Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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3 Customer Reviews

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a M3HZTWFxd3C2b4Ppd{BCe3OjeR?= MX61NO69VQ>? MlXsNlRp NXHpeYs5cW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? MkPaNlYyPjlyN{W=
HGL5 MYnBdI9xfG:|aYOgRZN{[Xl? NYHXbmEzPTEQvF2= M3fwdFI1cA>? NUC0NnhNcW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? M1;vO|I3OTZ7MEe1
HepG2 MWrBdI9xfG:|aYOgRZN{[Xl? MnvKNlDPxE1? MWixbC=> M3LTdoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MUeyOlE3PDd7NR?=
BEL-7402 MlvtRZBweHSxc3nzJGF{e2G7 NWfU[ZhYOjEQvF2= MVexbC=> MXfheJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg MnfHNlYyPjR5OUW=
CEF MoTKT4lv[XOnIFHzd4F6 NHHSdIQxNDN|LE[3MFExOM7:TR?= Ml;QNVVucW5? MmO1[I94di2{ZXf1cIF1\XNiUGKg[Y57gW2nIHHjeIl3cXS7IITvJFQx97zHIHH0JFExOM7:TR?= NITBVnkzPjFyMkOzPS=>
SP2/0 NG\S[YZCeG:ydH;zbZMhSXO|YYm= M4\XPFExOM7:TR?= MnfkNYg> MnzJSG1UVw>? NWjnToNi[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> MWmyOlA4PDd|Mh?=
HUVEC-2c M2DTZ2Fxd3C2b4Ppd{BCe3OjeR?= NFjuNms2OM7:TR?= NWfDbnplPmh? MWDk[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> MkjvNlYxOjF5Mkm=
U1 Mn\MRZBweHSxc3nzJGF{e2G7 MY[wMVExOM7:TR?= MWmybC=> MVPy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M2X5OlI2QThyOUSy
ACH-2 MnO5RZBweHSxc3nzJGF{e2G7 M4\nXFAuOjByzszN NI\xXlYzcA>? MorzdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M3\5[|I2QThyOUSy
U1 NHLpbG1McW6jc3WgRZN{[Xl? Mn20NVAx|ryP MkH6Nog> Ml30bY5pcWKrdIOgZ4F{eGG|ZT2z MmLpNlU6QDB7NEK=
A549/V16 M4fOPWFxd3C2b4Ppd{BCe3OjeR?= NUG3[JJxPTEQvF2= M3yxTFFp NVz0RVJxemWycnXzd4V{KFSJL2TNMYlv\HWlZXSgZZBweHSxc3nz MUmyOVk1PjB|Mx?=
SGN NXnIRVdPSXCxcITvd4l{KEG|c3H5 MWOyNI1O Mn\ZOFhp MoHVbIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= NHrPRWYzPTh5NE[zNy=>
HCT116  Mn7NRZBweHSxc3nzJGF{e2G7 M{jhUVUx|ryP MnO1Nog> NXrjPVNOcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S MlHINlU5Pjh6MUi=
DTK-SME NWDkTYNYSXCxcITvd4l{KEG|c3H5 NXnUcVF1PTEQvF2= NUfKVHlOOmh? NHi2NIJFVVOR MmHndIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> M4DUelI2QDR|OEm3
HL-60 NGj0VYFCeG:ydH;zbZMhSXO|YYm= NWi2Xo5{PTEQvF2= NYHGZpJzPDiq MnfpdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MnXGNlU5OjRyNEO=
U937 M3rZTGFxd3C2b4Ppd{BCe3OjeR?= M2roZ|Ux|ryP NUHHR3NEPDiq MnXCdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> M2K1UlI2QDJ2MESz
A549 MX7BdI9xfG:|aYOgRZN{[Xl? M1HITFIxKM7:TR?= M3r6WFI1cA>? MX\y[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JGhHS1BidILlZZRu\W62 M3:1O|I2Pzl2MUS5
HeLa NU\JZnNkSXCxcITvd4l{KEG|c3H5 NHXGdnEyOM7:TR?= M2jyS|Q5cA>? NVrKb4lP\GWlbHnu[ZMhfGinIILheIUhd2ZiYYDvdJRwe2m|IHTyZY1ifGmlYXzsfS=> NXXFOJJbOjV5N{K1OFU>
SGC-7901 MX3BdI9xfG:|aYOgRZN{[Xl? Mn3vNlDDqM7:TR?= Mlq1NYg> MlLwbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> M{X3[|I2PzZ5MEe2
MCF-7 NIXvR5JCeG:ydH;zbZMhSXO|YYm= NY\XdnpiOTEQvF2= NUTz[|luOmh? NEn1c49qdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JFND MlK3NlU4OjJzMUS=
A549 MlPhRZBweHSxc3nzJGF{e2G7 M{m1eVExKM7:TR?= M1\5V|I1cA>? M2rFNmROW09? MWjwdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= MUeyOVY5OzV4OB?=
U87 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n5UFUx|ryP Mn;4NYg> MmPRdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 M12xTlI2PjhzNk[4
Neocortical Neuron NV3pb5o{VmW3cn;0c5hq[2m2eTDBd5NigQ>? NGPPWngyODEQvF2= M{LhWFFp M1rZWoFvfGGpb37pfoV{KEixaXHtbYRmKEFvSX7keYNm\CCQZYXyc5RwgGmlaYT5 MVWyOVY4PTByMR?=
Primary human placental cytotrophoblasts MVXBdI9xfG:|aYOgRZN{[Xl? NUjKWFJqOzEQvF2= Mn7YNlRp MXfEUXNQ NFn6fFFz\X[ncoPld{B1cGViaX7obYJqfGmxbjDv[kAyOc7{LVjTSFIh[nlidILpZ4xwe2GwwrC= MXeyOVY1OjV7Mh?=
MM NFLyS2hCeG:ydH;zbZMhSXO|YYm= NWTKT4ZxPTEQvF2= MXqyNI1qdg>? NFHW[Y5x[XK2bImgbY5pcWKrdIOgV2hMNWmwZIXj[YQhKGOnbHyg[IVifGh? MkjMNlU2OzByOUi=
DLD1 MnfPRZBweHSxc3nzJGF{e2G7 NIDqdHQzOMLizszN Mn33NYg> NIfDPFlx[XK2bImgdoV3\XK|ZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGfTVFE> NUXFfXR2OjV3MkSyOFY>
MDA-MB-231 MVfDfZRwfG:6aXPpeJkhSXO|YYm= NHLDcpIyOM7:TR?= NWTIUHVXOWh? NGq0eFFifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 NGfUcZMzPTV{MUWwNS=>
MKN28 MnnkRZBweHSxc3nzJGF{e2G7 NE\JS4syOM7:TR?= NHTxV2w{OG2rbh?= NXLDTlQ4TE2VTx?= M2TXNYlvcGmkaYTzJHRPTi4QsTDwcJV{KEOKWD3pcoR2[2WmIHHwc5B1d3Orcx?= NIq3cokzPTVzM{m2NC=>
HL-60 M3XaXmN6fG:2b4jpZ4l1gSCDc4PhfS=> NFLBdHcyODEQvF2= M2LzTFFp MYfEUXNQ MX9CpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| NWXTNYQ6OjV3MEK5N|I>
AGS NYq3[oNDSXCxcITvd4l{KEG|c3H5 NH3KS4cyOM7:TR?= MYKxbC=> NIOycYpxemW4ZX70d{BkfXKldX3pck1qdmS3Y3XkJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUisJIFv\CBvOTDwdo91\Wmwcx?= NUnzNoc5OjV2OUKyNVQ>
A549  NVPEe2xXSXCxcITvd4l{KEG|c3H5 MUCxNO69VQ>? NYXKNmR[OjSq M37aN4Jtd2OtczDEUWFUNWmwZIXj[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHHu[EBieG:ydH;0bYMh[2WubDDk[YF1cA>? M1u2WVI2PDN2OUi5
INS-1 MX;BdI9xfG:|aYOgRZN{[Xl? MoXBOVDPxE1? NHzV[lc3cA>? MU\EUXNQ M1j5c4Rm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= M{XvZ|I2PDNyOEm3
Primary hepatocytes  NYjKeYFISXCxcITvd4l{KEG|c3H5 Mn3qOVDPxE1? M4XyU|E5cA>? MmH4bY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= MYCyOVQxPzV|OB?=
L929-A  MkK1R5l1d3SxeHnjbZR6KEG|c3H5 Ml\4NlDDqM7:TR?= Mkj6NlRp NWnKTGs2cW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo MXmyOVM6QDV2MB?=
L929-N NWnz[5VCS3m2b4TvfIlkcXS7IFHzd4F6 M4n0dVIxyqEQvF2= MVmyOIg> M{XWeoVvcGGwY3XzJIRm[XSqII\pZUBifXSxY4LpcoUhXE6IzsGgdJJw\HWldHnvci=> MlOyNlU{QTh3NEC=
Cytotoxicity Assay NWLNZlZiS2WubDDWbYFjcWyrdImgRZN{[Xl? NFn4[WkzOM7:TR?= MoLKOFhp NYDDeXdleHKndnXueEBOUE2GLXnu[JVk\WRiY3XscEBl\WG2aB?= NVfMb|gzOjV|OUKxNVY>
COS7 MV;LbY5ie2ViQYPzZZk> M4XSbVEx|ryP M4nXSlI1cA>? Mo[1bY5kemWjc3XzJINie3Cjc3WgN{84KGGldHn2bZRq\XN? MWOyOVM5PDB{NR?=
COS7 Ml7ORZBweHSxc3nzJGF{e2G7 MVixNO69VQ>? NEjEbmE1QGh? MoO3dIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= MUeyOVM5PDB{NR?=
A375 NEXo[2RCeG:ydH;zbZMhSXO|YYm= MWWzNO69VQ>? NEPHOWozcA>? NYfzd|FzeHKndnXueJMhfGinIHTyeYcucW6mdXPl[EBRSVKSIHPs[YF3[Wen MWCyOVM4PjFzNR?=
A549 NHHIOnhCeG:ydH;zbZMhSXO|YYm= NEXZSVM2OM7:TR?= MlTjNlRp M1mxeZJmfmW{c3XzJJJq[m:|b33lJIJqd2enbnXzbZMh[W6mIHHwc5B1d3OrczDjZZV{\WRiYomgJGNpcWqxbnfkZY4> NVXJZlVNOjV|NEm3PFE>
A549 MWjBdI9xfG:|aYOgRZN{[Xl? NGCxflIzNjVvMkZOwG0> M4PWN|Fp MYPk[YNz\WG|ZYOgeIhmKHCxcIXsZZRqd25ib3[gZZBweHSxdHnjJINmdGy|IHTldIVv\CCxbjDjc45k\W62cnH0bY9vew>? M1nBNlI2OzR{NEK3
 NBL-W-S  M3PXN2Fxd3C2b4Ppd{BCe3OjeR?= NH7RSpI2OM7:TR?= NIPSN3IycA>? NEGyUXFnfWyueTDy[ZNkfWW|IHPlcIwhfmmjYnnsbZR6KGGodHXyJGdCVlRvNkGgeJJm[XSvZX70 MUiyOVMzOzJ{Mh?=
Caki-1  M4HWWWFxd3C2b4Ppd{BCe3OjeR?= NU\QNWw5PDEQvF2= NYrkOlI2PDiq NWjWc2RwemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? M2HtfFI2Ojd7MUmx
769-P M{LFdmFxd3C2b4Ppd{BCe3OjeR?= Mn3ROFDPxE1? NF;ZToI1QGh? M3jqdZJm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> NETrTYszPTJ5OUG5NS=>
H9c2 Mlu4RZBweHSxc3nzJGF{e2G7 NF35eJI2OM7:TR?= M{fFWFFp MmHVbY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? MWqyOVI5OzhzOR?=
K562 MUfBdI9xfG:|aYOgRZN{[Xl? NUXaXHZFPTEQvF2= MonqOIg> MXvpcohq[mm2czDKZYMuSS2rbnT1Z4VlKGOnbHygZZBweHSxc3nz MkTiNlUzPDF4MUm=
L929 NVTteJBzSXCxcITvd4l{KEG|c3H5 MmjuNVDPxE1? NEHy[HQ3cA>? NXjJb|JLcW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? NH3rTHMzPTF7NU[2NC=>
A549 MkfRRZBweHSxc3nzJGF{e2G7 Mo\xNVDPxE1? M1;QOlNp MWry[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= NVnheXpoOjVzNkG2PVk>
MCF-7 MULBdI9xfG:|aYOgRZN{[Xl? NF7WWHMzOM7:TR?= NX\abYFMOmh? Mkjn[IVkemWjc3XzJGtFWi2|aWLORU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MUeyOVE5OjJ2MB?=
OS NV\OZ3BbSXCxcITvd4l{KEG|c3H5 NUPFW3VOOjBxNEFOwG0> M3fGR|czcA>? NIHqTJhqdmirYnn0d{BQWyClZXzsJJZq[WKrbHn0fUBz\WS3Y4Tpc44h[nliQ{[gZ4Vz[W2rZHW= NIf6bpIzPTF3MkO5PS=>
HUVECs MVTBdI9xfG:|aYOgRZN{[Xl? NV:w[FF{OTEQvF2= M2fhcVJp M3jsceKhcW6qaXLpeJMh[XCxcITvd4l{KGGwZDDmZYNqdGm2YYTld{BifXSxcHjh[5khcW5iRFXOWlIucW6oZXP0[YQhUFWYRVPz NVTiXoY6OjVzM{i3NFM>
EA.hy926 M4Lqc2Fxd3C2b4Ppd{BCe3OjeR?= NWfmNmhoOTEQvF2= MXWybC=> MVdCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGVCNmi7OUK2 NWXmNlBXOjVzM{i3NFM>
Ebs M37JRmFxd3C2b4Ppd{BCe3OjeR?= NX;IPFVzOTBvMUCw{txO NVvJ[5NzOjSq MlnkxsBOVVSVIHflcoVz[XSrb36gdoF1\SCmZXPy[YF{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36gc4Yhgi2YQVSu[o1sKGmwY4LlZZNm\A>? NUTrfYx3OjVzM{S4NVc>
Jurkat MoTtRZBweHSxc3nzJGF{e2G7 Mk\xNlDPxE1? MXmyOIg> NXX3V5NYTE2VTx?= NFHVW|Nx[XK2aXHscJkhcW6qaXLpeEBk\WyuIHTlZZRpKG:oIFr1dotifCClZXzsd{BqdmS3Y3XkJIJ6KDFyMEW4MWY1KGOxbXLpcoVlKHerdHigWnBCyqB? MmPsNlUyOjB5MkO=
K562 NHfB[VVCeG:ydH;zbZMhSXO|YYm= NXjuRpROOC5zLUJOwG0> MXmxbC=> MknobY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MWiyOVEyQTF6OB?=
IMR-32 M{HHXmFxd3C2b4Ppd{BCe3OjeR?= NHr4dmc1OMLizszNxsA> NXTPXGUzOmh? NGn2eGdl\WO{ZXHz[UBqdiCjcH;weI91cWNiY3XscJMh[2:vcHHy[YQhfG9iVD2yJJRwgGmw MkXUNlUxQDR5NUW=
RPMI 8226 M2HBZWFxd3C2b4Ppd{BCe3OjeR?= MkjkNVAx|ryP NXPoXlI6OWh? M4\Xd4FtdW:|dDDjc41xdGW2ZXz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z Mor5NlUxOzd6NUG=
U266  NWLDXo5LSXCxcITvd4l{KEG|c3H5 NUW2PW1yOTByzszN M1XFTFFp NILXXmxx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= M{DpNVI2ODN5OEWx
H929  MoL3RZBweHSxc3nzJGF{e2G7 M1;2ZlExOM7:TR?= NUjRPVNiOWh? NULtenZ1eGG{dHnhcIx6KGKub3Prd{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCwZXPyc5N1[XSrbj2x M{W5TVI2ODN5OEWx
MM.1S  M1;Qb2Fxd3C2b4Ppd{BCe3OjeR?= NX:4PIp5OTByzszN M3;GRlFp MWnl[oZq[2mnboTsfUBxemW4ZX70d{B{d3KjZnXubYIucW6mdXPl[EBk\WyuIHTlZZRpKGOxbXLpcoUhf2m2aDDu[YNzd3O2YYTpck0y M4DHU|I2ODN5OEWx
C6 M{HPRmFxd3C2b4Ppd{BCe3OjeR?= M2HOT|Ux|ryP NFvCUpY1QGh? NVHnS5FQeHKndnXueJMhfGinIHzvd5Mhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KHC{ZXfu[Y5wdG:wZR?= NHrKXYEzPTBzM{S3PS=>
AGS MnzjRZBweHSxc3nzJGF{e2G7 MUe1NO69VQ>? MlmwNlRp NIflSY9i[m:uaYPod{DPui2uYYDhZ4hwdmVvaX7keYNm\CClZXzsJIRm[XSqIHHu[EBqdmirYnn0[YQh\3Kxd4To MlHqNlUxODl4OUi=
HeLa  M1u4ZWFxd3C2b4Ppd{BCe3OjeR?= M3\kRlQx|ryP M4DlXFI1cA>? MlXpbY5pcWKrdIOgeIhmKGmwY4LlZZNm\CCjcH;weI9{cXNiaX7keYNm\CCkeTDzbXJPTjF{MR?= NUH3cGlnOjR7Mki2PFU>
THP-1  MXzBdI9xfG:|aYOgRZN{[Xl? M1Lv[VEx|ryP NVXtO5R3OWh? Mk\ydoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> Ml[2NlQ6OjN4NUO=
P815  MUPBdI9xfG:|aYOgRZN{[Xl? M4i1R|ExOCEEtV2= M4rleVEzcA>? MoLHSG1UVw>? M{fOS4lvcGmkaYTzJJZqenW|LXnu[JVk\WRiYYDvdJRwe2m| NV3mcFhJOjR7MkOyO|M>
HCT116 MnHQRZBweHSxc3nzJGF{e2G7 M1P6RVIx|ryP NFrTTI8zPGh? NEDXTHZi[nKxZ3H0[ZMhd2ZiVGGtbY5lfWOnZDDhdI9xfG:|aR?= NH7l[WczPDh7MES0PS=>
SW1116  NGjJNIpCeG:ydH;zbZMhSXO|YYm= NHfQWJEyOCEEtV2= NHPV[2UycA>? MU\EUXNQ NGXmVGxz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l MXeyOFg4PDJ6Nh?=
LOVO NUnDfFZwSXCxcITvd4l{KEG|c3H5 NFP4NIsyOCEEtV2= NXi2b4hsOWh? Mk[3SG1UVw>? NUfie5d3emW|dILhbY5{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkh\2WoaYTpcoljKHCudYOg[IVkcXSjYnnu[S=> NI\CNJczPDh5NEK4Oi=>
SNU449  NFKxfZRCeG:ydH;zbZMhSXO|YYm= NITxNmgzOM7:TR?= MnvOOFhp NHPmdmZFVVOR NVu5[nBq\GWlcnXhd4V{KG2rUj20OVEucW6mdXPl[EBieG:ydH;0bYM> Mn\uNlQ5PDF4M{i=
Caco-2 M4XxeWFxd3C2b4Ppd{BCe3OjeR?= M164fFQx6oDLzszN MX[0bC=> NYSwPXNQeHKndnXueJMhW1RvNz3pcoR2[2WmIGrPMVEh[2ijbnfld{BidmRiVFXSJIRzd3B? M1vJPVI1QDJ{MUiz
macrophage MXfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MWewMVIxOM7:TR?= M2T2XlI1cA>? M17le4lv\HWlZYOgWG5HNSCjbnSgVolxOy2mZYDlcoRmdnRibnXjdo9xfG:|aYOgbY4hdWGlcn;wbIFo\Q>? MVWyOFc6QTV4NR?=
AGS  MXPBdI9xfG:|aYOgRZN{[Xl? NVHmOIhPOjEQvF2= MY[xNog> NVjsS5dQTE2VTx?= MlKxdoVlfWOnczD0bIUhcW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBz\XOyb37z[UB1dyC2aHWgSZRQSWNiZoLhZ5Rqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MXWyOFc5QTdyMx?=
LCC9  MoX0R4VtdCCYaXHibYxqfHliQYPzZZk> NVT0XY5TOTByzszN NYW1[FJvPWR? MnnZZoxw[2u|IHPlcIwh\GWjdHigbY5lfWOnZDDifUBkd22kaX7heIlwdiCOMUegZY5lKGOqbH;yc5F2cW6n NVr0TIVlOjR5OEWyOVY>
U937  MojYcoVkem:ydH;zbZMhSXO|YYm= NGHnSocyOMLizszN NGLLeG4{OMLibXnu NHWyWnBqdmS3Y3XzJI5m[3KxcITvd4l{KGOxbXLpcoUhf2m2aDDUUmY> NXqzT4lmOjR5N{O3OVY>
T cell NFXwZ5JE\WyuIIDyc4xq\mW{YYTpc44h[XO|YYm= MXewMVExOM7:TR?= NIDyV2E4Omh? M3z4WWlEPTB;N{Cg{txONCCrbnjpZol1eyCjboTpMWNFOy2rbnT1Z4VlKFRiY3XscEBxem:uaX\ldoF1cW:wIHnuJHBDVUO| MWOyOFc3QDdyNx?=
HeLa  MWnBdI9xfG:|aYOgRZN{[Xl? Mnq1OVDPxE1? NWjxcXdIPzKq NGD6ZYNFVVOR MY\wdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkd22yb4Xu[JPDqDIkgKO1 MY[yOFc2PDd6Nh?=
HeLa  MVnBdI9xfG:|aYOgRZN{[Xl? MlfUNVAx|ryP NHPacXczPGh? MV7zeZBxemW|c3XzJJJifGVib3[gZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KG:4ZYLlfJBz\XO|aX;uJI9nKEd3OWOgc5IhTzdzUjDwNVUx\2y3ZXVCpC=> M3;RSFI1PzJ{NE[4
IEC-6  M13G[2Fxd3C2b4Ppd{BCe3OjeR?= M1rSTVEx|ryP NFr3OFUzPGh? NVP2fFJKeHKndnXueJMhXGOmQT3pcoR2[2WmIHPhd5Bie2VvMzDjcIVifmGpZTDhcoQh|rJvY3H0[Y5qdiCmZXfyZYRifGmxbh?= NUDkemtSOjR5MUG1O|E>
HCT116 M2G2bWFxd3C2b4Ppd{BCe3OjeR?= MY[yNO69VQ>? MVGyOIg> Mo\5bY5pcWKrdIOgeIhmKGOnbHygZZBweHSxdHnjJIlv\HWlZXSgZpkhYUyWMkC1 MXiyOFcyOzhzMh?=
L02 NIj2TphCeG:ydH;zbZMhSXO|YYm= MXuyNO69VQ>? Mor0NYg> M{[2epBz\X[nboTzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE2HSGC= Mk\rNlQ4ODZ2NkG=
A375 NVfZ[3IxSXCxcITvd4l{KEG|c3H5 MX6yNO69VQ>? M4jYU|I1cA>? M1K2PZJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? Ml[3NlQ3QTlzMUG=
HDPC M2jW[2Fxd3C2b4Ppd{BCe3OjeR?= MnPGOVDDvU1? NWrpUpRUOjSq M{XqTolvcGmkaYTzJG5QNWmwZIXj[YQh[XCxcITvd4l{ MkPKNlQ3OzR3OUO=
A549 NF21N|lCeG:ydH;zbZMhSXO|YYm= NFS0cXQ2OML3TR?= MUmybC=> M2jNTGROW09? NVrK[4Q6eHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= NYL6ZVI1OjR3OEixN|U>
 BV-2 NYDMN5pjSXCxcITvd4l{KEG|c3H5 M17aS|Ix|ryP M2jYPVJp NIjJW|B{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= NYDmOnhkOjR3NUixNVg>
HT-29  NWT5RWFLSXCxcITvd4l{KEG|c3H5 NHi0eJg2OM7:TR?= Mn;POFhp Mn3CZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u NUDHVIV7OjR3NEmxO|U>
A549 MkDsRZBweHSxc3nzJGF{e2G7 M2LCSVXPxE1? MofvNlRp M2fkPZN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg M1P0d|I1PTJ7OEex
MIA-PaCa-2 NH;CUG1CeG:ydH;zbZMhSXO|YYm= M1HCdFI1cA>? NYXNToIx[myxY3vzJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCrbnT1Z4VlKGK7IHLveIghSS12NEO2OVQh[W6mIIDhZ4xqfGG6ZXy= MYOyOFUyODl7Mh?=
Caki-1 M2HSRWFxd3C2b4Ppd{BCe3OjeR?= M2n2PFIx|ryP NXy4UohoOWh? NH\NOGNqdmirYnn0d{BUS1BvaX7keYNm\CCjcH;weI9{cXN? NYK4OYtJOjR3MES2PFE>
CLL M{[wNmFxd3C2b4Ppd{BCe3OjeR?= Mn7SNlXPxE1? MkPmNYg> MorDdIFzfGmjbHz5JIJtd2OtczDNUG4zOjN6LXnu[JVk\WRiY3XscEBieG:ydH;zbZM> NFi2OHIzPDR4N{[zOC=>
SGC-7901 MXjBdI9xfG:|aYOgRZN{[Xl? NIfTOnAyOM7:TR?= NVTuU4J1OjSq NGKxToJxem:vb4Tld{B1cGViQ1fJTU1qdmirYnn0[YQh[2WubDDndo94fGhiaX6gV2dENTd7MEGgZ4VtdHN? NHvtNGgzPDR3NES4PC=>
k1735 NXvPZWN3SXCxcITvd4l{KEG|c3H5 MoDxNlDjiIoQvH2= NXjZSoFCPGh? M3nIcYlvcGmkaYTzxsBU[Wyvb37lcIxiNWmwZIXj[YQh[XCxcITvd4l{ Mni0NlQ1PTFzMU[=
HaCaT  NILodXRCeG:ydH;zbZMhSXO|YYm= M3XPdVExOM7:TR?= NXfFfY9MOWh? M3uzcIJtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= MlvHNlQ{PTZ7OUe=
podocytes NU\IN2R6SXCxcITvd4l{KEG|c3H5 NWjNc4xtOjByzszN MlruOog> M{CzR4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> MkPBNlQ{Ozd5N{e=
 KB MUTBdI9xfG:|aYOgRZN{[Xl? M3;lfVUx|ryP MVuyOIg> MYTpcohq[mm2czDMbYNwNUFvaX7keYNm\CClYYPwZZNmNTNiYX7kJHBCWlBiYXP0bZZifGmxbh?= M37ueFI1OzN5NEmy
 HepG2  NVG5PWZwSXCxcITvd4l{KEG|c3H5 NWizOmM5OTEQvF2= MlvQNlRp NEDHR3Rz\WS3Y3XzJJZqdWWwdHnuJINt\WG4YXflJINifXOnZDDifUBNWFN? MWmyOFMzPThzNh?=
fetal rat lung fibroblasts  MYPLbY5ie2ViQYPzZZk> M{PjPFgx|ryPwrC= MmDvNYg> NEThOHdqdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? NFrDNo0zPDNzNEGzOS=>
PDL fibroblasts NUDGToJ2U2mwYYPlJGF{e2G7 MUW4NO69VcLi MWKxbC=> MmfBbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> NGnpco4zPDNzNEGzOS=>
MB49 NEjRb|lCeG:ydH;zbZMhSXO|YYm= MWCyNO69VQ>? NG\LVYoycA>? MnHJdoV3\XK|ZYOgR20ucW6mdXPl[EBk\WyuIHTlZZRp MVGyOFI5OjR|Mx?=
5637 MlfhRZBweHSxc3nzJGF{e2G7 Mk\VNlDPxE1? MXuxbC=> MYPy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> MV6yOFI5OjR|Mx?=
A549  M3L0NmFxd3C2b4Ppd{BCe3OjeR?= Ml7QNVAx|ryP NUGyTGhZPDiq Mkfmd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg MnTqNlQzPzJ{MEG=
MCC-2 NW\GdFdQSXCxcITvd4l{KEG|c3H5 MYKyNEDPxE1? NIO4Wmk3cA>? M4[3OWROW09? M1roOIJtd2OtczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmViYYDvdJRwe2m|IHPlcIwh\GWjdHi= NV\PNW1nOjR{NkK2OVg>
ADF NWTISnZwSXCxcITvd4l{KEG|c3H5 M4Gxc|Qx|ryP NUH1VJBXPmh? NWL3O4RzcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> M2LWVlI1OjJ6MkOy
 U373  M3XvfGFxd3C2b4Ppd{BCe3OjeR?= MlywOFDPxE1? MmjxOog> M2DD[YlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy NWD3cVg4OjR{MkiyN|I>
RKO-HIPK2i MV3BdI9xfG:|aYOgRZN{[Xl? Mlj6OFDPxE1? MmfOOog> MmXnbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NGO4VoczPDJ{OEKzNi=>
HEC-1B M4HTSGFxd3C2b4Ppd{BCe3OjeR?= NVP4OGxyOjEQvF2= M1:1V|Fp M{\uSpJm\HWlZYOgWHAucW6mdXPl[EBieG:ydH;zbZPDqGOjc4Dhd4UuOyCjbnSgZ4F{eGG|ZT25 NG[0[ZozPDJzM{O1PC=>
4T1 NWLrU4VHS2WubDDWbYFjcWyrdImgRZN{[Xl? NFr6OXQzNjVvMUFOwG0> NIT4O2Q1cA>? M{LkeGROW09? MV7y[ZNkfWW|IITo[UBkgXSxdH;4bYNqfHlib3[gOHQyKGOnbHzzJIlv\HWlZXSgZpkhW1CGVDDpckBiKGOxbnPlcpRz[XSrb36g[IVx\W6mZX70JI1idm6nch?= M1Hyb|I1OjB4MU[x
OS  NH23S5VCeG:ydH;zbZMhSXO|YYm= MnjXNlDPxE1? NWS3S2VTPGh? Ml\kbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IGDEWC=> M2LzeFI1OjB2OUO3
RPE NHvMdGxCeG:ydH;zbZMhSXO|YYm= MWmxNFDPxE1? MlHEOFhp NGLuco5x[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? M{DwWVI1OjB{MEWy
UD29a M4L1[2Fxd3C2b4Ppd{BCe3OjeR?= MkHyOVDPxE1? MVSyOIg> NXHRZ3I3cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JG5WXDN? MoHINlQyQTB3N{S=
SH-SY5Y  M4fTNmFxd3C2b4Ppd{BCe3OjeR?= MnPnNVDPxE1? NHvxOG4zPGh? MWLheJRmdnWjdHXzJINie3Cjc3WgZYN1cX[jdHnvckBidmRiY3XscEBl\WG2aDDpcoR2[2WmIHL5JGhPTS1{RFe= M1[xSFI1OTR3NE[z
HeLa  MnW1RZBweHSxc3nzJGF{e2G7 MVyxNE8zOM7:TR?= M2PGe|I1cA>? MXTpcohq[mm2czD0bIUh[WO2aY\peJkhd2ZidHjlJI1icm:{aYT5JI9nKHSqZTDt[Y1j\XK|IH;mJJRp\SClYYPwZZNmNW[jbXnsfS=> MmnmNlQyOzd{Nk[=
SCCVII  M{HMcWFxd3C2b4Ppd{BCe3OjeR?= MonoNlXPxE1? NH\Zbm0ycA>? M{mw[olvcGmkaYTzJJRp\SClZXzsJItqdGyrbnegZYZ1\XJiZHHzZZRqdmmk MmPMNlQyOjZ2NkS=
RAW 264.7 M1\pOmFxd3C2b4Ppd{BCe3OjeR?= MUmyNO69VQ>? M{HVNFE5cA>? Ml:4bY5kemWjc3XzJGxEOy2LST1Otk1i[3SrbjDyZZRqdyClb33wZZJm\CC2bzDFR3RXNU2RUzD0doVifG2nboSgc45tgQ>? M2DESVI1OTF4N{C3
A549  MnXzRZBweHSxc3nzJGF{e2G7 M4TmO|IvPc7:TR?= NFy4R2IzPGh? M4fycYRm[3KnYYPld{Bwemmmb37pck1qdmS3Y3XkJIF2fG:yaHHnfUBieyC5ZXzsJIFv\CCOb4PzJI9nKM7Wz5jtJIFte29ib3PjeZJz\WRiZIXybY5oKGG3dH;wbIFocWNicILvZ4V{ew>? NE\wS5gzPDFyMkWyNi=>
UM-SCC-10A  NF3XSHlCeG:ydH;zbZMhSXO|YYm= M4n1flUxyrWP MoHnNog> NWjC[I9NemWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCqaXfoMYRwe2ViaYPvZYxidnSxbHHjeI9v\Q>? M{[wVVI1ODl6N{Wz
BGC-823 MWfBdI9xfG:|aYOgRZN{[Xl? NF;MPIUyOCEQvF2= NWXyZlZiOjSq MVjy[YR2[2W|IITleJJidmS{aX7lMYlv\HWlZXSgZZBweHSxc3nzxsA> M2LBWVI1ODl6NUGx
Nalm-6  MWjBdI9xfG:|aYOgRZN{[Xl? M2i0R|Ix|ryP MlfmOIg> NH3nWlJqdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> MnjBNlQxOzl7Nke=
KHOS  M4HUbGFxd3C2b4Ppd{BCe3OjeR?= NH\zbno1OM7:TR?= NGHXTpAzPGh? MoPmZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MlLRNlQxOjV|NkG=
G292 NFLVUm5CeG:ydH;zbZMhSXO|YYm= M3fxeVQx|ryP NV7CfpZnOjSq NYXWboI6[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NYfrdHdpOjRyMkWzOlE>
MG-63 MlKxRZBweHSxc3nzJGF{e2G7 M3XySFQx|ryP M2PUfFI1cA>? MVjicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li M4GwN|I1ODJ3M{[x
EBV-transformed B cells NYm3VZl{SXCxcITvd4l{KEG|c3H5 MWKyNO69VQ>? M2fIU|Jp NF;lUnRFVVOR MmDtZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ NYfITWJCOjRyMEi2Nlg>
IM-9 B NFjlcHBCeG:ydH;zbZMhSXO|YYm= Ml76NlDPxE1? MkTONog> NWPyU2pnTE2VTx?= MnfBZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ NXPLVnp7OjRyMEi2Nlg>
CNE1 MUXBdI9xfG:|aYOgRZN{[Xl? MmTnNlDPxE1? MnTrOFhp Mk\WZoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> MlTTNlM6QDVyMkm=
CNE2 M3THO2Fxd3C2b4Ppd{BCe3OjeR?= Mlv3NlDPxE1? MnTGOFhp MnjIZoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> NY\oNWNQOjN7OEWwNlk>
HL-60 NUTDVYxySXCxcITvd4l{KEG|c3H5 M2HUV|UxyrWP NYntO4xIOWh? NWnqc5psTE2VTx?= M4HOW4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKDMUS1 MnPNNlM6PDh5NUG=
L929 NUTa[mlLSXCxcITvd4l{KEG|c3H5 MlHZNU4zPeLCk{ZCpO69VcLi NXnkNYw3OjSq MVvheYdu\W62czDUUmbPuS2rbnT1Z4VlKG6nY4LvdJRwe2m|IHHu[EBifXSxcHjh[5k> MWeyN|k1OTd4OR?=
Jurkat NVPhTW03S2WubDDWbYFjcWyrdImgRZN{[Xl? NEO5ZVgz|ryP NF3IR|c1cA>? M2L1R5JmfmW{c3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CEQsj3jZZRmdmmwIHTlZ5Jm[XOnIHL5JGhUNUGVQR?= NIX0Z4MzOzh7NkC2NS=>
RAW264.7  MoHWRZBweHSxc3nzJGF{e2G7 MXixNEDPxE1? NIDydHQzPGh? NEnXd2Zl\WO{ZXHz[ZMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JGdC M{G0e|I{QDJyMkCz
A431  NXvLVHpMU2mwYYPlJGF{e2G7 MoTTOFDPxE1? Mn7TNog> NYLiNGpD[myxY3vzJIZqe2W2aX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPld{BidmRiUFHSVC=> MUSyN|gxODB3OB?=
Jurkat M33M[mNmdGxiVnnhZoltcXS7IFHzd4F6 Mn\kNlUuOTByzszN NXXQTlVuPmh? M2j0b4lvcGmkaYTzJJouTkFvQ13LMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NH23TJYzOzl|M{WzNi=>
COS-7  NWLVR2pmTnWwY4Tpc44hSXO|YYm= M1TGfFUxyrWP M4jlR|I1cA>? NFT4WnZi\m[nY4TzJJRp\SCycn;j[ZN{cW6pIH;mJGFVVjG|IIfpeIgheG:ueWGgeJJi[3S| MlnpNlM6OzN{MEi=
CAL27 NIjadHdCeG:ydH;zbZMhSXO|YYm= M13LXlExKM7:TR?= MWeybC=> MWXzeZBxemW|c3XzJGN2ei2QUIOtdoVlfWOnZDD2bYFjcWyrdImgZpkhfXBidH:gPVAm MlPtNlM6OTd|OU[=
THP-1  NIrSSHdCeG:ydH;zbZMhSXO|YYm= M2DYfFExNTVyzszN NXLNW|hnOmh? NGSyfZNqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2cnnweI9tcWSn MVKyN|kxODJ7OR?=
K562 MXjBdI9xfG:|aYOgRZN{[Xl? NGG4dlQzOM7:TR?= Mkf4OFhp MYPpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X M1zsXlI{QDd4OEK2
HL-60 MkLHRZBweHSxc3nzJGF{e2G7 M{TGTFExOM7:TR?= NVXiZXAxOjSq NH;LUmhqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= NGO5dlYzOzh4NUe3PC=>
HeLa  NYX5fnFRSXCxcITvd4l{KEG|c3H5 M{L5[VIx|ryP M2DlR|Jp NEjtbFZqdmirYnn0d{BFVU2SIHnu[JVk\WRiYYDvdJRwe2m| MYeyN|g3Ozl4Nh?=
U251 MWPBdI9xfG:|aYOgRZN{[Xl? MXSyNO69VQ>? MY[yOIg> MWfpcohq[mm2czDjZZN1cWOrbjDpcoR2[2WmIFeyM20heGijc3WgZZJz\XO2IHHu[EBieG:ydH;zbZM> MWOyN|gyPjhzNh?=
HL-60 MmDlRZBweHSxc3nzJGF{e2G7 MXK1NOK2VQ>? NGLmfJE1cA>? MoHkZoxw[2u|IITo[UBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID25MEBidmRiUFHSVEBqdmS3Y3XkJIJ6KD[| NEnCUpUzOzhyNEewOi=>
Ec-109 Mn3PRZBweHSxc3nzJGF{e2G7 Mlv3NVAh|ryP M3ryTlQ5cA>? Mk\kdoVxemW|c3XzJHBGNW2nZHnheIVlKEWlLUGwPUBk\WyuIHHwc5B1d3Orcx?= NVnKfo83OjN5OEK2OFE>
RKO NUn2fI93S2WubDDWbYFjcWyrdImgRZN{[Xl? NYHa[m0xOTBizszN NWi5VZV7OjSq MVTpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= NWLCToZ{OjN5NUiwOlQ>
T98G MWLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MnnaNU0yODEQvF2= Mk[3NlRp NW[2NoJYcW2ycn;2[ZMh[2WubDD2bYFjcWyrdImgZ491emWjdH3lcpQhf2m2aDDUVy=> M1Tud|I{PzZ7Mke1
Jurkat NHf0bVRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGflU4oyODBvMkCw{txO NXTUdmVLOjSq MXXpcohq[mm2czDIZWE1KGmwZIXj[ZMh[XCxcITvd4l{KGSncHXu[IVvfCCxZjDjc45k\W62cnH0bY9vyqB? Mkf1NlM4OzJ2OEG=
Molt-3  M1LlNGFxd3C2b4Ppd{BCe3OjeR?= NVfsXHNSPTEQvF2= MXyybC=> MYPy[YR2[2W|IH3lcIF1d26rbj3pcoR2[2WmIHHwc5B1d3Orcx?= NETRcI0zOzd{NUCxNy=>
hMSC12 M13QdWFxd3C2b4Ppd{BCe3OjeR?= M1XyRVExOM7:TR?= M3W0ZlRl MlPobY5pcWKrdIOgc5N1\W:pZX7pZ{BkfWy2dYLlMYlv\HWlZXSgZ4VtdCCmZXH0bEBidmRiY3HsZ4lncWOjdHnvci=> MonHNlM3PTd6MkK=
HM7  M4f1PGFxd3C2b4Ppd{BCe3OjeR?= NHnjVFQzOM7:TdMg NXvxcmFXOWh? MlHoZoxw[2u|IHHwbYN2dGG{ZX6gRUBi[2W2YYTlMYlv\HWlZXSgZ4F{eGG|ZT2zJIFkfGm4YYTpc44h[W6mIGDBVnAh[2ynYY\h[4U> MUWyN|U5OzRzMh?=
Hep-2  NELJT2ZCeG:ydH;zbZMhSXO|YYm= M2nhcVIx|ryPwrC= NX7VOY1ZOjSq M4XNbmROW09? MmDFZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= MUCyN|U5ODB|Mh?=
HSCs Ml22RZBweHSxc3nzJGF{e2G7 NXXXd3p6PTEQvF2= NYXXO2VCOjSq NWWxd2V6TE2VTx?= NXjiTZVVcW6qaXLpeJMhdmmub4TpcoljNWmwZIXj[YQhTE6DIHThcYFo\SCrbnTpZ4F1\WRiYomgVGFTWCClbHXheoFo\Q>? MmXCNlM1QTl6N{S=
HL-60  MWLDfZRwfG:6aXPpeJkhSXO|YYm= NFPrRYUzOM7:TdMg M{\POlI1cA>? NX3yeHZzemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 NHzMdHIzOzR7NES4NC=>
HA NVjoSHpWSXCxcITvd4l{KEG|c3H5 NYjDXYJOPTEQvF2= NV3tTm05OjSq NYXzcFBpe3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD NF;xeVYzOzR5NUm1Oi=>
C666-1 NIS0W2xCeG:ydH;zbZMhSXO|YYm= MX21NO69VQ>? NUnTW455OjSq M4DCdZN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? MUiyN|Q4PTl3Nh?=
Hepa1-6 M2nTSmFxd3C2b4Ppd{BCe3OjeR?= NV3BVVBTPTEQvF2= NFjGbnozcA>? NF3jbXZqdmirYnn0d{BkfXKldX3pckBidmRicnXzeoVz[XS{b3ytbY5lfWOnZDDhdI9xfG:|aYO= NXK5cpFMOjN2NE[3OVM>
PLC/PRF/5c NHjIcYNCeG:ydH;zbZMhSXO|YYm= M2DDOVUx|ryP MkDiNYg> NF3LN2RxemW4ZX70d{BieG:ydH;zbZMhfHKrZ3fldoVlKGK7IFPJUi=> NYHmPFB4OjN2M{i4NlQ>
HCT116 MVHBdI9xfG:|aYOgRZN{[Xl? NULnRmhTOTByzszN MWOxMlVp MljabY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp NX35NZROOjN5NESzOVM>
HCEC MkLvSpVv[3Srb36gRZN{[Xl? MnX2OVDPxE1? M2n2cFczcA>? MXzEUXNQ MVPy[ZN1d3KnczDv[kB1cGVibn;ycYFtKEiFRVOgdIhmdm:2eYDl NVzINI1DOjN5NEKwNVE>
Primary rat cerebral cortical neurons MlXrRZBweHSxc3nzJGF{e2G7 NI[0blYyODEQvF2= NX;XXoFOOWh? NEmxdFVxemW4ZX70d{BE\C2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgZ4VtdCCmZXH0bC=> MXmyN|c1OTNzNx?=
MDA-MB-231  MljBRZBweHSxc3nzJGF{e2G7 NEnCOnUzPc7:TR?= M2HpV|I1cA>? NGHme5Zi[nKxZ3H0[ZMh[3m2b4TvfIlkcXS7IHHu[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDS[|M> NW\IeopXOjV|M{e1OFQ>
NLRP3-Tet-on-MC/9  NITtNItCeG:ydH;zbZMhSXO|YYm= MnHMNVAuPDEQvF2= NHfaUmYyOmh? MVvheJRmdnWjdHXzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDDRXBUNWG|c3;jbYF1\WRiTlzSVFMhdXW2YX70d{BqdiC2aHWgWIV1NW:wIIP5d5RmdQ>? NHrVWXozOzdyM{O4PS=>
KNS42  MXvBdI9xfG:|aYOgRZN{[Xl? MWS1NO69VQ>? M2PkOFFp MUfy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGOxbYDs[ZRmdHliYXLvcIl{cGWmIHPhd5Bie2ViMz:3JIFkfGm4aYT5JIlvKHKnc4DvcpNmKHSxIFHCWE0zPjNxMlTHM41mfG[xcn3pckBkd22kaX7heIlwdg>? NH\QZpgzOzZ7MUG0OS=>
MCF-7  MX7BdI9xfG:|aYOgRZN{[Xl? MUWyNO69VcLi NV\2OnZ{PzKq MWnpcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= M1fLPFI{Pjd3NkSz
hCMEC/D3  NVriOZFWSXCxcITvd4l{KEG|c3H5 MkLFNlXPxE1? MlrRO|Jp MXHy[YR2[2W|IFz0fGEhcW6mdXPl[EBieG:ydH;zbZM> NFfKW28zOzZ4NUG5PC=>
Jurkat MX3BdI9xfG:|aYOgRZN{[Xl? MmjtNVIvPS13MN88US=> NV\sb4NXOWh? NG[1U|Vld3OnIHTldIVv\GWwdHz5JJN2eHC{ZYPz[ZMhW1CKLXnu[JVk\WRiUHHyMVQh[2ynYY\h[4UtKFCDUmCgZ4xm[X[jZ3WsJGRPSSCocnHncYVvfGG2aX;uMEBidmRibH;zd{Bw\iC4aXHibYxqfHl? NUH3ZW1bOjN2NEK5O|Y>
CNE-1 MWHBdI9xfG:|aYOgRZN{[Xl? NGnwN3YzOM7:TdMg NWj1eoJEOjSq NWfMfXNFcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MkTYNlM1OjZ6NUC=
HONE-1 NIO1TnRCeG:ydH;zbZMhSXO|YYm= Mlm1NlDPxE4EoB?= M{fQZVI1cA>? MVLpcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq M{Kwb|I{PDJ4OEWw
astrocytes cell Mon4RZBweHSxc3nzJGF{e2G7 NFizO3g1OM7:TR?= NGTCfYI3cA>? NUf4UFNvemWmdXPld{Bm[XKueTDhdI9xfG:|aYOgbY5lfWOnZDDifUB{fGG3cn;zdI9zcW6n M2nlRlI{PDFzN{e4
U-937 NYTlfnFwSXCxcITvd4l{KEG|c3H5 MWixNO69VQ>? NXX1eZAyOzCvaX6= NWrsfWU1eHKndnXueJMhXE6ILXnu[JVk\WRibnXjdo9xfG:|aYO= M2rVZ|I{PDFyN{S4
MDA-MB-231 M3;RVWFxd3C2b4Ppd{BCe3OjeR?= M{XWOVExOM7:TR?= NGfORZIycA>? NX3rUGp1cW6qaXLpeJMhe2Wwc3n0bZpifGmxbjD0c{BVWkGLTDD1dI9vKE2WRFig[I94di2{ZXf1cIF1cW:w Mn\ENlM1ODh2Mkm=
HeLa  MmrSRZBweHSxc3nzJGF{e2G7 M{PsVlExOM7:TR?= M4j5cVJp NFXrRYZjdG:la4OgTnJUNTF3IFnu[JVk\XNiQYDvdJRwfGmlIFPlcIwhTGWjdHi= NFTPfIYzOzN2NEC0OS=>
Ec109 MWDBdI9xfG:|aYOgRZN{[Xl? MmfENVDPxE1? NGTVfmY3cA>? NYT2VZVO[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? NVvjS3ZVOjN|M{i1Olg>
H460  M2nKO2Fxd3C2b4Ppd{BCe3OjeR?= M1TqdlEx|ryP MUG2bC=> MXHicI9kc3NiYYDvdJRwfGmlIHPvcYJqdmG2aX;uJI9nKFSjdD3TcYFkVjdiYX7kJJJi\GmjdHnvci=> MmLQNlM{Ozh3Nki=
HeLa  MomyRZBweHSxc3nzJGF{e2G7 NUK3NYozPTEQvF2= MUGxMlVp NWPuNIdx[WK{b3fheIV{yqCFaHzhcZllcWFvaX7keYNm\CCjcH;weI9{cXN? NXvRV4RuOjN|MEO4NFQ>
SK-HEP1 NULXOYJvSXCxcITvd4l{KEG|c3H5 NUTJ[lhiOTByzszN NIj4fWwycA>? NHrMb5ZqdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= M2Hm[FI{OzB{NkWw
QGY7701 MYTBdI9xfG:|aYOgRZN{[Xl? NFOyNlIzPc7:TR?= NGfySoEyNjWq NGnmXHBqdmirYnn0d{Bi[2O3bYXsZZRqd25ib3[gd5VjNUdzIIDoZZNmKGmwZIXj[YQh[nliRF;YJEsheXWncnPleIlv MlHhNlMzPDByNkG=
HepG2 MY\BdI9xfG:|aYOgRZN{[Xl? MmKwNlDPxE1? NXvZXHR3OzCvaX6= M1rTVYlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? NXPr[3ZWOjN{MkSyN|k>
U87  NVi1flVCSXCxcITvd4l{KEG|c3H5 NGDmNYgzPc7:TR?= NXn0bHpqOmh? NHzNSHRl\WO{ZXHz[ZMhcXOxbHnxeYlzcXSrZ3XubY4hMEmVTDmtbY5lfWOnZDDhdI9xfG:2aXOgZ4VtdCCmZXH0bEwh[nW2IH7veEBv\WO{b4TpZ{Bk\WyuIHTlZZRp M2i1V|I{OjJ7NkK2
HSC-2 MWrBdI9xfG:|aYOgRZN{[Xl? NHnYUXIzPS93MN88US=> NVj4bmRiOWh? NYTEWnJPcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> MUWyN|E2PTJ2OB?=
HSC-4 MXrBdI9xfG:|aYOgRZN{[Xl? NIDUb5EzPS93MN88US=> M2jhRVFp NFrhVY9qdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> MXyyN|E2PTJ2OB?=
CL-1 NEnJdndCeG:ydH;zbZMhSXO|YYm= NVTiZ3o4OjEQvF2= MmDZNYg> M1PO[IJtd2OtczDPVFQ1QSCrbnT1Z4VlKGOnbHyg[IVifGh? MnSyNlMyOzF5OEK=
MEL MljmRZBweHSxc3nzJGF{e2G7 M33kWFIx|ryP MkLJNlRp NWHnWnhvTE2VTx?= MWjpcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ Mnq1NlMxOTR6OEe=
Bel-7402  NFz0[GxE[XOyYYPlJGFkfGm4YYTpc44hSXO|YYm= NEHXTWc2OM7:TR?= MVqybC=> NELhS2pqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ M2jWW|I{ODB6N{Sy
Eca-109 NUHzTG9MSXCxcITvd4l{KEG|c3H5 Mor1NlXPxE1? MoXWN|BucW5? NUDFenZUcW6qaXLpeJMhSkpvQkGxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M33pPFI{ODd4OU[3
MEL MoPyRZBweHSxc3nzJGF{e2G7 M1jRU|Ix|ryP MYixbC=> Ml30SG1UVw>? NFXJVIxqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NWfMdGYyOjNyMUS4PFc>
Bel-7402  M2HuSGFxd3C2b4Ppd{BCe3OjeR?= M1LZdlUx|ryP Mof6Nog> Mn3ObY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> M2W1OFI{ODB6N{Sy
L929 MVfGeY5kfGmxbjDBd5NigQ>? MYSyMlXPxE1? M{H0TlFp NVHsfJN2cW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? NUL3[ZdlOjNyMEC1NVg>
RCC  M3nWNmNmdGxiVnnhZoltcXS7IFHzd4F6 Mn3ONVAx|ryP MlPmNlRp M4H2OJJm[2:4ZYLld{B1cGVidnnhZoltcXS7IH;mJINmdGy|IHX4dI9{\WRidH:gNVVlNVCJSkK= M3G4elIzQTlzNEm0
NB2a/d1 NXm1OZdCSXCxcITvd4l{KEG|c3H5 MkG3NVAx|ryP MUe3Nog> NV;QWWln[XS2ZX71ZZRmeyC|dHH1do9{eG:{aX7lMYlv\HWlZXSgZ4F{eGG|ZTDhZ5Rqfmm2eTygVGFTWCxiYX7kJJRifSClbHXheoFo\Q>? M3:5[lIzQTh6NUSx
T cell MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWyOU0yODEQvF2= NFrXb4kzPGh? M1;aOoRwe2VvZHXw[Y5l\W62bImgbY5pcWKrdHXkJHQh[2WubDDwdo9tcW[ncnH0bY9vKG2nZHnheIVlKHSqcn;1[4ghfGinIHPvMZN1cW23bHH0bY9vKHerdHigZY51cS2FREOgZY5lKGGwdHmtR2QzQA>? M4DHU|IzQTh{NUO4
K562 M{KzVWFxd3C2b4Ppd{BCe3OjeR?= MojZNVAx|ryP MYCxbC=> NHLjT4JjdG:la4OgRYJvd2KjdnnzZ5VuyqCILXnu[JVk\WRiYYDvdJRwe2m| MoDyNlI6PzJ|N{K=
Jurkat  MWHBdI9xfG:|aYOgRZN{[Xl? NIj1OnM1OM7:TR?= NGfK[2cycA>? M3nCeYFjd2yrc3jld{BH[XOOLXnu[JVk\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp M3XNWVIzQTR{N{O4
BGC-823 MXPBdI9xfG:|aYOgRZN{[Xl? M4PHPVExOM7:TR?= M2XvUlFp MWTwZZJ1cWGubImgdoV{[3WnczDj[YxteyCjZ3HpcpN1KGSjbXHn[UBw\iCmYXnkfoVqdg>? Ml7oNlI6OjZ3NEW=
Hep3B NX3nXZBPSXCxcITvd4l{KEG|c3H5 NEXJPGs2OM7:TR?= M1jE[FFp NXnJbJBF[myxY3vzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEiHR1Pz NGPRRWgzOjl{M{G1OC=>
LLC-PK1 Mn;1RZBweHSxc3nzJGF{e2G7 M17GWVIx|ryP NFnqbmwycA>? M{Hp[JBz\X[nboTzJINqe3CuYYTpck1qdmS3Y3XkJIRm\3KjZHH0bY9vKG:oIFH0[|UtKGKnY3zpck0yNCCjbnSgRZRoOTJicILveIVqdnN? M1rNdVIzQDl4MEO3
A549 NEfqVW9CeG:ydH;zbZMhSXO|YYm= MkPkOVDPxE1? NEHU[owycA>? MWricI9kc3NidHjlJGJCUS2rbnT1Z4VlKGGyb4D0c5Nqe8Li M2XJSVIzQDh5MkG1
SGC-7901  MUXBdI9xfG:|aYOgRZN{[Xl? MoP6NVDPxE1? MnrFNlRp M{[5colvcGmkaYTzJO6zNM7{LXTpcYV1cHmuYXPyfYx{cGmtb37pck1qdmS3Y3XkJIFxd3C2b4Ppd:Kh M3L2UlIzQDR6NUm3
DM6 MXLBdI9xfG:|aYOgRZN{[Xl? NYrZPFRiOTByzszN NX6yVINsPzKq MnPYZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? NXOzUHhCOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK1NO69VQ>? M{jQVVQ5cA>? NWj1ZYVxcW6qaXLpeJMhfGinIHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44hcW6mdXPl[EBjgSC|YYDvcolv M3G2cVIzQDByOU[4
A2750  NGP5NIRCeG:ydH;zbZMhSXO|YYm= MVmyNO69VQ>? NUTwVVBJOmh? NUfzNW92TE2VTx?= NGjXOFNjdG:la4OgZ4F{eGG|ZTDjcIVifmGpZTDkeZJqdmdiaHXs[Y5idGmwIITy[YF1dWWwdDDhcoQhemWmdXPld{BifXSxcHjh[4lkKGOnbHyg[IVifGh? M4DFd|IzPzh2M{[z
U87  MoTTRZBweHSxc3nzJGF{e2G7 NVnKRo5MOjEQvF2= M3TmWFI1cA>? MVXy[YR2[2W|IITo[UBieG:ydH;zbZMhemG2ZTDpcoR2[2WmIHL5JHBNSUJ? Mkm0NlI4Pzh5OEC=
HT1080 Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLze5REPTEQvF2= Mln6O4Q> MnjGbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZ4F2e2WmIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCGQ1GgZY5lKE:PUB?= M3P4OlIzPzRyOUi0
A549  NUPTS4ppSXCxcITvd4l{KEG|c3H5 NIO5c5o2OM7:TR?= NGfrNJUzcA>? NUfhTHd{eGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> NFfsNnkzOjd{MUiwOC=>
Primary OPC MUHBdI9xfG:|aYOgRZN{[Xl? M17KOlHPxE1? MX22bE8zPGh? NUjDelNTemWmdXPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBm[XKueT2gZY5lKGyjdHWtZZBweHSxc3nzM45m[3Kxc3nz NFLYVW0zOjdyN{O4OS=>
PMNs NFHFXnJCeG:ydH;zbZMhSXO|YYm= M33ldlQx|ryP Ml7LOog> MVXEUXNQ MXHy[ZZmenOnZDD0bIUh[W2xdX70JI9nKGOuZXH2[YQh[2G|cHHz[U0{KHSxIH7lZZIhfmWqaXPs[UBt\X[nbIO= MnHoNlI3QTJ3N{e=
A549  NEn0No1CeG:ydH;zbZMhSXO|YYm= MWO1NO69VQ>? NUL4ZZJHOWh? NYTMW3NPeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQnHvbJVwe2mmZTDJ NWrlOWt7OjJ4OEe2N|U>
AGS NGn3RplCeG:ydH;zbZMhSXO|YYm= MXKyNO69VQ>? MnqyNVJp NXfHfnJIcW6qaXLpeJMhfGinIHHjeIl3[XSrb36gc4YheHKxLXPhd5Bie2VvMzDpckBz\XOyb37z[UB1dyC2aHWgSZRQSWNiZoLhZ5Rqd25? NEDaVpkzOjZ6N{O5PC=>
shC9  MmnVRZBweHSxc3nzJGF{e2G7 NILLT4kyOM7:TR?= NWPCe2dmOT[q NUfGe3Rz[my3boTzJHNJUCCneIDy[ZN{cW:wIHnuJJNpSzliY3XscJMh\Xiyb4Pl[EB1dyCnaYTo[ZIhWEFib4KgUHBE NEHlXHkzOjZ2MUC5OC=>
primary MEFs NUC3V5F[TnWwY4Tpc44hSXO|YYm= NG\r[GUyOmh? NEPC[WXDqGmwY4LlZZNmeyCndH;wc5Nq\GVvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJIRmeG:uYYLpfoF1cW:w NFT3XGozOjZzM{e2Oy=>
3T9 MEFs MVrGeY5kfGmxbjDBd5NigQ>? NXzI[3V1OT[q MnO0bY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> M3rISVIzPjF|N{[3
3T9 MEFs NWS0TppuTnWwY4Tpc44hSXO|YYm= MlvYNVhp MmnJeZBz\We3bHH0[ZMhcW6rdHnheI9zKGOjc4Dhd4UuQSCkdYSg[I94dnKnZ4XsZZRmeyCnZn\lZ5RweiClYYPwZZNmeyCjZoTldkBmfG:yb4Pp[IUhfHKnYYTt[Y51 MVSyNlYyOzd4Nx?=
MDA-MB-231  M13sfmFxd3C2b4Ppd{BCe3OjeR?= NUfvc4l4OjEQvF2= MnvEOIQ> NHPHeVRz\WS3Y3XzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KG2ndH\vdo1qdiC2cnXheI1mdnRid3HzJJNq\26rZnnjZY51dHl? M3P0WFIzPTl|NESx
C6  M{\uSGFxd3C2b4Ppd{BCe3OjeR?= MX:xNO69VQ>? Ml2yNlRp NWnYSVFL[myxY3vzJJRp\SC|dYDwdoV{e2m4ZTDl[oZm[3Rib3[geIhmKHCncITp[IUhd25idnnhZoltcXS7 M{LQbFIzPTh6OUiw
HL-60  NIe3RVZCeG:ydH;zbZMhSXO|YYm= NV\TcXRoOTByzszN MWiyOIg> MmjwbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxc3nzJJNmdGWldHXkJEgsMS2vZX70bJltKM7{LTix5qaTPilvZHnncJVkd3C7cnHuc5Nq\GYEoEW= MlXKNlI2PDZ4Nkm=
HL-60 NGDU[WtCeG:ydH;zbZMhSXO|YYm= MVSxNE05OM7:TR?= MV:0bC=> NVTtSHJ7cW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? NFPsNHozOjV{M{KyPS=>
BCC NGjwXFhCeG:ydH;zbZMhSXO|YYm= MVO1NO69VQ>? MmXmNYg> NVK5cmNucW6qaXLpeJMhTEGWUz3t[YRq[XSnZDDndo94fGhiaX7obYJqfGmxbh?= MX6yNlUyQTR|Nh?=
RAW 264.7 M3Kwc2Fxd3C2b4Ppd{BCe3OjeR?= NHS2O2M2OC9zMEFOwG0> NHr6bXQycA>? MUjjc45k\W62cnH0bY9vNWSncHXu[IVvfCCrbnjpZol1eyCGT16tbY5lfWOnZDDyVm5CKGOuZXH2ZYdm MUeyNlQ6OTR{Nh?=
K562 MUnBdI9xfG:|aYOgRZN{[Xl? M3T6cVI2|ryP NHzlTIczcA>? MXzwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkdy22cnXheI1mdnRid3n0bEBidXW{ZX7zbY4hTyCjbnSgWHJCUUx? M{\jNlIzPDh|N{e3
SGC-7901 MX;BdI9xfG:|aYOgRZN{[Xl? NXTzbJpnOjBizszNxsA> MXKybC=> NHLrcplifHSnboXheIV{KEh{T{NCpI9zKFSQRjFOtU1qdmS3Y3XkJINmdGxiYYDvdJRwe2m|IHHzJJdmdGxiYYOgZ4F{eGG|ZT2zJIFkfGm4aYT5xsA> MVOyNlQ4OTV6OR?=
PC3 NVXzdmZtSXCxcITvd4l{KEG|c3H5 MoD3NVDPxE1? MmXjOIg> MmDPZ492dnSncoOg[oxifm:lb4jp[E1qdmS3Y3XkJINie3Cjc3WtdoVt[XSnZDDhdI9xfG:|aYO= MmLXNlI1PzF7N{S=
SMMC-7721 Mo\zRZBweHSxc3nzJGF{e2G7 M{HqW|Ux|ryP MkLNOFhp NXHsc|VW[XS2ZX71ZZRmeyCxVGKtbY5lfWOnZDDhdI9xfG:|aYO= MWSyNlQ3PTh|Mx?=
HeLa  MWfBdI9xfG:|aYOgRZN{[Xl? MlvLOVDDqM7:TR?= NXTwWmhyPC96aB?= M1X0d4lvcGmkaYTzJHNVWy2rbnT1Z4VlKGyjdHWtdIhie2ViYYDvdJRwfGmlIHX2[Y51ew>? NVLPfW93OjJ2NkC1NFQ>
HeLa  NXfuOXk6SXCxcITvd4l{KEG|c3H5 MYO1NOKh|ryP NFjxO2cycA>? MoK1d5VxeHKnc4Pld{B1cGViRmLBVE1qdmS3Y3XkJIFk[3WvdXzheIlwdiCxZjDhco5mgGmwIG[gdI9{cXSrdnWgZ4VtdHN? MV:yNlQ1QTR2MB?=
T47D  MlzNRZBweHSxc3nzJGF{e2G7 M3LQflExOM7:TR?= NF2xPFgycA>? MnzzZoxw[2u|IITo[UBo\W6ncnH0bY9vKG:oIFWtZ4FlN0OWRkKgZpkhW1SV Ml34NlI1ODFzNki=
HeLa  MnzmRZBweHSxc3nzJGF{e2G7 MlTjN|DPxE1? MWi0bC=> NETVRlHDqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? MWGyNlM6PDJ2OB?=
HCC MmHZRZBweHSxc3nzJGF{e2G7 NF;TfpozOCEQvF5CpC=> MniwNog> M2O2eIF1fGWwdXH0[ZMhfGinIFTIRUBqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiUFHSVC=> MXWyNlM1Ojd|Mh?=
mESCs M2\BO2Fxd3C2b4Ppd{BCe3OjeR?= MmLqNk42|ryP MkTnNog> MY\pcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= NVf3NFdxOjJ{OEWyO|Q>
EMT-6  NXHnc4ZFS3m2b4TvfIlkcXS7IFHzd4F6 MXSxNFDPxE1? NYnYTVZMOWh? NFPPOIRx[XK2aXHscJkh[myxY3vl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nlic3nyZY1me2mwZR?= NW\0UWlkOjJ{NUG5NlE>
MCF7 Mn3HRZBweHSxc3nzJGF{e2G7 M4f4SFUxyqEQvF2= M1j2ZVFp NUTBPXlbcW6qaXLpeJMhWEFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= NELyUm4zOjJ{M{O0OS=>
K562 M2jRbGFxd3C2b4Ppd{BCe3OjeR?= NGDWTnQzOCEQvF5CpC=> MlP3OFhp NF3wOmdFVVOR Mo\kZoxw[2u|IHzhdIF1cW6rYj3pcoR2[2WmIHnubIljcXSrb36gc4YhfmmjYnnsbZR6KGGwZDDhdI9xfG:|aYOgbY5lfWO2aX;u NXLKT|JXOjJ{MU[xOVg>
Molt4-hyg NHnPTW1CeG:ydH;zbZMhSXO|YYm= M1HtUFEx|ryP MkG0NE42cA>? M2ntR4Jtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 M4CwR|I3Ojd3OEGx
HeLa NHu1[3FCeG:ydH;zbZMhSXO|YYm= NX3US5JrOTEQvF2= NUf2UlFtOC53aB?= MVjpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1cGViY3;tZolv\WRidILlZZRu\W62IIfpeIgh\2:vaYPpckBPKGGwZDDUVmFKVA>? MYGyNlE4QTZ4MR?=
Jurkat T M3LBU2Fxd3C2b4Ppd{BCe3OjeR?= NELWNHo{OM7:TR?= MlnqNE42cA>? M4fZUGROW09? MWXicI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| Mo\HNlIyPTl6OUi=
Neutrophil MoDxRZBweHSxc3nzJGF{e2G7 NVfqSpI4OjEQvF2= MYewMlVp Mon1ZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= NIjM[ngzPjF7Nki0OC=>
HCT116 Mn3kRZBweHSxc3nzJGF{e2G7 NIrQT|k2OMLizszN NV22Zol1Omh? NGTZTJVz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh MoDFNlIyPTl5NUK=
MDA-MB-231  NIPibGRCeG:ydH;zbZMhSXO|YYm= MYWyMlUuPy53zszN MYWybC=> NEHDfI5qdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ NF[0UFIzOjFzNUWyOi=>
LNCaP MXrBdI9xfG:|aYOgRZN{[Xl? M1rMOVQx|ryP NUHs[25nOmh? M3LQfolvcGmkaYTzJIJ2fGWrbjDpcoR2[2WmIHPlcIwh[XCxcITvd4l{ MlXpNlIyOTR5NkS=
MB231 NXqwc4hlSXCxcITvd4l{KEG|c3H5 M4XhNVExOM7:TR?= MnvKNYg> NUDKSZhFTE2VTx?= MYrhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v NFX1cGQzOjFzMkm0NC=>
HCC38  NEHNNXZCeG:ydH;zbZMhSXO|YYm= MmnXNVAx|ryP NXTYT|dIOWh? MnrPSG1UVw>? M{j5U4Fjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? MXKyNlEyOjl2MB?=
MDA-MB231 Mm\hRZBweHSxc3nzJGF{e2G7 Ml2yOVDDqM7:TR?= MoP5NlRp MlPvSG1UVw>? NUniU5Vj[WK{b3fheIV{KGO3cnP1cYlvNWmwZIXj[YQh[2WubDDk[YF1cA>? MnTJNlIyODF|M{W=
LNCaP M3yyS2Fxd3C2b4Ppd{BCe3OjeR?= NIPMN2s2OMLizszN NGnGTlYzPGh? NEnKfm1FVVOR MUPhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo MmTxNlIyODF|M{W=
HCT116 M2fNR2Fxd3C2b4Ppd{BCe3OjeR?= NHSwOZo2OMLizszN MViyOIg> M37r[WROW09? MnPyZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MkXONlIyODF|M{W=
Ishikawa  M4q1bWFxd3C2b4Ppd{BCe3OjeR?= MYmyOe69VQ>? MVmyOIg> MYDy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFLh[kBCOQ>? MXKyNlA5QDlzOB?=
 YD-8  MmrZRZBweHSxc3nzJGF{e2G7 NGi4ZYEyODEQvF2= MYWxbC=> MoLBbY5pcWKrdIOgVGxGVy2rbnT1Z4VlKGGyb4D0c5Nqew>? MkXwNlIxQDZzOEO=
eosinophil  MkLqRZBweHSxc3nzJGF{e2G7 NWOy[HNHQTEQvF2= MVeyOIg> NGPtdVNqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCIYYOgZY51cWKxZIpCpC=> NYe0VIRpOjJyN{mzN|Q>
L929 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUeyMlXPxE1? M2DDblI1cA>? Mk[1bY5pcWKrdIOgeIhmKGW6cILld5Nqd25ib3[gdE1xOzhiYX7kJG5HNc78QjD0c{BifWevZX70JHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? NGOyV48zOjB{N{C5Oy=>
YD-8  MUTBdI9xfG:|aYOgRZN{[Xl? MW[xNFDPxE1? M2qwVFFp NF7IZXNjdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> NHzjb|gzOjB{MEC3PC=>
HBx NWjNNFRkSXCxcITvd4l{KEG|c3H5 MmP6NlXPxE1? MnPSOFhp NUfIVmtiTE2VTx?= MWTy[YR2[2WmIHPlcIwh\GWjdHigbY5lfWOnZDDifUA{NU2D NV;6Wmg5OjJyMkCwO|g>
U937  M3vsb2Fxd3C2b4Ppd{BCe3OjeR?= NF\Xb5U2OMLizszN M1jGWlFp MYXpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NV3IdXZrOjF7OUi3N|E>
HL60 MX\BdI9xfG:|aYOgRZN{[Xl? NHnmbm41OM7:TR?= MX20NI1qdg>? M1fnTWROW09? NFPHN5djdG:la4OgRm5FSyClb33wc5Vv\HNiaX7keYNmKGW6cH;zeZJmKG:oIIDoc5NxcGG2aXT5cJNmemmwZTDhcoQhTE6DIH\yZYdu\W62YYTpc44> NYXDS4dvOjF7OEOyPVY>
M-14 NVm0NWRTSXCxcITvd4l{KEG|c3H5 Mn7UNlXPxE1? NHfh[4MxNjWq NUnpSIx4yqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? M4XtflIyQTV2OUW5
SK-BR-3 MkjPRZBweHSxc3nzJGF{e2G7 MUK1NOKh|ryP NWriXGx3Omh? NFLm[lNjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> Mn3hNlE6ODF|OE[=
MDA-MB-468 NH;1NIxCeG:ydH;zbZMhSXO|YYm= MXK1NOKh|ryP MUmybC=> M{jv[4Jtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> MWWyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Caspase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID