Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a M13FeWFxd3C2b4Ppd{BCe3OjeR?= M3PvPFUx|ryP Ml3PNlRp M3:wO4lv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm MmrENlYyPjlyN{W=
HGL5 M1Tvd2Fxd3C2b4Ppd{BCe3OjeR?= MWe1NO69VQ>? NIXKTIUzPGh? NFnleZZqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? MWCyOlE3QTB5NR?=
HepG2 MX\BdI9xfG:|aYOgRZN{[Xl? NUfPO2d6OjEQvF2= M{GzeFFp MWHheJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg NX[1WJU1OjZzNkS3PVU>
BEL-7402 NVzuUVVnSXCxcITvd4l{KEG|c3H5 MUeyNO69VQ>? M1iyXlFp MULheJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg MoWxNlYyPjR5OUW=
CEF NXvWRZdjU2mwYYPlJGF{e2G7 Mmq4NEw{Oyx4NzyxNFDPxE1? NUf2[GxVOTWvaX6= MoPz[I94di2{ZXf1cIF1\XNiUGKg[Y57gW2nIHHjeIl3cXS7IITvJFQx97zHIHH0JFExOM7:TR?= MnjBNlYyODJ|M{m=
SP2/0 NXPGTGJRSXCxcITvd4l{KEG|c3H5 NH\0dJYyODEQvF2= MUSxbC=> NHHj[HdFVVOR Mn7oZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= MkC3NlYxPzR5M{K=
HUVEC-2c MVrBdI9xfG:|aYOgRZN{[Xl? M1nKcVUx|ryP MoLnOog> MUjk[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> M1vRclI3ODJzN{K5
U1 MkWxRZBweHSxc3nzJGF{e2G7 NHf1VHgxNTFyMN88US=> NVLSfVlOOmh? M{[wT5Jm\HWlZYOg[JJ2\y2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgd5Vje2WzdXXueEBJUVZvMTDy[ZBtcWOjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NH;hfFgzPTl6MEm0Ni=>
ACH-2 NX;XemJvSXCxcITvd4l{KEG|c3H5 MUiwMVIxOM7:TR?= M3HW[FJp Mnn1doVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy MmDuNlU6QDB7NEK=
U1 NWrJNFd1U2mwYYPlJGF{e2G7 NUDTeIdnOTByzszN NVraUpJzOmh? NXLGVXUxcW6qaXLpeJMh[2G|cHHz[U0{ M4DnN|I2QThyOUSy
A549/V16 M3;vc2Fxd3C2b4Ppd{BCe3OjeR?= M4G2[lUx|ryP NGTz[|kycA>? M3PuN5JmeHKnc4Pld{BVTy:WTT3pcoR2[2WmIHHwc5B1d3Orcx?= NFG2dnEzPTl2NkCzNy=>
SGN Mnu1RZBweHSxc3nzJGF{e2G7 MknlNlBuVQ>? MUW0PIg> M3zOXIhieyCwbzDpcoZtfWWwY3Wgc44hSUmILDDjZYxx[WmwIHX4dJJme3Orb36gc5Ih[2WubDDhdI9xfG:|aYO= NHvMTGgzPTh5NE[zNy=>
HCT116  M13XUmFxd3C2b4Ppd{BCe3OjeR?= MlqyOVDPxE1? NHPxcm8zcA>? NGHUUVdqdmirYnn0d{B1cGViY3XscEBl\WG2aDDpcoR2[2WmIHL5JGRFXlB? NYHNO3JtOjV6Nki4NVg>
DTK-SME M3n2WmFxd3C2b4Ppd{BCe3OjeR?= M2XNPVUx|ryP NX3zOmhTOmh? MXPEUXNQ NGLqRWZx[XK2aXHscJkhcW6qaXLpeJMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JIJ2eGm4YXPhbY5m NWDxXlkxOjV6NEO4PVc>
HL-60 NF7J[ItCeG:ydH;zbZMhSXO|YYm= NUXBUJVqPTEQvF2= M3HPNFQ5cA>? NFzYUnFz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? MX:yOVgzPDB2Mx?=
U937 NX6wNmpoSXCxcITvd4l{KEG|c3H5 NHHSVWI2OM7:TR?= M37sSlQ5cA>? NHPnc5Vz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? M1:yd|I2QDJ2MESz
A549 MUDBdI9xfG:|aYOgRZN{[Xl? M1fCcFIxKM7:TR?= MVOyOIg> MorqdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBJTkOSIITy[YF1dWWwdB?= NVzidpJVOjV5OUSxOFk>
HeLa MXHBdI9xfG:|aYOgRZN{[Xl? NGKzb2oyOM7:TR?= MknpOFhp Mnjq[IVkdGmwZYOgeIhmKHKjdHWgc4Yh[XCxcITvd4l{KGS{YX3heIlk[WyueR?= MmThNlU4PzJ3NEW=
SGC-7901 M3HoS2Fxd3C2b4Ppd{BCe3OjeR?= M2rTXVIxyqEQvF2= MXyxbC=> MlLBbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> Mk\TNlU4PjdyN{[=
MCF-7 MmjPRZBweHSxc3nzJGF{e2G7 M3W0SlEx|ryP M{n3PFJp M17MWolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgN2I> NHPBelczPTd{MkGxOC=>
A549 MkjsRZBweHSxc3nzJGF{e2G7 NGntW3cyOCEQvF2= NUPrOG92OjSq NUDDOFlITE2VTx?= MUjwdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= NYKzOVljOjV4OEO1Olg>
U87 M2roWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrNemV1PTEQvF2= MVGxbC=> MnP4doVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 MlTqNlU3QDF4Nki=
Neocortical Neuron NFu3SoRP\XW{b4TvfIlkcXS7IFHzd4F6 MlL0NVAx|ryP M3H3VlFp MXLhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= MW[yOVY4PTByMR?=
Primary human placental cytotrophoblasts M1HRe2Fxd3C2b4Ppd{BCe3OjeR?= NVXTNoN5OzEQvF2= NGPhfm4zPGh? NXT3VWp2TE2VTx?= MmjkdoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi Mn\pNlU3PDJ3OUK=
MM MmLQRZBweHSxc3nzJGF{e2G7 NULLcGNRPTEQvF2= M1nEcVIxdWmw NHv2WGpx[XK2bImgbY5pcWKrdIOgV2hMNWmwZIXj[YQhKGOnbHyg[IVifGh? NYHT[oFlOjV3M{CwPVg>
DLD1 NF23TYFCeG:ydH;zbZMhSXO|YYm= MUGyNOKh|ryP MkG1NYg> MlXEdIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx MUKyOVUzPDJ2Nh?=
MDA-MB-231 MlXSR5l1d3SxeHnjbZR6KEG|c3H5 MYGxNO69VQ>? MX:xbC=> MUXheYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 NH3pNoszPTV{MUWwNS=>
MKN28 M{H3SmFxd3C2b4Ppd{BCe3OjeR?= NEnSfGkyOM7:TR?= MX6zNI1qdg>? M4nifmROW09? MWfpcohq[mm2czDUUmYu|rFicHz1d{BEUFhvaX7keYNm\CCjcH;weI9{cXN? M320[FI2PTF|OU[w
HL-60 M3LRN2N6fG:2b4jpZ4l1gSCDc4PhfS=> MUKxNFDPxE1? NYLDU29VOWh? MlrzSG1UVw>? MYFCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| M3X0SlI2PTB{OUOy
AGS M{C0U2Fxd3C2b4Ppd{BCe3OjeR?= M1nHdlEx|ryP MoXjNYg> NFG2UGNxemW4ZX70d{BkfXKldX3pck1qdmS3Y3XkJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUisJIFv\CBvOTDwdo91\Wmwcx?= Mk\GNlU1QTJ{MUS=
A549  MX\BdI9xfG:|aYOgRZN{[Xl? NXv1SoN[OTEQvF2= M2[2RVI1cA>? NYfP[JFp[myxY3vzJGROSVNvaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgZY5lKGGyb4D0c5Rq[yClZXzsJIRm[XSq MWiyOVQ{PDl6OR?=
INS-1 M1vEfGFxd3C2b4Ppd{BCe3OjeR?= NWDMNVBvPTEQvF2= MkW0Oog> NE\GU3RFVVOR M1LkXIRm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= MoLjNlU1OzB6OUe=
Primary hepatocytes  MmTxRZBweHSxc3nzJGF{e2G7 MUi1NO69VQ>? M17POlE5cA>? MXjpcohq[mm2czDhdI9xfG:|aYOgc4YhcGWyYYTvZ5l1\XNiaX7keYNm\CCkeTDBZ5QhTCCjbnSgWG5HNc7z MoLoNlU1ODd3M{i=
L929-A  NHu3[21EgXSxdH;4bYNqfHliQYPzZZk> MlXzNlDDqM7:TR?= MmjrNlRp NXrIZZFwcW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo MX[yOVM6QDV2MB?=
L929-N NUDoVIFXS3m2b4TvfIlkcXS7IFHzd4F6 NV\3Z5ZGOjEEoN88US=> NX3QOIhJOjSq M3fIU4VvcGGwY3XzJIRm[XSqII\pZUBifXSxY4LpcoUhXE6IzsGgdJJw\HWldHnvci=> MVOyOVM6QDV2MB?=
Cytotoxicity Assay NFjHdVdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{\hdFIx|ryP MnzTOFhp MoPwdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? NELjNG4zPTN7MkGxOi=>
COS7 M3zj[mtqdmG|ZTDBd5NigQ>? MnG2NVDPxE1? MXOyOIg> M1n4Volv[3KnYYPld{Bk[XOyYYPlJFMwPyCjY4Tpeol1cWW| M2W3NFI2Ozh2MEK1
COS7 M4CzOWFxd3C2b4Ppd{BCe3OjeR?= MUOxNO69VQ>? M3W5OlQ5cA>? Mnn3dIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= MoH2NlU{QDRyMkW=
A375 MYDBdI9xfG:|aYOgRZN{[Xl? MYWzNO69VQ>? MmXhNog> M1\ETJBz\X[nboTzJJRp\SCmcoXnMYlv\HWlZXSgVGFTWCClbHXheoFo\Q>? NYnvfo5{OjV|N{[xNVU>
A549 NGX4e49CeG:ydH;zbZMhSXO|YYm= MofPOVDPxE1? NIe4dmkzPGh? M2nDeJJmfmW{c3XzJJJq[m:|b33lJIJqd2enbnXzbZMh[W6mIHHwc5B1d3OrczDjZZV{\WRiYomgJGNpcWqxbnfkZY4> M2W1VVI2OzR7N{ix
A549 MnyxRZBweHSxc3nzJGF{e2G7 Mn\kNk42NTJ3zszN NYPDOnlCOWh? NHu4T2xl\WO{ZXHz[ZMhfGinIIDvdJVt[XSrb36gc4Yh[XCxcITveIlkKGOnbHzzJIRmeGWwZDDvckBkd26lZX70doF1cW:wcx?= NF7m[XozPTN2MkSyOy=>
 NBL-W-S  MmPQRZBweHSxc3nzJGF{e2G7 NV\HUFRHPTEQvF2= NWDDbIFJOWh? Mo\p[pVtdHlicnXzZ5VmeyClZXzsJJZq[WKrbHn0fUBi\nSncjDHRW5VNTZzIITy[YF1dWWwdB?= NGXFZpUzPTN{M{KyNi=>
Caki-1  MWTBdI9xfG:|aYOgRZN{[Xl? NHnSemY1OM7:TR?= NHTOVXg1QGh? NGPVfWtz\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ NFL0bm0zPTJ5OUG5NS=>
769-P M4n6NWFxd3C2b4Ppd{BCe3OjeR?= MoXuOFDPxE1? MkXPOFhp NH3uVoVz\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ NXjGUlJLOjV{N{mxPVE>
H9c2 NYO0TnpxSXCxcITvd4l{KEG|c3H5 NFHy[GE2OM7:TR?= NULKRlhmOWh? MkH2bY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? NGjMNIQzPTJ6M{ixPS=>
K562 NYT6coxMSXCxcITvd4l{KEG|c3H5 NWjiTWFIPTEQvF2= M1nINlRp NG\1bJBqdmirYnn0d{BL[WNvQT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ M4jLV|I2OjRzNkG5
L929 Mn[3RZBweHSxc3nzJGF{e2G7 MV[xNO69VQ>? M1nw[lZp NVTMNFJ6cW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? MlPGNlUyQTV4NkC=
A549 Mn[xRZBweHSxc3nzJGF{e2G7 MknWNVDPxE1? MXWzbC=> MWfy[YR2[2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCSUWG= NIThcVYzPTF4MU[5PS=>
MCF-7 NFfCPXhCeG:ydH;zbZMhSXO|YYm= MViyNO69VQ>? NXX0Vm9vOmh? NXT3[pho\GWlcnXhd4V{KEuGUj3zbXJPSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MWeyOVE5OjJ2MB?=
OS MoXIRZBweHSxc3nzJGF{e2G7 M1L0dlIxNzRyzszN M4O3UVczcA>? M4TqTolvcGmkaYTzJG9UKGOnbHygeoli[mmuaYT5JJJm\HWldHnvckBjgSCFNjDj[ZJidWmmZR?= NFHXPIkzPTF3MkO5PS=>
HUVECs MlH4RZBweHSxc3nzJGF{e2G7 MknGNVDPxE1? M2XRZlJp MmnwxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBJXV[HQ4O= M1H0elI2OTN6N{Cz
EA.hy926 M1W2emFxd3C2b4Ppd{BCe3OjeR?= MX:xNO69VQ>? NUO1fJF{Omh? M37aOOKhcW6qaXLpeJMh[XCxcITvd4l{KGGwZDDmZYNqdGm2YYTld{BifXSxcHjh[5khcW5iRFXOWlIucW6oZXP0[YQhTUFwaIm5NlY> NULUN5REOjVzM{i3NFM>
Ebs Ml63RZBweHSxc3nzJGF{e2G7 NF[2XVMyOC1zMEFOwG0> NFfnfHAzPGh? MlzWxsBOVVSVIHflcoVz[XSrb36gdoF1\SCmZXPy[YF{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36gc4Yhgi2YQVSu[o1sKGmwY4LlZZNm\A>? Mo\ENlUyOzR6MUe=
Jurkat NYDxOoVUSXCxcITvd4l{KEG|c3H5 NVPneJNrOjEQvF2= M3HYb|I1cA>? NIm0d2pFVVOR NVOz[Jd{eGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi Mn\FNlUyOjB5MkO=
K562 NGjGT21CeG:ydH;zbZMhSXO|YYm= MX:wMlEuOc7:TR?= MoDJNYg> MV\pcohq[mm2czDjcIVifmGpZTDv[kBJW1B7MDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NX\2SpFiOjVzMUmxPFg>
IMR-32 M4HxTWFxd3C2b4Ppd{BCe3OjeR?= MVO0NOKh|ryPwrC= MkP1Nog> M1PFVYRm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? Ml;zNlUxQDR5NUW=
RPMI 8226 M1LBeGFxd3C2b4Ppd{BCe3OjeR?= MVuxNFDPxE1? Mkn2NYg> M17sfYFtdW:|dDDjc41xdGW2ZXz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NVL4PFBVOjVyM{e4OVE>
U266  M4LzbmFxd3C2b4Ppd{BCe3OjeR?= MVKxNFDPxE1? MX:xbC=> NGfTUW5x[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NInSS44zPTB|N{i1NS=>
H929  NULZTHFySXCxcITvd4l{KEG|c3H5 NYnISo5zOTByzszN NYjjdXprOWh? NUXWemoyeGG{dHnhcIx6KGKub3Prd{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCwZXPyc5N1[XSrbj2x NGDhSJAzPTB|N{i1NS=>
MM.1S  MWnBdI9xfG:|aYOgRZN{[Xl? NV\iVHc1OTByzszN MYixbC=> Mojv[YZncWOrZX70cJkheHKndnXueJMhe2:{YX\lcoljNWmwZIXj[YQh[2WubDDk[YF1cCClb33ibY5mKHerdHigcoVkem:|dHH0bY4uOQ>? MYCyOVA{Pzh3MR?=
C6 NGjtfpZCeG:ydH;zbZMhSXO|YYm= NGrkfnY2OM7:TR?= MX:0PIg> MlmwdJJmfmWwdIOgeIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZ4F2e2WmIHL5JJBz\WewZX7vcI9v\Q>? MYOyOVAyOzR5OR?=
AGS NUHye|hmSXCxcITvd4l{KEG|c3H5 MYm1NO69VQ>? NUT3XWFFOjSq MYLhZo9tcXOqczFOtk1t[XCjY3jvcoUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDpcohq[mm2ZXSg[5Jwf3Sq MUmyOVAxQTZ7OB?=
HeLa  MXjBdI9xfG:|aYOgRZN{[Xl? NVnWWVR6PDEQvF2= MnroNlRp M1r3fIlvcGmkaYTzJJRp\SCrbnPy[YF{\WRiYYDvdJRwe2m|IHnu[JVk\WRiYomgd4lTVkZzMkG= MV2yOFkzQDZ6NR?=
THP-1  M3m2SWFxd3C2b4Ppd{BCe3OjeR?= MVixNO69VQ>? NHv3bZIycA>? NXjFS3B[emWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCDTFGtV2RVyqB? NWTWZ2Q5OjR7MkO2OVM>
P815  NH74WZBCeG:ydH;zbZMhSXO|YYm= MWexNFAhyrWP MWSxNog> NVe2VpN6TE2VTx?= Ml76bY5pcWKrdIOgeolzfXNvaX7keYNm\CCjcH;weI9{cXN? NGDIXW0zPDl{M{K3Ny=>
HCT116 NWPDNZpZSXCxcITvd4l{KEG|c3H5 MWCyNO69VQ>? M3zqfVI1cA>? M1nndYFjem:pYYTld{Bw\iCWUT3pcoR2[2WmIHHwc5B1d3Or NFOwXmgzPDh7MES0PS=>
SW1116  NUGyWItPSXCxcITvd4l{KEG|c3H5 MWKxNEDDvU1? MXmxbC=> MmjFSG1UVw>? NILMdZRz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l M{jmdFI1QDd2Mki2
LOVO M2nqSWFxd3C2b4Ppd{BCe3OjeR?= MXmxNEDDvU1? M1PGfVFp NXfKeGNzTE2VTx?= M2PpVZJme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= MUGyOFg4PDJ6Nh?=
SNU449  MlTrRZBweHSxc3nzJGF{e2G7 MlryNlDPxE1? M1;0XFQ5cA>? M1L5S2ROW09? Mnex[IVkemWjc3XzJI1qWi12NUGtbY5lfWOnZDDhdI9xfG:2aXO= M4[1fVI1QDRzNkO4
Caco-2 NXXMR5ZCSXCxcITvd4l{KEG|c3H5 NInUeJQ1OOLCid88US=> M1TjN|Rp NEfyTlJxemW4ZX70d{BUXC15LXnu[JVk\WRiWl:tNUBkcGGwZ3XzJIFv\CCWRWKg[JJweA>? MlrVNlQ5OjJzOEO=
macrophage MXjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NEjMSZQxNTJyMN88US=> MkHSNlRp M33NZYlv\HWlZYOgWG5HNSCjbnSgVolxOy2mZYDlcoRmdnRibnXjdo9xfG:|aYOgbY4hdWGlcn;wbIFo\Q>? NVjs[XlnOjR5OUm1OlU>
AGS  NGLiR3FCeG:ydH;zbZMhSXO|YYm= NYDiUmJwOjEQvF2= NWHPblhyOTKq MmfPSG1UVw>? M3TJV5Jm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NX\3RnNQOjR5OEm3NFM>
LCC9  MUXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M4PYVlExOM7:TR?= NUiwXIVoPWR? M3fjXoJtd2OtczDj[YxtKGSnYYToJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25iTEG3JIFv\CClaHzvdo9yfWmwZR?= M1f0[lI1Pzh3MkW2
U937  NYnnSGM6dmWlcn;weI9{cXNiQYPzZZk> NHnud40yOMLizszN MV[zNOKhdWmw NY\qRW9HcW6mdXPld{Bv\WO{b4D0c5NqeyClb33ibY5mKHerdHigWG5H NFPtfFgzPDd5M{e1Oi=>
T cell MWjD[YxtKHC{b3zp[oVz[XSrb36gZZN{[Xl? NXnQT|ZOOC1zMEFOwG0> MofWO|Jp NWfhc3pMUUN3ME23NEDPxE1uIHnubIljcXS|IHHueIkuS0R|LXnu[JVk\WRiVDDj[YxtKHC{b3zp[oVz[XSrb36gbY4hWEKPQ4O= M1jHfFI1PzZ6N{C3
HeLa  MW\BdI9xfG:|aYOgRZN{[Xl? MkfKOVDPxE1? NFTKSpM4Omh? NVzDTol{TE2VTx?= MnrPdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2:vcH;1coR{yqBz4pETOS=> NYTa[IQ1OjR5NUS3PFY>
HeLa  M1[wcWFxd3C2b4Ppd{BCe3OjeR?= MoHLNVAx|ryP NHrvfWczPGh? NYPNPWk2e3WycILld5NmeyC{YYTlJI9nKGOnbHyg[IVifGhiaX7keYNm\CCkeTDveoVz\XiycnXzd4lwdiCxZjDHOVlUKG:{IFe3NXIheDF3MHfseYVlyqB? MWWyOFczOjR4OB?=
IEC-6  MmfFRZBweHSxc3nzJGF{e2G7 MkfNNVDPxE1? M{jUSlI1cA>? M3LpcpBz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NE\vZmUzPDdzMUW3NS=>
HCT116 NFjqWo9CeG:ydH;zbZMhSXO|YYm= MXyyNO69VQ>? M{S4UVI1cA>? MnnPbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxdHnjJIlv\HWlZXSgZpkhYUyWMkC1 M1HHc|I1PzF|OEGy
L02 M2e1WmFxd3C2b4Ppd{BCe3OjeR?= NYfnZ3F3OjEQvF2= NVHWRVlDOWh? M365bpBz\X[nboTzJJRp\SClZXzsJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE2HSGC= NIPObHgzPDdyNkS2NS=>
A375 MY\BdI9xfG:|aYOgRZN{[Xl? MUSyNO69VQ>? M{DSRVI1cA>? MoDqdoV3\XK|ZYOg[IlkcXS{aX7vcoUhSi2rbnT1Z4VlKGGyb4D0c5Nqew>? M1jm[|I1Pjl7MUGx
HDPC Mk\WRZBweHSxc3nzJGF{e2G7 M3rjVlUxyrWP NFfQ[VkzPGh? MULpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> M1S2U|I1PjN2NUmz
A549 NXrOVot2SXCxcITvd4l{KEG|c3H5 MkPoOVDDvU1? NVHQUWJyOmh? NYm2Vo1VTE2VTx?= M3i4b5Bz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw MoS4NlQ2QDhzM{W=
 BV-2 MWrBdI9xfG:|aYOgRZN{[Xl? MV2yNO69VQ>? NUHxWZFvOmh? NIS0Vnh{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= MmrZNlQ2PThzMUi=
HT-29  NVH2[XRJSXCxcITvd4l{KEG|c3H5 M2Lxb|Ux|ryP M4PHVlQ5cA>? NXjuXYlV[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s MkXqNlQ2PDlzN{W=
A549 NFLYeHFCeG:ydH;zbZMhSXO|YYm= MWm1{txO NHnaR3ozPGh? M2fFfJN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg M3fnNVI1PTJ7OEex
MIA-PaCa-2 M3jseGFxd3C2b4Ppd{BCe3OjeR?= NEXVW4wzPGh? MVjicI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? NYrlXYc{OjR3MUC5PVI>
Caki-1 NVXhOm9zSXCxcITvd4l{KEG|c3H5 NVHWcFJ{OjEQvF2= MonrNYg> MVXpcohq[mm2czDTR3AucW6mdXPl[EBieG:ydH;zbZM> NVTZTXpGOjR3MES2PFE>
CLL NYHWWJBDSXCxcITvd4l{KEG|c3H5 M3LSUVI2|ryP NIPTVWIycA>? MV;wZZJ1cWGubImgZoxw[2u|IF3MUlIzOzhvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> M{Lrc|I1PDZ5NkO0
SGC-7901 NFP4WZZCeG:ydH;zbZMhSXO|YYm= NHXkN4QyOM7:TR?= MVOyOIg> MX\wdo9ud3SnczD0bIUhS0eLST3pcohq[mm2ZXSgZ4VtdCCpcn;3eIghcW5iU1fDMVc6ODFiY3XscJM> M37PUlI1PDV2NEi4
k1735 Mn3XRZBweHSxc3nzJGF{e2G7 M3zyT|Ix6oDLzszt MkLtOIg> MXzpcohq[mm2c9MgV4FtdW:wZXzsZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MnmzNlQ1PTFzMU[=
HaCaT  M4ewWWFxd3C2b4Ppd{BCe3OjeR?= M4LYd|ExOM7:TR?= M3W1[FFp MYXicJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| NFWyVGgzPDN3Nkm5Oy=>
podocytes MlrqRZBweHSxc3nzJGF{e2G7 Mn7NNlAx|ryP M1S4dlZp MmnHbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhOyx2LVTHSS=> NFn6T|MzPDN|N{e3Oy=>
 KB MkTSRZBweHSxc3nzJGF{e2G7 Ml[4OVDPxE1? M17QSlI1cA>? NFHPZ|NqdmirYnn0d{BNcWOxLVGtbY5lfWOnZDDjZZNx[XOnLUOgZY5lKFCDUmCgZYN1cX[jdHnvci=> NHnjVHYzPDN|N{S5Ni=>
 HepG2  NEOzRZBCeG:ydH;zbZMhSXO|YYm= M3vRVVEx|ryP MXiyOIg> NILuS4hz\WS3Y3XzJJZqdWWwdHnuJINt\WG4YXflJINifXOnZDDifUBNWFN? M3nWRVI1OzJ3OEG2
fetal rat lung fibroblasts  M2nHTmtqdmG|ZTDBd5NigQ>? M4L3dlgx|ryPwrC= MkfZNYg> NH3FZ4lqdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? NULxZ3REOjR|MUSxN|U>
PDL fibroblasts NGjkPHFMcW6jc3WgRZN{[Xl? M2HqcFgx|ryPwrC= NXqwR3c1OWh? M1rPVIlvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh MkX0NlQ{OTRzM{W=
MB49 NV7mc|ZjSXCxcITvd4l{KEG|c3H5 NXOw[29EOjEQvF2= MmHONYg> M3Oy[JJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MYCyOFI5OjR|Mx?=
5637 NX;0TY5ZSXCxcITvd4l{KEG|c3H5 MWKyNO69VQ>? M4ixSVFp NEf6WXdz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? NE\NRYgzPDJ6MkSzNy=>
A549  Mk\pRZBweHSxc3nzJGF{e2G7 NVzBSXpIOTByzszN MVO0PIg> MlHsd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg MkP0NlQzPzJ{MEG=
MCC-2 M362cGFxd3C2b4Ppd{BCe3OjeR?= M3zDT|IxKM7:TR?= MXS2bC=> MUfEUXNQ M3i2OYJtd2OtczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmViYYDvdJRwe2m|IHPlcIwh\GWjdHi= MYKyOFI3OjZ3OB?=
ADF MYnBdI9xfG:|aYOgRZN{[Xl? NF32XFg1OM7:TR?= MUK2bC=> NUXDZ4o5cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> M4TWbFI1OjJ6MkOy
 U373  MUPBdI9xfG:|aYOgRZN{[Xl? MmPwOFDPxE1? MknTOog> MX\pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NFrnZXkzPDJ{OEKzNi=>
RKO-HIPK2i NUKyb|VsSXCxcITvd4l{KEG|c3H5 MXW0NO69VQ>? M4D5O|Zp NYHaZ5J3cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> NX3RW3FwOjR{MkiyN|I>
HEC-1B NXztTIg5SXCxcITvd4l{KEG|c3H5 M{DJTlIx|ryP MYGxbC=> MoPXdoVlfWOnczDUVE1qdmS3Y3XkJIFxd3C2b4Ppd:Kh[2G|cHHz[U0{KGGwZDDjZZNx[XOnLUm= MVuyOFIyOzN3OB?=
4T1 MoLxR4VtdCCYaXHibYxqfHliQYPzZZk> NXPZWJdJOi53LUGw{txO NVKxTo9WPGh? NInmVJZFVVOR MlvsdoV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= MljINlQzODZzNkG=
OS  MVHBdI9xfG:|aYOgRZN{[Xl? MY[yNO69VQ>? MYK0bC=> MULpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliUFTU NEexVFYzPDJyNEmzOy=>
RPE M4LCTWFxd3C2b4Ppd{BCe3OjeR?= NGG2em0yODEQvF2= MYq0PIg> NWPPV3JveGG{dHnhcIx6KGmwaHnibZR{KHSqZTDjZYxx[WmwLUGgZY5lKC1{IHHjeIl3[XSrb36gZZMhf2WubDDhd{B1cGViY3HzdIF{\SCjY4TpeoF1cW:w NF7zXYwzPDJyMkC1Ni=>
UD29a MmjERZBweHSxc3nzJGF{e2G7 NGLQcYc2OM7:TR?= MYWyOIg> MkO5bY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> NX[0T2VXOjRzOUC1O|Q>
SH-SY5Y  NHPNWllCeG:ydH;zbZMhSXO|YYm= MlzDNVDPxE1? NFvxTGczPGh? M3;zSYF1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> M{D0TVI1OTR3NE[z
HeLa  NXrRSldUSXCxcITvd4l{KEG|c3H5 MYixNE8zOM7:TR?= Ml\BNlRp M1\ONolvcGmkaYTzJJRp\SCjY4Tpeol1gSCxZjD0bIUhdWGsb4LpeJkhd2ZidHjlJI1mdWKncoOgc4YhfGinIHPhd5Bie2VvZnHtbYx6 NF7LfpozPDF|N{K2Oi=>
SCCVII  MX\BdI9xfG:|aYOgRZN{[Xl? Mkm0NlXPxE1? M2\xVFFp MkHDbY5pcWKrdIOgeIhmKGOnbHygb4ltdGmwZzDh[pRmeiCmYYPheIlvcWJ? MmPTNlQyOjZ2NkS=
RAW 264.7 NVLVWZhISXCxcITvd4l{KEG|c3H5 MXmyNO69VQ>? NXXmdpE5OTiq MWLpcoNz\WG|ZYOgUGM{NUmLL98yMYFkfGmwIILheIlwKGOxbYDhdoVlKHSxIFXDWHYuVU:VIITy[YF1dWWwdDDvcox6 NGT1dFAzPDFzNkewOy=>
A549  M3;4UWFxd3C2b4Ppd{BCe3OjeR?= M4jaeFIvPc7:TR?= Mnj0NlRp M2XyXIRm[3KnYYPld{Bwemmmb37pck1qdmS3Y3XkJIF2fG:yaHHnfUBieyC5ZXzsJIFv\CCOb4PzJI9nKM7Wz5jtJIFte29ib3PjeZJz\WRiZIXybY5oKGG3dH;wbIFocWNicILvZ4V{ew>? MWSyOFExOjV{Mh?=
UM-SCC-10A  NXTBXoQ1SXCxcITvd4l{KEG|c3H5 MWC1NOK2VQ>? M2nySVJp NEDGT4Jz\WS3Y3XzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGirZ3it[I9{\SCrc3;hcIFvfG:uYXP0c45m M4G4bVI1ODl6N{Wz
BGC-823 NGPQOIhCeG:ydH;zbZMhSXO|YYm= NHnLUnQyOCEQvF2= NGj1UW4zPGh? NF;5V3Jz\WS3Y3XzJJRmfHKjbnTybY5mNWmwZIXj[YQh[XCxcITvd4l{yqB? NHvSdm4zPDB7OEWxNS=>
Nalm-6  NF\oTm5CeG:ydH;zbZMhSXO|YYm= M{XXSVIx|ryP NX3TVG1{PGh? NX7qUWg4cW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm MoPyNlQxOzl7Nke=
KHOS  MmrNRZBweHSxc3nzJGF{e2G7 MVq0NO69VQ>? M4LNeVI1cA>? M17uboJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MWmyOFAzPTN4MR?=
G292 MlPnRZBweHSxc3nzJGF{e2G7 NInnVXQ1OM7:TR?= NXO1T|F{OjSq M2L6eIJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MVGyOFAzPTN4MR?=
MG-63 M1;ZTmFxd3C2b4Ppd{BCe3OjeR?= NGLTO|M1OM7:TR?= M3[1N|I1cA>? NIHqd29jdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg M1PycFI1ODJ3M{[x
EBV-transformed B cells MkfwRZBweHSxc3nzJGF{e2G7 MUSyNO69VQ>? MmXUNog> MoTiSG1UVw>? NVziSmh4[myxY3vzJIFvfGlvQ1S4NEBidmRiYX70bU1ETDh4IHHueIljd2S7LXnu[JVk\WRiYYDvdJRwe2m| MoLJNlQxODh4Mki=
IM-9 B M4f6SGFxd3C2b4Ppd{BCe3OjeR?= MnviNlDPxE1? MlXVNog> Mkn5SG1UVw>? M1fZ[oJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? MUWyOFAxQDZ{OB?=
CNE1 NYfBTWpnSXCxcITvd4l{KEG|c3H5 M1PNOlIx|ryP MnPkOFhp NFKzXphjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MUCyN|k5PTB{OR?=
CNE2 MmnSRZBweHSxc3nzJGF{e2G7 NIf6SFYzOM7:TR?= MXy0PIg> NFrUcnNjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MoPzNlM6QDVyMkm=
HL-60 NIXzWHFCeG:ydH;zbZMhSXO|YYm= M{DwSlUxyrWP MoXYNYg> M2PjfWROW09? M2TESIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKDMUS1 MkflNlM6PDh5NUG=
L929 NWfnc3NRSXCxcITvd4l{KEG|c3H5 NF3idpQyNjJ34pETOeKh|ryPwrC= NVXT[3lKOjSq NYTCbXQ1[XWpbXXueJMhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 MnX3NlM6PDF5Nkm=
Jurkat NGXiRWlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUCy{txO M2T2XFRp M4H4RZJmfmW{c3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CEQsj3jZZRmdmmwIHTlZ5Jm[XOnIHL5JGhUNUGVQR?= MkjuNlM5QTZyNkG=
RAW264.7  NWjTbld1SXCxcITvd4l{KEG|c3H5 NIK4SXAyOCEQvF2= MVSyOIg> M3PyVoRm[3KnYYPld{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgS2E> M4jIZVI{QDJyMkCz
A431  NH:0XoxMcW6jc3WgRZN{[Xl? NE\wcnM1OM7:TR?= M1vQeFJp MmLGZoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= NYnse445OjN6MECwOVg>
Jurkat MVHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NEH1dWEzPS1zMEFOwG0> MlHvOog> M1PTTIlvcGmkaYTzJJouTkFvQ13LMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NHW2dGczOzl|M{WzNi=>
COS-7  MWnGeY5kfGmxbjDBd5NigQ>? NVTjNZdDPTEEtV2= NIP1RXQzPGh? M1KzUIFn\mWldIOgeIhmKHC{b3Pld5Nqdmdib3[gRXRPOXNid3n0bEBxd2y7UTD0doFkfHN? MV[yN|k{OzJyOB?=
CAL27 MkP3RZBweHSxc3nzJGF{e2G7 NYrDWW5qOTBizszN M{LuSFJp NV7sZYtqe3WycILld5NmeyCFdYKtUnB{NXKnZIXj[YQhfmmjYnnsbZR6KGK7IIXwJJRwKDlyJR?= NG\tUIQzOzlzN{O5Oi=>
THP-1  NFP5R4dCeG:ydH;zbZMhSXO|YYm= MoHrNVAuPTEQvF2= NF3GZowzcA>? MmHLbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfHKrcITvcIll\Q>? NXHrUm9HOjN7MECyPVk>
K562 M4r5XGFxd3C2b4Ppd{BCe3OjeR?= M4q2c|Ix|ryP NFLYVow1QGh? M2LueolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDRvTWW= M3\wXFI{QDd4OEK2
HL-60 NIXzSZdCeG:ydH;zbZMhSXO|YYm= Mn\vNVAx|ryP NYjZSZpzOjSq NUDUdVFlcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliYXLp[ZRidmViZHn0[ZJx\W6nc9Mg NFzwO2MzOzh4NUe3PC=>
HeLa  NIX4TpNCeG:ydH;zbZMhSXO|YYm= MmDCNlDPxE1? MmrVNog> NIfB[3ZqdmirYnn0d{BFVU2SIHnu[JVk\WRiYYDvdJRwe2m| M3zQblI{QDZ|OU[2
U251 NFX1R4hCeG:ydH;zbZMhSXO|YYm= M{Dl[VIx|ryP NV\vTnM5OjSq MmDHbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ NYKzWmFCOjN6MU[4NVY>
HL-60 MlzXRZBweHSxc3nzJGF{e2G7 NVHh[XR2PTEEtV2= NULyVmZkPGh? NUnHSHJt[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z MlPENlM5ODR5ME[=
Ec-109 MkTCRZBweHSxc3nzJGF{e2G7 MlrtNVAh|ryP NUK4Sm5QPDiq NUToTmtzemWycnXzd4V{KFCHLX3l[IlifGWmIFXjMVExQSClZXzsJIFxd3C2b4Ppdy=> MWCyN|c5OjZ2MR?=
RKO NG\IfmtE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NX;2[otQOTBizszN NF3L[oMzPGh? NIXsUoVqdmirYnn0d{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliY3H1d4VlKGK7IFTBRi=> MVGyN|c2QDB4NB?=
T98G MWXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1HwNFEuOTByzszN MU[yOIg> NHzyfVZqdXC{b4\ld{Bk\WyuII\pZYJqdGm2eTDjc5Rz\WG2bXXueEB4cXSqIGTT M4DHcFI{PzZ7Mke1
Jurkat MofUR4VtdCCYaXHibYxqfHliQYPzZZk> NIWyT4IyODBvMkCw{txO MX[yOIg> NXjORolbcW6qaXLpeJMhUGGDNDDpcoR2[2W|IHHwc5B1d3OrczDk[ZBmdmSnboSgc4Yh[2:wY3XueJJifGmxbtMg MoHoNlM4OzJ2OEG=
Molt-3  MljkRZBweHSxc3nzJGF{e2G7 Mn;JOVDPxE1? NXP3RWNMOmh? NELsVoZz\WS3Y3XzJI1mdGG2b37pck1qdmS3Y3XkJIFxd3C2b4Ppdy=> MVqyN|czPTBzMx?=
hMSC12 MoDCRZBweHSxc3nzJGF{e2G7 M3L2XFExOM7:TR?= MV20[C=> M3KzZ4lvcGmkaYTzJI9{fGWxZ3XubYMh[3WudIXy[U1qdmS3Y3XkJINmdGxiZHXheIgh[W6mIHPhcINq\mmlYYTpc44> M3HtXFI{PjV5OEKy
HM7  Mm[3RZBweHSxc3nzJGF{e2G7 M4nBSVIx|ryPwrC= MU[xbC=> M2r0[IJtd2OtczDhdIlkfWyjcnXuJGEh[WOndHH0[U1qdmS3Y3XkJINie3Cjc3WtN{Bi[3SrdnH0bY9vKGGwZDDQRXJRKGOuZXH2ZYdm NHrobZMzOzV6M{SxNi=>
Hep-2  NWrtTmk2SXCxcITvd4l{KEG|c3H5 MnnPNlDPxE4EoB?= M4r3c|I1cA>? M{TQSmROW09? Mn\lZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= MYeyN|U5ODB|Mh?=
HSCs M3;zSGFxd3C2b4Ppd{BCe3OjeR?= MkXsOVDPxE1? NUfzWGFqOjSq M4rUZWROW09? M{DxR4lvcGmkaYTzJI5qdG:2aX7pZk1qdmS3Y3XkJGRPSSCmYX3h[4UhcW6maXPheIVlKGK7IGDBVnAh[2ynYY\h[4U> NFi3PIwzOzR7OUi3OC=>
HL-60  NIn1R5NEgXSxdH;4bYNqfHliQYPzZZk> MknwNlDPxE4EoB?= NHXU[mEzPGh? NEe1O3Fz\WS3Y3XzJJRp\SCleYTveI95cWNiZX\m[YN1KG:oIFXyfVU> MlLiNlM1QTR2OEC=
HA NHfZ[npCeG:ydH;zbZMhSXO|YYm= MX21NO69VQ>? MnnGNlRp MYHzeZBxemW|c3XzJJRp\SClbHXheoFo\SCxZjDQRXJRKGGwZDDjZZNx[XOnLUOsJE04NCCjbnSgMVkhcW6mdXPl[EBjgSCkb4L0[ZpwdWmkL2PBTGE> M3nOUVI{PDd3OUW2
C666-1 NI\2Um1CeG:ydH;zbZMhSXO|YYm= MornOVDPxE1? MYKyOIg> NVjmOnJje3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD NYjBWoxUOjN2N{W5OVY>
Hepa1-6 NX\B[4cxSXCxcITvd4l{KEG|c3H5 MmL4OVDPxE1? MV:ybC=> MlTCbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| M2HDe|I{PDR4N{Wz
PLC/PRF/5c MmD4RZBweHSxc3nzJGF{e2G7 NFroZpk2OM7:TR?= MnnENYg> M2PUPZBz\X[nboTzJIFxd3C2b4Ppd{B1emmpZ3Xy[YQh[nliQ1nO NILxcJozOzR|OEiyOC=>
HCT116 NE\ud5FCeG:ydH;zbZMhSXO|YYm= MmT1NVAx|ryP M3Wzb|EvPWh? Ml3HbY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp MXyyN|c1PDN3Mx?=
HCEC MXnGeY5kfGmxbjDBd5NigQ>? NFHZOG02OM7:TR?= NF35cZQ4Omh? MYDEUXNQ NHHqfWVz\XO2b4Lld{Bw\iC2aHWgco9zdWGuIFjDSWMheGinbn;0fZBm MmHWNlM4PDJyMUG=
Primary rat cerebral cortical neurons NVi4S4MzSXCxcITvd4l{KEG|c3H5 M2TxRlExOM7:TR?= M1y3TVFp Mn7qdJJmfmWwdIOgR4QucW6mdXPl[EBieG:ydH;zbZMh[W6mIHPlcIwh\GWjdHi= NY\rSVh6OjN5NEGzNVc>
MDA-MB-231  M2\wSmFxd3C2b4Ppd{BCe3OjeR?= M2PqXVI2|ryP M2G1dFI1cA>? Mn\TZYJzd2ejdHXzJIN6fG:2b4jpZ4l1gSCjbnSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGGwZDDQRXJRKGmwZIXj[YQh[nliUnez NEfSNIQzPTN|N{W0OC=>
NLRP3-Tet-on-MC/9  NWfpUIZrSXCxcITvd4l{KEG|c3H5 M4DkOVExNTRyzszN NFPEWHAyOmh? NVXEPHNP[XS2ZX71ZZRmeyC2aHWgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhS0GSUz3hd5Nw[2mjdHXkJG5NWlB|IH31eIFvfHNiaX6geIhmKFSndD3vckB{gXO2ZX2= MYiyN|cxOzN6OR?=
KNS42  M{fhWmFxd3C2b4Ppd{BCe3OjeR?= NGHJXo82OM7:TR?= Mmn0NYg> NWPXb|BsemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDjc41xdGW2ZXz5JIFjd2yrc3jl[EBk[XOyYYPlJFMwPyCjY4Tpeol1gSCrbjDy[ZNxd26|ZTD0c{BCSlRvMk[zM|JFTy:vZYTmc5JucW5iY3;tZolv[XSrb36= MX6yN|Y6OTF2NR?=
MCF-7  NXTuW4Q2SXCxcITvd4l{KEG|c3H5 M4XNcVIx|ryPwrC= NXrzblkyPzKq NWSxboMzcW6qaXLpeJMh\XG3b3ytJIFv\CB2LV;IWE1u\WSrYYTl[EBieG:ydH;zbZM> MmXjNlM3PzV4NEO=
hCMEC/D3  MYDBdI9xfG:|aYOgRZN{[Xl? NEfxZlkzPc7:TR?= NVvEcXh6PzKq MkHadoVlfWOnczDMeJhCKGmwZIXj[YQh[XCxcITvd4l{ MWWyN|Y3PTF7OB?=
Jurkat MU\BdI9xfG:|aYOgRZN{[Xl? M4freVEzNjVvNUFOwG0> MUSxbC=> MVPkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> NES4OoEzOzR2Mkm3Oi=>
CNE-1 MnjNRZBweHSxc3nzJGF{e2G7 NI\XRY0zOM7:TdMg NFX4NGkzPGh? M3y5UYlvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= NEfEe|MzOzR{Nki1NC=>
HONE-1 NVHNT4RISXCxcITvd4l{KEG|c3H5 M{f6UlIx|ryPwrC= MlrGNlRp MmjpbY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= Mn;JNlM1OjZ6NUC=
astrocytes cell NIDTc2FCeG:ydH;zbZMhSXO|YYm= MWC0NO69VQ>? MoPYOog> MU\y[YR2[2W|IHXhdox6KGGyb4D0c5NqeyCrbnT1Z4VlKGK7IIP0ZZVzd3Oyb4LpcoU> NIK0OZQzOzRzMUe3PC=>
U-937 NHi0XoxCeG:ydH;zbZMhSXO|YYm= NWjPeIFzOTEQvF2= M2PGcFMxdWmw NYfWbo1veHKndnXueJMhXE6ILXnu[JVk\WRibnXjdo9xfG:|aYO= NHr4PYwzOzRzMEe0PC=>
MDA-MB-231 MXvBdI9xfG:|aYOgRZN{[Xl? MWKxNFDPxE1? NXSwXYFiOWh? NF:0eJVqdmirYnn0d{B{\W6|aYTpfoF1cW:wIITvJHRTSUmOIIXwc44hVVSGSDDkc5dvNXKnZ4XsZZRqd25? NV3lVZlOOjN2MEi0Nlk>
HeLa  NXPjW3VlSXCxcITvd4l{KEG|c3H5 NGXV[ZQyODEQvF2= NGmyTYMzcA>? MknEZoxw[2u|IFrSV{0yPSCLbnT1Z4V{KEGyb4D0c5Rq[yCFZXzsJGRm[XSq MXKyN|M1PDB2NR?=
Ec109 NF3zUINCeG:ydH;zbZMhSXO|YYm= MmK5NVDPxE1? M1rES|Zp MYPicI9kc3NiYYDvdJRwfGmlIHPvcYJqdmG2aX;uJI9nKFSjdD3TcYFkVjdiYX7kJJJi\GmjdHnvci=> NH3o[oozOzN|OEW2PC=>
H460  NHHGdZFCeG:ydH;zbZMhSXO|YYm= MVWxNO69VQ>? MonIOog> MmTUZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> NVvwZVZPOjN|M{i1Olg>
HeLa  NGPJUnlCeG:ydH;zbZMhSXO|YYm= M1zDTlUx|ryP NUT5SWg{OS53aB?= Mnf3ZYJzd2ejdHXzxsBEcGyjbYnkbYEucW6mdXPl[EBieG:ydH;zbZM> NH\lUZMzOzNyM{iwOC=>
SK-HEP1 NXzOeowxSXCxcITvd4l{KEG|c3H5 M1jZXlExOM7:TR?= NXf2NnNzOWh? M{GxUolvcGmkaYTzJGNzXDFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVctKC16LDCtPUwh[W6mIIDvcJkpSUSSLYLpZo9{\SlicH;sfY1memG|ZR?= NYXpR4tUOjN|MEK2OVA>
QGY7701 MXnBdI9xfG:|aYOgRZN{[Xl? MVKyOe69VQ>? MnizNU42cA>? NVHDZ3NKcW6qaXLpeJMh[WOldX31cIF1cW:wIH;mJJN2[i2JMTDwbIF{\SCrbnT1Z4VlKGK7IFTPXEAsKHG3ZYLj[ZRqdg>? MV6yN|I1ODB4MR?=
HepG2 MoCxRZBweHSxc3nzJGF{e2G7 NGXnVnMzOM7:TR?= MVGzNI1qdg>? MVPpcohq[mm2czD0bIUh\W6qYX7j[YQh[2WubDDk[YF1cCCkeTDjc41jcW6nZDD0doVifG2nboSgc4Yh[XCrZ3XubY4h[W6mIGTSRWlN M3XuRVI{OjJ2MkO5
U87  MX3BdI9xfG:|aYOgRZN{[Xl? M3npWVI2|ryP MU[ybC=> NHzkSlBl\WO{ZXHz[ZMhcXOxbHnxeYlzcXSrZ3XubY4hMEmVTDmtbY5lfWOnZDDhdI9xfG:2aXOgZ4VtdCCmZXH0bEwh[nW2IH7veEBv\WO{b4TpZ{Bk\WyuIHTlZZRp M{DCV|I{OjJ7NkK2
HSC-2 MWTBdI9xfG:|aYOgRZN{[Xl? NIK3WIszPS93MN88US=> NVP5WIdVOWh? M3WzbolvcGmkaYTzJHNPNTN6LXnu[JVk\WRiY4n0c5RwgGmlaYT5 MnTGNlMyPTV{NEi=
HSC-4 MUDBdI9xfG:|aYOgRZN{[Xl? M1\X[|I2NzVyzszN NEPXWooycA>? MlP2bY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= M2T0[FI{OTV3MkS4
CL-1 NF70PWNCeG:ydH;zbZMhSXO|YYm= NHP1fmEzOM7:TR?= MkLyNYg> NVTXTnFQ[myxY3vzJG9RPDR7IHnu[JVk\WRiY3XscEBl\WG2aB?= MUSyN|E{OTd6Mh?=
MEL MUTBdI9xfG:|aYOgRZN{[Xl? NWHIVFNWOjEQvF2= NXrY[41nOjSq NHj5bZdFVVOR MVTpcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ MUiyN|AyPDh6Nx?=
Bel-7402  NYTDPFNCS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 NUPFXHFsPTEQvF2= NEe1VoUzcA>? M2HOdIlvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> M{LWUVI{ODB6N{Sy
Eca-109 NFrhTGtCeG:ydH;zbZMhSXO|YYm= NYTnTWQ3OjYQvF2= M4C4VVMxdWmw MXTpcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq M2DOdVI{ODd4OU[3
MEL NWHhN3NvSXCxcITvd4l{KEG|c3H5 M3fTXlIx|ryP MoDaNYg> NIL0eI5FVVOR MnLWbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NYTRPHZ3OjNyMUS4PFc>
Bel-7402  MWrBdI9xfG:|aYOgRZN{[Xl? NH3kRYc2OM7:TR?= NWGwTINvOmh? NYDEZYV[cW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? NVvPZ2xGOjNyMEi3OFI>
L929 MWTGeY5kfGmxbjDBd5NigQ>? M1jwblIvPc7:TR?= NVPmU5BQOWh? NYC0U5NDcW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? MUmyN|AxODVzOB?=
RCC  NYqwdYkzS2WubDDWbYFjcWyrdImgRZN{[Xl? MXWxNFDPxE1? Mn7XNlRp MnzidoVkd3[ncnXzJJRp\SC4aXHibYxqfHlib3[gZ4VtdHNiZYjwc5Nm\CC2bzCxOYQuWEeMMh?= Mme5NlI6QTF2OUS=
NB2a/d1 Ml\HRZBweHSxc3nzJGF{e2G7 NYPoXWt5OTByzszN M{LNSVczcA>? NHHYdJdifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm NWPRWlNHOjJ7OEi1OFE>
T cell NXLOTZZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nkblI2NTFyMN88US=> NGHkeWszPGh? M3HvfYRwe2VvZHXw[Y5l\W62bImgbY5pcWKrdHXkJHQh[2WubDDwdo9tcW[ncnH0bY9vKG2nZHnheIVlKHSqcn;1[4ghfGinIHPvMZN1cW23bHH0bY9vKHerdHigZY51cS2FREOgZY5lKGGwdHmtR2QzQA>? MofkNlI6QDJ3M{i=
K562 NIHyXmNCeG:ydH;zbZMhSXO|YYm= NFPBSHIyODEQvF2= NX\0OIxvOWh? NHvOdJpjdG:la4OgRYJvd2KjdnnzZ5VuyqCILXnu[JVk\WRiYYDvdJRwe2m| MX6yNlk4OjN5Mh?=
Jurkat  NXfJeXR6SXCxcITvd4l{KEG|c3H5 M2fkcFQx|ryP MlHVNYg> M37nS4Fjd2yrc3jld{BH[XOOLXnu[JVk\WRiY3HzdIF{\SCjY4TpeoF1cW:wIHHu[EBk\WyuIHTlZZRp NFHyUnEzOjl2MkezPC=>
BGC-823 MY\BdI9xfG:|aYOgRZN{[Xl? NVP6Tm5OOTByzszN MoPBNYg> M1\zb5BienSrYXzsfUBz\XOldXXzJINmdGy|IHHnZYlve3RiZHHtZYdmKG:oIHThbYR7\Wmw NVnTOnd6OjJ7Mk[1OFU>
Hep3B MWrBdI9xfG:|aYOgRZN{[Xl? M1frSlUx|ryP NWP0c5JkOWh? NWHrfnpN[myxY3vzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEiHR1Pz M3jwUFIzQTJ|MUW0
LLC-PK1 MlewRZBweHSxc3nzJGF{e2G7 NFHRUGYzOM7:TR?= NXzWe5VqOWh? MlvPdJJmfmWwdIOgZ4l{eGyjdHnuMYlv\HWlZXSg[IVoemGmYYTpc44hd2ZiQYTnOUwh[mWlbHnuMVEtKGGwZDDBeIcyOiCycn;0[Ylvew>? M2fMVFIzQDl4MEO3
A549 MnXSRZBweHSxc3nzJGF{e2G7 NWjmNXRtPTEQvF2= NFjBPI8ycA>? NYTa[mtl[myxY3vzJJRp\SCEQVmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> M4mweFIzQDh5MkG1
SGC-7901  NX;lTWpvSXCxcITvd4l{KEG|c3H5 MlrzNVDPxE1? NYLl[|ZNOjSq MVTpcohq[mm2czFOtkzPui2maX3leIh6dGGlconsd4hqc2:waX6tbY5lfWOnZDDhdI9xfG:|aYRCpC=> NF3DXnAzOjh2OEW5Oy=>
DM6 MlfsRZBweHSxc3nzJGF{e2G7 MnOyNVAx|ryP M3znWlczcA>? Ml\LZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? NXzscm9VOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NX7NN453T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS4R|BWPTEQvF2= NYG5OGs{PDiq M4nGS4lvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> MknZNlI5ODB7Nki=
A2750  MkjMRZBweHSxc3nzJGF{e2G7 NXvTO4ZvOjEQvF2= MWSybC=> NX;tZ4xYTE2VTx?= NFexfohjdG:la4OgZ4F{eGG|ZTDjcIVifmGpZTDkeZJqdmdiaHXs[Y5idGmwIITy[YF1dWWwdDDhcoQhemWmdXPld{BifXSxcHjh[4lkKGOnbHyg[IVifGh? MoDvNlI4QDR|NkO=
U87  M{HKNWFxd3C2b4Ppd{BCe3OjeR?= NH3ReHozOM7:TR?= M{DaPFI1cA>? NHTyWY1z\WS3Y3XzJJRp\SCjcH;weI9{cXNicnH0[UBqdmS3Y3XkJIJ6KFCOQVK= M{TpZlIzPzd6N{iw
HT1080 M1vVfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImxZWs2OM7:TR?= NFi1OYs4\A>? M2\BOYlvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJINifXOnZDDifUBkd22kaX7l[EB1emWjdH3lcpQhd2ZiRFPBJIFv\CCRTWC= MYGyNlc1ODl6NB?=
A549  MWDBdI9xfG:|aYOgRZN{[Xl? MV21NO69VQ>? MmT0Nog> NWfZRopPeGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> NUmx[GRtOjJ5MkG4NFQ>
Primary OPC NF3pPVZCeG:ydH;zbZMhSXO|YYm= NG\rWXky|ryP MVe2bE8zPGh? MnyxdoVlfWOnczD0bIUheGW{Y3XueIFo\SCxZjDj[YxteyCrbjDlZZJtgS1iYX7kJIxifGVvYYDvdJRwe2m|L37lZ5Jwe2m| M3PQOFIzPzB5M{i1
PMNs MUDBdI9xfG:|aYOgRZN{[Xl? M1fx[lQx|ryP MUG2bC=> NVL5WGZ4TE2VTx?= NWqzNVJMemW4ZYLz[YQhfGinIHHtc5VvfCCxZjDjcIVifmWmIHPhd5Bie2VvMzD0c{Bv\WG{II\lbIlkdGVibHX2[Yx{ MmPONlI3QTJ3N{e=
A549  M2W0WmFxd3C2b4Ppd{BCe3OjeR?= M3\SdlUx|ryP M1jhbFFp NH3KcIFxemW4ZX70d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCEYX;oeY9{cWSnIFm= MoDqNlI3QDd4M{W=
AGS NGPD[IJCeG:ydH;zbZMhSXO|YYm= NIPOPXkzOM7:TR?= M1XUdFEzcA>? NWD3WYxTcW6qaXLpeJMhfGinIHHjeIl3[XSrb36gc4YheHKxLXPhd5Bie2VvMzDpckBz\XOyb37z[UB1dyC2aHWgSZRQSWNiZoLhZ5Rqd25? NHS5b|AzOjZ6N{O5PC=>
shC9  Mn\5RZBweHSxc3nzJGF{e2G7 Ml;XNVDPxE1? NF\yRWkyPmh? M3v2b4JtfW62czDTTGgh\XiycnXzd4lwdiCrbjDzbGM6KGOnbHzzJIV5eG:|ZXSgeI8h\Wm2aHXyJHBCKG:{IFzQRy=> Ml:0NlI3PDFyOUS=
primary MEFs M3jjUmZ2dmO2aX;uJGF{e2G7 M2TRUFEzcA>? NWDnNZZHyqCrbnPy[YF{\XNiZYTvdI9{cWSnLXnu[JVk\WRibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBl\XCxbHHybZpifGmxbh?= MoLYNlI3OTN5Nke=
3T9 MEFs NX\COJBGTnWwY4Tpc44hSXO|YYm= NFjyUJAyPmh? MYTpcoNz\WG|ZYOgZ5l1d2Oqcn;t[UBkKHKnbHXhd4Uh[W[2ZYKg[ZRweG:|aXTlMZRz\WG2bXXueC=> NHOwV|QzOjZzM{e2Oy=>
3T9 MEFs NX7XOFdXTnWwY4Tpc44hSXO|YYm= NX7TWZpZOTiq MkXheZBz\We3bHH0[ZMhcW6rdHnheI9zKGOjc4Dhd4UuQSCkdYSg[I94dnKnZ4XsZZRmeyCnZn\lZ5RweiClYYPwZZNmeyCjZoTldkBmfG:yb4Pp[IUhfHKnYYTt[Y51 NVz2N2FEOjJ4MUO3Olc>
MDA-MB-231  MXnBdI9xfG:|aYOgRZN{[Xl? NV7HcW1oOjEQvF2= M37YdFRl NX\tZ|FkemWmdXPld{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCvZYTmc5JucW5idILlZZRu\W62IIfhd{B{cWewaX\pZ4FvfGy7 NYW2[4tEOjJ3OUO0OFE>
C6  MVrBdI9xfG:|aYOgRZN{[Xl? MVixNO69VQ>? MVKyOIg> NHmzN|NjdG:la4OgeIhmKHO3cIDy[ZN{cX[nIHXm[oVkfCCxZjD0bIUheGWydHnk[UBwdiC4aXHibYxqfHl? NIm2Rm4zOjV6OEm4NC=>
HL-60  NUDTN|JHSXCxcITvd4l{KEG|c3H5 NEDQbpIyODEQvF2= M37NeFI1cA>? MVnpcohq[mm2czD0bIUh[2WubDDhdI9xfG:|aYOgd4Vt\WO2ZXSgLEsqNW2nboTofYwh|rJvKEJiirI3MS2maXfseYNweHm{YX7vd4ll\cLiNR?= Mn\FNlI2PDZ4Nkm=
HL-60 MYfBdI9xfG:|aYOgRZN{[Xl? M1TadlExNThyzszN NUHn[WV4PGh? MmLDbY5pcWKrdIOgWGdJWS2rbnT1Z4VlKGOnbHygZZBweHSxc3nzxsA> MXSyNlUzOzJ{OR?=
BCC MVfBdI9xfG:|aYOgRZN{[Xl? MnPaOVDPxE1? NUD0V2hoOWh? MXfpcohq[mm2czDERXRUNW2nZHnheIVlKGe{b4f0bEBqdmirYnn0bY9v NETSXFQzOjVzOUSzOi=>
RAW 264.7 NHz0S2lCeG:ydH;zbZMhSXO|YYm= MYC1NE8yODEQvF2= NIHaNHQycA>? NUH5UVVx[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgbY5pcWKrdIOgSG9PNWmwZIXj[YQhelKQQTDjcIVifmGpZR?= MUGyNlQ6OTR{Nh?=
K562 NF7qdoFCeG:ydH;zbZMhSXO|YYm= MnjWNlXPxE1? MX6ybC=> NV75Xm86eHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3:teJJm[XSvZX70JJdqfGhiYX31doVve2mwIFegZY5lKFSUQVnM NEPPcmYzOjR6M{e3Oy=>
SGC-7901 M{\YZ2Fxd3C2b4Ppd{BCe3OjeR?= Ml;FNlAh|ryPwrC= NYXxfWNtOmh? NFq1W29ifHSnboXheIV{KEh{T{NCpI9zKFSQRjFOtU1qdmS3Y3XkJINmdGxiYYDvdJRwe2m|IHHzJJdmdGxiYYOgZ4F{eGG|ZT2zJIFkfGm4aYT5xsA> NF73NlAzOjR5MUW4PS=>
PC3 Mn\wRZBweHSxc3nzJGF{e2G7 NGO5[WUyOM7:TR?= M1\W[FRp NGnLWHpkd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> NGPJb3UzOjR5MUm3OC=>
SMMC-7721 NHvnTGZCeG:ydH;zbZMhSXO|YYm= NWi4enlzPTEQvF2= Mn3lOFhp MWjheJRmdnWjdHXzJI9VWi2rbnT1Z4VlKGGyb4D0c5Nqew>? Ml7sNlI1PjV6M{O=
HeLa  MVvBdI9xfG:|aYOgRZN{[Xl? M4rzVFUxyqEQvF2= MXG0M|hp NUDQRXFJcW6qaXLpeJMhW1SVLXnu[JVk\WRibHH0[U1xcGG|ZTDhdI9xfG:2aXOg[ZZmdnS| M1mxcFIzPDZyNUC0
HeLa  MXjBdI9xfG:|aYOgRZN{[Xl? MYO1NOKh|ryP MVexbC=> MV7zeZBxemW|c3XzJJRp\SCIUlHQMYlv\HWlZXSgZYNkfW23bHH0bY9vKG:oIHHucoV5cW5iVjDwc5NqfGm4ZTDj[Yxtew>? NXSzTVZDOjJ2NEm0OFA>
T47D  M4TKSmFxd3C2b4Ppd{BCe3OjeR?= MlHjNVAx|ryP MWOxbC=> M3\wXYJtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NF[ydWszOjRyMUG2PC=>
HeLa  NWnLPZRvSXCxcITvd4l{KEG|c3H5 MlXuN|DPxE1? M4XMXlRp MV1CpIlv[3KnYYPld{B1cGViZ3Xu[ZJidCClZXzsJJZq[WKrbHn0fUA1QCCqIHHmeIVzKHCqb4Tv[Jlv[W2rYzD0doVifG2nboVCpC=> MnnmNlI{QTR{NEi=
HCC NVXEcWc3SXCxcITvd4l{KEG|c3H5 MkDsNlAh|ryPwrC= NVjlV5pNOmh? M17OfIF1fGWwdXH0[ZMhfGinIFTIRUBqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiUFHSVC=> MmS5NlI{PDJ5M{K=
mESCs NUXxZ3VwSXCxcITvd4l{KEG|c3H5 NIfaT2ozNjYQvF2= NUXvSJVEOmh? MoHybY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= NYTO[4pwOjJ{OEWyO|Q>
EMT-6  NHjkT45EgXSxdH;4bYNqfHliQYPzZZk> NX;kc41lOTByzszN NIroRYQycA>? NYn6eItXeGG{dHnhcIx6KGKub3Pr[YQh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IIPpdoFu\XOrbnW= NUnxdFN[OjJ{NUG5NlE>
MCF7 NXnFcHlESXCxcITvd4l{KEG|c3H5 M1r0dFUxyqEQvF2= MnXRNYg> MoH5bY5pcWKrdIOgVGEh[WO2aY\heIVlKGOjc4Dhd4UuOyxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? MlfKNlIzOjN|NEW=
K562 NF;qVFNCeG:ydH;zbZMhSXO|YYm= NHzEPFAzOCEQvF5CpC=> MYG0PIg> MYnEUXNQ NEXuTGRjdG:la4OgcIFx[XSrbnniMYlv\HWlZXSgbY5pcWKrdHnvckBw\iC4aXHibYxqfHliYX7kJIFxd3C2b4Ppd{BqdmS3Y4Tpc44> NUjK[mVXOjJ{MU[xOVg>
Molt4-hyg MWPBdI9xfG:|aYOgRZN{[Xl? MWixNO69VQ>? NVqxdolmOC53aB?= M1rQc4Jtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 MlzTNlYzPzV6MUG=
HeLa MVzBdI9xfG:|aYOgRZN{[Xl? MnnENVDPxE1? M3TDelAvPWh? NIrzVWhqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2aHWgZ49u[mmwZXSgeJJm[XSvZX70JJdqfGhiZ3;tbZNqdiCQIHHu[EBVWkGLTB?= NFS3VXQzOjF5OU[2NS=>
Jurkat T NH;ZOnFCeG:ydH;zbZMhSXO|YYm= NFvrTZc{OM7:TR?= NH6zT48xNjWq MnGwSG1UVw>? MnPmZoxw[2u|IITo[UB7cXKjbT3pcoR2[2WmIHHwc5B1d3Orcx?= MX2yNlE2QTh7OB?=
Neutrophil Ml7LRZBweHSxc3nzJGF{e2G7 MWeyNO69VQ>? NE[xU5cxNjWq NGXRc3VifHSnboXheIV{KHSqZTDwdo8u[XCxcITveIlkKGWoZnXjeEBw\iCPYWKx NYXsXpF2OjZzOU[4OFQ>
HCT116 NWTDU201SXCxcITvd4l{KEG|c3H5 NYLnOoJQPTEEoN88US=> MmHGNog> MnnvdoV3\XK|ZYOgd5lv\XKpaYP0bYMh[XCxcITvd4l{KGWoZnXjeJMhd2ZiY3Xs[YNwgGmkIHHu[EBPWENvMUdCpC=> NWHzNI5YOjJzNUm3OVI>
MDA-MB-231  M4fzeWFxd3C2b4Ppd{BCe3OjeR?= NU\1O5NHOi53LUeuOe69VQ>? NG\mdFIzcA>? M3qxdolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? NUe1UHpLOjJzMUW1NlY>
LNCaP NG\zVoVCeG:ydH;zbZMhSXO|YYm= Ml64OFDPxE1? NGmyc3YzcA>? M4\OdIlvcGmkaYTzJIJ2fGWrbjDpcoR2[2WmIHPlcIwh[XCxcITvd4l{ M4DkelIzOTF2N{[0
MB231 M1nGUGFxd3C2b4Ppd{BCe3OjeR?= MVexNFDPxE1? MV6xbC=> NFvIZXZFVVOR NYH5Z3hP[WK{b3fheIV{KHSqZTDpcoR2[3Srb36gc4Yh[2WubDDk[YF1cCCkeTDXSWUyKGmwaHnibZRqd25uIGTSRWlNKHS{ZXH0cYVvfCxiYX7kJJRp\SClb33ibY5ifGmxbh?= NXjqTFY6OjJzMUK5OFA>
HCC38  NGnMbHZCeG:ydH;zbZMhSXO|YYm= MYqxNFDPxE1? MnfUNYg> NWjUSJBbTE2VTx?= NXjjNJRQ[WK{b3fheIV{KHSqZTDpcoR2[3Srb36gc4Yh[2WubDDk[YF1cCCkeTDXSWUyKGmwaHnibZRqd25uIGTSRWlNKHS{ZXH0cYVvfCxiYX7kJJRp\SClb33ibY5ifGmxbh?= NX;uTmt4OjJzMUK5OFA>
MDA-MB231 M2T5VGFxd3C2b4Ppd{BCe3OjeR?= NFm3NnI2OMLizszN MmSyNlRp MYnEUXNQ MVrhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M3HhdVIzOTBzM{O1
LNCaP MX3BdI9xfG:|aYOgRZN{[Xl? M3TUO|UxyqEQvF2= MUWyOIg> NVzn[otXTE2VTx?= MnLMZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M{PWZlIzOTBzM{O1
HCT116 M3PMZ2Fxd3C2b4Ppd{BCe3OjeR?= NIT1R2E2OMLizszN NYjwPJlQOjSq M2jLdWROW09? NEfRTJhi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp NFr5NpczOjFyMUOzOS=>
Ishikawa  NHfwUWFCeG:ydH;zbZMhSXO|YYm= M{XRcFI2|ryP NGq2VWgzPGh? NFnp[Hlz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHHwc5B1d3OrczDpcoR2[2WmIHL5JGJi\iCDMR?= M4LWdVIzODh6OUG4
 YD-8  NXnsNlczSXCxcITvd4l{KEG|c3H5 M2\hN|ExOM7:TR?= MmCxNYg> MoDJbY5pcWKrdIOgVGxGVy2rbnT1Z4VlKGGyb4D0c5Nqew>? M{jDNFIzODh4MUiz
eosinophil  MYHBdI9xfG:|aYOgRZN{[Xl? Mn;kPVDPxE1? MVKyOIg> NYnlOFBqcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliRnHzJIFvfGmkb3T5xsA> NU\DVHdlOjJyN{mzN|Q>
L929 NITlWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWWyMlXPxE1? M1\ZW|I1cA>? NHfBTJNqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBxNXB|ODDhcoQhVkZvzsrCJJRwKGG3Z33lcpQhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 NED6fIUzOjB{N{C5Oy=>
YD-8  NHvH[ZZCeG:ydH;zbZMhSXO|YYm= MWqxNFDPxE1? Ml31NYg> NH2xWVNjdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> M3XFPVIzODJyMEe4
HBx M2XkUGFxd3C2b4Ppd{BCe3OjeR?= MX:yOe69VQ>? MoL6OFhp NFrPbmhFVVOR M{ewe5Jm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= NHPDepczOjB{MEC3PC=>
U937  NW\3eIJZSXCxcITvd4l{KEG|c3H5 NXrveGI6PTEEoN88US=> NFPsTZQycA>? MWjpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh M3i5ZVIyQTl6N{Ox
HL60 MXjBdI9xfG:|aYOgRZN{[Xl? MnzjOFDPxE1? M3;WXFQxdWmw NG\1V4pFVVOR NWPiWINz[myxY3vzJGJPTENiY3;tdI92dmS|IHnu[JVk\SCneIDvd5Vz\SCxZjDwbI9{eGijdHnkfYx{\XKrbnWgZY5lKESQQTDmdoFodWWwdHH0bY9v MWKyNVk5OzJ7Nh?=
M-14 NXO3VlBUSXCxcITvd4l{KEG|c3H5 MkjPNlXPxE1? MWOwMlVp MlvOxsBqdmirYnn0d{Bjd3SqIITo[UBkenWmZTDlfJRz[WO2LTDhcoQh[2:vcH;1coQucW6mdXPl[EBieG:ydH;zbZM> M3vPN|IyQTV2OUW5
SK-BR-3 M2PySGFxd3C2b4Ppd{BCe3OjeR?= MVe1NOKh|ryP MnLpNog> NVnyS2Vv[myxY3vzJIFxd3C2b4TpZ{BFVkFiZoLh[41mdnSjdHnvckBqdmS3Y3XkJIJ6KGOxbXLpcoF1cW:wIH;mJHNONTF4NDDhcoQhemGmaXH0bY9v M3j3R|IyQTBzM{i2
MDA-MB-468 NUXa[5hPSXCxcITvd4l{KEG|c3H5 NWP5NFFlPTEEoN88US=> NV3aZVdkOmh? NFrzT5NjdG:la4OgZZBweHSxdHnjJGRPSSCocnHncYVvfGG2aX;uJIlv\HWlZXSgZpkh[2:vYnnuZZRqd25ib3[gV20uOTZ2IHHu[EBz[WSrYYTpc44> NUSwcpRzOjF7MEGzPFY>

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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