Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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3 Customer Reviews

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NF3YOZRCeG:ydH;zbZMhSXO|YYm= M4nmV|Ux|ryP MkfNNlRp MnHDbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> MlHnNlYyPjlyN{W=
HGL5 NGrUPFRCeG:ydH;zbZMhSXO|YYm= NHXlcnE2OM7:TR?= NHu4T4gzPGh? NF;3[4hqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? NUnDdWRnOjZzNkmwO|U>
HepG2 MW\BdI9xfG:|aYOgRZN{[Xl? MV6yNO69VQ>? MnzONYg> Mo[xZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> NIDifHMzPjF4NEe5OS=>
BEL-7402 M1rpZmFxd3C2b4Ppd{BCe3OjeR?= NHPXTnQzOM7:TR?= NV[zVXpPOWh? NVXQellJ[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? M36yeFI3OTZ2N{m1
CEF M2nacWtqdmG|ZTDBd5NigQ>? NILJTZQxNDN|LE[3MFExOM7:TR?= MnX4NVVucW5? NVzpbZRX\G:5bj3y[Yd2dGG2ZYOgVHIh\W68eX3lJIFkfGm4aYT5JJRwKDRy78{FJIF1KDFyMN88US=> NWrqRoZ2OjZzMEKzN|k>
SP2/0 NFTjW|RCeG:ydH;zbZMhSXO|YYm= NFrVO4wyODEQvF2= MkXTNYg> MkDKSG1UVw>? M4XFXYJtd2OtczD0bIUh[XCxcITvd4l{KG:oIGPQNk8xKGOnbHzz NX\B[HcyOjZyN{S3N|I>
HUVEC-2c MUDBdI9xfG:|aYOgRZN{[Xl? NETZ[WU2OM7:TR?= MkXMOog> NHvaNYxl\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? M{TkbVI3ODJzN{K5
U1 MmWxRZBweHSxc3nzJGF{e2G7 MVSwMVExOM7:TR?= Ml7jNog> NUTjdnV{emWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NIDONXMzPTl6MEm0Ni=>
ACH-2 M3XLNGFxd3C2b4Ppd{BCe3OjeR?= NGHReJIxNTJyMN88US=> NUHBVHVbOmh? MUDy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MlnsNlU6QDB7NEK=
U1 MXTLbY5ie2ViQYPzZZk> MkDzNVAx|ryP MkSyNog> MXPpcohq[mm2czDjZZNx[XOnLUO= MmDINlU6QDB7NEK=
A549/V16 NHjjcmJCeG:ydH;zbZMhSXO|YYm= Ml3COVDPxE1? M3HLdVFp M1T5XpJmeHKnc4Pld{BVTy:WTT3pcoR2[2WmIHHwc5B1d3Orcx?= M1mxT|I2QTR4MEOz
SGN NHjLR4hCeG:ydH;zbZMhSXO|YYm= NXXVU|FXOjCvTR?= MX20PIg> MkWzbIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= NVjBdmw5OjV6N{S2N|M>
HCT116  NGr0dJlCeG:ydH;zbZMhSXO|YYm= NGqxRlQ2OM7:TR?= M2\WUlJp M1e2ZYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgSGRXWA>? MlrkNlU5Pjh6MUi=
DTK-SME MUPBdI9xfG:|aYOgRZN{[Xl? Mn25OVDPxE1? NFvnWXczcA>? NIO2UINFVVOR NF62R3Jx[XK2aXHscJkhcW6qaXLpeJMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JIJ2eGm4YXPhbY5m MUWyOVg1Ozh7Nx?=
HL-60 M2LzV2Fxd3C2b4Ppd{BCe3OjeR?= MoPMOVDPxE1? M4naV|Q5cA>? NGroOppz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? Mn7nNlU5OjRyNEO=
U937 MVvBdI9xfG:|aYOgRZN{[Xl? MlnBOVDPxE1? M2fUSFQ5cA>? NGfEdoxz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? M2nqeFI2QDJ2MESz
A549 Mlv4RZBweHSxc3nzJGF{e2G7 M2r5PFIxKM7:TR?= NIi4[HozPGh? MV3y[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JGhHS1BidILlZZRu\W62 NYnhOmkzOjV5OUSxOFk>
HeLa NXfEd4plSXCxcITvd4l{KEG|c3H5 M1yzfFEx|ryP M2XhfFQ5cA>? NFPiTZdl\WOuaX7ld{B1cGVicnH0[UBw\iCjcH;weI9{cXNiZILhcYF1cWOjbHz5 MljLNlU4PzJ3NEW=
SGC-7901 MXXBdI9xfG:|aYOgRZN{[Xl? NX;kNnZYOjEEoN88US=> MUCxbC=> NHjWO2pqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JI95[WyrcHzheIlv Mom4NlU4PjdyN{[=
MCF-7 NWrkPZdFSXCxcITvd4l{KEG|c3H5 NX3BUlFKOTEQvF2= MV6ybC=> NYfIeXM5cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUA{Sg>? MXWyOVczOjFzNB?=
A549 Mle3RZBweHSxc3nzJGF{e2G7 MUmxNEDPxE1? MYGyOIg> MUHEUXNQ M1jXOZBzd22xdHXzJGhDSy22cnXheIVlKEF3NEmgZ4VtdCC|dYL2bZZidCBoIHH0eIVvfWG2ZYOgeIhmKGOuZXH2[YQhWEGUUDDlfJBz\XO|aX;u M{jwblI2Pjh|NU[4
U87 M2XtWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWe1NO69VQ>? MnzVNYg> MkDSdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 M{D2eVI2PjhzNk[4
Neocortical Neuron MVTO[ZVzd3SxeHnjbZR6KEG|c3H5 NXntd4w4OTByzszN M4XtN|Fp NYO0NZo2[W62YXfvcol7\XNiSH;pZY1q\GViQT3JcoR2[2WmIF7leZJwfG:6aXPpeJk> NFPRcXczPTZ5NUCwNS=>
Primary human placental cytotrophoblasts NHn1eYNCeG:ydH;zbZMhSXO|YYm= MmHSN|DPxE1? NVnGVXNSOjSq MYXEUXNQ NX[4UHRnemW4ZYLz[ZMhfGinIHnubIljcXSrb36gc4YhOTIQsj3IV2QzKGK7IITybYNtd3OjbtMg MXOyOVY1OjV7Mh?=
MM MUXBdI9xfG:|aYOgRZN{[Xl? Mlq2OVDPxE1? MlTqNlBucW5? MoO1dIFzfGy7IHnubIljcXS|IGPIT{1qdmS3Y3XkJEBk\WyuIHTlZZRp NIPuflEzPTV|MEC5PC=>
DLD1 MmTvRZBweHSxc3nzJGF{e2G7 MX2yNOKh|ryP M3rjbFFp NVfkRotveGG{dHz5JJJmfmW{c3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDXV3Ay MoHjNlU2OjR{NE[=
MDA-MB-231 NVXuNHBsS3m2b4TvfIlkcXS7IFHzd4F6 M4TlUFEx|ryP NFXxPJkycA>? NInZcGFifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 MVyyOVUzOTVyMR?=
MKN28 NF\k[HdCeG:ydH;zbZMhSXO|YYm= Mn65NVDPxE1? NXTkc|BjOzCvaX6= MUHEUXNQ M3jwd4lvcGmkaYTzJHRPTi4QsTDwcJV{KEOKWD3pcoR2[2WmIHHwc5B1d3Orcx?= MWCyOVUyOzl4MB?=
HL-60 MW\DfZRwfG:6aXPpeJkhSXO|YYm= M1KyflExOM7:TR?= M4XNelFp MnrFSG1UVw>? NHvucGLDqGmvcILveoV{KH[rYXLpcIl1gSCxZjDUR25Cey22cnXheIVlKGOnbHzz NX;RSJdDOjV3MEK5N|I>
AGS MXHBdI9xfG:|aYOgRZN{[Xl? M3qzNVEx|ryP NHXRXYMycA>? M4TWW5Bz\X[nboTzJIN2emO3bXnuMYlv\HWlZXSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{NCBvODygZY5lKC17IIDyc5RmcW6| NH7DR4QzPTR7MkKxOC=>
A549  MnXWRZBweHSxc3nzJGF{e2G7 MY[xNO69VQ>? MVyyOIg> NXj4VGNz[myxY3vzJGROSVNvaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgZY5lKGGyb4D0c5Rq[yClZXzsJIRm[XSq NHLvOWUzPTR|NEm4PS=>
INS-1 MXvBdI9xfG:|aYOgRZN{[Xl? MVK1NO69VQ>? NYrvOIhTPmh? M1XrdmROW09? NHH4R45l\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh\WG{bImgZZBweHSxdHnjJINmdGy|wrC= MXiyOVQ{ODh7Nx?=
Primary hepatocytes  MVLBdI9xfG:|aYOgRZN{[Xl? MWi1NO69VQ>? NEnYWWkyQGh? Ml3EbY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= NIHYcYczPTRyN{WzPC=>
L929-A  Mk\WR5l1d3SxeHnjbZR6KEG|c3H5 M1zyflIxyqEQvF2= M3\sTlI1cA>? NFTOeY9qdmirYnn0d{BVVkcQsT3pcoR2[2WmIHPlcIwh\GWjdHi= MW[yOVM6QDV2MB?=
L929-N M1PV[mN6fG:2b4jpZ4l1gSCDc4PhfS=> NEDld4kzOMLizszN MYKyOIg> NXnwT4ky\W6qYX7j[ZMh\GWjdHigeoliKGG3dH;jdolv\SCWTldOtUBxem:mdXP0bY9v MnyxNlU{QTh3NEC=
Cytotoxicity Assay MXrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> Ml6xNlDPxE1? MoX5OFhp NXuxT3RWeHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= MW[yOVM6OjFzNh?=
COS7 MmHHT4lv[XOnIFHzd4F6 NFjDeIsyOM7:TR?= MYOyOIg> NGK2O5NqdmO{ZXHz[ZMh[2G|cHHz[UA{NzdiYXP0bZZqfGmncx?= NVTYcHNlOjV|OESwNlU>
COS7 NV7NOZRGSXCxcITvd4l{KEG|c3H5 M3rKOlEx|ryP NFLpcpo1QGh? MXPwZZJ1cWGubImgdJJmfmWwdHXkJGZEOTBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NHmzWGgzPTN6NECyOS=>
A375 MWnBdI9xfG:|aYOgRZN{[Xl? NIPq[XU{OM7:TR?= MnnWNog> MlPmdJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm MYOyOVM4PjFzNR?=
A549 M{fuSmFxd3C2b4Ppd{BCe3OjeR?= M1;mWFUx|ryP MXyyOIg> NH;pb21z\X[ncoPld{BzcWKxc3;t[UBjcW:pZX7ld4l{KGGwZDDhdI9xfG:|aYOgZ4F2e2WmIHL5JEBEcGmsb37n[IFv M1zyU|I2OzR7N{ix
A549 NV3yUVlRSXCxcITvd4l{KEG|c3H5 NGfYU28zNjVvMkZOwG0> MWexbC=> MmD1[IVkemWjc3XzJJRp\SCyb4D1cIF1cW:wIH;mJIFxd3C2b4TpZ{Bk\WyuczDk[ZBmdmRib36gZ49v[2WwdILheIlwdnN? Mo\PNlU{PDJ2Mke=
 NBL-W-S  M33FcmFxd3C2b4Ppd{BCe3OjeR?= NVvINod6PTEQvF2= NHLXSpUycA>? M3XwS4Z2dGy7IILld4N2\XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgS2FPXC14MTD0doVifG2nboS= NWO5UmxPOjV|MkOyNlI>
Caki-1  M4n6NmFxd3C2b4Ppd{BCe3OjeR?= Mo\jOFDPxE1? M{DMT|Q5cA>? MULy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz MYGyOVI4QTF7MR?=
769-P NVO1SYFiSXCxcITvd4l{KEG|c3H5 MXO0NO69VQ>? MkDzOFhp NVXqNYlwemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? NEO2O4UzPTJ5OUG5NS=>
H9c2 M{XKXmFxd3C2b4Ppd{BCe3OjeR?= MnjkOVDPxE1? MmTVNYg> NYPwWm9EcW6qaXLpeJMhTE:[LXnu[JVk\WRiY3HzdIF{\SB|IHHjeIl3[XSrb36gZpV1KG6xdDD0bIUhdG:|czDv[kBk\Wyucx?= MWqyOVI5OzhzOR?=
K562 MkTQRZBweHSxc3nzJGF{e2G7 M2\2PFUx|ryP M2nSeFRp MlnTbY5pcWKrdIOgToFkNUFvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NEHMUYMzPTJ2MU[xPS=>
L929 NGe0PXNCeG:ydH;zbZMhSXO|YYm= NVzifZRxOTEQvF2= NFjJO5Q3cA>? MXnpcoR2[2W|IH7lZ5JweHSxc3nzJJdqfGhiVF7G M1LnWVI2OTl3Nk[w
A549 Ml;KRZBweHSxc3nzJGF{e2G7 MVKxNO69VQ>? M2PoflNp Mn3TdoVlfWOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliUGHR NWW3SmRzOjVzNkG2PVk>
MCF-7 MluwRZBweHSxc3nzJGF{e2G7 NYe0O|ZrOjEQvF2= M2HrdlJp MX;k[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz M2D1c|I2OTh{MkSw
OS M3H6R2Fxd3C2b4Ppd{BCe3OjeR?= M4m4PVIxNzRyzszN NH:ybmI4Omh? NIf2ZWxqdmirYnn0d{BQWyClZXzsJJZq[WKrbHn0fUBz\WS3Y4Tpc44h[nliQ{[gZ4Vz[W2rZHW= Mkf6NlUyPTJ|OUm=
HUVECs NXfyXWV{SXCxcITvd4l{KEG|c3H5 NWfiO3ZEOTEQvF2= MnXyNog> NXS2eZE4yqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCKVW\FR5M> M4fSOFI2OTN6N{Cz
EA.hy926 MmSzRZBweHSxc3nzJGF{e2G7 Mkm2NVDPxE1? MoDwNog> NX7XZm9WyqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? Ml3MNlUyOzh5MEO=
Ebs MV7BdI9xfG:|aYOgRZN{[Xl? MXqxNE0yODEQvF2= MVOyOIg> NG[1clTDqE2PVGOg[4Vv\XKjdHnvckBz[XSnIHTlZ5Jm[XOnZDDhd{B1cGViY3;uZ4VvfHKjdHnvckBw\iC8LW\BSE5ndWtiaX7jdoVie2Wm NVrCVYxjOjVzM{S4NVc>
Jurkat MXTBdI9xfG:|aYOgRZN{[Xl? Mkf6NlDPxE1? NHj6XWEzPGh? NYHocpU1TE2VTx?= NUPac2w4eGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi NYT0NFEzOjVzMkC3NlM>
K562 NX3uVoVPSXCxcITvd4l{KEG|c3H5 NGr1fmkxNjFvMd88US=> MUWxbC=> NH\5doRqdmirYnn0d{BkdGWjdnHn[UBw\iCKU2C5NEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MmjrNlUyOTlzOEi=
IMR-32 NYj5[WtKSXCxcITvd4l{KEG|c3H5 MlHBOFDDqM7:TdMg M17HcVJp NEfwem1l\WO{ZXHz[UBqdiCjcH;weI91cWNiY3XscJMh[2:vcHHy[YQhfG9iVD2yJJRwgGmw M2L1SFI2ODh2N{W1
RPMI 8226 MXPBdI9xfG:|aYOgRZN{[Xl? MX6xNFDPxE1? MmXBNYg> NYnUcnFZ[Wyvb4P0JINwdXCuZYTlcJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= MlLWNlUxOzd6NUG=
U266  M2fCV2Fxd3C2b4Ppd{BCe3OjeR?= NFTGOGgyODEQvF2= NIjjdVQycA>? NEDkOXRx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NETOVIUzPTB|N{i1NS=>
H929  MVTBdI9xfG:|aYOgRZN{[Xl? M{HxXVExOM7:TR?= M4H1SVFp M4myUJBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= NXflTY9mOjVyM{e4OVE>
MM.1S  MWDBdI9xfG:|aYOgRZN{[Xl? NWTjeY5COTByzszN NYTsU4hROWh? MU\l[oZq[2mnboTsfUBxemW4ZX70d{B{d3KjZnXubYIucW6mdXPl[EBk\WyuIHTlZZRpKGOxbXLpcoUhf2m2aDDu[YNzd3O2YYTpck0y M{fBbVI2ODN5OEWx
C6 NHLySnJCeG:ydH;zbZMhSXO|YYm= NIPQOpg2OM7:TR?= NY\Pd5BqPDiq MlLWdJJmfmWwdIOgeIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZ4F2e2WmIHL5JJBz\WewZX7vcI9v\Q>? NHPpOHozPTBzM{S3PS=>
AGS NX;JfVkySXCxcITvd4l{KEG|c3H5 NWHZc|JkPTEQvF2= NX\SNWZTOjSq MkD6ZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= MV6yOVAxQTZ7OB?=
HeLa  M{LTPGFxd3C2b4Ppd{BCe3OjeR?= M17xdlQx|ryP NIL0c24zPGh? MXLpcohq[mm2czD0bIUhcW6lcnXhd4VlKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPpVm5HOTJz NUfEdlduOjR7Mki2PFU>
THP-1  NV73Z5RiSXCxcITvd4l{KEG|c3H5 M1XZNlEx|ryP NIjxS2gycA>? Mli4doVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> MlTRNlQ6OjN4NUO=
P815  NF7jb2RCeG:ydH;zbZMhSXO|YYm= MWWxNFAhyrWP MX[xNog> M{TqVGROW09? MUXpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? NH31eWwzPDl{M{K3Ny=>
HCT116 NUPnSI8ySXCxcITvd4l{KEG|c3H5 NH:yVoIzOM7:TR?= MUmyOIg> M2X0VYFjem:pYYTld{Bw\iCWUT3pcoR2[2WmIHHwc5B1d3Or MnP5NlQ5QTB2NEm=
SW1116  MkTIRZBweHSxc3nzJGF{e2G7 NFm4emQyOCEEtV2= Mn:wNYg> NE\TdlNFVVOR NFW1T3Jz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l MV6yOFg4PDJ6Nh?=
LOVO MVnBdI9xfG:|aYOgRZN{[Xl? M3zr[VExKML3TR?= MonBNYg> NFXQO5pFVVOR MXry[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n MkPiNlQ5PzR{OE[=
SNU449  NETjSVVCeG:ydH;zbZMhSXO|YYm= NHjxUY4zOM7:TR?= NGWw[Gg1QGh? MV;EUXNQ NVHhXmtP\GWlcnXhd4V{KG2rUj20OVEucW6mdXPl[EBieG:ydH;0bYM> NV\6[3pQOjR6NEG2N|g>
Caco-2 M1TmSWFxd3C2b4Ppd{BCe3OjeR?= NHf5R2Q1OOLCid88US=> MmmzOIg> MnLpdJJmfmWwdIOgV3QuPy2rbnT1Z4VlKFqRLUGgZ4hidmenczDhcoQhXEWUIHTyc5A> M3nqNVI1QDJ{MUiz
macrophage NEi1boxE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MXSwMVIxOM7:TR?= M4G4R|I1cA>? MXLpcoR2[2W|IGTOSk0h[W6mIGLpdFMu\GWyZX7k[Y51KG6nY4LvdJRwe2m|IHnuJI1i[3KxcHjh[4U> M3q2WVI1Pzl7NU[1
AGS  M2PPVmFxd3C2b4Ppd{BCe3OjeR?= NUHnZ2diOjEQvF2= NHT1flcyOmh? MWLEUXNQ NHzNc2tz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3[gZZBweHSxc3nzJIlvKHKnc4DvcpNmKHSxIITo[UBGfE:DYzDmdoFkfGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NW\De|RzOjR5OEm3NFM>
LCC9  MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MkjGNVAx|ryP NIHvcmM2\A>? Mn\kZoxw[2u|IHPlcIwh\GWjdHigbY5lfWOnZDDifUBkd22kaX7heIlwdiCOMUegZY5lKGOqbH;yc5F2cW6n M4KycVI1Pzh3MkW2
U937  M1\LRo5m[3KxcITvd4l{KEG|c3H5 MoLnNVDDqM7:TR?= NU[4NVRuOzEEoH3pci=> NYnUdHUycW6mdXPld{Bv\WO{b4D0c5NqeyClb33ibY5mKHerdHigWG5H NITvNGEzPDd5M{e1Oi=>
T cell M1L3bGNmdGxicILvcIln\XKjdHnvckBie3OjeR?= M{i3[VAuOTByzszN MoHLO|Jp NGXB[FZKSzVyPUewJO69VSxiaX7obYJqfHNiYX70bU1ETDNvaX7keYNm\CCWIHPlcIwheHKxbHnm[ZJifGmxbjDpckBRSk2Fcx?= MUKyOFc3QDdyNx?=
HeLa  Mn3ERZBweHSxc3nzJGF{e2G7 M1TLZ|Ux|ryP MVG3Nog> MkjkSG1UVw>? MVvwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkd22yb4Xu[JPDqDIkgKO1 MorGNlQ4PTR5OE[=
HeLa  NV[4bVJDSXCxcITvd4l{KEG|c3H5 MoP6NVAx|ryP MVOyOIg> MmXid5VxeHKnc4Pld{Bz[XSnIH;mJINmdGxiZHXheIghcW6mdXPl[EBjgSCxdnXy[ZhxemW|c3nvckBw\iCJNUnTJI9zKEd5MWKgdFE2OGeudXXkxsA> MoXVNlQ4OjJ2Nki=
IEC-6  NXHJ[oR4SXCxcITvd4l{KEG|c3H5 MYSxNO69VQ>? MlTXNlRp M3O0TZBz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NH:1NVYzPDdzMUW3NS=>
HCT116 MV7BdI9xfG:|aYOgRZN{[Xl? MX2yNO69VQ>? NFe3d4czPGh? NFLDeWFqdmirYnn0d{B1cGViY3XscEBieG:ydH;0bYMhcW6mdXPl[EBjgSC\TGSyNFU> MUiyOFcyOzhzMh?=
L02 NWTrd2k1SXCxcITvd4l{KEG|c3H5 MVGyNO69VQ>? MXOxbC=> MlP0dJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= NGLNZ|UzPDdyNkS2NS=>
A375 M{P2T2Fxd3C2b4Ppd{BCe3OjeR?= MVGyNO69VQ>? M1PVeVI1cA>? MVzy[ZZmenOnczDkbYNqfHKrbn;u[UBDNWmwZIXj[YQh[XCxcITvd4l{ NWrVO5p5OjR4OUmxNVE>
HDPC MkO1RZBweHSxc3nzJGF{e2G7 M3TBRVUxyrWP NWDrXWhnOjSq M1TlbIlvcGmkaYTzJG5QNWmwZIXj[YQh[XCxcITvd4l{ NH36[nQzPDZ|NEW5Ny=>
A549 NF;EemxCeG:ydH;zbZMhSXO|YYm= NH;qc|Q2OML3TR?= M{Pse|Jp NV3XRndUTE2VTx?= M1TVPZBz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw MWKyOFU5QDF|NR?=
 BV-2 Mkf3RZBweHSxc3nzJGF{e2G7 NXnxc5NROjEQvF2= M3;Lb|Jp MX7zeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? M1H4d|I1PTV6MUG4
HT-29  NXL2fIJ7SXCxcITvd4l{KEG|c3H5 M3fTVlUx|ryP Mk\ZOFhp M3nkR4Jtd2OtczD0bIUh[XCxcITvd4l{KGmwZIXj[YQh[nlia3HlcZBn\XKxbB?= M2LTRlI1PTR7MUe1
A549 NGXWSYlCeG:ydH;zbZMhSXO|YYm= NF2xZnU2|ryP NFP6W|IzPGh? NYjhVGIxe3WycILld5NmeyB4ZdMgLGJMOTByNECpMYlv\HWlZXSgZZBweHSxc3nzxsA> MmTPNlQ2Ojl6N{G=
MIA-PaCa-2 NYjJN5V{SXCxcITvd4l{KEG|c3H5 M3fBS|I1cA>? NIXWNldjdG:la4OgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGmwZIXj[YQh[nliYn;0bEBCNTR2M{[1OEBidmRicHHjcIl1[XinbB?= NVLlb2lFOjR3MUC5PVI>
Caki-1 NEP0cnFCeG:ydH;zbZMhSXO|YYm= NWqxWWV6OjEQvF2= M13NclFp NF7WW5hqdmirYnn0d{BUS1BvaX7keYNm\CCjcH;weI9{cXN? M1HyVVI1PTB2Nkix
CLL NUnxZotvSXCxcITvd4l{KEG|c3H5 MWqyOe69VQ>? NGra[FIycA>? MXrwZZJ1cWGubImgZoxw[2u|IF3MUlIzOzhvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NYjU[2pjOjR2Nke2N|Q>
SGC-7901 M3;MV2Fxd3C2b4Ppd{BCe3OjeR?= MXWxNO69VQ>? MXmyOIg> NFvMSnpxem:vb4Tld{B1cGViQ1fJTU1qdmirYnn0[YQh[2WubDDndo94fGhiaX6gV2dENTd7MEGgZ4VtdHN? MUiyOFQ2PDR6OB?=
k1735 NU\1N2JTSXCxcITvd4l{KEG|c3H5 MUGyNQKBkc7:bR?= NGnTXXI1cA>? MUTpcohq[mm2c9MgV4FtdW:wZXzsZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NHrlU4IzPDR3MUGxOi=>
HaCaT  NIH6PVBCeG:ydH;zbZMhSXO|YYm= MUWxNFDPxE1? MUmxbC=> MV\icJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| NUTQelFQOjR|NU[5PVc>
podocytes NWSxdoxmSXCxcITvd4l{KEG|c3H5 NV;PT4dJOjByzszN M3rxXVZp NY\3R5RwcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? NIGwSoQzPDN|N{e3Oy=>
 KB MoDYRZBweHSxc3nzJGF{e2G7 MUC1NO69VQ>? NEfsWYgzPGh? M1vvVIlvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u M2fMdlI1OzN5NEmy
 HepG2  MVTBdI9xfG:|aYOgRZN{[Xl? MVqxNO69VQ>? M176eVI1cA>? MmLndoVlfWOnczD2bY1mdnSrbjDjcIVifmGpZTDjZZV{\WRiYomgUHBU MXKyOFMzPThzNh?=
fetal rat lung fibroblasts  M3;HV2tqdmG|ZTDBd5NigQ>? NFLsOoM5OM7:TdMg M3TTfFFp M2myZolvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh MkDGNlQ{OTRzM{W=
PDL fibroblasts NUTTOmRvU2mwYYPlJGF{e2G7 M4PVWFgx|ryPwrC= NXH0[YpzOWh? MWXpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> Mn;vNlQ{OTRzM{W=
MB49 MYHBdI9xfG:|aYOgRZN{[Xl? NX2yXmZiOjEQvF2= NHHRZ2YycA>? NWXBblhFemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq MWKyOFI5OjR|Mx?=
5637 NUDGdHBoSXCxcITvd4l{KEG|c3H5 MWOyNO69VQ>? NGLBbFEycA>? MX\y[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> NX3JU4x5OjR{OEK0N|M>
A549  M3K0fmFxd3C2b4Ppd{BCe3OjeR?= M3fE[lExOM7:TR?= NV;2NVRsPDiq MkLUd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg Ml\QNlQzPzJ{MEG=
MCC-2 MX;BdI9xfG:|aYOgRZN{[Xl? NYHQb4dyOjBizszN MUO2bC=> Mm\FSG1UVw>? M{DxZoJtd2OtczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmViYYDvdJRwe2m|IHPlcIwh\GWjdHi= NWThc3lyOjR{NkK2OVg>
ADF NUO1V4VkSXCxcITvd4l{KEG|c3H5 NUGzTnpmPDEQvF2= MoO1Oog> NULJcFhqcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> M3HFW|I1OjJ6MkOy
 U373  NFz4XJNCeG:ydH;zbZMhSXO|YYm= NYDsUo86PDEQvF2= M{PPNlZp MlTPbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MlTwNlQzOjh{M{K=
RKO-HIPK2i NIDVT21CeG:ydH;zbZMhSXO|YYm= Mk\QOFDPxE1? MXy2bC=> MoT3bY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MW[yOFIzQDJ|Mh?=
HEC-1B NV7zbJp7SXCxcITvd4l{KEG|c3H5 Ml3zNlDPxE1? Ml;mNYg> MVXy[YR2[2W|IGTQMYlv\HWlZXSgZZBweHSxc3nzxsBk[XOyYYPlMVMh[W6mIHPhd5Bie2VvOR?= M{LVeFI1OjF|M{W4
4T1 NFzhcWFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M37hd|IvPS1zMN88US=> NFzQ[VA1cA>? M1LLVGROW09? MXvy[ZNkfWW|IITo[UBkgXSxdH;4bYNqfHlib3[gOHQyKGOnbHzzJIlv\HWlZXSgZpkhW1CGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= MkfRNlQzODZzNkG=
OS  NETXToRCeG:ydH;zbZMhSXO|YYm= M{WwflIx|ryP MUe0bC=> M1nSeYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDQSHQ> MViyOFIxPDl|Nx?=
RPE NYHV[Zc1SXCxcITvd4l{KEG|c3H5 MYSxNFDPxE1? MYS0PIg> NICzZllx[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? MkLnNlQzODJyNUK=
UD29a M3TLcWFxd3C2b4Ppd{BCe3OjeR?= NXnjZZV7PTEQvF2= M33VdFI1cA>? MVPpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliTmXUNy=> MlTtNlQyQTB3N{S=
SH-SY5Y  M{P5SmFxd3C2b4Ppd{BCe3OjeR?= NVHsSGV6OTEQvF2= M2O0ZlI1cA>? NVXOc3RV[XS2ZX71ZZRmeyClYYPwZZNmKGGldHn2ZZRqd25iYX7kJINmdGxiZHXheIghcW6mdXPl[EBjgSCKTlWtNmRI MonwNlQyPDV2NkO=
HeLa  NUm1dVk5SXCxcITvd4l{KEG|c3H5 M1T5blExNzJyzszN NH\4d3AzPGh? NIDYUlFqdmirYnn0d{B1cGViYXP0bZZqfHlib3[geIhmKG2jan;ybZR6KG:oIITo[UBu\W2kZYLzJI9nKHSqZTDjZZNx[XOnLX\hcYltgQ>? M4PuOFI1OTN5Mk[2
SCCVII  NUX1[FZ6SXCxcITvd4l{KEG|c3H5 NUjCeXVLOjYQvF2= NF3ncnIycA>? NIrD[3VqdmirYnn0d{B1cGViY3XscEBscWyuaX7nJIFnfGW{IHThd4F1cW6rYh?= Ml\YNlQyOjZ2NkS=
RAW 264.7 MVfBdI9xfG:|aYOgRZN{[Xl? MmjHNlDPxE1? NHj2NmMyQGh? M4rxNolv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? NHjIZ4QzPDFzNkewOy=>
A549  NFPPWpdCeG:ydH;zbZMhSXO|YYm= NHvCfZozNjYQvF2= NFXHSYMzPGh? MXnk[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> M{HDXFI1OTB{NUKy
UM-SCC-10A  NVPaVJk2SXCxcITvd4l{KEG|c3H5 Ml\zOVDDvU1? M17rZVJp NVPSV2ZPemWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCqaXfoMYRwe2ViaYPvZYxidnSxbHHjeI9v\Q>? Mk\rNlQxQTh5NUO=
BGC-823 MVPBdI9xfG:|aYOgRZN{[Xl? Mnf5NVAh|ryP MmH4NlRp MnLUdoVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NHjXTVYzPDB7OEWxNS=>
Nalm-6  NITaRnJCeG:ydH;zbZMhSXO|YYm= NF7SS3YzOM7:TR?= MofhOIg> NUXyNGVpcW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm NFHCVnIzPDB|OUm2Oy=>
KHOS  NV\RTXpDSXCxcITvd4l{KEG|c3H5 NVn1VXhuPDEQvF2= MWqyOIg> MknsZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MX2yOFAzPTN4MR?=
G292 NXLFdFliSXCxcITvd4l{KEG|c3H5 NFPZWFU1OM7:TR?= MlLVNlRp NEfiSXdjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg M2PmbFI1ODJ3M{[x
MG-63 NXvzR3QzSXCxcITvd4l{KEG|c3H5 M2\DWlQx|ryP NWqwR3g1OjSq M3\OV4Jtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= NHvLWJUzPDB{NUO2NS=>
EBV-transformed B cells MkHZRZBweHSxc3nzJGF{e2G7 M2\KRVIx|ryP Ml\WNog> MWjEUXNQ MYTicI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> NVXMc5ZROjRyMEi2Nlg>
IM-9 B NGracVBCeG:ydH;zbZMhSXO|YYm= M4i2OFIx|ryP MWeybC=> Moq4SG1UVw>? M4PxSYJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? NH;jXYQzPDByOE[yPC=>
CNE1 NFG0SIlCeG:ydH;zbZMhSXO|YYm= NVq5XHRROjEQvF2= NE\IO2g1QGh? M13B[oJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ Ml\2NlM6QDVyMkm=
CNE2 MVXBdI9xfG:|aYOgRZN{[Xl? MXuyNO69VQ>? M3TU[VQ5cA>? MX;icI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NVHLeGg6OjN7OEWwNlk>
HL-60 NUDpcZdNSXCxcITvd4l{KEG|c3H5 NIT0Z4U2OML3TR?= MX6xbC=> NFLlblNFVVOR MULpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBDSTF2NR?= MV[yN|k1QDd3MR?=
L929 MVfBdI9xfG:|aYOgRZN{[Xl? MlTSNU4zPeLCk{ZCpO69VcLi MnS4NlRp M3:1SoF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? Mk\tNlM6PDF5Nkm=
Jurkat M{TOdmNmdGxiVnnhZoltcXS7IFHzd4F6 MXyy{txO NInNPXU1cA>? MVLy[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? MUWyN|g6PjB4MR?=
RAW264.7  MW\BdI9xfG:|aYOgRZN{[Xl? MkXXNVAh|ryP NHzXN2UzPGh? MXnk[YNz\WG|ZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFfB Mo[1NlM5OjB{MEO=
A431  M4LSTmtqdmG|ZTDBd5NigQ>? NVHYSVc4PDEQvF2= NFHIOokzcA>? MnjGZoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= NWHFOll7OjN6MECwOVg>
Jurkat MXjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NED1[mgzPS1zMEFOwG0> NVHqVVliPmh? MYfpcohq[mm2czD6MWZCNUOPSz3pcoR2[2WmIHPlcIwh\GWjdHi= M4rPO|I{QTN|NUOy
COS-7  M2[3SmZ2dmO2aX;uJGF{e2G7 M2XOeFUxyrWP NV;BfoJWOjSq NGrKVnRi\m[nY4TzJJRp\SCycn;j[ZN{cW6pIH;mJGFVVjG|IIfpeIgheG:ueWGgeJJi[3S| MV[yN|k{OzJyOB?=
CAL27 NIryRWVCeG:ydH;zbZMhSXO|YYm= NUjlRpZ7OTBizszN MnPlNog> MnXTd5VxeHKnc4Pld{BEfXJvTmDzMZJm\HWlZXSgeoli[mmuaYT5JIJ6KHWyIITvJFkxLQ>? MX2yN|kyPzN7Nh?=
THP-1  NXPkO4pQSXCxcITvd4l{KEG|c3H5 M4Xyb|ExNTVyzszN M3jLXFJp M4XUfYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHS{aYD0c4xq\GV? MljuNlM6ODB{OUm=
K562 MoTqRZBweHSxc3nzJGF{e2G7 NXPKe5BvOjEQvF2= NHTveZI1QGh? MoDGbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhPC2PVR?= NV\lfXVQOjN6N{[4NlY>
HL-60 M4TlNmFxd3C2b4Ppd{BCe3OjeR?= MmPlNVAx|ryP MXKyOIg> MYXpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBi[mmndHHu[UBlcXSncoDlcoV{yqB? MV6yN|g3PTd5OB?=
HeLa  NIm3UldCeG:ydH;zbZMhSXO|YYm= NUXU[GdsOjEQvF2= MVeybC=> NYrGXnM3cW6qaXLpeJMhTE2PUDDpcoR2[2WmIHHwc5B1d3Orcx?= NYrscYMyOjN6NkO5OlY>
U251 MVjBdI9xfG:|aYOgRZN{[Xl? NVjySVBuOjEQvF2= NVTJUZA6OjSq M1rDOYlvcGmkaYTzJINie3SrY3nuJIlv\HWlZXSgS|IwVSCyaHHz[UBienKnc4SgZY5lKGGyb4D0c5Nqew>? NXrweFROOjN6MU[4NVY>
HL-60 Moi2RZBweHSxc3nzJGF{e2G7 MXG1NOK2VQ>? MUS0bC=> MWTicI9kc3NidHjlJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUmsJIFv\CCSQWLQJIlv\HWlZXSgZpkhPnN? Ml;vNlM5ODR5ME[=
Ec-109 MVfBdI9xfG:|aYOgRZN{[Xl? MmXVNVAh|ryP MUC0PIg> NFjwT4dz\XC{ZYPz[ZMhWEVvbXXkbYF1\WRiRXOtNVA6KGOnbHygZZBweHSxc3nz NHrjUoozOzd6Mk[0NS=>
RKO NEXPOopE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NX\5ZnNGOTBizszN Mlu2NlRp MVHpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= NH\sOWwzOzd3OEC2OC=>
T98G M{PjPGNmdGxiVnnhZoltcXS7IFHzd4F6 NXfzUo5EOS1zMEFOwG0> NV\Ud4xTOjSq NFzhdnZqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT MUOyN|c3QTJ5NR?=
Jurkat M4XMR2NmdGxiVnnhZoltcXS7IFHzd4F6 Mk[zNVAxNTJyMN88US=> MX6yOIg> MnTpbY5pcWKrdIOgTIFCPCCrbnT1Z4V{KGGyb4D0c5NqeyCmZYDlcoRmdnRib3[gZ49v[2WwdILheIlwdsLi MljWNlM4OzJ2OEG=
Molt-3  NUDzVY1{SXCxcITvd4l{KEG|c3H5 Mn\1OVDPxE1? MUGybC=> NI\STndz\WS3Y3XzJI1mdGG2b37pck1qdmS3Y3XkJIFxd3C2b4Ppdy=> NGH5[pczOzd{NUCxNy=>
hMSC12 MlzwRZBweHSxc3nzJGF{e2G7 NXzac45HOTByzszN NHT2SoM1\A>? NGG4bVdqdmirYnn0d{Bwe3Snb3flcolkKGO3bIT1doUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDjZYxkcW[rY3H0bY9v MXKyN|Y2Pzh{Mh?=
HM7  NEXrPZFCeG:ydH;zbZMhSXO|YYm= MnHuNlDPxE4EoB?= NUPx[YtOOWh? NYH3SXp5[myxY3vzJIFxcWO3bHHy[Y4hSSCjY3X0ZZRmNWmwZIXj[YQh[2G|cHHz[U0{KGGldHn2ZZRqd25iYX7kJHBCWlBiY3zlZZZi\2V? M2HZbFI{PTh|NEGy
Hep-2  M3jUN2Fxd3C2b4Ppd{BCe3OjeR?= MnnSNlDPxE4EoB?= MoXZNlRp MUnEUXNQ Ml\QZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= NFnDWnQzOzV6MECzNi=>
HSCs NH;WfGhCeG:ydH;zbZMhSXO|YYm= NX7tV4pNPTEQvF2= M4PXRlI1cA>? MWjEUXNQ NGDCdVlqdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm NFuzbIkzOzR7OUi3OC=>
HL-60  NGixbYNEgXSxdH;4bYNqfHliQYPzZZk> NGj1XXQzOM7:TdMg NV6ycYplOjSq NGPJZm1z\WS3Y3XzJJRp\SCleYTveI95cWNiZX\m[YN1KG:oIFXyfVU> MY[yN|Q6PDR6MB?=
HA MUjBdI9xfG:|aYOgRZN{[Xl? MUO1NO69VQ>? M4rOeVI1cA>? NWP6eHE6e3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD M3OyfFI{PDd3OUW2
C666-1 Mlm4RZBweHSxc3nzJGF{e2G7 M4W3WlUx|ryP NXXUO5F4OjSq NHXzc41{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? NGnkNXczOzR5NUm1Oi=>
Hepa1-6 NED0eHZCeG:ydH;zbZMhSXO|YYm= MUe1NO69VQ>? MXuybC=> MlvZbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| NFLPeZMzOzR2Nke1Ny=>
PLC/PRF/5c MlTTRZBweHSxc3nzJGF{e2G7 M4jKTVUx|ryP NXizUI5OOWh? MoOxdJJmfmWwdIOgZZBweHSxc3nzJJRzcWepZYLl[EBjgSCFSV6= MmPUNlM1Ozh6MkS=
HCT116 M1LzfmFxd3C2b4Ppd{BCe3OjeR?= MYGxNFDPxE1? MmX5NU42cA>? M{LYe4lvcGmkaYTzJG9{NWmwZIXj[YQh[2WubDDk[YF1cA>? MkHKNlM4PDR|NUO=
HCEC NUSwVYV5TnWwY4Tpc44hSXO|YYm= NIPnVG82OM7:TR?= NIP5Ung4Omh? MYPEUXNQ NVPGVoVzemW|dH;y[ZMhd2ZidHjlJI5wem2jbDDIR2VEKHCqZX7veJlx\Q>? NEPHNIozOzd2MkCxNS=>
Primary rat cerebral cortical neurons M{L3WGFxd3C2b4Ppd{BCe3OjeR?= M{fab|ExOM7:TR?= NGTo[ncycA>? MYTwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= NIPiXoUzOzd2MUOxOy=>
MDA-MB-231  MUDBdI9xfG:|aYOgRZN{[Xl? NFLycXQzPc7:TR?= NGjidWEzPGh? Ml;iZYJzd2ejdHXzJIN6fG:2b4jpZ4l1gSCjbnSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGGwZDDQRXJRKGmwZIXj[YQh[nliUnez Mnq0NlU{Ozd3NES=
NLRP3-Tet-on-MC/9  NUTuVo9NSXCxcITvd4l{KEG|c3H5 MknENVAuPDEQvF2= NGjKXGcyOmh? NXH4TJUy[XS2ZX71ZZRmeyC2aHWgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhS0GSUz3hd5Nw[2mjdHXkJG5NWlB|IH31eIFvfHNiaX6geIhmKFSndD3vckB{gXO2ZX2= NGDSOY4zOzdyM{O4PS=>
KNS42  M2HIXWFxd3C2b4Ppd{BCe3OjeR?= NEL2dWU2OM7:TR?= NFj0U2IycA>? M{T0fpJm\HWlZYOgZ4VtdCCmZXH0bEBidmRiY3;tdIxmfGWueTDhZo9tcXOqZXSgZ4F{eGG|ZTCzM|ch[WO2aY\peJkhcW5icnXzdI9ve2VidH:gRWJVNTJ4Mz:ySGcwdWW2Zn;ycYlvKGOxbXLpcoF1cW:w MWCyN|Y6OTF2NR?=
MCF-7  NWCzWIhXSXCxcITvd4l{KEG|c3H5 NVT2W3ppOjEQvF5CpC=> NUPBdpVXPzKq M{j1eYlvcGmkaYTzJIVyfW:uLTDhcoQhPC2RSGStcYVlcWG2ZXSgZZBweHSxc3nz MXyyN|Y4PTZ2Mx?=
hCMEC/D3  M4HXcWFxd3C2b4Ppd{BCe3OjeR?= NWnwPWZ3OjYQvF2= NWfLOG5iPzKq NF;Q[3Jz\WS3Y3XzJGx1gEFiaX7keYNm\CCjcH;weI9{cXN? MV2yN|Y3PTF7OB?=
Jurkat NIXYelJCeG:ydH;zbZMhSXO|YYm= M4LI[|EzNjVvNUFOwG0> MUOxbC=> MnnF[I9{\SCmZYDlcoRmdnSueTDzeZBxemW|c3XzJHNRUC2rbnT1Z4VlKFCjcj20JINt\WG4YXflMEBRSVKSIHPs[YF3[WenLDDEUmEh\nKjZ33lcpRifGmxbjygZY5lKGyxc4Ogc4YhfmmjYnnsbZR6 NGXObJozOzR2Mkm3Oi=>
CNE-1 Mo\iRZBweHSxc3nzJGF{e2G7 MlvVNlDPxE4EoB?= NWrm[FVWOjSq NVvqUHUzcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NHfnepQzOzR{Nki1NC=>
HONE-1 NYLXeIt[SXCxcITvd4l{KEG|c3H5 MVSyNO69VcLi MnzvNlRp MoeybY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= MVuyN|QzPjh3MB?=
astrocytes cell MoDkRZBweHSxc3nzJGF{e2G7 MoLNOFDPxE1? M3L5bVZp MlT0doVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m M3nZblI{PDFzN{e4
U-937 NXXCdnNLSXCxcITvd4l{KEG|c3H5 MUSxNO69VQ>? NYG5[3ZXOzCvaX6= M{S2SZBz\X[nboTzJHRPTi2rbnT1Z4VlKG6nY4LvdJRwe2m| NISwZYgzOzRzMEe0PC=>
MDA-MB-231 NULLU3dtSXCxcITvd4l{KEG|c3H5 NEDjVokyODEQvF2= M{XDW|Fp M4PJSYlvcGmkaYTzJJNmdnOrdHn6ZZRqd25idH:gWHJCUUxidYDvckBOXESKIHTve44uemWpdXzheIlwdg>? M{TKZlI{PDB6NEK5
HeLa  MXrBdI9xfG:|aYOgRZN{[Xl? MWOxNFDPxE1? NIO5fokzcA>? MoTwZoxw[2u|IFrSV{0yPSCLbnT1Z4V{KEGyb4D0c5Rq[yCFZXzsJGRm[XSq NUXBcW5XOjN|NESwOFU>
Ec109 NXjQZXZqSXCxcITvd4l{KEG|c3H5 MYexNO69VQ>? M1rvblZp MmjwZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> MX2yN|M{QDV4OB?=
H460  NWD6NVJ{SXCxcITvd4l{KEG|c3H5 M1zNVlEx|ryP NWjibpBoPmh? NIOzUZdjdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? MmXGNlM{Ozh3Nki=
HeLa  M2O5XGFxd3C2b4Ppd{BCe3OjeR?= NUnIbldEPTEQvF2= NVSzbop6OS53aB?= NFryS3Ni[nKxZ3H0[ZPDqEOqbHHtfYRq[S2rbnT1Z4VlKGGyb4D0c5Nqew>? NVHLeWJJOjN|MEO4NFQ>
SK-HEP1 MUTBdI9xfG:|aYOgRZN{[Xl? NWjYcIRYOTByzszN NE\aWmkycA>? MkfGbY5pcWKrdIOgR5JVOSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtO{whNThuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn M3HyXVI{OzB{NkWw
QGY7701 NYHvd41OSXCxcITvd4l{KEG|c3H5 NEXJNpUzPc7:TR?= NYrL[2d5OS53aB?= MYHpcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu MnL2NlMzPDByNkG=
HepG2 NV3hdpVjSXCxcITvd4l{KEG|c3H5 MYeyNO69VQ>? NH3v[pQ{OG2rbh?= M2D0PYlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? MXOyN|IzPDJ|OR?=
U87  MoPjRZBweHSxc3nzJGF{e2G7 MoP6NlXPxE1? M1:3W|Jp NYrHRZpM\GWlcnXhd4V{KGm|b3zpdZVqemm2aXflcolvKCiLU1ypMYlv\HWlZXSgZZBweHSxdHnjJINmdGxiZHXheIgtKGK3dDDuc5QhdmWlcn;0bYMh[2WubDDk[YF1cA>? M2jYWVI{OjJ7NkK2
HSC-2 NWfvfYtbSXCxcITvd4l{KEG|c3H5 MVGyOU82OM7:TR?= MojBNYg> M1PlbolvcGmkaYTzJHNPNTN6LXnu[JVk\WRiY4n0c5RwgGmlaYT5 NHTyZpIzOzF3NUK0PC=>
HSC-4 NVXGNGtXSXCxcITvd4l{KEG|c3H5 M1HyVlI2NzVyzszN NXjTd|V3OWh? M17OO4lvcGmkaYTzJHNPNTN6LXnu[JVk\WRiY4n0c5RwgGmlaYT5 MXKyN|E2PTJ2OB?=
CL-1 NHPwbnRCeG:ydH;zbZMhSXO|YYm= NV;XbYJ1OjEQvF2= MnrlNYg> MoDXZoxw[2u|IF;QOFQ6KGmwZIXj[YQh[2WubDDk[YF1cA>? M4j1d|I{OTNzN{iy
MEL MUPBdI9xfG:|aYOgRZN{[Xl? NEnwc3kzOM7:TR?= NX7YdYR2OjSq MWrEUXNQ NGjnZnBqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NEPH[4MzOzBzNEi4Oy=>
Bel-7402  MmS0R4F{eGG|ZTDBZ5RqfmG2aX;uJGF{e2G7 MYW1NO69VQ>? MoXuNog> MnGybY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NXfSfo1TOjNyMEi3OFI>
Eca-109 MX3BdI9xfG:|aYOgRZN{[Xl? NX;6O2xkOjYQvF2= M{jkSVMxdWmw MUPpcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq MVeyN|A4Pjl4Nx?=
MEL NHnMT|BCeG:ydH;zbZMhSXO|YYm= MV[yNO69VQ>? NX33cYhxOWh? NYjIb2x4TE2VTx?= MmjrbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NF7TSZUzOzBzNEi4Oy=>
Bel-7402  NHHXSItCeG:ydH;zbZMhSXO|YYm= MoruOVDPxE1? M3[2WVJp M2rOXolvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NVjiNIpIOjNyMEi3OFI>
L929 M3OxPGZ2dmO2aX;uJGF{e2G7 MY[yMlXPxE1? NILpSmMycA>? NYjBS2NJcW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? Mlf6NlMxODB3MUi=
RCC  NHfnWGNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{HqOVExOM7:TR?= M{LpO|I1cA>? NVLtcIR3emWlb4\ldoV{KHSqZTD2bYFjcWyrdImgc4Yh[2WubIOg[Zhxd3OnZDD0c{AyPWRvUFfKNi=> M2HSOlIzQTlzNEm0
NB2a/d1 NGCyOFdCeG:ydH;zbZMhSXO|YYm= MkHBNVAx|ryP MkLvO|Jp NH7JdW9ifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm NFyxOpgzOjl6OEW0NS=>
T cell M1uwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjnfYIzPS1zMEFOwG0> M3fZbVI1cA>? MXXkc5NmNWSncHXu[IVvfGy7IHnubIljcXSnZDDUJINmdGxicILvcIln\XKjdHnvckBu\WSrYYTl[EB1cHKxdXfoJJRp\SClbz3zeIlufWyjdHnvckB4cXSqIHHueIkuS0R|IHHu[EBidnSrLVPENlg> M4DYUFIzQTh{NUO4
K562 MVjBdI9xfG:|aYOgRZN{[Xl? NVXzdYJlOTByzszN MWexbC=> M2ThWoJtd2OtczDBZo5w[mG4aYPjeY3DqEZvaX7keYNm\CCjcH;weI9{cXN? MnzoNlI6PzJ|N{K=
Jurkat  NY\6W41USXCxcITvd4l{KEG|c3H5 M3fxPVQx|ryP MkjENYg> M{PXXYFjd2yrc3jld{BH[XOOLXnu[JVk\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp Mn3TNlI6PDJ5M{i=
BGC-823 NGHQToNCeG:ydH;zbZMhSXO|YYm= M4DjRVExOM7:TR?= M1v0VlFp NEnRZ5Nx[XK2aXHscJkhemW|Y4Xld{Bk\WyuczDh[4FqdnO2IHThcYFo\SCxZjDkZYllgmWrbh?= NYrDVFhqOjJ7Mk[1OFU>
Hep3B NUPOOWpmSXCxcITvd4l{KEG|c3H5 M2m5VVUx|ryP NY\vN5NxOWh? M2fJUYJtd2OtczDhdI9xfG:|aYOgbY5lfWOnZDDifUBJTUeFcx?= NVXFbHpnOjJ7MkOxOVQ>
LLC-PK1 NInTXmNCeG:ydH;zbZMhSXO|YYm= NWLod3BvOjEQvF2= NGrSU4UycA>? MX;wdoV3\W62czDjbZNxdGG2aX6tbY5lfWOnZDDk[Ydz[WSjdHnvckBw\iCDdHe1MEBj\WOuaX6tNUwh[W6mIFH0[|EzKHC{b4TlbY5{ NV\sbVVzOjJ6OU[wN|c>
A549 M3PjOmFxd3C2b4Ppd{BCe3OjeR?= Mkj0OVDPxE1? NHGxSG8ycA>? MXzicI9kc3NidHjlJGJCUS2rbnT1Z4VlKGGyb4D0c5Nqe8Li NFjIZnYzOjh6N{KxOS=>
SGC-7901  M{DaWGFxd3C2b4Ppd{BCe3OjeR?= Mke1NVDPxE1? MXyyOIg> NWXrXldIcW6qaXLpeJMh|rJuzsKt[Ilu\XSqeXzhZ5J6dHOqaXvvcolvNWmwZIXj[YQh[XCxcITvd4l{yqB? M{LRW|IzQDR6NUm3
DM6 NGPiV2tCeG:ydH;zbZMhSXO|YYm= NGXvdpoyODEQvF2= NWr3cXNOPzKq MUjicI9kc3NiYn;0bEBGOkZvMTDhcoQhTTKIdIKtcYVlcWG2ZXSgZ5l1d3SxeHnjbZR6 NV3aRnhSOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NE\NNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe0TIY2OM7:TR?= M1y4Z|Q5cA>? M3uzNIlvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> MkTuNlI5ODB7Nki=
A2750  MnG1RZBweHSxc3nzJGF{e2G7 MYeyNO69VQ>? MUKybC=> NWPpTodKTE2VTx?= MYHicI9kc3NiY3HzdIF{\SClbHXheoFo\SCmdYLpcochcGWuZX7hcIlvKHS{ZXH0cYVvfCCjbnSgdoVlfWOnczDheZRweGijZ3njJINmdGxiZHXheIg> NEHQWVgzOjd6NEO2Ny=>
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A549  M{fIUGFxd3C2b4Ppd{BCe3OjeR?= M1XQNFUx|ryP MlX6Nog> MnTqdIFzfGmjbHz5JIRm[3KnYYPld{B{d2SrdX2gd4Vt\W6rdHWtbY5lfWOnZDDhdI9xfG:|aYO= MlzuNlI4OjF6MES=
Primary OPC NWjHS2w5SXCxcITvd4l{KEG|c3H5 M3Ts[|HPxE1? NFLpd2M3cC9{NHi= NHPFWYRz\WS3Y3XzJJRp\SCyZYLj[Y51[WenIH;mJINmdGy|IHnuJIViemy7LTDhcoQhdGG2ZT3hdI9xfG:|aYOvcoVkem:|aYO= MmLHNlI4ODd|OEW=
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A549  Ml7PRZBweHSxc3nzJGF{e2G7 MlXCOVDPxE1? Mlq2NYg> MWfwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? NVniSIdEOjJ4OEe2N|U>
AGS M{WwfWFxd3C2b4Ppd{BCe3OjeR?= NVPVXmE2OjEQvF2= MWixNog> NE[yPINqdmirYnn0d{B1cGViYXP0bZZifGmxbjDv[kBxem9vY3HzdIF{\S1|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdg>? M2PiclIzPjh5M{m4
shC9  NEf0OVhCeG:ydH;zbZMhSXO|YYm= NVz4c25MOTEQvF2= MYGxOog> NYW4dI1b[my3boTzJHNJUCCneIDy[ZN{cW:wIHnuJJNpSzliY3XscJMh\Xiyb4Pl[EB1dyCnaYTo[ZIhWEFib4KgUHBE Mlm4NlI3PDFyOUS=
primary MEFs M4riSWZ2dmO2aX;uJGF{e2G7 Mn3ENVJp MX1CpIlv[3KnYYPld{BmfG:yb4Pp[IUucW6mdXPl[EBucXSxY3jvcoRzcWGuIH3lcYJz[W6nIHTldI9t[XKrenH0bY9v NX7rTodZOjJ4MUO3Olc>
3T9 MEFs NHPB[JlHfW6ldHnvckBCe3OjeR?= NUjNOVFGOT[q M{P0Xolv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 NX[2Vnc5OjJ4MUO3Olc>
3T9 MEFs M2DzbWZ2dmO2aX;uJGF{e2G7 NYmxOGh3OTiq NUPFfmN2fXC{ZXf1cIF1\XNiaX7peIlifG:{IHPhd5Bie2VvOTDieZQh\G:5boLl[5Vt[XSnczDl[oZm[3SxcjDjZZNx[XOnczDh[pRmeiCndH;wc5Nq\GVidILlZZRu\W62 M3XQdVIzPjF|N{[3
MDA-MB-231  NWizVJkxSXCxcITvd4l{KEG|c3H5 M2TrOVIx|ryP MnnOOIQ> M3TyPJJm\HWlZYOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhdWW2Zn;ycYlvKHS{ZXH0cYVvfCC5YYOgd4lodmmoaXPhcpRtgQ>? MlPFNlI2QTN2NEG=
C6  MYXBdI9xfG:|aYOgRZN{[Xl? NHvKVIgyOM7:TR?= M2X1flI1cA>? NFHlO4tjdG:la4OgeIhmKHO3cIDy[ZN{cX[nIHXm[oVkfCCxZjD0bIUheGWydHnk[UBwdiC4aXHibYxqfHl? NVGxNY1NOjJ3OEi5PFA>
HL-60  NHzKRoFCeG:ydH;zbZMhSXO|YYm= NGewRmEyODEQvF2= M3;CWlI1cA>? MlzRbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxc3nzJJNmdGWldHXkJEgsMS2vZX70bJltKM7{LTix5qaTPilvZHnncJVkd3C7cnHuc5Nq\GYEoEW= NF\JNYIzOjV2Nk[2PS=>
HL-60 MoHzRZBweHSxc3nzJGF{e2G7 Mm\qNVAuQDEQvF2= NF\QXHU1cA>? M3SwT4lvcGmkaYTzJHRIUFFvaX7keYNm\CClZXzsJIFxd3C2b4Ppd:Kh M1rhblIzPTJ|MkK5
BCC NHfXcmxCeG:ydH;zbZMhSXO|YYm= Ml;OOVDPxE1? NUWxVW5mOWh? M{jBbolvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? NIS5NW4zOjVzOUSzOi=>
RAW 264.7 NWrB[2pLSXCxcITvd4l{KEG|c3H5 MmnPOVAwOTByzszN MX2xbC=> NEXHeXdkd26lZX70doF1cW:wLXTldIVv\GWwdDDpcohq[mm2czDEU24ucW6mdXPl[EBzWk6DIHPs[YF3[Wen NFGxNmgzOjR7MUSyOi=>
K562 MVLBdI9xfG:|aYOgRZN{[Xl? NXHubJoxOjYQvF2= MXiybC=> MoPldJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[29vdILlZZRu\W62IIfpeIgh[W23cnXud4lvKEdiYX7kJHRTSUmO NIXoNZUzOjR6M{e3Oy=>
SGC-7901 MXzBdI9xfG:|aYOgRZN{[Xl? Mk\pNlAh|ryPwrC= MXiybC=> M{PWUYF1fGWwdXH0[ZMhUDKRMtMgc5IhXE6IIN8xMYlv\HWlZXSgZ4VtdCCjcH;weI9{cXNiYYOge4VtdCCjczDjZZNx[XOnLUOgZYN1cX[rdIpCpC=> NWLDNFE1OjJ2N{G1PFk>
PC3 NIDoPY5CeG:ydH;zbZMhSXO|YYm= NInEbo8yOM7:TR?= MYq0bC=> NIjpOYFkd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> M3;hTVIzPDdzOUe0
SMMC-7721 M4LCOmFxd3C2b4Ppd{BCe3OjeR?= NGTYfWI2OM7:TR?= NEXweIE1QGh? NF\oU2NifHSnboXheIV{KG:WUj3pcoR2[2WmIHHwc5B1d3Orcx?= NGXlZ48zOjR4NUizNy=>
HeLa  MYfBdI9xfG:|aYOgRZN{[Xl? M2THT|UxyqEQvF2= MXG0M|hp NGDabFVqdmirYnn0d{BUXFNvaX7keYNm\CCuYYTlMZBp[XOnIHHwc5B1d3SrYzDleoVvfHN? NH;OVW4zOjR4MEWwOC=>
HeLa  MVvBdI9xfG:|aYOgRZN{[Xl? M4nSSFUxyqEQvF2= MYWxbC=> MVPzeZBxemW|c3XzJJRp\SCIUlHQMYlv\HWlZXSgZYNkfW23bHH0bY9vKG:oIHHucoV5cW5iVjDwc5NqfGm4ZTDj[Yxtew>? NWW4RVVbOjJ2NEm0OFA>
T47D  MWnBdI9xfG:|aYOgRZN{[Xl? MUmxNFDPxE1? NYjRR3RIOWh? M2nCVIJtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NFnT[WYzOjRyMUG2PC=>
HeLa  Mkn4RZBweHSxc3nzJGF{e2G7 NVLRZWgxOzEQvF2= MYm0bC=> MVxCpIlv[3KnYYPld{B1cGViZ3Xu[ZJidCClZXzsJJZq[WKrbHn0fUA1QCCqIHHmeIVzKHCqb4Tv[Jlv[W2rYzD0doVifG2nboVCpC=> M4KzWlIzOzl2MkS4
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mESCs MWTBdI9xfG:|aYOgRZN{[Xl? MYeyMlXPxE1? NXXZSoxCOmh? NGr5eItqdmirYnn0d{B1cGViTnHGMY1m\GmjdHXkJINie3Cjc3WgZYN1cX[jdHnvci=> MorFNlIzQDV{N{S=
EMT-6  MWjDfZRwfG:6aXPpeJkhSXO|YYm= M1HDS|ExOM7:TR?= MnG0NYg> NVn2dmpyeGG{dHnhcIx6KGKub3Pr[YQh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IIPpdoFu\XOrbnW= MlLUNlIzPTF7MkG=
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Molt4-hyg MVrBdI9xfG:|aYOgRZN{[Xl? M{HlelEx|ryP MlX0NE42cA>? MnK1Zoxw[2u|IH\hdo5me2:uLXnu[JVk\WRiY3HzdIF{\S1|LXzpb4Uh[WO2aY\peJk> MoXLNlYzPzV6MUG=
HeLa M1K0VGFxd3C2b4Ppd{BCe3OjeR?= NETqfI0yOM7:TR?= Mlq4NE42cA>? MnL4bY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfGinIHPvcYJqdmWmIITy[YF1dWWwdDD3bZRpKGexbXnzbY4hViCjbnSgWHJCUUx? NIDGeYUzOjF5OU[2NS=>
Jurkat T NIrmcIRCeG:ydH;zbZMhSXO|YYm= MWqzNO69VQ>? MUGwMlVp MmfpSG1UVw>? NYjXfpdx[myxY3vzJJRp\SC8aYLhcU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MVyyNlE2QTh7OB?=
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HCT116 MVTBdI9xfG:|aYOgRZN{[Xl? NHvVV4U2OMLizszN MUKybC=> MoLEdoV3\XK|ZYOgd5lv\XKpaYP0bYMh[XCxcITvd4l{KGWoZnXjeJMhd2ZiY3Xs[YNwgGmkIHHu[EBPWENvMUdCpC=> MmDzNlIyPTl5NUK=
MDA-MB-231  NVLRW3FLSXCxcITvd4l{KEG|c3H5 Mn;ENk42NTdwNd88US=> M4npWlJp NHnMcZNqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ MYqyNlEyPTV{Nh?=
LNCaP MkWyRZBweHSxc3nzJGF{e2G7 MojqOFDPxE1? NFHHSm4zcA>? MX7pcohq[mm2czDieZRmcW5iaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NF;DOYszOjFzNEe2OC=>
MB231 MYfBdI9xfG:|aYOgRZN{[Xl? MWqxNFDPxE1? M2HIcVFp MlfqSG1UVw>? M3LLVYFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? M{DVfFIzOTF{OUSw
HCC38  NWLXcZE5SXCxcITvd4l{KEG|c3H5 NUjvXVJjOTByzszN M4jCUFFp NX3UV4VFTE2VTx?= NUfqOY5j[WK{b3fheIV{KHSqZTDpcoR2[3Srb36gc4Yh[2WubDDk[YF1cCCkeTDXSWUyKGmwaHnibZRqd25uIGTSRWlNKHS{ZXH0cYVvfCxiYX7kJJRp\SClb33ibY5ifGmxbh?= MUKyNlEyOjl2MB?=
MDA-MB231 Mm\kRZBweHSxc3nzJGF{e2G7 M{HLTVUxyqEQvF2= NXH1d5RHOjSq NEDMcGFFVVOR MWDhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NYPLOoJnOjJzMEGzN|U>
LNCaP NFHCd5JCeG:ydH;zbZMhSXO|YYm= M2\MdlUxyqEQvF2= M1XKSVI1cA>? M3z3V2ROW09? MVzhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NUntRolsOjJzMEGzN|U>
HCT116 MkTtRZBweHSxc3nzJGF{e2G7 NYP1SYJ6PTEEoN88US=> MkOyNlRp NI\ocZZFVVOR M4DyUIFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> M1OwfFIzOTBzM{O1
Ishikawa  Mnq0RZBweHSxc3nzJGF{e2G7 NVP6[4VrOjYQvF2= NHvrS3QzPGh? M1jZR5Jm\HWlZYOgZ4VtdCCmZXH0bEBidmRiYYDvdJRwe2m|IHnu[JVk\WRiYomgRoFnKEFz NEfHVpMzOjB6OEmxPC=>
 YD-8  NI\DWVNCeG:ydH;zbZMhSXO|YYm= Mof3NVAx|ryP MWWxbC=> MkDxbY5pcWKrdIOgVGxGVy2rbnT1Z4VlKGGyb4D0c5Nqew>? NWX0epVPOjJyOE[xPFM>
eosinophil  NUTHeFJQSXCxcITvd4l{KEG|c3H5 NX7tbW9jQTEQvF2= M3PMTlI1cA>? Mnj0bY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhTmG|IHHueIljd2S7wrC= NWH4UYd4OjJyN{mzN|Q>
L929 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTjbm9ZOi53zszN NF[0fVUzPGh? MnPybY5pcWKrdIOgeIhmKGW6cILld5Nqd25ib3[gdE1xOzhiYX7kJG5HNc78QjD0c{BifWevZX70JHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? MVOyNlAzPzB7Nx?=
YD-8  MYHBdI9xfG:|aYOgRZN{[Xl? NWLTWZpJOTByzszN MnntNYg> M{HZU4Jtd2OtczD0bIUhT1NvSFPsMYlv\HWlZXSgZZBweHSxc3nz M17tOlIzODJyMEe4
HBx NFn2ZXJCeG:ydH;zbZMhSXO|YYm= M3i5dVI2|ryP M1ywNVQ5cA>? M3TSN2ROW09? NXnnVVFHemWmdXPl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nliMz3NRS=> M1Xue|IzODJyMEe4
U937  M37DTWFxd3C2b4Ppd{BCe3OjeR?= M2CyTlUxyqEQvF2= Mm\sNYg> MXHpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh MnvmNlE6QTh5M{G=
HL60 MWPBdI9xfG:|aYOgRZN{[Xl? M2PY[VQx|ryP MXK0NI1qdg>? MYDEUXNQ NYjMfWVT[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MnO1NlE6QDN{OU[=
M-14 MV\BdI9xfG:|aYOgRZN{[Xl? NUK1bZJ7OjYQvF2= MnG0NE42cA>? M3fPWuKhcW6qaXLpeJMh[m:2aDD0bIUh[3K3ZHWg[Zh1emGldD2gZY5lKGOxbYDveY5lNWmwZIXj[YQh[XCxcITvd4l{ NXmyW2NOOjF7NUS5OVk>
SK-BR-3 M1q0c2Fxd3C2b4Ppd{BCe3OjeR?= MYK1NOKh|ryP NV2ye3ZuOmh? M13vboJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> NXXZZoJ{OjF7MEGzPFY>
MDA-MB-468 M2\vS2Fxd3C2b4Ppd{BCe3OjeR?= NVjKV|F5PTEEoN88US=> NXjVeZZZOmh? M4PSVYJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> NX\zNpp1OjF7MEGzPFY>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Caspase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID