MoPYNE42cA>? M2DFSWROW09? MVXicI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| NFfUTWQzOjF3OUi5PC=>
Neutrophil M{jGVGFxd3C2b4Ppd{BCe3OjeR?= NXfH[GtGOjEQvF2= NIDDOoUxNjWq MWXheJRmdnWjdHXzJJRp\SCycn:tZZBweHSxdHnjJIVn\mWldDDv[kBO[VJz M{\tOlI3OTl4OES0
HCT116 NEfufVRCeG:ydH;zbZMhSXO|YYm= MkXsOVDDqM7:TR?= MXuybC=> M2\ISZJmfmW{c3XzJJN6dmW{Z3nzeIlkKGGyb4D0c5NqeyCnZn\lZ5R{KG:oIHPlcIVkd3irYjDhcoQhVlCFLUG2xsA> MoraNlIyPTl5NUK=
MDA-MB-231  NF;nW2RCeG:ydH;zbZMhSXO|YYm= M4TkdFIvPS15LkZOwG0> MWSybC=> M{\FVIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? NE\iWXYzOjFzNUWyOi=>
LNCaP NFTDdG1CeG:ydH;zbZMhSXO|YYm= NXHmfFlzPDEQvF2= NWe5PIh4Omh? NHnDPFhqdmirYnn0d{BjfXSnaX6gbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NXrvcXNLOjJzMUS3OlQ>
MB231 Ml;SRZBweHSxc3nzJGF{e2G7 M1[4OVExOM7:TR?= MkG1NYg> Mon3SG1UVw>? NH:3N|Vi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w M4XjZlIzOTF{OUSw
HCC38  MWHBdI9xfG:|aYOgRZN{[Xl? MUCxNFDPxE1? MWKxbC=> NHvWUmZFVVOR MmnUZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? NVPIPW5COjJzMUK5OFA>
MDA-MB231 NY\QdFVnSXCxcITvd4l{KEG|c3H5 M3nzfFUxyqEQvF2= M1\CVFI1cA>? MXXEUXNQ NFHSNVZi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MYqyNlExOTN|NR?=
LNCaP MlX3RZBweHSxc3nzJGF{e2G7 Mkj3OVDDqM7:TR?= M{jpWFI1cA>? NF\5VWhFVVOR MULhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NGW5co4zOjFyMUOzOS=>
HCT116 Ml;ZRZBweHSxc3nzJGF{e2G7 Ml7JOVDDqM7:TR?= NY\kVJp2OjSq NWrNZ5Y{TE2VTx?= MYHhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo MY[yNlExOTN|NR?=
Ishikawa  MnPBRZBweHSxc3nzJGF{e2G7 MofCNlXPxE1? NGPRR3kzPGh? MnTLdoVlfWOnczDj[YxtKGSnYYToJIFv\CCjcH;weI9{cXNiaX7keYNm\CCkeTDCZYYhSTF? M1GydVIzODh6OUG4
 YD-8  Ml7GRZBweHSxc3nzJGF{e2G7 NWLMPI9SOTByzszN NWX6R2xyOWh? NFXER29qdmirYnn0d{BRVEWRLXnu[JVk\WRiYYDvdJRwe2m| NH7J[mwzOjB6NkG4Ny=>
eosinophil  NXLxTpZTSXCxcITvd4l{KEG|c3H5 MnjGPVDPxE1? MX[yOIg> NF3SXpRqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCIYYOgZY51cWKxZIpCpC=> NYTvTWtZOjJyN{mzN|Q>
L929 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[yS|FTOi53zszN NXjTbItLOjSq M3Swe4lvcGmkaYTzJJRp\SCneIDy[ZN{cW:wIH;mJJAueDN6IHHu[EBPTi4QulKgeI8h[XWpbXXueEBVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? NUCxXHRZOjJyMkewPVc>
YD-8  NYnHbIFrSXCxcITvd4l{KEG|c3H5 Mnj3NVAx|ryP MUOxbC=> NYrEc4lW[myxY3vzJJRp\SCJUz3IR4wucW6mdXPl[EBieG:ydH;zbZM> Mkn5NlIxOjByN{i=
HBx M3\ZdGFxd3C2b4Ppd{BCe3OjeR?= MmHiNlXPxE1? NILre2o1QGh? MX\EUXNQ Mm\MdoVlfWOnZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhOy2PQR?= NX\LRZh2OjJyMkCwO|g>
U937  Mn7kRZBweHSxc3nzJGF{e2G7 NIj2dVA2OMLizszN NUDqZVA2OWh? M{jQRolvcGmkaYTzJGhHNWmwZIXj[YQh[XCxcITvd4l{yqB? MXqyNVk6QDd|MR?=
HL60 M{HBSWFxd3C2b4Ppd{BCe3OjeR?= NH\scmU1OM7:TR?= NXHVOJJkPDCvaX6= M33uOmROW09? NYXCZ3NT[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MVOyNVk5OzJ7Nh?=
M-14 NH7mcXhCeG:ydH;zbZMhSXO|YYm= NGrnXVIzPc7:TR?= MYGwMlVp NV7sRlc1yqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? NXjVZ2xNOjF7NUS5OVk>
SK-BR-3 MmTKRZBweHSxc3nzJGF{e2G7 MWC1NOKh|ryP MknwNog> MoTkZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u MmKwNlE6ODF|OE[=
MDA-MB-468 MnuwRZBweHSxc3nzJGF{e2G7 NX76VZJ3PTEEoN88US=> NGH2[IgzcA>? NH3xfXFjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> MnTrNlE6ODF|OE[=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Caspase Signaling Pathway Map

Related Caspase Products

Tags: buy Z-VAD-FMK | Z-VAD-FMK supplier | purchase Z-VAD-FMK | Z-VAD-FMK cost | Z-VAD-FMK manufacturer | order Z-VAD-FMK | Z-VAD-FMK distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID