Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a M4\yemFxd3C2b4Ppd{BCe3OjeR?= M1HH[|Ux|ryP Ml3LNlRp Mni5bY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NEH5PFAzPjF4OUC3OS=>
HGL5 NWHGe|BnSXCxcITvd4l{KEG|c3H5 NYDJe|ZGPTEQvF2= MViyOIg> NGD4V4dqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? M4D6N|I3OTZ7MEe1
HepG2 M3\VdGFxd3C2b4Ppd{BCe3OjeR?= MnLVNlDPxE1? MWWxbC=> MnXuZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MX[yOlE3PDd7NR?=
BEL-7402 MUDBdI9xfG:|aYOgRZN{[Xl? MlnvNlDPxE1? NXrMfYx{OWh? MmjGZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> NVrBSGxvOjZzNkS3PVU>
CEF MVLLbY5ie2ViQYPzZZk> NI\aO|ExNDN|LE[3MFExOM7:TR?= M16xOFE2dWmw NUDrfG1R\G:5bj3y[Yd2dGG2ZYOgVHIh\W68eX3lJIFkfGm4aYT5JJRwKDRy78{FJIF1KDFyMN88US=> MX:yOlExOjN|OR?=
SP2/0 M1;ON2Fxd3C2b4Ppd{BCe3OjeR?= MXmxNFDPxE1? NGDMe4YycA>? NYHOS5JLTE2VTx?= NVvrU2tV[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> MmLHNlYxPzR5M{K=
HUVEC-2c Mn;tRZBweHSxc3nzJGF{e2G7 NHPpPXQ2OM7:TR?= MoDkOog> M173UoRm[3KnYYPl[EB1cGVib4itUGRNNWmwZIXj[YQh[XW2b4DoZYd6 NEHBbZIzPjB{MUeyPS=>
U1 Mm\TRZBweHSxc3nzJGF{e2G7 MX[wMVExOM7:TR?= NFzYXIczcA>? NGHhZZpz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M1nFeFI2QThyOUSy
ACH-2 M2TS[WFxd3C2b4Ppd{BCe3OjeR?= M1Poe|AuOjByzszN NYS1N5ZOOmh? M{PUXJJm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NYPxclFxOjV7OEC5OFI>
U1 MYXLbY5ie2ViQYPzZZk> M4XyTlExOM7:TR?= NHroPIUzcA>? NVO4VpJLcW6qaXLpeJMh[2G|cHHz[U0{ NXnlUWdMOjV7OEC5OFI>
A549/V16 NGD2S2RCeG:ydH;zbZMhSXO|YYm= NIjrNpQ2OM7:TR?= MVexbC=> MYny[ZBz\XO|ZYOgWGcwXE1vaX7keYNm\CCjcH;weI9{cXN? MljDNlU6PDZyM{O=
SGN NIK0eppCeG:ydH;zbZMhSXO|YYm= MUGyNI1O NHTRbZA1QGh? MkPjbIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= NGXlWVgzPTh5NE[zNy=>
HCT116  NX\kUIZySXCxcITvd4l{KEG|c3H5 NGrMUm02OM7:TR?= M{XvZVJp NGC4ZWxqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JGRFXlB? MWqyOVg3QDhzOB?=
DTK-SME MX7BdI9xfG:|aYOgRZN{[Xl? MmrLOVDPxE1? NIDIZY0zcA>? NX31S2d6TE2VTx?= MWDwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHL1dIl3[WOjaX7l MUGyOVg1Ozh7Nx?=
HL-60 M2XTfWFxd3C2b4Ppd{BCe3OjeR?= M2Ph[FUx|ryP MYO0PIg> NV;j[oR4emWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? M{DwOFI2QDJ2MESz
U937 MWnBdI9xfG:|aYOgRZN{[Xl? MnfQOVDPxE1? MXe0PIg> MmX2doVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> NF\VWI0zPTh{NEC0Ny=>
A549 MXPBdI9xfG:|aYOgRZN{[Xl? MorONlAh|ryP NVjJcnhXOjSq M17vSpJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= NFPoVoEzPTd7NEG0PS=>
HeLa NFi3PIxCeG:ydH;zbZMhSXO|YYm= MWexNO69VQ>? NXfzfHBWPDiq MXHk[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 NX\uZWxwOjV5N{K1OFU>
SGC-7901 MXfBdI9xfG:|aYOgRZN{[Xl? NVrKUI91OjEEoN88US=> M1jUVlFp NFK0cG5qdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JI95[WyrcHzheIlv MkToNlU4PjdyN{[=
MCF-7 MmrRRZBweHSxc3nzJGF{e2G7 NH\wTXQyOM7:TR?= M2D0UlJp M3WzUYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgN2I> Mo\wNlU4OjJzMUS=
A549 MWTBdI9xfG:|aYOgRZN{[Xl? MYWxNEDPxE1? M1GxTVI1cA>? M4LT[WROW09? M{XDZ5Bzd22xdHXzJGhDSy22cnXheIVlKEF3NEmgZ4VtdCC|dYL2bZZidCBoIHH0eIVvfWG2ZYOgeIhmKGOuZXH2[YQhWEGUUDDlfJBz\XO|aX;u M36zTlI2Pjh|NU[4
U87 NFzY[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUC1NO69VQ>? NHPxU|YycA>? NIPRSFhz\WOxdnXyd{Bk\WyuIHfyc5d1cCCocn;tJHROYiC2cnXheI1mdnR? NFjvfogzPTZ6MU[2PC=>
Neocortical Neuron M4HlSW5mfXKxdH;4bYNqfHliQYPzZZk> M3HueVExOM7:TR?= NFv3V3kycA>? MoLoZY51[Wexbnn6[ZMhUG:rYX3p[IUhSS2LbnT1Z4VlKE6ndYLveI95cWOrdIm= NIPkWpAzPTZ5NUCwNS=>
Primary human placental cytotrophoblasts M1H0NGFxd3C2b4Ppd{BCe3OjeR?= NYHT[odVOzEQvF2= NUe1ZlM1OjSq M13SW2ROW09? M4m3TJJmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= NEjhUI8zPTZ2MkW5Ni=>
MM MVnBdI9xfG:|aYOgRZN{[Xl? NWDTb4tQPTEQvF2= NUC5UXRrOjCvaX6= NGfXPWVx[XK2bImgbY5pcWKrdIOgV2hMNWmwZIXj[YQhKGOnbHyg[IVifGh? Mn74NlU2OzByOUi=
DLD1 MYjBdI9xfG:|aYOgRZN{[Xl? M3fYelIxyqEQvF2= M4rVNlFp MV3wZZJ1dHlicnX2[ZJ{\XNiY3XscEBieG:ydH;zbZMh[2G3c3XkJIJ6KFeVUEG= MXOyOVUzPDJ2Nh?=
MDA-MB-231 NYH2OnpVS3m2b4TvfIlkcXS7IFHzd4F6 MX[xNO69VQ>? MojINYg> NIHnb5RifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 NH3LOm0zPTV{MUWwNS=>
MKN28 M{jROmFxd3C2b4Ppd{BCe3OjeR?= NHy2XYsyOM7:TR?= MmToN|BucW5? M{mwR2ROW09? MkjxbY5pcWKrdIOgWG5HNc7zIIDseZMhS0i[LXnu[JVk\WRiYYDvdJRwe2m| MYmyOVUyOzl4MB?=
HL-60 MluwR5l1d3SxeHnjbZR6KEG|c3H5 NUPFfGwzOTByzszN MX2xbC=> MUXEUXNQ NIq5S5fDqGmvcILveoV{KH[rYXLpcIl1gSCxZjDUR25Cey22cnXheIVlKGOnbHzz M{H6OFI2PTB{OUOy
AGS MnLqRZBweHSxc3nzJGF{e2G7 NEL6NlQyOM7:TR?= NVLuVHNCOWh? MY\wdoV3\W62czDjeZJkfW2rbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3WtN{whNThuIHHu[EAuQSCycn;0[Ylvew>? M1W5NFI2PDl{MkG0
A549  M2HQTGFxd3C2b4Ppd{BCe3OjeR?= NYKyO5BMOTEQvF2= MUCyOIg> MVXicI9kc3NiRF3BV{1qdmS3Y3XkJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCjbnSgZZBweHSxdHnjJINmdGxiZHXheIg> MmDDNlU1OzR7OEm=
INS-1 NVH0O4JuSXCxcITvd4l{KEG|c3H5 M2K5WFUx|ryP NETic|M3cA>? MUTEUXNQ NIrXUmZl\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh\WG{bImgZZBweHSxdHnjJINmdGy|wrC= M4DjWlI2PDNyOEm3
Primary hepatocytes  MVjBdI9xfG:|aYOgRZN{[Xl? MVy1NO69VQ>? NYG4PZpCOTiq MUnpcohq[mm2czDhdI9xfG:|aYOgc4YhcGWyYYTvZ5l1\XNiaX7keYNm\CCkeTDBZ5QhTCCjbnSgWG5HNc7z M{nBT|I2PDB5NUO4
L929-A  NILvcY1EgXSxdH;4bYNqfHliQYPzZZk> NFX4bXQzOMLizszN NVntR4V3OjSq MkjQbY5pcWKrdIOgWG5H|rFvaX7keYNm\CClZXzsJIRm[XSq MUWyOVM6QDV2MB?=
L929-N Mnn0R5l1d3SxeHnjbZR6KEG|c3H5 M1z2NFIxyqEQvF2= MkLnNlRp Mof5[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u M1rPW|I2Ozl6NUSw
Cytotoxicity Assay MWTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MYWyNO69VQ>? MnrZOFhp MlHqdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? MWCyOVM6OjFzNh?=
COS7 NEfxO21McW6jc3WgRZN{[Xl? MnfGNVDPxE1? NYnVPFFKOjSq MWTpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? MnfFNlU{QDRyMkW=
COS7 NISxc3dCeG:ydH;zbZMhSXO|YYm= MVSxNO69VQ>? MUG0PIg> M1;COJBienSrYXzsfUBxemW4ZX70[YQhTkNzMEGtbY5lfWOnZDDj[YxtKGSnYYTo MWCyOVM5PDB{NR?=
A375 NVjoPFNUSXCxcITvd4l{KEG|c3H5 NHH2PWI{OM7:TR?= NIm3VI4zcA>? M{HK[JBz\X[nboTzJJRp\SCmcoXnMYlv\HWlZXSgVGFTWCClbHXheoFo\Q>? NGnqNZkzPTN5NkGxOS=>
A549 M4L2UWFxd3C2b4Ppd{BCe3OjeR?= MlTDOVDPxE1? NW\1eGVMOjSq M3LibJJmfmW{c3XzJJJq[m:|b33lJIJqd2enbnXzbZMh[W6mIHHwc5B1d3OrczDjZZV{\WRiYomgJGNpcWqxbnfkZY4> Mn:0NlU{PDl5OEG=
A549 NHnxR21CeG:ydH;zbZMhSXO|YYm= MkjaNk42NTJ3zszN MoDxNYg> Mn7n[IVkemWjc3XzJJRp\SCyb4D1cIF1cW:wIH;mJIFxd3C2b4TpZ{Bk\WyuczDk[ZBmdmRib36gZ49v[2WwdILheIlwdnN? NFjlbWozPTN2MkSyOy=>
 NBL-W-S  MnLtRZBweHSxc3nzJGF{e2G7 MXS1NO69VQ>? NHyzdGgycA>? MkK4[pVtdHlicnXzZ5VmeyClZXzsJJZq[WKrbHn0fUBi\nSncjDHRW5VNTZzIITy[YF1dWWwdB?= M3PhdFI2OzJ|MkKy
Caki-1  NXjHXoVJSXCxcITvd4l{KEG|c3H5 NXf5T4FkPDEQvF2= MX:0PIg> M4D4RZJm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> NUHXbFNiOjV{N{mxPVE>
769-P NVvTWYlkSXCxcITvd4l{KEG|c3H5 MUi0NO69VQ>? M1rOfFQ5cA>? NXva[mlJemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? M1\LWlI2Ojd7MUmx
H9c2 NX7pNVEySXCxcITvd4l{KEG|c3H5 MnzNOVDPxE1? M2Hj[FFp Mn\mbY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? MlPkNlUzQDN6MUm=
K562 NIPLbGNCeG:ydH;zbZMhSXO|YYm= NIHXeZM2OM7:TR?= NFvYOnQ1cA>? M1H5RYlvcGmkaYTzJGpi[y2DLXnu[JVk\WRiY3XscEBieG:ydH;zbZM> M1PDTVI2OjRzNkG5
L929 NEfNOFhCeG:ydH;zbZMhSXO|YYm= MWexNO69VQ>? M2PGRlZp NUjSOlhucW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? MXyyOVE6PTZ4MB?=
A549 NF6xeIdCeG:ydH;zbZMhSXO|YYm= M{[ySFEx|ryP NX[yW|A4O2h? MYLy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= MXKyOVE3OTZ7OR?=
MCF-7 MYDBdI9xfG:|aYOgRZN{[Xl? M3rKR|Ix|ryP M2K4TlJp Mmfn[IVkemWjc3XzJGtFWi2|aWLORU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MlqzNlUyQDJ{NEC=
OS MVHBdI9xfG:|aYOgRZN{[Xl? MV2yNE81OM7:TR?= NFHuW|k4Omh? NYDDdWQzcW6qaXLpeJMhV1NiY3XscEB3cWGkaXzpeJkhemWmdXP0bY9vKGK7IFO2JINmemGvaXTl M3XXPFI2OTV{M{m5
HUVECs MV3BdI9xfG:|aYOgRZN{[Xl? NUDkXWFIOTEQvF2= MkLVNog> NVzwcIo1yqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCKVW\FR5M> MYSyOVE{QDdyMx?=
EA.hy926 MVnBdI9xfG:|aYOgRZN{[Xl? M2LOclEx|ryP MYSybC=> NV\jfGdEyqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCHQT7ofVkzPg>? MYmyOVE{QDdyMx?=
Ebs M1zSTWFxd3C2b4Ppd{BCe3OjeR?= MkHoNVAuOTByzszN MUiyOIg> MVJCpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl MXWyOVE{PDhzNx?=
Jurkat M2ryRmFxd3C2b4Ppd{BCe3OjeR?= Mn[0NlDPxE1? MX6yOIg> NYrKXXJzTE2VTx?= NEXY[2px[XK2aXHscJkhcW6qaXLpeEBk\WyuIHTlZZRpKG:oIFr1dotifCClZXzsd{BqdmS3Y3XkJIJ6KDFyMEW4MWY1KGOxbXLpcoVlKHerdHigWnBCyqB? Mn3DNlUyOjB5MkO=
K562 MoftRZBweHSxc3nzJGF{e2G7 NXfVdZB5OC5zLUJOwG0> NIq0bG8ycA>? Mlf6bY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= M{TINlI2OTF7MUi4
IMR-32 NH[xb2JCeG:ydH;zbZMhSXO|YYm= NF;JXI01OMLizszNxsA> NHzqS3IzcA>? NXzxcYd1\GWlcnXhd4UhcW5iYYDvdJRwfGmlIHPlcIx{KGOxbYDhdoVlKHSxIGStNkB1d3irbh?= NHHtdo8zPTB6NEe1OS=>
RPMI 8226 MYDBdI9xfG:|aYOgRZN{[Xl? M4DBO|ExOM7:TR?= MnfONYg> M4TtRYFtdW:|dDDjc41xdGW2ZXz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z Moj5NlUxOzd6NUG=
U266  MVfBdI9xfG:|aYOgRZN{[Xl? NWXwTFZ[OTByzszN NXLJUFRpOWh? MYnwZZJ1cWGubImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? M2fITVI2ODN5OEWx
H929  NFP5U|dCeG:ydH;zbZMhSXO|YYm= MlfONVAx|ryP MXexbC=> MkTOdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NYrmV5FnOjVyM{e4OVE>
MM.1S  Mn;oRZBweHSxc3nzJGF{e2G7 MVmxNFDPxE1? MV[xbC=> NFXDV|Zm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z MlLCNlUxOzd6NUG=
C6 M4TGeWFxd3C2b4Ppd{BCe3OjeR?= Mnf2OVDPxE1? NUfHNphxPDiq M3H6SJBz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? MVSyOVAyOzR5OR?=
AGS NYftT4pZSXCxcITvd4l{KEG|c3H5 NWr5TppLPTEQvF2= Mm[5NlRp M{XEPIFjd2yrc3jzJO6zNWyjcHHjbI9v\S2rbnT1Z4VlKGOnbHyg[IVifGhiYX7kJIlvcGmkaYTl[EBoem:5dHi= NGT4b|czPTByOU[5PC=>
HeLa  M1f4RmFxd3C2b4Ppd{BCe3OjeR?= M{DLfFQx|ryP NHvYNJozPGh? M4TjXolvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= MWWyOFkzQDZ6NR?=
THP-1  NXXRcXBySXCxcITvd4l{KEG|c3H5 MWCxNO69VQ>? MYWxbC=> NWHlToRYemWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCDTFGtV2RVyqB? M4WweVI1QTJ|NkWz
P815  NHvJ[pZCeG:ydH;zbZMhSXO|YYm= NWjSd29QOTByINM1US=> M3jYZVEzcA>? M3uyXmROW09? MVfpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? MYOyOFkzOzJ5Mx?=
HCT116 NX2yO4M3SXCxcITvd4l{KEG|c3H5 MnzaNlDPxE1? MVOyOIg> MVLhZpJw\2G2ZYOgc4YhXFFvaX7keYNm\CCjcH;weI9{cQ>? NEH5eoQzPDh7MES0PS=>
SW1116  NH72[4JCeG:ydH;zbZMhSXO|YYm= MYmxNEDDvU1? NF3WT3AycA>? NHzkcWlFVVOR MU\y[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n M2flbFI1QDd2Mki2
LOVO MUTBdI9xfG:|aYOgRZN{[Xl? MXKxNEDDvU1? Mlq3NYg> NWrxVlNvTE2VTx?= MVny[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n MXuyOFg4PDJ6Nh?=
SNU449  MkD2RZBweHSxc3nzJGF{e2G7 MUiyNO69VQ>? NXLBcpVjPDiq NFrhdG9FVVOR NIjCTpVl\WO{ZXHz[ZMhdWmULUS1NU1qdmS3Y3XkJIFxd3C2b4TpZy=> MkP5NlQ5PDF4M{i=
Caco-2 NF;1XJlCeG:ydH;zbZMhSXO|YYm= NYW4U3JOPDEkgJpOwG0> M4DWfFRp NHX3XlBxemW4ZX70d{BUXC15LXnu[JVk\WRiWl:tNUBkcGGwZ3XzJIFv\CCWRWKg[JJweA>? NVfpbVhZOjR6MkKxPFM>
macrophage M4TYRWNmdGxiVnnhZoltcXS7IFHzd4F6 MlfTNE0zODEQvF2= MnjyNlRp NEPSbYNqdmS3Y3XzJHRPTi1iYX7kJHJqeDNvZHXw[Y5l\W62IH7lZ5JweHSxc3nzJIlvKG2jY4LvdIhi\2V? NXG4WGt6OjR5OUm1OlU>
AGS  MYjBdI9xfG:|aYOgRZN{[Xl? MVSyNO69VQ>? MoDONVJp MkX1SG1UVw>? MW\y[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? Mo\jNlQ4QDl5MEO=
LCC9  NGPzc45E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NHPGOGMyODEQvF2= NW\GfWwxPWR? NVS0ZZI{[myxY3vzJINmdGxiZHXheIghcW6mdXPl[EBjgSClb33ibY5ifGmxbjDMNVch[W6mIHPocI9zd3G3aX7l MUKyOFc5PTJ3Nh?=
U937  MXvu[YNzd3C2b4Ppd{BCe3OjeR?= M33uSFExyqEQvF2= MY[zNOKhdWmw NV;jPHUxcW6mdXPld{Bv\WO{b4D0c5NqeyClb33ibY5mKHerdHigWG5H NF:zeWQzPDd5M{e1Oi=>
T cell NYK2Z2JsS2WubDDwdo9tcW[ncnH0bY9vKGG|c3H5 MoDiNE0yODEQvF2= NXW1XnBKPzKq NH;obZhKSzVyPUewJO69VSxiaX7obYJqfHNiYX70bU1ETDNvaX7keYNm\CCWIHPlcIwheHKxbHnm[ZJifGmxbjDpckBRSk2Fcx?= MlnxNlQ4Pjh5MEe=
HeLa  NW\JXVhxSXCxcITvd4l{KEG|c3H5 NYC4UZNJPTEQvF2= MnrLO|Jp M{C4b2ROW09? MnHhdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2:vcH;1coR{yqBz4pETOS=> MkXiNlQ4PTR5OE[=
HeLa  MnHlRZBweHSxc3nzJGF{e2G7 MUSxNFDPxE1? MXWyOIg> MnOxd5VxeHKnc4Pld{Bz[XSnIH;mJINmdGxiZHXheIghcW6mdXPl[EBjgSCxdnXy[ZhxemW|c3nvckBw\iCJNUnTJI9zKEd5MWKgdFE2OGeudXXkxsA> NGTBWYQzPDd{MkS2PC=>
IEC-6  M33zXGFxd3C2b4Ppd{BCe3OjeR?= NHTNbJcyOM7:TR?= NF;0b2MzPGh? NH;Oc3lxemW4ZX70d{BV[2SDLXnu[JVk\WRiY3HzdIF{\S1|IHPs[YF3[WenIHHu[EDPui2lYYTlcolvKGSnZ4Lh[IF1cW:w M4LJ[lI1PzFzNUex
HCT116 M{fmPWFxd3C2b4Ppd{BCe3OjeR?= MVeyNO69VQ>? NWDHbZp7OjSq NVTXdnVNcW6qaXLpeJMhfGinIHPlcIwh[XCxcITveIlkKGmwZIXj[YQh[nliWVzUNlA2 M{DJ[VI1PzF|OEGy
L02 MVTBdI9xfG:|aYOgRZN{[Xl? NEnqNlMzOM7:TR?= MoDjNYg> NYjqWG5veHKndnXueJMhfGinIHPlcIwh[XCxcITvd4l{KGmwZIXj[YQh[nliTVXIVC=> NFn3Z2wzPDdyNkS2NS=>
A375 MYPBdI9xfG:|aYOgRZN{[Xl? MnnINlDPxE1? NEDWSoczPGh? M4fwRpJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? NYDvZY4yOjR4OUmxNVE>
HDPC MWHBdI9xfG:|aYOgRZN{[Xl? MnLtOVDDvU1? M1G0cVI1cA>? MXnpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> NIDob3IzPDZ|NEW5Ny=>
A549 NEXs[FlCeG:ydH;zbZMhSXO|YYm= NGnPd4k2OML3TR?= MojYNog> NFLzbFNFVVOR MY\wdoV3\W62czD0bIUhcHmyb3TpdIxwcWRiRF7BJINwdnSnboSgdIhie2ViaX7keYNm\CCkeTDj[ZBp[WyxY3jyc41qdg>? MnnUNlQ2QDhzM{W=
 BV-2 NHPF[2dCeG:ydH;zbZMhSXO|YYm= MlvLNlDPxE1? MV6ybC=> MmHFd5VxeHKnc4Pld{BWXi2rbnT1Z4VlKGOqcn;tZZRqdiCneITyeZNqd25iYX7kJIRqdGG2aX;uJI9nKHSqZTDueYNt\WG{IHXueoVtd3Cn NF;hZXMzPDV3OEGxPC=>
HT-29  MlL5RZBweHSxc3nzJGF{e2G7 M2[0UlUx|ryP NWDNc4QxPDiq NVTkZXRW[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s MXOyOFU1QTF5NR?=
A549 M4\VZWFxd3C2b4Ppd{BCe3OjeR?= NVOxTZhiPc7:TR?= M{C0N|I1cA>? M2fXT5N2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg Ml3GNlQ2Ojl6N{G=
MIA-PaCa-2 M2XO[2Fxd3C2b4Ppd{BCe3OjeR?= MknHNlRp NGG4R49jdG:la4OgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGmwZIXj[YQh[nliYn;0bEBCNTR2M{[1OEBidmRicHHjcIl1[XinbB?= NYDFNoxWOjR3MUC5PVI>
Caki-1 NISwOphCeG:ydH;zbZMhSXO|YYm= MkHKNlDPxE1? MYexbC=> NYLvfZFVcW6qaXLpeJMhW0OSLXnu[JVk\WRiYYDvdJRwe2m| NH23c4czPDVyNE[4NS=>
CLL M3Lve2Fxd3C2b4Ppd{BCe3OjeR?= NWnLeJFGOjYQvF2= NXjKTYt{OWh? MYPwZZJ1cWGubImgZoxw[2u|IF3MUlIzOzhvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> M1;uOlI1PDZ5NkO0
SGC-7901 MVzBdI9xfG:|aYOgRZN{[Xl? NVr2PFVQOTEQvF2= NH7ycWQzPGh? M1XkU5Bzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? M2nn[VI1PDV2NEi4
k1735 NYf3c2xLSXCxcITvd4l{KEG|c3H5 M{\JUVIx6oDLzszt MVy0bC=> MVPpcohq[mm2c9MgV4FtdW:wZXzsZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> Ml7kNlQ1PTFzMU[=
HaCaT  M1rO[GFxd3C2b4Ppd{BCe3OjeR?= NInXdosyODEQvF2= M2LFPFFp MUXicJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| NW[5WI9jOjR|NU[5PVc>
podocytes NHLwPXdCeG:ydH;zbZMhSXO|YYm= NHjz[5AzODEQvF2= MYS2bC=> NXLsPXVncW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? NX\RT242OjR|M{e3O|c>
 KB NXzpcmh[SXCxcITvd4l{KEG|c3H5 MkDYOVDPxE1? NV3yVIZDOjSq MkHDbY5pcWKrdIOgUIlkdy2DLXnu[JVk\WRiY3HzdIF{\S1|IHHu[EBRSVKSIHHjeIl3[XSrb36= M334RVI1OzN5NEmy
 HepG2  NY\NPJlpSXCxcITvd4l{KEG|c3H5 NHuy[WgyOM7:TR?= M3z3dFI1cA>? M4HDO5Jm\HWlZYOgeolu\W62aX6gZ4xm[X[jZ3WgZ4F2e2WmIHL5JGxRWw>? NIDXXYozPDN{NUixOi=>
fetal rat lung fibroblasts  NFzt[Y9McW6jc3WgRZN{[Xl? NWrGRZNOQDEQvF5CpC=> MmHVNYg> MofubY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> MXiyOFMyPDF|NR?=
PDL fibroblasts MmPtT4lv[XOnIFHzd4F6 NWC5dYx5QDEQvF5CpC=> MYKxbC=> M{fDcolvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh NIrocmczPDNzNEGzOS=>
MB49 M2TKRmFxd3C2b4Ppd{BCe3OjeR?= MkW3NlDPxE1? NU\zRVhPOWh? NV7GUY1PemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq M3rZZVI1Ojh{NEOz
5637 M3LldmFxd3C2b4Ppd{BCe3OjeR?= MVWyNO69VQ>? MkHONYg> M4C5RZJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? NHjlTowzPDJ6MkSzNy=>
A549  MmT0RZBweHSxc3nzJGF{e2G7 M3j2dVExOM7:TR?= Ml33OFhp NX\oZYFke3WycILld5NmeyC2aHWgZZBweHSxc3nzJINifXOnZDDifUBxcXCncnnu[eKh NIixc44zPDJ5MkKwNS=>
MCC-2 MV\BdI9xfG:|aYOgRZN{[Xl? M2jxcFIxKM7:TR?= MlPZOog> NVTBco1vTE2VTx?= MW\icI9kc3NiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5mKGGyb4D0c5NqeyClZXzsJIRm[XSq NGjOVWMzPDJ4Mk[1PC=>
ADF NFHO[YFCeG:ydH;zbZMhSXO|YYm= Ml7ROFDPxE1? MoPxOog> NUXaTFA1cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> MlHrNlQzOjh{M{K=
 U373  MoG2RZBweHSxc3nzJGF{e2G7 NHWwbFE1OM7:TR?= MlPJOog> MortbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MVeyOFIzQDJ|Mh?=
RKO-HIPK2i NVLMNpNkSXCxcITvd4l{KEG|c3H5 NX3ReVhXPDEQvF2= MUe2bC=> NFnU[ZRqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NXXCWnc6OjR{MkiyN|I>
HEC-1B M2HuS2Fxd3C2b4Ppd{BCe3OjeR?= M3XOWFIx|ryP MVqxbC=> NUPTdWJ4emWmdXPld{BVWC2rbnT1Z4VlKGGyb4D0c5Nqe8LiY3HzdIF{\S1|IHHu[EBk[XOyYYPlMVk> MYOyOFIyOzN3OB?=
4T1 MkLhR4VtdCCYaXHibYxqfHliQYPzZZk> M2Xv[|IvPS1zMN88US=> NYezc3FCPGh? MV3EUXNQ M1HicZJme2O3ZYOgeIhmKGO7dH;0c5hq[2m2eTDv[kA1XDFiY3XscJMhcW6mdXPl[EBjgSCVUFTUJIlvKGFiY3;uZ4VvfHKjdHnvckBl\XCnbnTlcpQhdWGwbnXy NV\5OopiOjR{ME[xOlE>
OS  MYnBdI9xfG:|aYOgRZN{[Xl? M3jveVIx|ryP MlTaOIg> MWjpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliUFTU NHmy[YUzPDJyNEmzOy=>
RPE M3u5fGFxd3C2b4Ppd{BCe3OjeR?= NV7zdlZSOTByzszN MXu0PIg> MonRdIFzfGmjbHz5JIlvcGmkaYTzJJRp\SClYXzwZYlvNTFiYX7kJE0zKGGldHn2ZZRqd25iYYOge4VtdCCjczD0bIUh[2G|cHHz[UBi[3SrdnH0bY9v NFX0eXozPDJyMkC1Ni=>
UD29a NEHyfJJCeG:ydH;zbZMhSXO|YYm= NUTLN44zPTEQvF2= M1\WbFI1cA>? Ml7QbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> NGPSdFYzPDF7MEW3OC=>
SH-SY5Y  MnHMRZBweHSxc3nzJGF{e2G7 M1LsSFEx|ryP MXSyOIg> M3LuN4F1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> NWX5fnA6OjRzNEW0OlM>
HeLa  NInGN5RCeG:ydH;zbZMhSXO|YYm= M2PVdlExNzJyzszN NF;nU2MzPGh? NXzoWmR5cW6qaXLpeJMhfGinIHHjeIl3cXS7IH;mJJRp\SCvYXrvdol1gSCxZjD0bIUhdWWvYnXyd{Bw\iC2aHWgZ4F{eGG|ZT3mZY1qdHl? NEjTV4wzPDF|N{K2Oi=>
SCCVII  M1zqO2Fxd3C2b4Ppd{BCe3OjeR?= MVSyOe69VQ>? MWexbC=> Mn7VbY5pcWKrdIOgeIhmKGOnbHygb4ltdGmwZzDh[pRmeiCmYYPheIlvcWJ? NYG3dGhWOjRzMk[0OlQ>
RAW 264.7 NFewRVVCeG:ydH;zbZMhSXO|YYm= Mn7kNlDPxE1? M1;6dFE5cA>? M3G0Wolv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? NHPCfHEzPDFzNkewOy=>
A549  MoDwRZBweHSxc3nzJGF{e2G7 MnHxNk42|ryP NICzNokzPGh? NIDCNoRl\WO{ZXHz[ZMhd3KrZH;ubY4ucW6mdXPl[EBifXSxcHjh[5kh[XNid3XscEBidmRiTH;zd{Bw\iEQlN-IcUBidHOxIH;jZ5VzemWmIHT1dolv\yCjdYTvdIhi\2mlIIDyc4Nme3N? M1ryb|I1OTB{NUKy
UM-SCC-10A  M4HkbGFxd3C2b4Ppd{BCe3OjeR?= MlvWOVDDvU1? M2XZTFJp NWDl[FZxemWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCqaXfoMYRwe2ViaYPvZYxidnSxbHHjeI9v\Q>? M4Pmc|I1ODl6N{Wz
BGC-823 MlviRZBweHSxc3nzJGF{e2G7 M{jzVlExKM7:TR?= NGO4ZZkzPGh? NXj5[3lVemWmdXPld{B1\XS{YX7kdolv\S2rbnT1Z4VlKGGyb4D0c5Nqe8Li M3\YblI1ODl6NUGx
Nalm-6  MX;BdI9xfG:|aYOgRZN{[Xl? M3vFN|Ix|ryP NYrCdml{PGh? NEnQNGxqdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> MWqyOFA{QTl4Nx?=
KHOS  MXXBdI9xfG:|aYOgRZN{[Xl? MV20NO69VQ>? NX\BOnBjOjSq MVPicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li M4H3OFI1ODJ3M{[x
G292 MYnBdI9xfG:|aYOgRZN{[Xl? NYX3dpk{PDEQvF2= NHX2V3YzPGh? M1i5S4Jtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MmPQNlQxOjV|NkG=
MG-63 NIT4eHZCeG:ydH;zbZMhSXO|YYm= MlHuOFDPxE1? M2[1NlI1cA>? MV\icI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li NETpRm8zPDB{NUO2NS=>
EBV-transformed B cells MoPsRZBweHSxc3nzJGF{e2G7 MnX2NlDPxE1? M3HpU|Jp MWLEUXNQ MWHicI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> MW[yOFAxQDZ{OB?=
IM-9 B NFH5PIVCeG:ydH;zbZMhSXO|YYm= NVXmVoNyOjEQvF2= NGTKNXgzcA>? NGCxVYdFVVOR MnPGZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ MViyOFAxQDZ{OB?=
CNE1 NInmeWNCeG:ydH;zbZMhSXO|YYm= M3HlZ|Ix|ryP M4L0[VQ5cA>? NWiwWVQ1[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? NWe1b|hGOjN7OEWwNlk>
CNE2 NInDSppCeG:ydH;zbZMhSXO|YYm= M{PqTFIx|ryP NFzPW2Y1QGh? M{PQd4Jtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ NX7oN5lMOjN7OEWwNlk>
HL-60 MXjBdI9xfG:|aYOgRZN{[Xl? MVK1NOK2VQ>? NEPOdJkycA>? NX;vOnN3TE2VTx?= M{TNbIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKDMUS1 MXGyN|k1QDd3MR?=
L929 MmS1RZBweHSxc3nzJGF{e2G7 NXyyZZA4OS5{NfMAl|XDqM7:TdMg M2DhZlI1cA>? MmLCZZVodWWwdIOgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 NX23b3NuOjN7NEG3Olk>
Jurkat M1HxOWNmdGxiVnnhZoltcXS7IFHzd4F6 MlH6Nu69VQ>? NXPHT49PPGh? MlnmdoV3\XK|ZYOg[5Jwf3SqIHnubIljcXSrb36gZY5lKM7{LXPheIVvcW5iZHXjdoVie2ViYomgTHMuSVOD NGjzU2YzOzh7NkC2NS=>
RAW264.7  M4PJbmFxd3C2b4Ppd{BCe3OjeR?= MnW3NVAh|ryP MYmyOIg> Mkmz[IVkemWjc3XzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDHRS=> NF7IN2czOzh{MEKwNy=>
A431  NGGxWWJMcW6jc3WgRZN{[Xl? NFrNSGY1OM7:TR?= M4O5N|Jp NHizWY1jdG:la4Og[ol{\XSrbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3XzJIFv\CCSQWLQ M1rTV|I{QDByMEW4
Jurkat NIT5dpBE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGTZO4QzPS1zMEFOwG0> MV:2bC=> MkjVbY5pcWKrdIOgfk1HSS2FTVutbY5lfWOnZDDj[YxtKGSnYYTo M4DZS|I{QTN|NUOy
COS-7  NGH3UopHfW6ldHnvckBCe3OjeR?= M37ERlUxyrWP M1\ubVI1cA>? MUfh[oZm[3S|IITo[UBxem:lZYPzbY5oKG:oIFHUUlF{KHerdHigdI9tgVFidILhZ5R{ M3qzfVI{QTN|MkC4
CAL27 M2e2UmFxd3C2b4Ppd{BCe3OjeR?= NID1VFYyOCEQvF2= NYTGWoIzOmh? MofDd5VxeHKnc4Pld{BEfXJvTmDzMZJm\HWlZXSgeoli[mmuaYT5JIJ6KHWyIITvJFkxLQ>? NGLOV3YzOzlzN{O5Oi=>
THP-1  NEf3VG5CeG:ydH;zbZMhSXO|YYm= MYSxNE02OM7:TR?= MV2ybC=> NUTPT3lZcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= MYmyN|kxODJ7OR?=
K562 Mn;tRZBweHSxc3nzJGF{e2G7 NG\uTlczOM7:TR?= MVG0PIg> M1\aNolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDRvTWW= MmDmNlM5PzZ6Mk[=
HL-60 NWDsepNRSXCxcITvd4l{KEG|c3H5 MXmxNFDPxE1? MXWyOIg> M{HoXIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGGkaXX0ZY5mKGSrdHXydIVv\XQEoB?= MojGNlM5PjV5N{i=
HeLa  NVvVemk4SXCxcITvd4l{KEG|c3H5 MWeyNO69VQ>? Mn;kNog> MmnobY5pcWKrdIOgSG1OWCCrbnT1Z4VlKGGyb4D0c5Nqew>? NXTRNpk{OjN6NkO5OlY>
U251 MV\BdI9xfG:|aYOgRZN{[Xl? M3vDVVIx|ryP NFmyb20zPGh? MonTbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ MkP4NlM5OTZ6MU[=
HL-60 MmnzRZBweHSxc3nzJGF{e2G7 MmX4OVDDvU1? Ml3NOIg> MYjicI9kc3NidHjlJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUmsJIFv\CCSQWLQJIlv\HWlZXSgZpkhPnN? NUDLOZo6OjN6MES3NFY>
Ec-109 NWjTUmhmSXCxcITvd4l{KEG|c3H5 M130XlExKM7:TR?= MnLMOFhp MUny[ZBz\XO|ZYOgVGUudWWmaXH0[YQhTWNvMUC5JINmdGxiYYDvdJRwe2m| M1LaZVI{Pzh{NkSx
RKO MWXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NHfEOW0yOCEQvF2= NYLnfpB1OjSq MX3pcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= MYGyN|c2QDB4NB?=
T98G MmnDR4VtdCCYaXHibYxqfHliQYPzZZk> MmHJNU0yODEQvF2= M3zLcVI1cA>? NF[0cmJqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT MXOyN|c3QTJ5NR?=
Jurkat MnL3R4VtdCCYaXHibYxqfHliQYPzZZk> NVzSR4ZWOTByLUKwNO69VQ>? MWOyOIg> MnflbY5pcWKrdIOgTIFCPCCrbnT1Z4V{KGGyb4D0c5NqeyCmZYDlcoRmdnRib3[gZ49v[2WwdILheIlwdsLi NFvkTYMzOzd|MkS4NS=>
Molt-3  NFL6T|hCeG:ydH;zbZMhSXO|YYm= MVm1NO69VQ>? MlvsNog> M2DNOZJm\HWlZYOgcYVt[XSxbnnuMYlv\HWlZXSgZZBweHSxc3nz M2jS[|I{PzJ3MEGz
hMSC12 M1\HdGFxd3C2b4Ppd{BCe3OjeR?= NGLpZXgyODEQvF2= NX\4W3Q3PGR? MkPlbY5pcWKrdIOgc5N1\W:pZX7pZ{BkfWy2dYLlMYlv\HWlZXSgZ4VtdCCmZXH0bEBidmRiY3HsZ4lncWOjdHnvci=> NVSzRZE5OjN4NUe4NlI>
HM7  MV;BdI9xfG:|aYOgRZN{[Xl? NYn4bXVHOjEQvF5CpC=> NX\qR3A1OWh? NInwNGpjdG:la4OgZZBq[3WuYYLlckBCKGGlZYTheIUucW6mdXPl[EBk[XOyYYPlMVMh[WO2aY\heIlwdiCjbnSgVGFTWCClbHXheoFo\Q>? M1jkVFI{PTh|NEGy
Hep-2  Mm\kRZBweHSxc3nzJGF{e2G7 NETGXY4zOM7:TdMg MWiyOIg> M2qzfmROW09? NFTn[mlidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> NXK2Zm9{OjN3OECwN|I>
HSCs M4rHc2Fxd3C2b4Ppd{BCe3OjeR?= NFjY[VA2OM7:TR?= NVnIUXZTOjSq NWDtN2RMTE2VTx?= MVHpcohq[mm2czDubYxwfGmwaXKtbY5lfWOnZDDEUmEh\GGvYXflJIlv\GmlYYTl[EBjgSCSQWLQJINt\WG4YXfl MknBNlM1QTl6N{S=
HL-60  MWjDfZRwfG:6aXPpeJkhSXO|YYm= M17iflIx|ryPwrC= MVSyOIg> NWPpc4JzemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 NIrFZpczOzR7NES4NC=>
HA M3r0V2Fxd3C2b4Ppd{BCe3OjeR?= M3rCfFUx|ryP NV;IXXUyOjSq MkPDd5VxeHKnc4Pld{B1cGViY3zlZZZi\2Vib3[gVGFTWCCjbnSgZ4F{eGG|ZT2zMEAuPyxiYX7kJE06KGmwZIXj[YQh[nliYn;yeIV7d22rYj;TRWhC NV7JVVAyOjN2N{W5OVY>
C666-1 NH23SYJCeG:ydH;zbZMhSXO|YYm= NGL0[ow2OM7:TR?= NVuwN3dTOjSq M3XMNZN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? MUWyN|Q4PTl3Nh?=
Hepa1-6 Ml3aRZBweHSxc3nzJGF{e2G7 MnTBOVDPxE1? MorVNog> Mn\BbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| MWiyN|Q1Pjd3Mx?=
PLC/PRF/5c MXnBdI9xfG:|aYOgRZN{[Xl? MXO1NO69VQ>? MmTONYg> NYTuempxeHKndnXueJMh[XCxcITvd4l{KHS{aXfn[ZJm\CCkeTDDTW4> NW\XToZvOjN2M{i4NlQ>
HCT116 Mlv3RZBweHSxc3nzJGF{e2G7 MoLJNVAx|ryP NYe5WGxqOS53aB?= NUS5VIhucW6qaXLpeJMhV3NvaX7keYNm\CClZXzsJIRm[XSq MUmyN|c1PDN3Mx?=
HCEC MlvFSpVv[3Srb36gRZN{[Xl? M2XvflUx|ryP MUO3Nog> NFvoT4dFVVOR Mln6doV{fG:{ZYOgc4YhfGinIH7vdo1idCCKQ1XDJJBp\W6xdInw[S=> MnXvNlM4PDJyMUG=
Primary rat cerebral cortical neurons MnLpRZBweHSxc3nzJGF{e2G7 NGCxVWoyODEQvF2= NI[xSlYycA>? NVntOpRUeHKndnXueJMhS2RvaX7keYNm\CCjcH;weI9{cXNiYX7kJINmdGxiZHXheIg> MmDVNlM4PDF|MUe=
MDA-MB-231  M{TUcmFxd3C2b4Ppd{BCe3OjeR?= NV\NcFJXOjYQvF2= NXfaW|dKOjSq MVjhZpJw\2G2ZYOgZ5l1d3SxeHnjbZR6KGGwZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMh[W6mIGDBVnAhcW6mdXPl[EBjgSCUZ{O= MlzBNlU{Ozd3NES=
NLRP3-Tet-on-MC/9  M3\EPGFxd3C2b4Ppd{BCe3OjeR?= MkTtNVAuPDEQvF2= MV6xNog> M1yxeoF1fGWwdXH0[ZMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JGNCWFNvYYPzc4Nq[XSnZDDOUHJROyCvdYThcpR{KGmwIITo[UBV\XRvb36gd5l{fGWv MlrzNlM4ODN|OEm=
KNS42  M3LWTGFxd3C2b4Ppd{BCe3OjeR?= Ml\3OVDPxE1? NYK0NlJ4OWh? MoLydoVlfWOnczDj[YxtKGSnYYToJIFv\CClb33wcIV1\Wy7IHHic4xqe2inZDDjZZNx[XOnIEOvO{Bi[3Srdnn0fUBqdiC{ZYPwc45{\SC2bzDBRnQuOjZ|L{LES{9u\XSob4LtbY4h[2:vYnnuZZRqd25? MXSyN|Y6OTF2NR?=
MCF-7  MYDBdI9xfG:|aYOgRZN{[Xl? M2m4UVIx|ryPwrC= M4PXdFczcA>? MYDpcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= MXuyN|Y4PTZ2Mx?=
hCMEC/D3  NGW5[YpCeG:ydH;zbZMhSXO|YYm= MUWyOe69VQ>? MlSzO|Jp NWL5SIxQemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| MVqyN|Y3PTF7OB?=
Jurkat MWHBdI9xfG:|aYOgRZN{[Xl? MkP0NVIvPS13MN88US=> NF\MXVUycA>? MnW0[I9{\SCmZYDlcoRmdnSueTDzeZBxemW|c3XzJHNRUC2rbnT1Z4VlKFCjcj20JINt\WG4YXflMEBRSVKSIHPs[YF3[WenLDDEUmEh\nKjZ33lcpRifGmxbjygZY5lKGyxc4Ogc4YhfmmjYnnsbZR6 NIjicokzOzR2Mkm3Oi=>
CNE-1 MorkRZBweHSxc3nzJGF{e2G7 MlL2NlDPxE4EoB?= Mn6zNlRp NIfNdVZqdmirYnn0d{BTSURyMEGtbY5lfWOnZDDj[YxtKGSnYYTo MojSNlM1OjZ6NUC=
HONE-1 MVfBdI9xfG:|aYOgRZN{[Xl? MmSzNlDPxE4EoB?= M4TUSVI1cA>? M1rRc4lvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= MYeyN|QzPjh3MB?=
astrocytes cell NULiPHRNSXCxcITvd4l{KEG|c3H5 MX60NO69VQ>? M2\yOlZp NFThcldz\WS3Y3XzJIViemy7IHHwc5B1d3OrczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmV? MmrqNlM1OTF5N{i=
U-937 NYWzcXNNSXCxcITvd4l{KEG|c3H5 MnTYNVDPxE1? MkPJN|BucW5? MWHwdoV3\W62czDUUmYucW6mdXPl[EBv\WO{b4D0c5Nqew>? M4\jb|I{PDFyN{S4
MDA-MB-231 MlGzRZBweHSxc3nzJGF{e2G7 MVSxNFDPxE1? MlPrNYg> NUnFR3NYcW6qaXLpeJMhe2Wwc3n0bZpifGmxbjD0c{BVWkGLTDD1dI9vKE2WRFig[I94di2{ZXf1cIF1cW:w NWfydYhJOjN2MEi0Nlk>
HeLa  MVjBdI9xfG:|aYOgRZN{[Xl? MVuxNFDPxE1? NXzh[Y1wOmh? M{KzOIJtd2OtczDKVnMuOTViSX7keYNmeyCDcH;weI91cWNiQ3XscEBF\WG2aB?= MmTZNlM{PDRyNEW=
Ec109 MUjBdI9xfG:|aYOgRZN{[Xl? M{\OW|Ex|ryP MoDUOog> NYTOeHBz[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? NV\2d3h{OjN|M{i1Olg>
H460  MWfBdI9xfG:|aYOgRZN{[Xl? NUnnfol1OTEQvF2= NUDTXFhjPmh? MontZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> M{CxUlI{OzN6NU[4
HeLa  Mn3GRZBweHSxc3nzJGF{e2G7 MnLOOVDPxE1? M2e4c|EvPWh? MVvhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NFO2TlczOzNyM{iwOC=>
SK-HEP1 MX7BdI9xfG:|aYOgRZN{[Xl? MVGxNFDPxE1? M1nZVFFp MV7pcohq[mm2czDDdnQyKGGldHn2ZZRm\CClYYPwZZNmNTNuID23MEAuQCxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? NHnifFMzOzNyMk[1NC=>
QGY7701 M1T3UmFxd3C2b4Ppd{BCe3OjeR?= MkXsNlXPxE1? MkPFNU42cA>? MX3pcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu MUmyN|I1ODB4MR?=
HepG2 M1fhOmFxd3C2b4Ppd{BCe3OjeR?= NEPaUmYzOM7:TR?= NG\CSIc{OG2rbh?= MWnpcohq[mm2czD0bIUh\W6qYX7j[YQh[2WubDDk[YF1cCCkeTDjc41jcW6nZDD0doVifG2nboSgc4Yh[XCrZ3XubY4h[W6mIGTSRWlN MV[yN|IzPDJ|OR?=
U87  NVXMeoFsSXCxcITvd4l{KEG|c3H5 NYPheYlNOjYQvF2= NIrpeY8zcA>? NVzxV3Vr\GWlcnXhd4V{KGm|b3zpdZVqemm2aXflcolvKCiLU1ypMYlv\HWlZXSgZZBweHSxdHnjJINmdGxiZHXheIgtKGK3dDDuc5QhdmWlcn;0bYMh[2WubDDk[YF1cA>? MVKyN|IzQTZ{Nh?=
HSC-2 MnmwRZBweHSxc3nzJGF{e2G7 MluwNlUwPTEQvF2= NH\pW|YycA>? MVfpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= MkDCNlMyPTV{NEi=
HSC-4 M4f4ZmFxd3C2b4Ppd{BCe3OjeR?= M13yUlI2NzVyzszN MUGxbC=> NGrOWpVqdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> NWHy[XI6OjNzNUWyOFg>
CL-1 NULOO|ZQSXCxcITvd4l{KEG|c3H5 Ml3INlDPxE1? NWHRd|JYOWh? M3iwVoJtd2OtczDPVFQ1QSCrbnT1Z4VlKGOnbHyg[IVifGh? MmrBNlMyOzF5OEK=
MEL MY\BdI9xfG:|aYOgRZN{[Xl? M2mwSVIx|ryP MYmyOIg> NGHL[oRFVVOR M1rZbIlueGGrcnXzJHAzYDdvaX7keYNm\CCPRVygZ4VtdCCjcH;weI9{cXN? MoDTNlMxOTR6OEe=
Bel-7402  MWnDZZNx[XOnIFHjeIl3[XSrb36gRZN{[Xl? NIrTW|Y2OM7:TR?= M4jhR|Jp Mlr5bY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> M3TxTlI{ODB6N{Sy
Eca-109 NEC1VHdCeG:ydH;zbZMhSXO|YYm= NHvPSZYzPc7:TR?= M4OwPVMxdWmw NFrRfZlqdmirYnn0d{BDUi2EMUGtbY5lfWOnZDDj[YxtKGSnYYTo M2q5Z|I{ODd4OU[3
MEL MonpRZBweHSxc3nzJGF{e2G7 NYfqPHMyOjEQvF2= MX6xbC=> MnTjSG1UVw>? MkDIbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? M2TzfVI{ODF2OEi3
Bel-7402  MlfoRZBweHSxc3nzJGF{e2G7 NIH4bpM2OM7:TR?= NGruTYozcA>? MXfpcohq[mm2czDQR2UucW6mdXPl[EBidm:ra3nz MYWyN|AxQDd2Mh?=
L929 MWDGeY5kfGmxbjDBd5NigQ>? NYXBZpJ7Oi53zszN MUSxbC=> MX;pcoNz\WG|ZYOgVmlROSCneIDy[ZN{cW:wIHHu[EBmgGGlZYLiZZRm\CCWTldOtU1qdmS3Y3XkJI1qfG:laH;u[JJq[WxiZInz[pVv[3Srb36gZY5lKFKRUzDwdo9lfWO2aX;u M2X0T|I{ODByNUG4
RCC  MmHnR4VtdCCYaXHibYxqfHliQYPzZZk> MVGxNFDPxE1? M33Rb|I1cA>? NEfhXphz\WOxdnXy[ZMhfGinII\pZYJqdGm2eTDv[kBk\WyuczDlfJBwe2WmIITvJFE2\C2SR1qy M3O2UVIzQTlzNEm0
NB2a/d1 MYTBdI9xfG:|aYOgRZN{[Xl? MVixNFDPxE1? NWHxe49KPzKq M2q4UoF1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> NUjjRXpxOjJ7OEi1OFE>
T cell M3nVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnkNWYzPS1zMEFOwG0> MkLjNlRp MW\kc5NmNWSncHXu[IVvfGy7IHnubIljcXSnZDDUJINmdGxicILvcIln\XKjdHnvckBu\WSrYYTl[EB1cHKxdXfoJJRp\SClbz3zeIlufWyjdHnvckB4cXSqIHHueIkuS0R|IHHu[EBidnSrLVPENlg> M1fSTVIzQTh{NUO4
K562 M3jjbWFxd3C2b4Ppd{BCe3OjeR?= M{nGcFExOM7:TR?= NWnxWHd[OWh? Mlq2Zoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? NXzjV481OjJ7N{KzO|I>
Jurkat  M1zXXWFxd3C2b4Ppd{BCe3OjeR?= Ml7xOFDPxE1? NYX0fG9xOWh? NVrkR4xr[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? MU[yNlk1Ojd|OB?=
BGC-823 NVTNd3BZSXCxcITvd4l{KEG|c3H5 MV:xNFDPxE1? M{\Sd|Fp NXv4[mVteGG{dHnhcIx6KHKnc3P1[ZMh[2WubIOgZYdicW6|dDDkZY1i\2Vib3[g[IFq\HqnaX6= MV:yNlkzPjV2NR?=
Hep3B MYPBdI9xfG:|aYOgRZN{[Xl? NUfE[|VsPTEQvF2= M{S0W|Fp MkPZZoxw[2u|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGhGT0O| NYnoRmYxOjJ7MkOxOVQ>
LLC-PK1 NITa[lNCeG:ydH;zbZMhSXO|YYm= Mk[zNlDPxE1? M2TlPFFp M4nQV5Bz\X[nboTzJINqe3CuYYTpck1qdmS3Y3XkJIRm\3KjZHH0bY9vKG:oIFH0[|UtKGKnY3zpck0yNCCjbnSgRZRoOTJicILveIVqdnN? M17Ie|IzQDl4MEO3
A549 NF;FOoVCeG:ydH;zbZMhSXO|YYm= NVP4XoFsPTEQvF2= M1PxOVFp M4jDe4Jtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= M2[0XFIzQDh5MkG1
SGC-7901  M3vVb2Fxd3C2b4Ppd{BCe3OjeR?= MV[xNO69VQ>? MXqyOIg> NGLFd2dqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? MVqyNlg1QDV7Nx?=
DM6 NGPw[oVCeG:ydH;zbZMhSXO|YYm= NEnqUJYyODEQvF2= MmPkO|Jp NXf5T3Nj[myxY3vzJIJwfGhiRULGMVEh[W6mIFWySpRzNW2nZHnheIVlKGO7dH;0c5hq[2m2eR?= NFy3fVMzOjh{NUOyPC=>
MCF-7, MDA-MB-468, Caco-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHPNJA2OM7:TR?= M2rKWVQ5cA>? NXvOboVmcW6qaXLpeJMhfGinIHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44hcW6mdXPl[EBjgSC|YYDvcolv NYP5UWVqOjJ6MEC5Olg>
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T47D  MX3BdI9xfG:|aYOgRZN{[Xl? MkfWNVAx|ryP MYqxbC=> MknRZoxw[2u|IITo[UBo\W6ncnH0bY9vKG:oIFWtZ4FlN0OWRkKgZpkhW1SV MYKyNlQxOTF4OB?=
HeLa  NFuyZo1CeG:ydH;zbZMhSXO|YYm= M1PLZVMx|ryP NES2Z5I1cA>? NGTsV47DqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? Mn7GNlI{QTR{NEi=
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Jurkat T MkTFRZBweHSxc3nzJGF{e2G7 M2HXbVMx|ryP NIjHb3kxNjWq NGXpNm5FVVOR NHTZR4ZjdG:la4OgeIhmKHqrcnHtMYlv\HWlZXSgZZBweHSxc3nz MkTjNlIyPTl6OUi=
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HCT116 NIrEWmRCeG:ydH;zbZMhSXO|YYm= MVS1NOKh|ryP NEHMfY8zcA>? M{fRV5JmfmW{c3XzJJN6dmW{Z3nzeIlkKGGyb4D0c5NqeyCnZn\lZ5R{KG:oIHPlcIVkd3irYjDhcoQhVlCFLUG2xsA> NXHwUXFQOjJzNUm3OVI>
MDA-MB-231  M4jl[mFxd3C2b4Ppd{BCe3OjeR?= Ml7zNk42NTdwNd88US=> MXKybC=> MXfpcohq[mm2czD0bIUh[2WubDDk[YF1cCCxZjDNSGEuVUJvMkOxJINmdGy|IHnu[JVk\WRiYomgV2RVKGmwIHGgZ49v[2WwdILheIlwdiCmZYDlcoRmdnRibXHucoVz MlvnNlIyOTV3Mk[=
LNCaP NYjkcVM5SXCxcITvd4l{KEG|c3H5 MWS0NO69VQ>? MXiybC=> MUjpcohq[mm2czDieZRmcW5iaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> MnXNNlIyOTR5NkS=
MB231 MnTGRZBweHSxc3nzJGF{e2G7 MUWxNFDPxE1? NUfkVmdlOWh? MYTEUXNQ MknvZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? NGrLXGwzOjFzMkm0NC=>
HCC38  MomzRZBweHSxc3nzJGF{e2G7 MWOxNFDPxE1? NYXQS4ZCOWh? MmGwSG1UVw>? M2XO[IFjem:pYYTld{B1cGViaX7keYN1cW:wIH;mJINmdGxiZHXheIgh[nliV1XFNUBqdmirYnn0bY9vNCCWUlHJUEB1emWjdH3lcpQtKGGwZDD0bIUh[2:vYnnuZZRqd25? NVmxVo9xOjJzMUK5OFA>
MDA-MB231 MmDwRZBweHSxc3nzJGF{e2G7 MWq1NOKh|ryP MkL4NlRp MnnHSG1UVw>? MYLhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo Mn\0NlIyODF|M{W=
LNCaP MYPBdI9xfG:|aYOgRZN{[Xl? NIrLNVc2OMLizszN NEP0R4ozPGh? NV\IR3diTE2VTx?= M2nS[4Fjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> M1ziTlIzOTBzM{O1
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Ishikawa  MXXBdI9xfG:|aYOgRZN{[Xl? MkTVNlXPxE1? MoDoNlRp NFTLemxz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHHwc5B1d3OrczDpcoR2[2WmIHL5JGJi\iCDMR?= NHPwZWMzOjB6OEmxPC=>
 YD-8  NUjCeXRTSXCxcITvd4l{KEG|c3H5 NVfIZYNjOTByzszN MmOxNYg> MUjpcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ MUiyNlA5PjF6Mx?=
eosinophil  MXHBdI9xfG:|aYOgRZN{[Xl? NVHlbpY5QTEQvF2= NF24[XYzPGh? MVvpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBH[XNiYX70bYJw\HoEoB?= MnTKNlIxPzl|M{S=
L929 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XzUVIvPc7:TR?= NVnEZZVGOjSq MX\pcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDwMZA{QCCjbnSgUmYu|rqEIITvJIF2\22nboSgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 M1mxWlIzODJ5MEm3
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HBx MWPBdI9xfG:|aYOgRZN{[Xl? MmrRNlXPxE1? Mn2xOFhp NFvJTGNFVVOR NFfRTm9z\WS3Y3XkJINmdGxiZHXheIghcW6mdXPl[EBjgSB|LV3B NE\LemEzOjB{MEC3PC=>
U937  M1\jVWFxd3C2b4Ppd{BCe3OjeR?= NGrGXnQ2OMLizszN NVHqTHA5OWh? M4jJfolvcGmkaYTzJGhHNWmwZIXj[YQh[XCxcITvd4l{yqB? M4XQbFIyQTl6N{Ox
HL60 NGf0[oVCeG:ydH;zbZMhSXO|YYm= MmrwOFDPxE1? Mnu0OFBucW5? M3XIXmROW09? NGLrVo1jdG:la4OgRm5FSyClb33wc5Vv\HNiaX7keYNmKGW6cH;zeZJmKG:oIIDoc5NxcGG2aXT5cJNmemmwZTDhcoQhTE6DIH\yZYdu\W62YYTpc44> NU\meoNxOjF7OEOyPVY>
M-14 MVHBdI9xfG:|aYOgRZN{[Xl? NXm1PFJUOjYQvF2= NEnmTlAxNjWq M1XYPeKhcW6qaXLpeJMh[m:2aDD0bIUh[3K3ZHWg[Zh1emGldD2gZY5lKGOxbYDveY5lNWmwZIXj[YQh[XCxcITvd4l{ M2nofVIyQTV2OUW5
SK-BR-3 MWrBdI9xfG:|aYOgRZN{[Xl? NITvNZc2OMLizszN NWXEZWJGOmh? MoLiZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u MlyzNlE6ODF|OE[=
MDA-MB-468 MYPBdI9xfG:|aYOgRZN{[Xl? MoXOOVDDqM7:TR?= M1y2T|Jp NUX2U4t5[myxY3vzJIFxd3C2b4TpZ{BFVkFiZoLh[41mdnSjdHnvckBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIH;mJHNONTF4NDDhcoQhemGmaXH0bY9v MUSyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Caspase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID