Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a M{fsT2Fxd3C2b4Ppd{BCe3OjeR?= M{\kRlUx|ryP MXWyOIg> NGTMdZVqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? NGrMRXMzPjF4OUC3OS=>
HGL5 MoO1RZBweHSxc3nzJGF{e2G7 MmDkOVDPxE1? Mk\tNlRp MmrmbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NUfCUFk3OjZzNkmwO|U>
HepG2 Mn60RZBweHSxc3nzJGF{e2G7 NIPZeIYzOM7:TR?= MkjVNYg> M4PIbYF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MUCyOlE3PDd7NR?=
BEL-7402 MVXBdI9xfG:|aYOgRZN{[Xl? NF3rcXczOM7:TR?= NH\pdmcycA>? NY\zUpR5[XS2ZX71ZZRm\CC2aHWgZZBweHSxdHnjJIlv\HWldHnvckBw\iCLSVmtNVDDqA>? NELkPHgzPjF4NEe5OS=>
CEF NWjhUVJ[U2mwYYPlJGF{e2G7 NFHBSZgxNDN|LE[3MFExOM7:TR?= M{HCNFE2dWmw MYTkc5dvNXKnZ4XsZZRmeyCSUjDlcpp6dWViYXP0bZZqfHlidH:gOFDwxIViYYSgNVAx|ryP MVKyOlExOjN|OR?=
SP2/0 Mmr4RZBweHSxc3nzJGF{e2G7 M1SwXlExOM7:TR?= NUTLcXB3OWh? M2nifWROW09? MkXyZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= M3:y[VI3ODd2N{Oy
HUVEC-2c NWf5WXlkSXCxcITvd4l{KEG|c3H5 MnS0OVDPxE1? MmrjOog> NUTu[5ZP\GWlcnXhd4VlKHSqZTDvfE1NTExvaX7keYNm\CCjdYTvdIhi\3l? NHnqb|QzPjB{MUeyPS=>
U1 NIXGRZlCeG:ydH;zbZMhSXO|YYm= NUTaPFlTOC1zMEFOwG0> M1zKU|Jp MULy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NXTRSoFGOjV7OEC5OFI>
ACH-2 NE\4[|NCeG:ydH;zbZMhSXO|YYm= M1O2VVAuOjByzszN M3PuN|Jp MmrBdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M2\iNFI2QThyOUSy
U1 NF7S[4xMcW6jc3WgRZN{[Xl? MWixNFDPxE1? NXTUd3k5Omh? MWfpcohq[mm2czDjZZNx[XOnLUO= M3rqPFI2QThyOUSy
A549/V16 MYfBdI9xfG:|aYOgRZN{[Xl? NYjNSWY6PTEQvF2= M2m0[FFp NHOyXIxz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= M1H2[|I2QTR4MEOz
SGN NFfVV|dCeG:ydH;zbZMhSXO|YYm= NHjTeJEzOG2P MVq0PIg> NEXZSY1p[XNibn:gbY5ndHWnbnPlJI9vKEGLRjygZ4FteGGrbjDlfJBz\XO|aX;uJI9zKGOnbHygZZBweHSxc3nz NX;yTHJsOjV6N{S2N|M>
HCT116  MoSzRZBweHSxc3nzJGF{e2G7 M1rtU|Ux|ryP MXSybC=> NX;mTmsxcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S MXGyOVg3QDhzOB?=
DTK-SME MX3BdI9xfG:|aYOgRZN{[Xl? M{Gwc|Ux|ryP MUmybC=> Ml\tSG1UVw>? M2HpNZBienSrYXzsfUBqdmirYnn0d{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgZpVxcX[jY3HpcoU> MlvxNlU5PDN6OUe=
HL-60 M37FWWFxd3C2b4Ppd{BCe3OjeR?= NViy[o03PTEQvF2= MVS0PIg> M3\YTJJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh MnjpNlU5OjRyNEO=
U937 NWLqNJJ{SXCxcITvd4l{KEG|c3H5 NGj1d3I2OM7:TR?= MnXnOFhp MVvy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> MVeyOVgzPDB2Mx?=
A549 NV7keo5kSXCxcITvd4l{KEG|c3H5 MoPINlAh|ryP NWrXflBTOjSq Mo\0doVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBJTkOSIITy[YF1dWWwdB?= MXSyOVc6PDF2OR?=
HeLa MUDBdI9xfG:|aYOgRZN{[Xl? M1L2b|Ex|ryP NW[3cnBwPDiq M2DSN4Rm[2yrbnXzJJRp\SC{YYTlJI9nKGGyb4D0c5NqeyCmcnHtZZRq[2GubIm= M{PwelI2Pzd{NUS1
SGC-7901 Mon6RZBweHSxc3nzJGF{e2G7 NFq0UpozOMLizszN NX:zb3pVOWh? MknabY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> MonyNlU4PjdyN{[=
MCF-7 M2e1b2Fxd3C2b4Ppd{BCe3OjeR?= NVzydHZFOTEQvF2= NXvEb3lHOmh? MnHFbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTCzRi=> NFPiOXIzPTd{MkGxOC=>
A549 M4fyVGFxd3C2b4Ppd{BCe3OjeR?= NWDvWVI{OTBizszN NYDoWHF{OjSq M2HBOGROW09? M3;RV5Bzd22xdHXzJGhDSy22cnXheIVlKEF3NEmgZ4VtdCC|dYL2bZZidCBoIHH0eIVvfWG2ZYOgeIhmKGOuZXH2[YQhWEGUUDDlfJBz\XO|aX;u M{T4e|I2Pjh|NU[4
U87 M4nUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGixZpo2OM7:TR?= MX2xbC=> M3TaTZJm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? NUTsdFhtOjV4OEG2Olg>
Neocortical Neuron NFLJ[WlP\XW{b4TvfIlkcXS7IFHzd4F6 MVixNFDPxE1? MYSxbC=> M4nmToFvfGGpb37pfoV{KEixaXHtbYRmKEFvSX7keYNm\CCQZYXyc5RwgGmlaYT5 MX:yOVY4PTByMR?=
Primary human placental cytotrophoblasts NILRXlVCeG:ydH;zbZMhSXO|YYm= M1PvcVMx|ryP NF[3W5QzPGh? MorWSG1UVw>? MoPidoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi MXWyOVY1OjV7Mh?=
MM NFvoXG5CeG:ydH;zbZMhSXO|YYm= M3WxWFUx|ryP MUmyNI1qdg>? NVy3eYlreGG{dHz5JIlvcGmkaYTzJHNJUy2rbnT1Z4VlKCClZXzsJIRm[XSq NILkT2IzPTV|MEC5PC=>
DLD1 MnG1RZBweHSxc3nzJGF{e2G7 Mn\MNlDDqM7:TR?= MnnDNYg> NYPab3R3eGG{dHz5JJJmfmW{c3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDXV3Ay MYeyOVUzPDJ2Nh?=
MDA-MB-231 NYLGOW5iS3m2b4TvfIlkcXS7IFHzd4F6 M2rDPFEx|ryP M3;NT|Fp NWnLZ5R1[XWpbXXueJMh[2WubDDk[YF1cCCjZoTldkBEUFWDIITy[YF1dWWwdB?= M3LTUlI2PTJzNUCx
MKN28 NV3pOFJQSXCxcITvd4l{KEG|c3H5 MlvJNVDPxE1? NGPLOZI{OG2rbh?= MUjEUXNQ NGLVPFlqdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= MmTUNlU2OTN7NkC=
HL-60 MnLhR5l1d3SxeHnjbZR6KEG|c3H5 MWixNFDPxE1? M3fPclFp MkHmSG1UVw>? NXvRb4hXyqCrbYDyc5ZmeyC4aXHibYxqfHlib3[gWGNPSXNvdILlZZRm\CClZXzsdy=> M4jx[FI2PTB{OUOy
AGS M3XKVGFxd3C2b4Ppd{BCe3OjeR?= MnTuNVDPxE1? NWW0b5MyOWh? MlzwdJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? Mk\BNlU1QTJ{MUS=
A549  M4LWVmFxd3C2b4Ppd{BCe3OjeR?= NF\odIoyOM7:TR?= NH7EN3UzPGh? MYDicI9kc3NiRF3BV{1qdmS3Y3XkJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCjbnSgZZBweHSxdHnjJINmdGxiZHXheIg> NY\lV2VGOjV2M{S5PFk>
INS-1 M3uwZmFxd3C2b4Ppd{BCe3OjeR?= MlHlOVDPxE1? NV\YOHV[Pmh? MlTjSG1UVw>? NYjwWGZJ\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGWjcnz5JIFxd3C2b4TpZ{Bk\Wyuc9Mg MYSyOVQ{ODh7Nx?=
Primary hepatocytes  MUjBdI9xfG:|aYOgRZN{[Xl? M4\hNVUx|ryP Mn;SNVhp M1raTYlvcGmkaYTzJIFxd3C2b4Ppd{Bw\iCqZYDheI9kgXSnczDpcoR2[2WmIHL5JGFkfCCGIHHu[EBVVkZvzsG= MWSyOVQxPzV|OB?=
L929-A  MVvDfZRwfG:6aXPpeJkhSXO|YYm= NETwXFQzOMLizszN NVzn[5h7OjSq NYTPWmMzcW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo NXLkNHdMOjV|OUi1OFA>
L929-N NH7CfJFEgXSxdH;4bYNqfHliQYPzZZk> NG\MOJIzOMLizszN MWOyOIg> MnTw[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u MUSyOVM6QDV2MB?=
Cytotoxicity Assay NUnhbGtLS2WubDDWbYFjcWyrdImgRZN{[Xl? MljvNlDPxE1? NHT6UHU1QGh? MljOdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? MkDRNlU{QTJzMU[=
COS7 MVXLbY5ie2ViQYPzZZk> NYXHdWs6OTEQvF2= NHjRPIUzPGh? MkXNbY5kemWjc3XzJINie3Cjc3WgN{84KGGldHn2bZRq\XN? M1;pblI2Ozh2MEK1
COS7 MWLBdI9xfG:|aYOgRZN{[Xl? NFLoOHAyOM7:TR?= MYq0PIg> NWnjRW1ieGG{dHnhcIx6KHC{ZY\lcpRm\CCIQ{GwNU1qdmS3Y3XkJINmdGxiZHXheIg> NGrk[VUzPTN6NECyOS=>
A375 M2LseGFxd3C2b4Ppd{BCe3OjeR?= MoL0N|DPxE1? MmrhNog> NGG2d29xemW4ZX70d{B1cGViZIL1[{1qdmS3Y3XkJHBCWlBiY3zlZZZi\2V? M3nzVVI2Ozd4MUG1
A549 M4e2RWFxd3C2b4Ppd{BCe3OjeR?= M2DT[|Ux|ryP NF7BN40zPGh? NGji[pJz\X[ncoPld{BzcWKxc3;t[UBjcW:pZX7ld4l{KGGwZDDhdI9xfG:|aYOgZ4F2e2WmIHL5JEBEcGmsb37n[IFv MnL1NlU{PDl5OEG=
A549 NHvEWldCeG:ydH;zbZMhSXO|YYm= MYKyMlUuOjYQvF2= NELmRXYycA>? M1S0SoRm[3KnYYPld{B1cGVicH;weYxifGmxbjDv[kBieG:ydH;0bYMh[2WubIOg[IVx\W6mIH;uJINwdmOnboTyZZRqd26| NUTtUpNqOjV|NEK0Nlc>
 NBL-W-S  M3rlcWFxd3C2b4Ppd{BCe3OjeR?= MVm1NO69VQ>? MljyNYg> MoHl[pVtdHlicnXzZ5VmeyClZXzsJJZq[WKrbHn0fUBi\nSncjDHRW5VNTZzIITy[YF1dWWwdB?= Ml7YNlU{OjN{MkK=
Caki-1  NVXJeowxSXCxcITvd4l{KEG|c3H5 MmLtOFDPxE1? NWDKSYJqPDiq Mlm5doVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> MmDPNlUzPzlzOUG=
769-P NHTwfmtCeG:ydH;zbZMhSXO|YYm= NXHZflF{PDEQvF2= NF2wVWs1QGh? MUXy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz M1iyOFI2Ojd7MUmx
H9c2 MmW5RZBweHSxc3nzJGF{e2G7 NGnvVlk2OM7:TR?= MXKxbC=> M1\QV4lvcGmkaYTzJGRQYC2rbnT1Z4VlKGOjc4Dhd4UhOyCjY4TpeoF1cW:wIHL1eEBvd3RidHjlJIxwe3Nib3[gZ4VtdHN? MmLpNlUzQDN6MUm=
K562 NVzjN2NOSXCxcITvd4l{KEG|c3H5 MXi1NO69VQ>? MmXMOIg> NXG1UmlTcW6qaXLpeJMhUmGlLVGtbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? NIXwRmQzPTJ2MU[xPS=>
L929 MlfGRZBweHSxc3nzJGF{e2G7 NIjvfIMyOM7:TR?= NFPLcm43cA>? NHzM[JFqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H MX6yOVE6PTZ4MB?=
A549 MknNRZBweHSxc3nzJGF{e2G7 MVixNO69VQ>? NFXYco8{cA>? NXizVXczemWmdXPld{Bk\WyuIHHwc5B1d3OrczDjZZV{\WRiYomgVHFS M1P4T|I2OTZzNkm5
MCF-7 MYfBdI9xfG:|aYOgRZN{[Xl? MVyyNO69VQ>? MmL2Nog> MVPk[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz MVqyOVE5OjJ2MB?=
OS NF;DeHBCeG:ydH;zbZMhSXO|YYm= NG\2T28zOC92MN88US=> NF2zfVM4Omh? MXLpcohq[mm2czDPV{Bk\WyuII\pZYJqdGm2eTDy[YR2[3Srb36gZpkhSzZiY3XyZY1q\GV? NIHSOmgzPTF3MkO5PS=>
HUVECs M2S2cmFxd3C2b4Ppd{BCe3OjeR?= MnuyNVDPxE1? MViybC=> MXdCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGhWXkWFcx?= M135TlI2OTN6N{Cz
EA.hy926 NYL4V5BZSXCxcITvd4l{KEG|c3H5 NYPKXXF[OTEQvF2= NV[zOW9bOmh? NXzlcmcxyqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? NWj6T|huOjVzM{i3NFM>
Ebs NVnQdGxWSXCxcITvd4l{KEG|c3H5 NEL6TG8yOC1zMEFOwG0> M2P0b|I1cA>? MVZCpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl NILMO3czPTF|NEixOy=>
Jurkat MmC0RZBweHSxc3nzJGF{e2G7 NVzsd|ZsOjEQvF2= MnPoNlRp MmXRSG1UVw>? MXnwZZJ1cWGubImgbY5pcWKrdDDj[YxtKGSnYYToJI9nKEq3cnvheEBk\WyuczDpcoR2[2WmIHL5JFExODV6LV[0JINwdWKrbnXkJJdqfGhiVmDBxsA> NWn2TnFsOjVzMkC3NlM>
K562 NFnBXnRCeG:ydH;zbZMhSXO|YYm= NYnmWlVLOC5zLUJOwG0> MYKxbC=> Moe3bY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NGqxflczPTFzOUG4PC=>
IMR-32 MVXBdI9xfG:|aYOgRZN{[Xl? MnTCOFDDqM7:TdMg NULaSHczOmh? MYTk[YNz\WG|ZTDpckBieG:ydH;0bYMh[2WubIOgZ49ueGG{ZXSgeI8hXC1{IITvfIlv NF;6S44zPTB6NEe1OS=>
RPMI 8226 MX;BdI9xfG:|aYOgRZN{[Xl? M4X1U|ExOM7:TR?= NF23fHUycA>? M2XI[YFtdW:|dDDjc41xdGW2ZXz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z MVeyOVA{Pzh3MR?=
U266  M3zhVWFxd3C2b4Ppd{BCe3OjeR?= MkXqNVAx|ryP MVKxbC=> NFfKPGpx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NU\tUohkOjVyM{e4OVE>
H929  Mn3xRZBweHSxc3nzJGF{e2G7 MorTNVAx|ryP M3XH[|Fp MlTKdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z M4DrfVI2ODN5OEWx
MM.1S  MljmRZBweHSxc3nzJGF{e2G7 MoCwNVAx|ryP NGHjTlYycA>? NFjUPHVm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z NHfNRo4zPTB|N{i1NS=>
C6 NYLM[ow5SXCxcITvd4l{KEG|c3H5 NH3ld2w2OM7:TR?= Mm\5OFhp M3fST5Bz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? NFzPdXozPTBzM{S3PS=>
AGS M{TVSWFxd3C2b4Ppd{BCe3OjeR?= NU[yb5AxPTEQvF2= NUPScGZ{OjSq MmrNZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= NUPleIwxOjVyMEm2PVg>
HeLa  MkH0RZBweHSxc3nzJGF{e2G7 M1v4WVQx|ryP NETQU3IzPGh? MUfpcohq[mm2czD0bIUhcW6lcnXhd4VlKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIPpVm5HOTJz M4HRO|I1QTJ6Nki1
THP-1  NVj6eI15SXCxcITvd4l{KEG|c3H5 NVXSUm5QOTEQvF2= M4L2V|Fp MXTy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGFNSS2VRGVCpC=> M1jpTVI1QTJ|NkWz
P815  M1u0SGFxd3C2b4Ppd{BCe3OjeR?= MkXjNVAxKML3TR?= MmW5NVJp NFjUfHJFVVOR NIPzV2pqdmirYnn0d{B3cXK3cz3pcoR2[2WmIHHwc5B1d3Orcx?= M4rxcVI1QTJ|Mkez
HCT116 MWrBdI9xfG:|aYOgRZN{[Xl? M3TQS|Ix|ryP MnzZNlRp MU\hZpJw\2G2ZYOgc4YhXFFvaX7keYNm\CCjcH;weI9{cQ>? NGTSeZIzPDh7MES0PS=>
SW1116  MmXTRZBweHSxc3nzJGF{e2G7 NHXNd4kyOCEEtV2= NV3nb|l{OWh? MnPoSG1UVw>? M3ThVZJme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= NFrydnkzPDh5NEK4Oi=>
LOVO MWrBdI9xfG:|aYOgRZN{[Xl? MXyxNEDDvU1? NGrjXGcycA>? MlfFSG1UVw>? NHnLXpRz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l M1PVTFI1QDd2Mki2
SNU449  NXr2V|VmSXCxcITvd4l{KEG|c3H5 MnfFNlDPxE1? MoHZOFhp M3PXV2ROW09? MYTk[YNz\WG|ZYOgcYlTNTR3MT3pcoR2[2WmIHHwc5B1d3SrYx?= M2TTOVI1QDRzNkO4
Caco-2 MX7BdI9xfG:|aYOgRZN{[Xl? NVv3NFJrPDEkgJpOwG0> NHznc|c1cA>? NIX5XoNxemW4ZX70d{BUXC15LXnu[JVk\WRiWl:tNUBkcGGwZ3XzJIFv\CCWRWKg[JJweA>? MnrjNlQ5OjJzOEO=
macrophage NWrXSFFlS2WubDDWbYFjcWyrdImgRZN{[Xl? NFq5O3YxNTJyMN88US=> NXja[ZBvOjSq M2HHUolv\HWlZYOgWG5HNSCjbnSgVolxOy2mZYDlcoRmdnRibnXjdo9xfG:|aYOgbY4hdWGlcn;wbIFo\Q>? MkP0NlQ4QTl3NkW=
AGS  M4CweWFxd3C2b4Ppd{BCe3OjeR?= MonxNlDPxE1? MUexNog> MnHtSG1UVw>? M2DQPJJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NFPSRo4zPDd6OUewNy=>
LCC9  Ml7uR4VtdCCYaXHibYxqfHliQYPzZZk> MlnhNVAx|ryP NVXlN2dlPWR? MmrJZoxw[2u|IHPlcIwh\GWjdHigbY5lfWOnZDDifUBkd22kaX7heIlwdiCOMUegZY5lKGOqbH;yc5F2cW6n MoXQNlQ4QDV{NU[=
U937  NF;uNIdv\WO{b4D0c5NqeyCDc4PhfS=> MnPGNVDDqM7:TR?= MnvlN|DDqG2rbh?= NGXmcWpqdmS3Y3XzJI5m[3KxcITvd4l{KGOxbXLpcoUhf2m2aDDUUmY> Mk\QNlQ4PzN5NU[=
T cell M3P2TmNmdGxicILvcIln\XKjdHnvckBie3OjeR?= NI[4cYgxNTFyMN88US=> NITKV4Y4Omh? NXvnd4tMUUN3ME23NEDPxE1uIHnubIljcXS|IHHueIkuS0R|LXnu[JVk\WRiVDDj[YxtKHC{b3zp[oVz[XSrb36gbY4hWEKPQ4O= NXvvclZQOjR5Nki3NFc>
HeLa  M{LESWFxd3C2b4Ppd{BCe3OjeR?= NV7PS5htPTEQvF2= NXe4XWJpPzKq MV\EUXNQ MoThdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2:vcH;1coR{yqBz4pETOS=> NYHNdGhCOjR5NUS3PFY>
HeLa  NGW2O29CeG:ydH;zbZMhSXO|YYm= NEnLTZgyODEQvF2= MlXFNlRp NXH3N4dwe3WycILld5NmeyC{YYTlJI9nKGOnbHyg[IVifGhiaX7keYNm\CCkeTDveoVz\XiycnXzd4lwdiCxZjDHOVlUKG:{IFe3NXIheDF3MHfseYVlyqB? NInlcpUzPDd{MkS2PC=>
IEC-6  MljhRZBweHSxc3nzJGF{e2G7 MVexNO69VQ>? M{LVSVI1cA>? Mlq0dJJmfmWwdIOgWINlSS2rbnT1Z4VlKGOjc4Dhd4UuOyClbHXheoFo\SCjbnSg{tIu[2G2ZX7pckBl\We{YXTheIlwdg>? M2XiXFI1PzFzNUex
HCT116 M3fGfWFxd3C2b4Ppd{BCe3OjeR?= NFrHfmUzOM7:TR?= MlnZNlRp MlTJbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxdHnjJIlv\HWlZXSgZpkhYUyWMkC1 M4W2fFI1PzF|OEGy
L02 NH7RTnVCeG:ydH;zbZMhSXO|YYm= M4rRZ|Ix|ryP MlrENYg> M4\5Z5Bz\X[nboTzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE2HSGC= M4Tqb|I1PzB4NE[x
A375 NXLZR3NmSXCxcITvd4l{KEG|c3H5 MWiyNO69VQ>? M1nFbFI1cA>? NGX4PYtz\X[ncoPld{BlcWOrdILpco9v\SCELXnu[JVk\WRiYYDvdJRwe2m| MkHRNlQ3QTlzMUG=
HDPC MoTkRZBweHSxc3nzJGF{e2G7 NIXKVGQ2OML3TR?= NXP6PGt3OjSq M1vsfYlvcGmkaYTzJG5QNWmwZIXj[YQh[XCxcITvd4l{ MknrNlQ3OzR3OUO=
A549 M2HpUmFxd3C2b4Ppd{BCe3OjeR?= M17QblUxyrWP NWW2[|RtOmh? NWXCXVRnTE2VTx?= MX\wdoV3\W62czD0bIUhcHmyb3TpdIxwcWRiRF7BJINwdnSnboSgdIhie2ViaX7keYNm\CCkeTDj[ZBp[WyxY3jyc41qdg>? MnT2NlQ2QDhzM{W=
 BV-2 MVjBdI9xfG:|aYOgRZN{[Xl? NIT1clEzOM7:TR?= MoHuNog> MYTzeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? M4DqNFI1PTV6MUG4
HT-29  MnjtRZBweHSxc3nzJGF{e2G7 MVq1NO69VQ>? NGTUN4U1QGh? M33PWoJtd2OtczD0bIUh[XCxcITvd4l{KGmwZIXj[YQh[nlia3HlcZBn\XKxbB?= NYHXU|c{OjR3NEmxO|U>
A549 NX;NW40{SXCxcITvd4l{KEG|c3H5 MUO1{txO M1zHSFI1cA>? M1LncpN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg MoDDNlQ2Ojl6N{G=
MIA-PaCa-2 M1;TXWFxd3C2b4Ppd{BCe3OjeR?= M2P1Z|I1cA>? NETaPIhjdG:la4OgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGmwZIXj[YQh[nliYn;0bEBCNTR2M{[1OEBidmRicHHjcIl1[XinbB?= M1HhZ|I1PTFyOUmy
Caki-1 NXnRR2NpSXCxcITvd4l{KEG|c3H5 Mnv0NlDPxE1? NUDjWnR3OWh? NWTwO5FXcW6qaXLpeJMhW0OSLXnu[JVk\WRiYYDvdJRwe2m| MXeyOFUxPDZ6MR?=
CLL MoLFRZBweHSxc3nzJGF{e2G7 NYnUXXdCOjYQvF2= MoTFNYg> NWL3[IxpeGG{dHnhcIx6KGKub3Prd{BOVE5{MkO4MYlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? MXOyOFQ3PzZ|NB?=
SGC-7901 MW\BdI9xfG:|aYOgRZN{[Xl? NHvZb3MyOM7:TR?= NGLIeVUzPGh? M1eybJBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? NYj1SodYOjR2NUS0PFg>
k1735 MmnLRZBweHSxc3nzJGF{e2G7 M17wZ|Ix6oDLzszt NUnrOmd2PGh? M1TwTYlvcGmkaYTzxsBU[Wyvb37lcIxiNWmwZIXj[YQh[XCxcITvd4l{ NGHlcI4zPDR3MUGxOi=>
HaCaT  NEPsTZNCeG:ydH;zbZMhSXO|YYm= M{nRcVExOM7:TR?= NHTjXlkycA>? M4jXV4JtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= NXnsc5I6OjR|NU[5PVc>
podocytes M33r[GFxd3C2b4Ppd{BCe3OjeR?= NX;WOlJ5OjByzszN MWG2bC=> M1iySYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> M1q3R|I1OzN5N{e3
 KB MmTjRZBweHSxc3nzJGF{e2G7 NH[ybWY2OM7:TR?= NYjvbpBWOjSq MX7pcohq[mm2czDMbYNwNUFvaX7keYNm\CClYYPwZZNmNTNiYX7kJHBCWlBiYXP0bZZifGmxbh?= MnrJNlQ{Ozd2OUK=
 HepG2  NWrV[VBkSXCxcITvd4l{KEG|c3H5 MWWxNO69VQ>? MojpNlRp MkHWdoVlfWOnczD2bY1mdnSrbjDjcIVifmGpZTDjZZV{\WRiYomgUHBU MVqyOFMzPThzNh?=
fetal rat lung fibroblasts  MWXLbY5ie2ViQYPzZZk> NXXqPZVUQDEQvF5CpC=> NUC4N21EOWh? MmqxbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> NYrjeo43OjR|MUSxN|U>
PDL fibroblasts M3\5TGtqdmG|ZTDBd5NigQ>? MnjSPFDPxE4EoB?= MmT6NYg> MoS0bY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> M1fUblI1OzF2MUO1
MB49 NX;nU2sxSXCxcITvd4l{KEG|c3H5 NF\3V4ozOM7:TR?= MmOxNYg> M2OyRZJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NVj3OJhoOjR{OEK0N|M>
5637 NF7XSo5CeG:ydH;zbZMhSXO|YYm= NX7FbpMyOjEQvF2= MkX6NYg> NX;4To4yemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq MnnpNlQzQDJ2M{O=
A549  MYHBdI9xfG:|aYOgRZN{[Xl? NEn1OowyODEQvF2= M3\NeVQ5cA>? M2XOZpN2eHC{ZYPz[ZMhfGinIHHwc5B1d3OrczDjZZV{\WRiYomgdIlx\XKrbnZCpC=> MknnNlQzPzJ{MEG=
MCC-2 Mn\3RZBweHSxc3nzJGF{e2G7 M1XmUFIxKM7:TR?= MV22bC=> MVvEUXNQ MoTuZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= Ml3XNlQzPjJ4NUi=
ADF MVjBdI9xfG:|aYOgRZN{[Xl? NXTQV|lOPDEQvF2= NEjoS4U3cA>? MkfObY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NYjBfFA3OjR{MkiyN|I>
 U373  NUD2eHBGSXCxcITvd4l{KEG|c3H5 M2rDO|Qx|ryP NEPaeGI3cA>? NHLtWI5qdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> MV6yOFIzQDJ|Mh?=
RKO-HIPK2i NW\aVXpnSXCxcITvd4l{KEG|c3H5 MVe0NO69VQ>? NYLDRnFGPmh? MUDpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MVyyOFIzQDJ|Mh?=
HEC-1B MVrBdI9xfG:|aYOgRZN{[Xl? NWTrbGlQOjEQvF2= NGH0clgycA>? MoDndoVlfWOnczDUVE1qdmS3Y3XkJIFxd3C2b4Ppd:Kh[2G|cHHz[U0{KGGwZDDjZZNx[XOnLUm= MUiyOFIyOzN3OB?=
4T1 NXL5e3FTS2WubDDWbYFjcWyrdImgRZN{[Xl? NI\6O|gzNjVvMUFOwG0> MVK0bC=> MULEUXNQ NEHBcIJz\XOldXXzJJRp\SCleYTveI95cWOrdImgc4YhPFRzIHPlcIx{KGmwZIXj[YQh[nliU2DEWEBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> NILiVWUzPDJyNkG2NS=>
OS  NYTFR|lKSXCxcITvd4l{KEG|c3H5 M1f6dlIx|ryP NFnzNoY1cA>? NXLoO5ZIcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? MX6yOFIxPDl|Nx?=
RPE M3XnOGFxd3C2b4Ppd{BCe3OjeR?= MlL4NVAx|ryP M3vFO|Q5cA>? NH3Jemhx[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? M2PQflI1OjB{MEWy
UD29a NHjnTG1CeG:ydH;zbZMhSXO|YYm= MUK1NO69VQ>? NEnre|QzPGh? NWT5d2hGcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JG5WXDN? NGLZPIczPDF7MEW3OC=>
SH-SY5Y  MkXZRZBweHSxc3nzJGF{e2G7 NGD3O3oyOM7:TR?= NF7BcZIzPGh? MkiyZZR1\W63YYTld{Bk[XOyYYPlJIFkfGm4YYTpc44h[W6mIHPlcIwh\GWjdHigbY5lfWOnZDDifUBJVkVvMlTH MkLGNlQyPDV2NkO=
HeLa  NF36dXRCeG:ydH;zbZMhSXO|YYm= NWK4fZRFOTBxMkFOwG0> NELkZY0zPGh? NHz4Vo9qdmirYnn0d{B1cGViYXP0bZZqfHlib3[geIhmKG2jan;ybZR6KG:oIITo[UBu\W2kZYLzJI9nKHSqZTDjZZNx[XOnLX\hcYltgQ>? M1rEWFI1OTN5Mk[2
SCCVII  MUDBdI9xfG:|aYOgRZN{[Xl? M2izV|I2|ryP Mmn5NYg> M1zUW4lvcGmkaYTzJJRp\SClZXzsJItqdGyrbnegZYZ1\XJiZHHzZZRqdmmk MV6yOFEzPjR4NB?=
RAW 264.7 NGqxcpFCeG:ydH;zbZMhSXO|YYm= M3r2fFIx|ryP Mm\XNVhp NWn6ZmVQcW6lcnXhd4V{KEyFMz3JTU/Pui2jY4TpckBz[XSrbzDjc41x[XKnZDD0c{BGS1SYLV3PV{B1emWjdH3lcpQhd26ueR?= NUG1dIRZOjRzMU[3NFc>
A549  MYXBdI9xfG:|aYOgRZN{[Xl? M2WwTVIvPc7:TR?= Ml\YNlRp MXzk[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> NUi1SYNMOjRzMEK1NlI>
UM-SCC-10A  MmW4RZBweHSxc3nzJGF{e2G7 M4HURlUxyrWP MXWybC=> MVvy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JIhq\2hvZH;z[UBqe2:jbHHueI9t[WO2b37l NVrWUngyOjRyOUi3OVM>
BGC-823 MWnBdI9xfG:|aYOgRZN{[Xl? M{X2WVExKM7:TR?= MoG4NlRp M{P6V5Jm\HWlZYOgeIV1emGwZILpcoUucW6mdXPl[EBieG:ydH;zbZPDqA>? NGDmVGUzPDB7OEWxNS=>
Nalm-6  MXHBdI9xfG:|aYOgRZN{[Xl? NIK4XFEzOM7:TR?= NH7Pb4Q1cA>? M17ZXYlvcGmkaYTzJINie3Cjc3WtPEBidmRiY3HzdIF{\S1|IHHjeIl3[XSrb36gZY5lKFCDUmCtNUBkdGWjdnHn[S=> M2jtRlI1ODN7OU[3
KHOS  MX;BdI9xfG:|aYOgRZN{[Xl? NEno[3g1OM7:TR?= MlLrNlRp M17KUYJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MUWyOFAzPTN4MR?=
G292 MmnHRZBweHSxc3nzJGF{e2G7 M3ruR|Qx|ryP MmfjNlRp NET1[YNjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg MVSyOFAzPTN4MR?=
MG-63 M4DN[WFxd3C2b4Ppd{BCe3OjeR?= NEjSXmo1OM7:TR?= NUG2fXg1OjSq MoD2Zoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MnL2NlQxOjV|NkG=
EBV-transformed B cells MWLBdI9xfG:|aYOgRZN{[Xl? NWO3TJZ6OjEQvF2= NVXP[|NlOmh? MV;EUXNQ M3LSV4Jtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? Mo\4NlQxODh4Mki=
IM-9 B MmjHRZBweHSxc3nzJGF{e2G7 MWGyNO69VQ>? M2LxSlJp MnPqSG1UVw>? MU\icI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> MYGyOFAxQDZ{OB?=
CNE1 NGHhZotCeG:ydH;zbZMhSXO|YYm= MmDUNlDPxE1? MWK0PIg> NUXOO3pv[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? NXq0XXpTOjN7OEWwNlk>
CNE2 M2OzT2Fxd3C2b4Ppd{BCe3OjeR?= MVGyNO69VQ>? NYPSV5FsPDiq MmX4Zoxw[2u|IFzLMWEucW6mdXPl[EBieG:ydH;zbZM> MnLZNlM6QDVyMkm=
HL-60 MVjBdI9xfG:|aYOgRZN{[Xl? MoXYOVDDvU1? MmfwNYg> NFzscZVFVVOR MWDpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBDSTF2NR?= MkjwNlM6PDh5NUG=
L929 M1rQ[GFxd3C2b4Ppd{BCe3OjeR?= NXPMXplFOS5{NfMAl|XDqM7:TdMg M{LXNVI1cA>? NIH1ZWlifWevZX70d{BVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? MUiyN|k1OTd4OR?=
Jurkat MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUSy{txO MkD4OIg> M1Pwc5JmfmW{c3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CEQsj3jZZRmdmmwIHTlZ5Jm[XOnIHL5JGhUNUGVQR?= NIHFfmozOzh7NkC2NS=>
RAW264.7  M{fnTmFxd3C2b4Ppd{BCe3OjeR?= Mor2NVAh|ryP NFmxeoMzPGh? NHjTUJdl\WO{ZXHz[ZMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JGdC NG\MXFczOzh{MEKwNy=>
A431  M2ryTmtqdmG|ZTDBd5NigQ>? NYnO[po4PDEQvF2= MUWybC=> MoP1Zoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= MWmyN|gxODB3OB?=
Jurkat NFLjPWdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M4frWlI2NTFyMN88US=> NF34bVg3cA>? NFnXZVlqdmirYnn0d{B7NU[DLVPNT{1qdmS3Y3XkJINmdGxiZHXheIg> M2LjVVI{QTN|NUOy
COS-7  MoDoSpVv[3Srb36gRZN{[Xl? MnTsOVDDvU1? M4PNRlI1cA>? MY\h[oZm[3S|IITo[UBxem:lZYPzbY5oKG:oIFHUUlF{KHerdHigdI9tgVFidILhZ5R{ MlPrNlM6OzN{MEi=
CAL27 MXLBdI9xfG:|aYOgRZN{[Xl? NEfn[pUyOCEQvF2= NGnBPWQzcA>? M165VZN2eHC{ZYPz[ZMhS3W{LV7Qd{1z\WS3Y3XkJJZq[WKrbHn0fUBjgSC3cDD0c{A6OCV? NGDQXpgzOzlzN{O5Oi=>
THP-1  M3vX[GFxd3C2b4Ppd{BCe3OjeR?= M1L6NlExNTVyzszN NUfJXJNrOmh? MXjpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1emmydH;sbYRm NYrDVpdFOjN7MECyPVk>
K562 MmXTRZBweHSxc3nzJGF{e2G7 NEDjR2czOM7:TR?= NYfGXZlMPDiq MWfpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X M3XJVlI{QDd4OEK2
HL-60 NI\TZ|hCeG:ydH;zbZMhSXO|YYm= M{TG[VExOM7:TR?= NHvGN|UzPGh? MV7pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBi[mmndHHu[UBlcXSncoDlcoV{yqB? M1nLfFI{QDZ3N{e4
HeLa  MVvBdI9xfG:|aYOgRZN{[Xl? MlrpNlDPxE1? MV[ybC=> MkD3bY5pcWKrdIOgSG1OWCCrbnT1Z4VlKGGyb4D0c5Nqew>? M{X6fFI{QDZ|OU[2
U251 MWXBdI9xfG:|aYOgRZN{[Xl? MVyyNO69VQ>? MmLMNlRp NGXtTmlqdmirYnn0d{Bk[XO2aXPpckBqdmS3Y3XkJGczN01icHjhd4Uh[XK{ZYP0JIFv\CCjcH;weI9{cXN? MmrkNlM5OTZ6MU[=
HL-60 MV7BdI9xfG:|aYOgRZN{[Xl? NI\4Npg2OML3TR?= NYDzUGk{PGh? M4jMcIJtd2OtczD0bIUh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|LDCtPUwh[W6mIGDBVnAhcW6mdXPl[EBjgSB4cx?= NFz5Vo8zOzhyNEewOi=>
Ec-109 Ml3yRZBweHSxc3nzJGF{e2G7 MWOxNEDPxE1? NF60PZI1QGh? NVz1cXBzemWycnXzd4V{KFCHLX3l[IlifGWmIFXjMVExQSClZXzsJIFxd3C2b4Ppdy=> NH\tRlAzOzd6Mk[0NS=>
RKO Mle1R4VtdCCYaXHibYxqfHliQYPzZZk> M1XCOFExKM7:TR?= NFTZWI0zPGh? M322TYlvcGmkaYTzJJRp\SCmZXPy[YF{\SCxZjDj[YxtKH[rYXLpcIl1gSClYYXz[YQh[nliRFHC MUKyN|c2QDB4NB?=
T98G MknIR4VtdCCYaXHibYxqfHliQYPzZZk> Ml[3NU0yODEQvF2= NGPOUFIzPGh? NGXuXFlqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT M1;U[FI{PzZ7Mke1
Jurkat NGjPV2ZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1XzelExOC1{MEFOwG0> M4rHZ|I1cA>? MYDpcohq[mm2czDIZWE1KGmwZIXj[ZMh[XCxcITvd4l{KGSncHXu[IVvfCCxZjDjc45k\W62cnH0bY9vyqB? MmrZNlM4OzJ2OEG=
Molt-3  M2DjTmFxd3C2b4Ppd{BCe3OjeR?= NITRZWo2OM7:TR?= MWSybC=> M4fZeJJm\HWlZYOgcYVt[XSxbnnuMYlv\HWlZXSgZZBweHSxc3nz M2X1RlI{PzJ3MEGz
hMSC12 NVznNGV6SXCxcITvd4l{KEG|c3H5 NGL0R20yODEQvF2= NWmxdIF6PGR? MXrpcohq[mm2czDvd5Rmd2enbnnjJIN2dHS3cnWtbY5lfWOnZDDj[YxtKGSnYYToJIFv\CClYXzjbYZq[2G2aX;u MX:yN|Y2Pzh{Mh?=
HM7  M1PUemFxd3C2b4Ppd{BCe3OjeR?= NVfwV45iOjEQvF5CpC=> MVixbC=> MXficI9kc3NiYYDpZ5Vt[XKnbjDBJIFk\XSjdHWtbY5lfWOnZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVEBkdGWjdnHn[S=> NXK1dHFOOjN3OEO0NVI>
Hep-2  NYfScYljSXCxcITvd4l{KEG|c3H5 NH\XOY0zOM7:TdMg MYKyOIg> MY\EUXNQ MoHYZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= MXuyN|U5ODB|Mh?=
HSCs M{T6cWFxd3C2b4Ppd{BCe3OjeR?= NHHGRlE2OM7:TR?= M{\RPVI1cA>? NWDjdppbTE2VTx?= NITlN3ZqdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm NGnDU3kzOzR7OUi3OC=>
HL-60  Mn7nR5l1d3SxeHnjbZR6KEG|c3H5 NVW2NGw6OjEQvF5CpC=> MVGyOIg> MVLy[YR2[2W|IITo[UBkgXSxdH;4bYMh\W[oZXP0JI9nKEW{eUW= M1rwblI{PDl2NEiw
HA NIDFZYNCeG:ydH;zbZMhSXO|YYm= MnPpOVDPxE1? NVO1TmI6OjSq M3PjSZN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? M3L6XVI{PDd3OUW2
C666-1 NYXue4FFSXCxcITvd4l{KEG|c3H5 M2DmXVUx|ryP MXGyOIg> M4fETZN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? MWKyN|Q4PTl3Nh?=
Hepa1-6 M4r2fGFxd3C2b4Ppd{BCe3OjeR?= NFexOlY2OM7:TR?= Mn3aNog> MlO5bY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| NHTuPZYzOzR2Nke1Ny=>
PLC/PRF/5c NV7XdpFWSXCxcITvd4l{KEG|c3H5 NGXLVHc2OM7:TR?= NFW4U5UycA>? NX3aVllGeHKndnXueJMh[XCxcITvd4l{KHS{aXfn[ZJm\CCkeTDDTW4> NHrBUmUzOzR|OEiyOC=>
HCT116 MXzBdI9xfG:|aYOgRZN{[Xl? MmX2NVAx|ryP M4rHWVEvPWh? MlnJbY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp MUiyN|c1PDN3Mx?=
HCEC MX;GeY5kfGmxbjDBd5NigQ>? MlLJOVDPxE1? Mmj6O|Jp NFTldI1FVVOR M37VfJJme3SxcnXzJI9nKHSqZTDuc5Ju[WxiSFPFR{BxcGWwb4T5dIU> M{PuflI{PzR{MEGx
Primary rat cerebral cortical neurons NHfQdoZCeG:ydH;zbZMhSXO|YYm= Mlu3NVAx|ryP M3LmT|Fp MYHwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= NVnWZWN[OjN5NEGzNVc>
MDA-MB-231  NFvWSIpCeG:ydH;zbZMhSXO|YYm= NX\pZmdGOjYQvF2= NHv1cnIzPGh? M4\wdYFjem:pYYTld{BkgXSxdH;4bYNqfHliYX7kJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCrbnT1Z4VlKGK7IGLnNy=> MW[yOVM{PzV2NB?=
NLRP3-Tet-on-MC/9  MUPBdI9xfG:|aYOgRZN{[Xl? NEnXV|MyOC12MN88US=> NIHobngyOmh? NWftPYNk[XS2ZX71ZZRmeyC2aHWgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhS0GSUz3hd5Nw[2mjdHXkJG5NWlB|IH31eIFvfHNiaX6geIhmKFSndD3vckB{gXO2ZX2= NGDkXogzOzdyM{O4PS=>
KNS42  NGfWRmxCeG:ydH;zbZMhSXO|YYm= NYmzeJlNPTEQvF2= NYn0V5hbOWh? NUX2c5pCemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDjc41xdGW2ZXz5JIFjd2yrc3jl[EBk[XOyYYPlJFMwPyCjY4Tpeol1gSCrbjDy[ZNxd26|ZTD0c{BCSlRvMk[zM|JFTy:vZYTmc5JucW5iY3;tZolv[XSrb36= M4qxW|I{PjlzMUS1
MCF-7  M4n2fGFxd3C2b4Ppd{BCe3OjeR?= MYOyNO69VcLi MX[3Nog> NYPVU5lIcW6qaXLpeJMh\XG3b3ytJIFv\CB2LV;IWE1u\WSrYYTl[EBieG:ydH;zbZM> NYPIfWN5OjN4N{W2OFM>
hCMEC/D3  MXPBdI9xfG:|aYOgRZN{[Xl? NX22fohsOjYQvF2= MVG3Nog> NYXiVm9TemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| NYLXSZRmOjN4NkWxPVg>
Jurkat MX3BdI9xfG:|aYOgRZN{[Xl? MXexNk42NTVyzszN M{LkUFFp MVLkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> M3LhdFI{PDR{OUe2
CNE-1 MU\BdI9xfG:|aYOgRZN{[Xl? M3[3fFIx|ryPwrC= Mny3NlRp NWn5TlZNcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MV6yN|QzPjh3MB?=
HONE-1 NXLQe|ltSXCxcITvd4l{KEG|c3H5 MVGyNO69VcLi M4PON|I1cA>? NFT0epZqdmirYnn0d{BTSURyMEGtbY5lfWOnZDDj[YxtKGSnYYTo MkS1NlM1OjZ6NUC=
astrocytes cell MWDBdI9xfG:|aYOgRZN{[Xl? MonaOFDPxE1? NXfHeVI5Pmh? MoTodoVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m MY[yN|QyOTd5OB?=
U-937 NWfCV5ZISXCxcITvd4l{KEG|c3H5 Mn7GNVDPxE1? MVKzNI1qdg>? MoXwdJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? M2\mWVI{PDFyN{S4
MDA-MB-231 M3rEb2Fxd3C2b4Ppd{BCe3OjeR?= MWCxNFDPxE1? NF71UGsycA>? MWDpcohq[mm2czDz[Y5{cXSrenH0bY9vKHSxIGTSRWlNKHWyb36gUXRFUCCmb4fuMZJm\3WuYYTpc44> NF;zRoUzOzRyOESyPS=>
HeLa  NHi5[ZBCeG:ydH;zbZMhSXO|YYm= M4XkdlExOM7:TR?= M4XJZVJp MWricI9kc3NiSmLTMVE2KEmwZIXj[ZMhSXCxcITveIlkKEOnbHygSIVifGh? NXLWdlZIOjN|NESwOFU>
Ec109 NFzVeoJCeG:ydH;zbZMhSXO|YYm= NWnJZllvOTEQvF2= MWC2bC=> NGPtW3ljdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? MV6yN|M{QDV4OB?=
H460  NF;sT3ZCeG:ydH;zbZMhSXO|YYm= Ml\DNVDPxE1? Mn\kOog> NHXVeohjdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? NUHtTnpVOjN|M{i1Olg>
HeLa  M2rvUmFxd3C2b4Ppd{BCe3OjeR?= MkT3OVDPxE1? MV2xMlVp M1fQWIFjem:pYYTld:KhS2iuYX35[IliNWmwZIXj[YQh[XCxcITvd4l{ MknwNlM{ODN6MES=
SK-HEP1 MmTHRZBweHSxc3nzJGF{e2G7 NXe0SoR2OTByzszN MnfmNYg> NFfoV2RqdmirYnn0d{BEelRzIHHjeIl3[XSnZDDjZZNx[XOnLUOsJE04NCBvODygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= MYCyN|MxOjZ3MB?=
QGY7701 M1z2NGFxd3C2b4Ppd{BCe3OjeR?= M3WweFI2|ryP NGDzZnkyNjWq M1\tcolvcGmkaYTzJIFk[3WvdXzheIlwdiCxZjDzeYIuTzFicHjhd4UhcW6mdXPl[EBjgSCGT2igL{ByfWW{Y3X0bY4> NVzsZ4NtOjN{NECwOlE>
HepG2 MU\BdI9xfG:|aYOgRZN{[Xl? MkPONlDPxE1? NFrkdGU{OG2rbh?= M3vQWYlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? MnW1NlMzOjR{M{m=
U87  M3P2c2Fxd3C2b4Ppd{BCe3OjeR?= MYKyOe69VQ>? NXSzbWtWOmh? MnfN[IVkemWjc3XzJIl{d2yrcYXpdol1cWenbnnuJEhKW0xrLXnu[JVk\WRiYYDvdJRwfGmlIHPlcIwh\GWjdHisJIJ2fCCwb4SgcoVkem:2aXOgZ4VtdCCmZXH0bC=> NGjoenczOzJ{OU[yOi=>
HSC-2 NX3GW5g2SXCxcITvd4l{KEG|c3H5 NY[4O4c2OjVxNUFOwG0> MoT0NYg> NUn2WHpNcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> NEDo[nMzOzF3NUK0PC=>
HSC-4 NGDMZWhCeG:ydH;zbZMhSXO|YYm= M1fYVFI2NzVyzszN M3n0WFFp MXPpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NVToPY5sOjNzNUWyOFg>
CL-1 M17ERmFxd3C2b4Ppd{BCe3OjeR?= MoLuNlDPxE1? MnG4NYg> MWPicI9kc3NiT2C0OFkhcW6mdXPl[EBk\WyuIHTlZZRp MY[yN|E{OTd6Mh?=
MEL MVPBdI9xfG:|aYOgRZN{[Xl? MlfvNlDPxE1? MVyyOIg> MnvQSG1UVw>? MmPJbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NXPxOFR2OjNyMUS4PFc>
Bel-7402  MV3DZZNx[XOnIFHjeIl3[XSrb36gRZN{[Xl? M3G2VlUx|ryP MWKybC=> NGfFR5VqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ MXWyN|AxQDd2Mh?=
Eca-109 MmfKRZBweHSxc3nzJGF{e2G7 NGHafIszPc7:TR?= NHPpeIo{OG2rbh?= NULqbFg2cW6qaXLpeJMhSkpvQkGxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M{K5SVI{ODd4OU[3
MEL NHrJW3VCeG:ydH;zbZMhSXO|YYm= NUPQOIl7OjEQvF2= NHnsfncycA>? MnjuSG1UVw>? MlrVbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NIfORngzOzBzNEi4Oy=>
Bel-7402  M{jrN2Fxd3C2b4Ppd{BCe3OjeR?= M3:4V|Ux|ryP NV[yOZlzOmh? NIjHflJqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ NUfjb2RvOjNyMEi3OFI>
L929 MlLGSpVv[3Srb36gRZN{[Xl? MXKyMlXPxE1? NVnpb5h6OWh? Ml7JbY5kemWjc3XzJHJKWDFiZYjwdoV{e2mxbjDhcoQh\XijY3XyZoF1\WRiVF7G{tEucW6mdXPl[EBucXSxY3jvcoRzcWGuIHT5d4Z2dmO2aX;uJIFv\CCUT2OgdJJw\HWldHnvci=> M3jKblI{ODByNUG4
RCC  MVrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGPkTWMyODEQvF2= MUKyOIg> NX;tN2oyemWlb4\ldoV{KHSqZTD2bYFjcWyrdImgc4Yh[2WubIOg[Zhxd3OnZDD0c{AyPWRvUFfKNi=> MkX2NlI6QTF2OUS=
NB2a/d1 M1HTOWFxd3C2b4Ppd{BCe3OjeR?= M{nCUlExOM7:TR?= NHnOXpA4Omh? NI\SeW5ifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm M3q3blIzQTh6NUSx
T cell M4DrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFGyO4IzPS1zMEFOwG0> NIDGNYYzPGh? NGDqRpRld3OnLXTldIVv\GWwdHz5JIlvcGmkaYTl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCvZXTpZZRm\CC2aILveYdpKHSqZTDjc{1{fGmvdXzheIlwdiC5aYToJIFvfGlvQ1SzJIFv\CCjboTpMWNFOjh? NF63UoUzOjl6MkWzPC=>
K562 NXHyOIttSXCxcITvd4l{KEG|c3H5 M{Dxc|ExOM7:TR?= NXHlOGR[OWh? MYficI9kc3NiQXLuc4Jifmm|Y4XtxsBHNWmwZIXj[YQh[XCxcITvd4l{ NWKw[YFoOjJ7N{KzO|I>
Jurkat  NInPdmFCeG:ydH;zbZMhSXO|YYm= NGjaSVM1OM7:TR?= MXuxbC=> M4HtfIFjd2yrc3jld{BH[XOOLXnu[JVk\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp NH;yd4QzOjl2MkezPC=>
BGC-823 MlfsRZBweHSxc3nzJGF{e2G7 MljCNVAx|ryP NH:0TWcycA>? M4TWXpBienSrYXzsfUBz\XOldXXzJINmdGy|IHHnZYlve3RiZHHtZYdmKG:oIHThbYR7\Wmw MXWyNlkzPjV2NR?=
Hep3B NX;rUIZXSXCxcITvd4l{KEG|c3H5 M4\zNlUx|ryP NX25OWlyOWh? MVricI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? MV[yNlkzOzF3NB?=
LLC-PK1 MnXWRZBweHSxc3nzJGF{e2G7 MoDoNlDPxE1? NYL6RZdsOWh? M4f2RpBz\X[nboTzJINqe3CuYYTpck1qdmS3Y3XkJIRm\3KjZHH0bY9vKG:oIFH0[|UtKGKnY3zpck0yNCCjbnSgRZRoOTJicILveIVqdnN? MXqyNlg6PjB|Nx?=
A549 M3e5[2Fxd3C2b4Ppd{BCe3OjeR?= M3HYe|Ux|ryP MXyxbC=> M{f2PIJtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= NYTifHZuOjJ6OEeyNVU>
SGC-7901  MWnBdI9xfG:|aYOgRZN{[Xl? MoLiNVDPxE1? MVKyOIg> M3z4fYlvcGmkaYTzJO6zNM7{LXTpcYV1cHmuYXPyfYx{cGmtb37pck1qdmS3Y3XkJIFxd3C2b4Ppd:Kh MmPPNlI5PDh3OUe=
DM6 MYnBdI9xfG:|aYOgRZN{[Xl? NFrDVYIyODEQvF2= NYW4WlA6PzKq MXHicI9kc3NiYn;0bEBGOkZvMTDhcoQhTTKIdIKtcYVlcWG2ZXSgZ5l1d3SxeHnjbZR6 NG\QcFgzOjh{NUOyPC=>
MCF-7, MDA-MB-468, Caco-2 NHHkVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fmSlUx|ryP NGnicYc1QGh? NISye2lqdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBqdmS3Y3XkJIJ6KHOjcH;ubY4> NYTHcYJwOjJ6MEC5Olg>
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A549  NXX3bGgySXCxcITvd4l{KEG|c3H5 NEj1Xpg2OM7:TR?= MX6ybC=> M4n0XJBienSrYXzsfUBl\WO{ZXHz[ZMhe2:maYXtJJNmdGWwaYTlMYlv\HWlZXSgZZBweHSxc3nz MnLwNlI4OjF6MES=
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MCF7 MV\BdI9xfG:|aYOgRZN{[Xl? MWO1NOKh|ryP NWfyUmxPOWh? M4O5e4lvcGmkaYTzJHBCKGGldHn2ZZRm\CClYYPwZZNmNTNuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn NWXVbG5SOjJ{MkOzOFU>
K562 M4q2dGFxd3C2b4Ppd{BCe3OjeR?= M1rucVIxKM7:TdMg NH3iRYE1QGh? NXXWNm9iTE2VTx?= M1LlVIJtd2OtczDsZZBifGmwaXKtbY5lfWOnZDDpcohq[mm2aX;uJI9nKH[rYXLpcIl1gSCjbnSgZZBweHSxc3nzJIlv\HWldHnvci=> M3jtR|IzOjF4MUW4
Molt4-hyg M{\Ne2Fxd3C2b4Ppd{BCe3OjeR?= M3HlOFEx|ryP MlGwNE42cA>? M4PIZYJtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 NGrs[nEzPjJ5NUixNS=>
HeLa NEi4d29CeG:ydH;zbZMhSXO|YYm= MYCxNO69VQ>? NVL1bGJ2OC53aB?= MYTpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1cGViY3;tZolv\WRidILlZZRu\W62IIfpeIgh\2:vaYPpckBPKGGwZDDUVmFKVA>? MXSyNlE4QTZ4MR?=
Jurkat T NVHTSIJpSXCxcITvd4l{KEG|c3H5 NETmeXQ{OM7:TR?= NF[1PIQxNjWq NVWyNlZITE2VTx?= NWO5Tm5l[myxY3vzJJRp\SC8aYLhcU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NEj1OHczOjF3OUi5PC=>
Neutrophil NV3DVmFVSXCxcITvd4l{KEG|c3H5 M4r2ZlIx|ryP NYm2RXc6OC53aB?= NYizbmkx[XS2ZX71ZZRmeyC2aHWgdJJwNWGyb4D0c5Rq[yCnZn\lZ5Qhd2ZiTXHSNS=> MmjVNlYyQTZ6NES=
HCT116 MnnzRZBweHSxc3nzJGF{e2G7 NIjqb|A2OMLizszN M3XPNlJp M3WzTZJmfmW{c3XzJJN6dmW{Z3nzeIlkKGGyb4D0c5NqeyCnZn\lZ5R{KG:oIHPlcIVkd3irYjDhcoQhVlCFLUG2xsA> M1jRN|IzOTV7N{Wy
MDA-MB-231  NUT1W4t1SXCxcITvd4l{KEG|c3H5 NVTHd404Oi53LUeuOe69VQ>? M3O2fFJp NEPCWWhqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ NIr3W5czOjFzNUWyOi=>
LNCaP NXfKbphsSXCxcITvd4l{KEG|c3H5 MVm0NO69VQ>? MmfUNog> NW\PRVQ3cW6qaXLpeJMh[nW2ZXnuJIlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? M3LDOFIzOTF2N{[0
MB231 NV\keY5pSXCxcITvd4l{KEG|c3H5 MUGxNFDPxE1? MnzQNYg> NWTKbmFjTE2VTx?= M1r1dYFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? Mmr5NlIyOTJ7NEC=
HCC38  M{nXZmFxd3C2b4Ppd{BCe3OjeR?= MY[xNFDPxE1? NXX2VVVbOWh? NX3xOYg6TE2VTx?= MYrhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v NUjYXGlrOjJzMUK5OFA>
MDA-MB231 MYHBdI9xfG:|aYOgRZN{[Xl? MW[1NOKh|ryP MX6yOIg> NEnZeY9FVVOR NFyzfI5i[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp M3zoOVIzOTBzM{O1
LNCaP MWfBdI9xfG:|aYOgRZN{[Xl? NEDaNGM2OMLizszN Mn\PNlRp MY\EUXNQ MWXhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M2jRRlIzOTBzM{O1
HCT116 NF\FVVhCeG:ydH;zbZMhSXO|YYm= NF;LZ3c2OMLizszN M3zMVVI1cA>? MWjEUXNQ NGr0d|Ji[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp M3LYZ|IzOTBzM{O1
Ishikawa  NXTzRVJsSXCxcITvd4l{KEG|c3H5 NVOyVXlROjYQvF2= NXO1[Go2OjSq NU\uVlA3emWmdXPld{Bk\WyuIHTlZZRpKGGwZDDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[WZiQUG= MYOyNlA5QDlzOB?=
 YD-8  NGP2PIZCeG:ydH;zbZMhSXO|YYm= NV;IT21NOTByzszN MnHPNYg> NEPUTotqdmirYnn0d{BRVEWRLXnu[JVk\WRiYYDvdJRwe2m| MUiyNlA5PjF6Mx?=
eosinophil  M4j5WmFxd3C2b4Ppd{BCe3OjeR?= Mn7tPVDPxE1? MUmyOIg> M4rUXIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE[jczDhcpRq[m:medMg NITjZ28zOjB5OUOzOC=>
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YD-8  MWrBdI9xfG:|aYOgRZN{[Xl? MnrlNVAx|ryP NV3lU3lLOWh? NILnepBjdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> Mn7mNlIxOjByN{i=
HBx MYfBdI9xfG:|aYOgRZN{[Xl? NH;uUJgzPc7:TR?= NWq3S412PDiq NH:0e2hFVVOR MlvjdoVlfWOnZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhOy2PQR?= M13lZlIzODJyMEe4
U937  NXP6NWpLSXCxcITvd4l{KEG|c3H5 NF;2NGU2OMLizszN MoDUNYg> NUC0Z2NpcW6qaXLpeJMhUEZvaX7keYNm\CCjcH;weI9{cXQEoB?= M2jTfVIyQTl6N{Ox
HL60 NF\DOIVCeG:ydH;zbZMhSXO|YYm= NWTmeHBQPDEQvF2= NUGwc5VwPDCvaX6= NGLvUm9FVVOR Mn:zZoxw[2u|IFLOSGMh[2:vcH;1coR{KGmwZIXj[UBmgHCxc4Xy[UBw\iCyaH;zdIhifGmmeXzz[ZJqdmViYX7kJGRPSSCocnHncYVvfGG2aX;u NG\FO2IzOTl6M{K5Oi=>
M-14 MYLBdI9xfG:|aYOgRZN{[Xl? Mn\ENlXPxE1? MVGwMlVp NI\4UWbDqGmwaHnibZR{KGKxdHigeIhmKGO{dXTlJIV5fHKjY4StJIFv\CClb33wc5Vv\C2rbnT1Z4VlKGGyb4D0c5Nqew>? NVXPNnJvOjF7NUS5OVk>
SK-BR-3 NYrveHl7SXCxcITvd4l{KEG|c3H5 MoHzOVDDqM7:TR?= NYrycXByOmh? Mn3hZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u MmnTNlE6ODF|OE[=
MDA-MB-468 NE[xTWZCeG:ydH;zbZMhSXO|YYm= M3XWNVUxyqEQvF2= MUCybC=> MmXMZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u NUfPUZR2OjF7MEGzPFY>

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • Answer:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • Question 2:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID