Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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3 Customer Reviews

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MkHBRZBweHSxc3nzJGF{e2G7 MXS1NO69VQ>? MWOyOIg> MUTpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> NVLORYV{OjZzNkmwO|U>
HGL5 MnfvRZBweHSxc3nzJGF{e2G7 NX2xTll[PTEQvF2= NIjHcGIzPGh? NGLXXnJqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? NUD4cXpCOjZzNkmwO|U>
HepG2 M1;iWWFxd3C2b4Ppd{BCe3OjeR?= MVGyNO69VQ>? Mm\aNYg> M1rWXoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> NXXzS284OjZzNkS3PVU>
BEL-7402 MmTURZBweHSxc3nzJGF{e2G7 M37KVFIx|ryP NWjkUWduOWh? MkXhZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> M3PwWFI3OTZ2N{m1
CEF MonMT4lv[XOnIFHzd4F6 M3LXXlAtOzNuNkesNVAx|ryP MXexOY1qdg>? MXXkc5dvNXKnZ4XsZZRmeyCSUjDlcpp6dWViYXP0bZZqfHlidH:gOFDwxIViYYSgNVAx|ryP MY[yOlExOjN|OR?=
SP2/0 M4nUNmFxd3C2b4Ppd{BCe3OjeR?= MVyxNFDPxE1? NHrLSXkycA>? NXnQdoQxTE2VTx?= MXHicI9kc3NidHjlJIFxd3C2b4Ppd{Bw\iCVUEKvNEBk\Wyucx?= M1Px[lI3ODd2N{Oy
HUVEC-2c MWLBdI9xfG:|aYOgRZN{[Xl? MWO1NO69VQ>? NUG1O49rPmh? M2\3UYRm[3KnYYPl[EB1cGVib4itUGRNNWmwZIXj[YQh[XW2b4DoZYd6 MkPNNlYxOjF5Mkm=
U1 MWXBdI9xfG:|aYOgRZN{[Xl? NGDoV4QxNTFyMN88US=> Ml7BNog> MVXy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MU[yOVk5ODl2Mh?=
ACH-2 NXz0UnJlSXCxcITvd4l{KEG|c3H5 M3zuVlAuOjByzszN MmPLNog> MX3y[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NIi4PZUzPTl6MEm0Ni=>
U1 NF\kc2NMcW6jc3WgRZN{[Xl? NF\pTJkyODEQvF2= MV6ybC=> MnnibY5pcWKrdIOgZ4F{eGG|ZT2z NYf2dmY6OjV7OEC5OFI>
A549/V16 NHWwRolCeG:ydH;zbZMhSXO|YYm= M3LTd|Ux|ryP NXfuV4RFOWh? MoXudoVxemW|c3XzJHRIN1SPLXnu[JVk\WRiYYDvdJRwe2m| M1TIXlI2QTR4MEOz
SGN NF;v[G9CeG:ydH;zbZMhSXO|YYm= MmXqNlBuVQ>? MXW0PIg> MWHoZZMhdm9iaX7mcJVmdmOnIH;uJGFKTixiY3HsdIFqdiCneIDy[ZN{cW:wIH;yJINmdGxiYYDvdJRwe2m| M4nSNFI2QDd2NkOz
HCT116  MkPVRZBweHSxc3nzJGF{e2G7 NVjOe49MPTEQvF2= M1fmNVJp NUTDXWF5cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S MWKyOVg3QDhzOB?=
DTK-SME MlrLRZBweHSxc3nzJGF{e2G7 NXPxOFd7PTEQvF2= MXGybC=> NUXSR4x5TE2VTx?= NVnibGt7eGG{dHnhcIx6KGmwaHnibZR{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBjfXCrdnHjZYlv\Q>? M3n4cFI2QDR|OEm3
HL-60 MkXKRZBweHSxc3nzJGF{e2G7 MXy1NO69VQ>? MmT3OFhp NETJPYdz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? NXzoRWs1OjV6MkSwOFM>
U937 NFXUbJFCeG:ydH;zbZMhSXO|YYm= NX7jbVl2PTEQvF2= MX[0PIg> MnXodoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MV:yOVgzPDB2Mx?=
A549 NWruTHBHSXCxcITvd4l{KEG|c3H5 M{fScFIxKM7:TR?= NUXPcZBGOjSq M2\tdZJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= M4LYUVI2Pzl2MUS5
HeLa MmDLRZBweHSxc3nzJGF{e2G7 MXSxNO69VQ>? NIPrT4Q1QGh? MYrk[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 NEmxSGIzPTd5MkW0OS=>
SGC-7901 M3HvW2Fxd3C2b4Ppd{BCe3OjeR?= M1nTNVIxyqEQvF2= NFnufZYycA>? Mkm4bY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> MXmyOVc3PzB5Nh?=
MCF-7 NI\uXJNCeG:ydH;zbZMhSXO|YYm= Ml3LNVDPxE1? MUKybC=> MoDFbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTCzRi=> MoOwNlU4OjJzMUS=
A549 NF;ie3JCeG:ydH;zbZMhSXO|YYm= MnrWNVAh|ryP MVWyOIg> MYDEUXNQ NX7xXFJzeHKxbX;0[ZMhUEKFLYTy[YF1\WRiQUW0PUBk\WyuIIP1dpZqfmGuID[gZZR1\W63YYTld{B1cGViY3zlZZZm\CCSQWLQJIV5eHKnc4Ppc44> M4rqXlI2Pjh|NU[4
U87 NVi3UW1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUiwWJV4PTEQvF2= NH\rXZcycA>? NX3tV403emWlb4\ldpMh[2WubDDndo94fGhiZoLvcUBVVVpidILlZZRu\W62 MX2yOVY5OTZ4OB?=
Neocortical Neuron MX7O[ZVzd3SxeHnjbZR6KEG|c3H5 NGf6WXgyODEQvF2= NIHhSWsycA>? NGPZdlhidnSjZ3;ubZpmeyCKb3nhcYll\SCDLVnu[JVk\WRiTnX1do91d3irY3n0fS=> NWqySVVPOjV4N{WwNFE>
Primary human placental cytotrophoblasts Mn3ZRZBweHSxc3nzJGF{e2G7 M2e3OFMx|ryP NXvoT3hwOjSq NInFXW5FVVOR NEm3XZRz\X[ncoPld{B1cGViaX7obYJqfGmxbjDv[kAyOc7{LVjTSFIh[nlidILpZ4xwe2GwwrC= MUeyOVY1OjV7Mh?=
MM NVv5RYZGSXCxcITvd4l{KEG|c3H5 NVnQU49mPTEQvF2= NG\QN2QzOG2rbh?= MWfwZZJ1dHliaX7obYJqfHNiU1jLMYlv\HWlZXSgJINmdGxiZHXheIg> M2rXN|I2PTNyMEm4
DLD1 NF\wTHJCeG:ydH;zbZMhSXO|YYm= MWiyNOKh|ryP MnHWNYg> NVnnOW5HeGG{dHz5JJJmfmW{c3XzJINmdGxiYYDvdJRwe2m|IHPheZNm\CCkeTDXV3Ay NVn2TYI5OjV3MkSyOFY>
MDA-MB-231 NGi4bZpEgXSxdH;4bYNqfHliQYPzZZk> MlzwNVDPxE1? NWfyfXVYOWh? M1m0PIF2\22nboTzJINmdGxiZHXheIgh[W[2ZYKgR2hWSSC2cnXheI1mdnR? MWSyOVUzOTVyMR?=
MKN28 NGnHOY1CeG:ydH;zbZMhSXO|YYm= MYOxNO69VQ>? MV6zNI1qdg>? M1\XOWROW09? Mn3vbY5pcWKrdIOgWG5HNc7zIIDseZMhS0i[LXnu[JVk\WRiYYDvdJRwe2m| MXGyOVUyOzl4MB?=
HL-60 MnHoR5l1d3SxeHnjbZR6KEG|c3H5 M4O0[FExOM7:TR?= Ml;FNYg> NHXoVFBFVVOR MWFCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MV[yOVUxOjl|Mh?=
AGS NVG3R2pKSXCxcITvd4l{KEG|c3H5 MV[xNO69VQ>? NIr2VIUycA>? MmHpdJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? MVqyOVQ6OjJzNB?=
A549  NEPQ[INCeG:ydH;zbZMhSXO|YYm= MmG4NVDPxE1? NV3U[lJJOjSq NUfEXWtl[myxY3vzJGROSVNvaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgZY5lKGGyb4D0c5Rq[yClZXzsJIRm[XSq M1y5c|I2PDN2OUi5
INS-1 M2rRd2Fxd3C2b4Ppd{BCe3OjeR?= M3q4[VUx|ryP MljoOog> NW[5eo1tTE2VTx?= NYD3[Flu\GWlcnXhd4V{KHSqZTDwdo9xd3K2aX;uJI9nKGWjcnz5JIFxd3C2b4TpZ{Bk\Wyuc9Mg NHzQfIEzPTR|MEi5Oy=>
Primary hepatocytes  MV3BdI9xfG:|aYOgRZN{[Xl? NX3wPIg6PTEQvF2= MYKxPIg> NXvld406cW6qaXLpeJMh[XCxcITvd4l{KG:oIHjldIF1d2O7dHXzJIlv\HWlZXSgZpkhSWO2IFSgZY5lKFSQRj5OtS=> M2DHNlI2PDB5NUO4
L929-A  M1rhWmN6fG:2b4jpZ4l1gSCDc4PhfS=> MVyyNOKh|ryP MWqyOIg> NHi3W5NqdmirYnn0d{BVVkcQsT3pcoR2[2WmIHPlcIwh\GWjdHi= NY[5UpB1OjV|OUi1OFA>
L929-N NYn4Z|dQS3m2b4TvfIlkcXS7IFHzd4F6 NXLSPW93OjEEoN88US=> NFvvNpUzPGh? M1LXXYVvcGGwY3XzJIRm[XSqII\pZUBifXSxY4LpcoUhXE6IzsGgdJJw\HWldHnvci=> NUfMTJczOjV|OUi1OFA>
Cytotoxicity Assay M3rnd2NmdGxiVnnhZoltcXS7IFHzd4F6 NHX5fY4zOM7:TR?= NUXaVXUzPDiq NEHMTYlxemW4ZX70JG1JVURvaX7keYNm\CClZXzsJIRm[XSq NVjxWYhzOjV|OUKxNVY>
COS7 NUHSUHNUU2mwYYPlJGF{e2G7 NVKySnk1OTEQvF2= NHL5OoozPGh? NIXFNXFqdmO{ZXHz[ZMh[2G|cHHz[UA{NzdiYXP0bZZqfGmncx?= M{LvcVI2Ozh2MEK1
COS7 MV3BdI9xfG:|aYOgRZN{[Xl? NGHmeHgyOM7:TR?= NV6ybYp6PDiq MULwZZJ1cWGubImgdJJmfmWwdHXkJGZEOTBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NFnsZXczPTN6NECyOS=>
A375 MVTBdI9xfG:|aYOgRZN{[Xl? MXWzNO69VQ>? M{GyNFJp MYPwdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> Mni3NlU{PzZzMUW=
A549 MYDBdI9xfG:|aYOgRZN{[Xl? Ml;IOVDPxE1? M2\ablI1cA>? MoXMdoV3\XK|ZYOgdoljd3OxbXWgZolw\2WwZYPpd{BidmRiYYDvdJRwe2m|IHPheZNm\CCkeTCgR4hqcm:wZ3Thci=> Mn7XNlU{PDl5OEG=
A549 MlrsRZBweHSxc3nzJGF{e2G7 NXPHOJFJOi53LUK1{txO MkC4NYg> Ml6x[IVkemWjc3XzJJRp\SCyb4D1cIF1cW:wIH;mJIFxd3C2b4TpZ{Bk\WyuczDk[ZBmdmRib36gZ49v[2WwdILheIlwdnN? MV:yOVM1OjR{Nx?=
 NBL-W-S  MWLBdI9xfG:|aYOgRZN{[Xl? NXjiXYhiPTEQvF2= NUDBbmo1OWh? M1v0eYZ2dGy7IILld4N2\XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgS2FPXC14MTD0doVifG2nboS= Ml3WNlU{OjN{MkK=
Caki-1  Ml3oRZBweHSxc3nzJGF{e2G7 MY[0NO69VQ>? NH:zWI81QGh? NIrhdJFz\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ NWPVSGlqOjV{N{mxPVE>
769-P MXvBdI9xfG:|aYOgRZN{[Xl? MlW0OFDPxE1? NH\Weok1QGh? MYPy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz MW[yOVI4QTF7MR?=
H9c2 NGTKWGlCeG:ydH;zbZMhSXO|YYm= MoL4OVDPxE1? M1:2OVFp M4fFOIlvcGmkaYTzJGRQYC2rbnT1Z4VlKGOjc4Dhd4UhOyCjY4TpeoF1cW:wIHL1eEBvd3RidHjlJIxwe3Nib3[gZ4VtdHN? M1vQS|I2Ojh|OEG5
K562 M1XjWmFxd3C2b4Ppd{BCe3OjeR?= M4XBSFUx|ryP NV7KWYV7PGh? MYHpcohq[mm2czDKZYMuSS2rbnT1Z4VlKGOnbHygZZBweHSxc3nz NXvSb5BSOjV{NEG2NVk>
L929 M4T1cGFxd3C2b4Ppd{BCe3OjeR?= NIjIdlUyOM7:TR?= MkfvOog> NX;PXoxHcW6mdXPld{Bv\WO{b4D0c5NqeyC5aYToJHRPTg>? M3XoOFI2OTl3Nk[w
A549 NVXhbWdLSXCxcITvd4l{KEG|c3H5 MYqxNO69VQ>? M2nQbFNp M3rvZpJm\HWlZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGDRVS=> MWmyOVE3OTZ7OR?=
MCF-7 M4LsWWFxd3C2b4Ppd{BCe3OjeR?= NH\EfWMzOM7:TR?= MYiybC=> Mn3I[IVkemWjc3XzJGtFWi2|aWLORU1qdmS3Y3XkJIFxd3C2b4Ppdy=> M2fzRlI2OTh{MkSw
OS NF3BUItCeG:ydH;zbZMhSXO|YYm= NVjNeZpPOjBxNEFOwG0> NHO5bHo4Omh? NX;CbJRLcW6qaXLpeJMhV1NiY3XscEB3cWGkaXzpeJkhemWmdXP0bY9vKGK7IFO2JINmemGvaXTl MVWyOVE2OjN7OR?=
HUVECs MmjFRZBweHSxc3nzJGF{e2G7 MkPKNVDPxE1? NGL3eWszcA>? MXlCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGhWXkWFcx?= NYnIS|NEOjVzM{i3NFM>
EA.hy926 NIXmdJVCeG:ydH;zbZMhSXO|YYm= Mo\JNVDPxE1? MlT4Nog> MmrnxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBGSS6qeUmyOi=> NHXl[GQzPTF|OEewNy=>
Ebs MnPmRZBweHSxc3nzJGF{e2G7 NG\xWVMyOC1zMEFOwG0> M4DTRVI1cA>? NVzhNI9LyqCPTWTTJIdmdmW{YYTpc44hemG2ZTDk[YNz\WG|ZXSgZZMhfGinIHPvcoNmdnS{YYTpc44hd2Ziej3WRWQv\m2tIHnuZ5Jm[XOnZB?= M1nNUVI2OTN2OEG3
Jurkat NIPMcYdCeG:ydH;zbZMhSXO|YYm= NIrOboozOM7:TR?= M2i2clI1cA>? M3vY[GROW09? NEfm[pBx[XK2aXHscJkhcW6qaXLpeEBk\WyuIHTlZZRpKG:oIFr1dotifCClZXzsd{BqdmS3Y3XkJIJ6KDFyMEW4MWY1KGOxbXLpcoVlKHerdHigWnBCyqB? NELHV5MzPTF{MEeyNy=>
K562 NHzWPIpCeG:ydH;zbZMhSXO|YYm= NHu0dpIxNjFvMd88US=> M{jCelFp NI\p[|NqdmirYnn0d{BkdGWjdnHn[UBw\iCKU2C5NEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NFPSRoYzPTFzOUG4PC=>
IMR-32 NXXPTpFXSXCxcITvd4l{KEG|c3H5 M2TpSFQxyqEQvF5CpC=> NH3OSGIzcA>? M1X4[IRm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? MViyOVA5PDd3NR?=
RPMI 8226 NXi0OlFpSXCxcITvd4l{KEG|c3H5 M{PHOlExOM7:TR?= MXmxbC=> NHTWfJJidG2xc4SgZ49ueGyndHXsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= M3SxUFI2ODN5OEWx
U266  M{PqcmFxd3C2b4Ppd{BCe3OjeR?= MluyNVAx|ryP M3;tOFFp MmOwdIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NIX6R4UzPTB|N{i1NS=>
H929  NYnPT4ZySXCxcITvd4l{KEG|c3H5 M1\ne|ExOM7:TR?= NF21cIgycA>? NF3LUnJx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NY\aNoFXOjVyM{e4OVE>
MM.1S  NWn4T3FjSXCxcITvd4l{KEG|c3H5 MXmxNFDPxE1? M3S5dFFp M4PLbYVn\mmlaXXueIx6KHC{ZY\lcpR{KHOxcnHm[Y5q[i2rbnT1Z4VlKGOnbHyg[IVifGhiY3;tZolv\SC5aYToJI5m[3Kxc4TheIlvNTF? NULNOG9{OjVyM{e4OVE>
C6 NHvBeVhCeG:ydH;zbZMhSXO|YYm= MVO1NO69VQ>? NF\CZYE1QGh? MV3wdoV3\W62czD0bIUhdG:|czDv[kBk\WyuII\pZYJqdGm2eTDjZZV{\WRiYomgdJJm\26nbn;sc45m NWfnfGZnOjVyMUO0O|k>
AGS MYXBdI9xfG:|aYOgRZN{[Xl? MmTzOVDPxE1? MnPCNlRp MkTiZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= MXGyOVAxQTZ7OB?=
HeLa  MkTmRZBweHSxc3nzJGF{e2G7 NFq2PYM1OM7:TR?= NXO3N2VXOjSq MnnybY5pcWKrdIOgeIhmKGmwY4LlZZNm\CCjcH;weI9{cXNiaX7keYNm\CCkeTDzbXJPTjF{MR?= M1\NOVI1QTJ6Nki1
THP-1  NIS0OYRCeG:ydH;zbZMhSXO|YYm= MnrINVDPxE1? MlGzNYg> MVfy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGFNSS2VRGVCpC=> Mnm3NlQ6OjN4NUO=
P815  MlH4RZBweHSxc3nzJGF{e2G7 Mn25NVAxKML3TR?= MoLxNVJp M17TeWROW09? M4Dmd4lvcGmkaYTzJJZqenW|LXnu[JVk\WRiYYDvdJRwe2m| M1zqUlI1QTJ|Mkez
HCT116 NUfCRlAySXCxcITvd4l{KEG|c3H5 M2fnOVIx|ryP MW[yOIg> M1vVeoFjem:pYYTld{Bw\iCWUT3pcoR2[2WmIHHwc5B1d3Or M4TxNVI1QDlyNES5
SW1116  MVrBdI9xfG:|aYOgRZN{[Xl? M1ixeFExKML3TR?= M4DBOlFp NIGwcJlFVVOR M1XBd5Jme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= MkHLNlQ5PzR{OE[=
LOVO MnnIRZBweHSxc3nzJGF{e2G7 NFnBW3MyOCEEtV2= Ml3FNYg> MVjEUXNQ NWfD[2RPemW|dILhbY5{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkh\2WoaYTpcoljKHCudYOg[IVkcXSjYnnu[S=> MkHTNlQ5PzR{OE[=
SNU449  NHjNS3VCeG:ydH;zbZMhSXO|YYm= MonzNlDPxE1? Mor6OFhp NIr5OlFFVVOR Mn3y[IVkemWjc3XzJI1qWi12NUGtbY5lfWOnZDDhdI9xfG:2aXO= MXuyOFg1OTZ|OB?=
Caco-2 NEHlNXJCeG:ydH;zbZMhSXO|YYm= MmPmOFDjiIoQvF2= MnX6OIg> MYXwdoV3\W62czDTWE04NWmwZIXj[YQhYk9vMTDjbIFv\2W|IHHu[EBVTVJiZILvdC=> MUCyOFgzOjF6Mx?=
macrophage M1PETWNmdGxiVnnhZoltcXS7IFHzd4F6 NXjGXVlIOC1{MEFOwG0> MWmyOIg> MV7pcoR2[2W|IGTOSk0h[W6mIGLpdFMu\GWyZX7k[Y51KG6nY4LvdJRwe2m|IHnuJI1i[3KxcHjh[4U> NID1Xo8zPDd7OUW2OS=>
AGS  NETseIhCeG:ydH;zbZMhSXO|YYm= Mnj0NlDPxE1? NH;NcXkyOmh? NFPiNWtFVVOR NITxb3Bz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3[gZZBweHSxc3nzJIlvKHKnc4DvcpNmKHSxIITo[UBGfE:DYzDmdoFkfGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M375PFI1Pzh7N{Cz
LCC9  MVrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NH;VPZQyODEQvF2= MYC1[C=> NVfiXoxj[myxY3vzJINmdGxiZHXheIghcW6mdXPl[EBjgSClb33ibY5ifGmxbjDMNVch[W6mIHPocI9zd3G3aX7l Mo\HNlQ4QDV{NU[=
U937  M3XmdI5m[3KxcITvd4l{KEG|c3H5 MVSxNOKh|ryP NFTZZlM{OMLibXnu NVTM[nY2cW6mdXPld{Bv\WO{b4D0c5NqeyClb33ibY5mKHerdHigWG5H NHrr[HQzPDd5M{e1Oi=>
T cell MVnD[YxtKHC{b3zp[oVz[XSrb36gZZN{[Xl? MYCwMVExOM7:TR?= MUe3Nog> NGfyTI5KSzVyPUewJO69VSxiaX7obYJqfHNiYX70bU1ETDNvaX7keYNm\CCWIHPlcIwheHKxbHnm[ZJifGmxbjDpckBRSk2Fcx?= Ml32NlQ4Pjh5MEe=
HeLa  M3PyW2Fxd3C2b4Ppd{BCe3OjeR?= MYq1NO69VQ>? M3HZUFczcA>? MXvEUXNQ NWOyb3B5eHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3;tdI92dmS|wrCx5qCUPQ>? MmrvNlQ4PTR5OE[=
HeLa  NVnhd5V3SXCxcITvd4l{KEG|c3H5 MkHBNVAx|ryP NWLRRW1{OjSq NYfhO3pSe3WycILld5NmeyC{YYTlJI9nKGOnbHyg[IVifGhiaX7keYNm\CCkeTDveoVz\XiycnXzd4lwdiCxZjDHOVlUKG:{IFe3NXIheDF3MHfseYVlyqB? NV3zdGxVOjR5MkK0Olg>
IEC-6  Ml7YRZBweHSxc3nzJGF{e2G7 Ml[4NVDPxE1? MnfqNlRp NIPhc2pxemW4ZX70d{BV[2SDLXnu[JVk\WRiY3HzdIF{\S1|IHPs[YF3[WenIHHu[EDPui2lYYTlcolvKGSnZ4Lh[IF1cW:w NF\nWlIzPDdzMUW3NS=>
HCT116 NYnxdGtQSXCxcITvd4l{KEG|c3H5 MWSyNO69VQ>? M{\ifVI1cA>? NIjCc2FqdmirYnn0d{B1cGViY3XscEBieG:ydH;0bYMhcW6mdXPl[EBjgSC\TGSyNFU> M4fuVFI1PzF|OEGy
L02 M{nqT2Fxd3C2b4Ppd{BCe3OjeR?= NUCwblhNOjEQvF2= MlvlNYg> MlH4dJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= NVrTdJlPOjR5ME[0OlE>
A375 M4roSGFxd3C2b4Ppd{BCe3OjeR?= MlTZNlDPxE1? M3zvR|I1cA>? M1r4[pJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? MmfRNlQ3QTlzMUG=
HDPC NHKyXmpCeG:ydH;zbZMhSXO|YYm= NFLOW3c2OML3TR?= MlzBNlRp M{niU4lvcGmkaYTzJG5QNWmwZIXj[YQh[XCxcITvd4l{ NYD2TnluOjR4M{S1PVM>
A549 NVjTeGVpSXCxcITvd4l{KEG|c3H5 M13Rd|UxyrWP NEPLUlQzcA>? MnHtSG1UVw>? NIS4NnNxemW4ZX70d{B1cGViaInwc4RqeGyxaXSgSG5CKGOxboTlcpQheGijc3WgbY5lfWOnZDDifUBk\XCqYXzvZ4hzd22rbh?= MmXCNlQ2QDhzM{W=
 BV-2 M4\1XWFxd3C2b4Ppd{BCe3OjeR?= NIi3[ZIzOM7:TR?= NIPuWnYzcA>? NUL5eGU1e3WycILld5NmeyCXVj3pcoR2[2WmIHPodo9u[XSrbjDlfJRzfXOrb36gZY5lKGSrbHH0bY9vKG:oIITo[UBvfWOuZXHyJIVvfmWub4Dl M3f6WlI1PTV6MUG4
HT-29  MnPwRZBweHSxc3nzJGF{e2G7 MknvOVDPxE1? MYe0PIg> NUjLT|Zo[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s MnLWNlQ2PDlzN{W=
A549 NHLyO2hCeG:ydH;zbZMhSXO|YYm= MnvnOe69VQ>? NH7WOGwzPGh? NE[zRo1{fXCycnXzd4V{KD[nwrCoRmsyODB2MDmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> MonGNlQ2Ojl6N{G=
MIA-PaCa-2 NIDBcHdCeG:ydH;zbZMhSXO|YYm= MYqyOIg> MkLNZoxw[2u|IHPs[YF3[WenIH;mJINie3Cjc3WtN{BqdmS3Y3XkJIJ6KGKxdHigRU01PDN4NUSgZY5lKHCjY3zpeIF5\Wx? MUSyOFUyODl7Mh?=
Caki-1 MV7BdI9xfG:|aYOgRZN{[Xl? M4mzfFIx|ryP M16yblFp M{fBfIlvcGmkaYTzJHNEWC2rbnT1Z4VlKGGyb4D0c5Nqew>? MlrKNlQ2ODR4OEG=
CLL NIqzc4VCeG:ydH;zbZMhSXO|YYm= NIrPXZQzPc7:TR?= MUOxbC=> MV3wZZJ1cWGubImgZoxw[2u|IF3MUlIzOzhvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> Mo\oNlQ1Pjd4M{S=
SGC-7901 NV\Pc|JHSXCxcITvd4l{KEG|c3H5 NHvvUHAyOM7:TR?= NXmwWYYxOjSq M1rtNZBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? MofyNlQ1PTR2OEi=
k1735 MX;BdI9xfG:|aYOgRZN{[Xl? NIn6R3gzOOLCid88cS=> M2n5SlRp NYfpR4NNcW6qaXLpeJPDqFOjbH3vcoVtdGFvaX7keYNm\CCjcH;weI9{cXN? NESzPFQzPDR3MUGxOi=>
HaCaT  MUHBdI9xfG:|aYOgRZN{[Xl? MV2xNFDPxE1? M4Hkc|Fp M4Tqc4JtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= NUnsTJljOjR|NU[5PVc>
podocytes NXXISZJqSXCxcITvd4l{KEG|c3H5 MmL4NlAx|ryP MYO2bC=> M2DSRolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> NEPqV40zPDN|N{e3Oy=>
 KB M{PsemFxd3C2b4Ppd{BCe3OjeR?= M2Dtd|Ux|ryP NFq1dFUzPGh? M1ribolvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u MkLnNlQ{Ozd2OUK=
 HepG2  Mnr4RZBweHSxc3nzJGF{e2G7 MofENVDPxE1? NGm4WpIzPGh? NX;xdmo2emWmdXPld{B3cW2nboTpckBkdGWjdnHn[UBk[XW|ZXSgZpkhVFCV MonoNlQ{OjV6MU[=
fetal rat lung fibroblasts  Mmi3T4lv[XOnIFHzd4F6 M2XkRlgx|ryPwrC= NXz3WnJzOWh? NWTSNlJPcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? MnfPNlQ{OTRzM{W=
PDL fibroblasts NIPH[4ZMcW6jc3WgRZN{[Xl? M3zEPVgx|ryPwrC= NInaUm0ycA>? NIjOOG5qdmirYnn0d{BE[XOyYYPlMVMh[WO2aY\peJnDqA>? NIK4O2YzPDNzNEGzOS=>
MB49 M3HXbWFxd3C2b4Ppd{BCe3OjeR?= NI\4dXAzOM7:TR?= NYGxNmZnOWh? MlTrdoV3\XK|ZYOgR20ucW6mdXPl[EBk\WyuIHTlZZRp M4DJNVI1Ojh{NEOz
5637 MmXvRZBweHSxc3nzJGF{e2G7 NEPCSXMzOM7:TR?= MYixbC=> NGPyOIpz\X[ncoPld{BEVS2rbnT1Z4VlKGOnbHyg[IVifGh? NFrZ[5ozPDJ6MkSzNy=>
A549  MXLBdI9xfG:|aYOgRZN{[Xl? MlnkNVAx|ryP M3G4ZVQ5cA>? NEPpNHV{fXCycnXzd4V{KHSqZTDhdI9xfG:|aYOgZ4F2e2WmIHL5JJBqeGW{aX7lxsA> M1\5TlI1Ojd{MkCx
MCC-2 MoXKRZBweHSxc3nzJGF{e2G7 NFvYSoYzOCEQvF2= Mmn6Oog> M3vpXGROW09? MWficI9kc3NiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5mKGGyb4D0c5NqeyClZXzsJIRm[XSq MknXNlQzPjJ4NUi=
ADF NWH4OJE6SXCxcITvd4l{KEG|c3H5 M{L1U|Qx|ryP NWPVPZJyPmh? NGf6bY9qdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NVLUPWpkOjR{MkiyN|I>
 U373  MWTBdI9xfG:|aYOgRZN{[Xl? MYG0NO69VQ>? NVTYOlR4Pmh? M4[1OIlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy NH;ROZYzPDJ{OEKzNi=>
RKO-HIPK2i Ml;xRZBweHSxc3nzJGF{e2G7 M2XWTVQx|ryP NFXne3k3cA>? MmnBbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MXmyOFIzQDJ|Mh?=
HEC-1B NEXXcW9CeG:ydH;zbZMhSXO|YYm= M33Id|Ix|ryP NU\6dFY2OWh? NETqbJlz\WS3Y3XzJHRRNWmwZIXj[YQh[XCxcITvd4l{yqClYYPwZZNmNTNiYX7kJINie3Cjc3WtPS=> NVXWfmN1OjR{MUOzOVg>
4T1 NIPkU4NE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MUiyMlUuOTEQvF2= NHfYTGM1cA>? NHnXPFVFVVOR NFzXcnNz\XOldXXzJJRp\SCleYTveI95cWOrdImgc4YhPFRzIHPlcIx{KGmwZIXj[YQh[nliU2DEWEBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> NWrxRnBKOjR{ME[xOlE>
OS  MULBdI9xfG:|aYOgRZN{[Xl? NWC1S3U6OjEQvF2= MUK0bC=> NHHHcmxqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgVGRV M4nteVI1OjB2OUO3
RPE MUnBdI9xfG:|aYOgRZN{[Xl? NYm5cJh{OTByzszN MnrqOFhp NUHqcZcxeGG{dHnhcIx6KGmwaHnibZR{KHSqZTDjZYxx[WmwLUGgZY5lKC1{IHHjeIl3[XSrb36gZZMhf2WubDDhd{B1cGViY3HzdIF{\SCjY4TpeoF1cW:w M{KyOVI1OjB{MEWy
UD29a NIPMZWpCeG:ydH;zbZMhSXO|YYm= NYXvdGJTPTEQvF2= NV;VN4JyOjSq MWXpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliTmXUNy=> M2joPFI1OTlyNUe0
SH-SY5Y  NXrLe4V5SXCxcITvd4l{KEG|c3H5 M4TV[VEx|ryP NYOyRWZEOjSq MXHheJRmdnWjdHXzJINie3Cjc3WgZYN1cX[jdHnvckBidmRiY3XscEBl\WG2aDDpcoR2[2WmIHL5JGhPTS1{RFe= NIG5OZYzPDF2NUS2Ny=>
HeLa  NHXWd|RCeG:ydH;zbZMhSXO|YYm= MX6xNE8zOM7:TR?= NXO4Wmt[OjSq NHzZdZRqdmirYnn0d{B1cGViYXP0bZZqfHlib3[geIhmKG2jan;ybZR6KG:oIITo[UBu\W2kZYLzJI9nKHSqZTDjZZNx[XOnLX\hcYltgQ>? M3zLVFI1OTN5Mk[2
SCCVII  NXrDUmFKSXCxcITvd4l{KEG|c3H5 NIP1cI8zPc7:TR?= M3LJV|Fp MVzpcohq[mm2czD0bIUh[2WubDDrbYxtcW6pIHHmeIVzKGSjc3H0bY5q[g>? NIrxZXUzPDF{NkS2OC=>
RAW 264.7 MkLkRZBweHSxc3nzJGF{e2G7 M{TtblIx|ryP Mn;sNVhp M{\lXolv[3KnYYPld{BNSzNvSVmv{tIu[WO2aX6gdoF1cW9iY3;tdIFz\WRidH:gSWNVXi2PT2OgeJJm[XSvZX70JI9vdHl? MlfxNlQyOTZ5MEe=
A549  NULrXoF7SXCxcITvd4l{KEG|c3H5 MYWyMlXPxE1? M2PCR|I1cA>? M3zp[IRm[3KnYYPld{Bwemmmb37pck1qdmS3Y3XkJIF2fG:yaHHnfUBieyC5ZXzsJIFv\CCOb4PzJI9nKM7Wz5jtJIFte29ib3PjeZJz\WRiZIXybY5oKGG3dH;wbIFocWNicILvZ4V{ew>? NWmw[4d2OjRzMEK1NlI>
UM-SCC-10A  NHP6eFBCeG:ydH;zbZMhSXO|YYm= M3TjNVUxyrWP M3;HXFJp MULy[YR2[2W|IHHwc5B1d3OrczDpcoR2[2WmIHL5JIhq\2hvZH;z[UBqe2:jbHHueI9t[WO2b37l NV\uZXljOjRyOUi3OVM>
BGC-823 NYXGTm86SXCxcITvd4l{KEG|c3H5 M1;veVExKM7:TR?= MV6yOIg> NVzMb4toemWmdXPld{B1\XS{YX7kdolv\S2rbnT1Z4VlKGGyb4D0c5Nqe8Li Ml7pNlQxQTh3MUG=
Nalm-6  MkDIRZBweHSxc3nzJGF{e2G7 MkXHNlDPxE1? NWrxe2E1PGh? MnzsbY5pcWKrdIOgZ4F{eGG|ZT24JIFv\CClYYPwZZNmNTNiYXP0bZZifGmxbjDhcoQhWEGUUD2xJINt\WG4YXfl MoDUNlQxOzl7Nke=
KHOS  MUTBdI9xfG:|aYOgRZN{[Xl? NH3Rb2U1OM7:TR?= MVeyOIg> M{XucoJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= MnnvNlQxOjV|NkG=
G292 NUTtcmpCSXCxcITvd4l{KEG|c3H5 M4K3NlQx|ryP NEXpeJczPGh? NIXIWIVjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg NXLlepFHOjRyMkWzOlE>
MG-63 MXXBdI9xfG:|aYOgRZN{[Xl? M{i3TlQx|ryP NIOzUWozPGh? MYLicI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li MVSyOFAzPTN4MR?=
EBV-transformed B cells M1q3dmFxd3C2b4Ppd{BCe3OjeR?= M{DTU|Ix|ryP Mn21Nog> MorTSG1UVw>? M3fnUYJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? NX61XJlEOjRyMEi2Nlg>
IM-9 B MoDIRZBweHSxc3nzJGF{e2G7 MVGyNO69VQ>? NF3lT5ozcA>? NFHYR3pFVVOR NFvHR2xjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? MUCyOFAxQDZ{OB?=
CNE1 MYfBdI9xfG:|aYOgRZN{[Xl? MYeyNO69VQ>? MlrBOFhp NH;jW4JjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? NGHtdGIzOzl6NUCyPS=>
CNE2 NWHnNmMySXCxcITvd4l{KEG|c3H5 MVmyNO69VQ>? NXTZ[FVQPDiq NU\Lc5FG[myxY3vzJGxMNUFvaX7keYNm\CCjcH;weI9{cXN? MY[yN|k5PTB{OR?=
HL-60 NILFcI1CeG:ydH;zbZMhSXO|YYm= MmL5OVDDvU1? NWHzW5VXOWh? MWfEUXNQ MonSbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSkFzNEW= MnT2NlM6PDh5NUG=
L929 NXPhd41bSXCxcITvd4l{KEG|c3H5 Mlv0NU4zPeLCk{ZCpO69VcLi NXTEXnNIOjSq MWnheYdu\W62czDUUmbPuS2rbnT1Z4VlKG6nY4LvdJRwe2m|IHHu[EBifXSxcHjh[5k> M{e4NFI{QTRzN{[5
Jurkat M3\vcWNmdGxiVnnhZoltcXS7IFHzd4F6 MVuy{txO Mnr3OIg> Mn7MdoV3\XK|ZYOg[5Jwf3SqIHnubIljcXSrb36gZY5lKM7{LXPheIVvcW5iZHXjdoVie2ViYomgTHMuSVOD MkXKNlM5QTZyNkG=
RAW264.7  NUe1Npp6SXCxcITvd4l{KEG|c3H5 MX[xNEDPxE1? MljiNlRp NXj1N3FY\GWlcnXhd4V{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBISQ>? MmHrNlM5OjB{MEO=
A431  Mny1T4lv[XOnIFHzd4F6 NV\GZZdsPDEQvF2= NX7HeHd5Omh? NXvsT|RN[myxY3vzJIZqe2W2aX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPld{BidmRiUFHSVC=> MWqyN|gxODB3OB?=
Jurkat MkTRR4VtdCCYaXHibYxqfHliQYPzZZk> NEXSdIYzPS1zMEFOwG0> M{m1VVZp NHjGe2VqdmirYnn0d{B7NU[DLVPNT{1qdmS3Y3XkJINmdGxiZHXheIg> MnTjNlM6OzN3M{K=
COS-7  M2f4SmZ2dmO2aX;uJGF{e2G7 NIXnd3Q2OML3TR?= NGT3WYMzPGh? M2HpbIFn\mWldIOgeIhmKHC{b3Pld5Nqdmdib3[gRXRPOXNid3n0bEBxd2y7UTD0doFkfHN? NFz2bG8zOzl|M{KwPC=>
CAL27 NXO0S|FQSXCxcITvd4l{KEG|c3H5 MWmxNEDPxE1? NFrGVXgzcA>? NV\5TYpUe3WycILld5NmeyCFdYKtUnB{NXKnZIXj[YQhfmmjYnnsbZR6KGK7IIXwJJRwKDlyJR?= M1L1O|I{QTF5M{m2
THP-1  NXXKO3ZPSXCxcITvd4l{KEG|c3H5 M1LWR|ExNTVyzszN M4THPVJp M3TMb4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KHS{aYD0c4xq\GV? MUKyN|kxODJ7OR?=
K562 MU\BdI9xfG:|aYOgRZN{[Xl? M1\ZUlIx|ryP M{HybFQ5cA>? MmLIbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhPC2PVR?= MmLrNlM5PzZ6Mk[=
HL-60 NYjUOm5lSXCxcITvd4l{KEG|c3H5 MYWxNFDPxE1? MXeyOIg> NE\XdHhqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= NVf4OFhWOjN6NkW3O|g>
HeLa  M4LsXmFxd3C2b4Ppd{BCe3OjeR?= NXfSUXdXOjEQvF2= MVKybC=> NFr4R49qdmirYnn0d{BFVU2SIHnu[JVk\WRiYYDvdJRwe2m| M2TFUlI{QDZ|OU[2
U251 NXPLdo96SXCxcITvd4l{KEG|c3H5 NFvuVZMzOM7:TR?= M{PYd|I1cA>? MkfRbY5pcWKrdIOgZ4F{fGmlaX6gbY5lfWOnZDDHNk9OKHCqYYPlJIFzemW|dDDhcoQh[XCxcITvd4l{ NV;wdmFbOjN6MU[4NVY>
HL-60 MYrBdI9xfG:|aYOgRZN{[Xl? M3PoW|UxyrWP MmrpOIg> M{DhfoJtd2OtczD0bIUh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|LDCtPUwh[W6mIGDBVnAhcW6mdXPl[EBjgSB4cx?= NXrwTnVzOjN6MES3NFY>
Ec-109 NFvrZVZCeG:ydH;zbZMhSXO|YYm= NX;pbWc3OTBizszN MmTWOFhp MWfy[ZBz\XO|ZYOgVGUudWWmaXH0[YQhTWNvMUC5JINmdGxiYYDvdJRwe2m| MoLENlM4QDJ4NEG=
RKO MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MXWxNEDPxE1? NF7QNpAzPGh? NVXwWlNscW6qaXLpeJMhfGinIHTlZ5Jm[XOnIH;mJINmdGxidnnhZoltcXS7IHPheZNm\CCkeTDERWI> NHnKb3MzOzd3OEC2OC=>
T98G NVXRV5h[S2WubDDWbYFjcWyrdImgRZN{[Xl? MWCxMVExOM7:TR?= NVf4W3BEOjSq MUXpcZBzd3[nczDj[YxtKH[rYXLpcIl1gSClb4Ty[YF1dWWwdDD3bZRpKFSV M4j4cVI{PzZ7Mke1
Jurkat M4LwRmNmdGxiVnnhZoltcXS7IFHzd4F6 M3;YTVExOC1{MEFOwG0> MYOyOIg> NXjtR4ROcW6qaXLpeJMhUGGDNDDpcoR2[2W|IHHwc5B1d3OrczDk[ZBmdmSnboSgc4Yh[2:wY3XueJJifGmxbtMg MlvhNlM4OzJ2OEG=
Molt-3  MnvBRZBweHSxc3nzJGF{e2G7 M4XQe|Ux|ryP NYeySJdjOmh? M2rKeZJm\HWlZYOgcYVt[XSxbnnuMYlv\HWlZXSgZZBweHSxc3nz M3LkNFI{PzJ3MEGz
hMSC12 MnHWRZBweHSxc3nzJGF{e2G7 NFHrTlIyODEQvF2= Moe3OIQ> NFjRSZFqdmirYnn0d{Bwe3Snb3flcolkKGO3bIT1doUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDjZYxkcW[rY3H0bY9v MXKyN|Y2Pzh{Mh?=
HM7  NYq5ZXhYSXCxcITvd4l{KEG|c3H5 MmniNlDPxE4EoB?= NYnVT5hiOWh? MmHOZoxw[2u|IHHwbYN2dGG{ZX6gRUBi[2W2YYTlMYlv\HWlZXSgZ4F{eGG|ZT2zJIFkfGm4YYTpc44h[W6mIGDBVnAh[2ynYY\h[4U> NEnBeZAzOzV6M{SxNi=>
Hep-2  NXqxXHhlSXCxcITvd4l{KEG|c3H5 M4LhTFIx|ryPwrC= NUfBc3RKOjSq NUfaSIx1TE2VTx?= NEfBS2lidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> M4DGOlI{PThyMEOy
HSCs M2nQRWFxd3C2b4Ppd{BCe3OjeR?= NGf0[Wo2OM7:TR?= NV\aeHNqOjSq M334NmROW09? Mm\BbY5pcWKrdIOgcoltd3SrbnniMYlv\HWlZXSgSG5CKGSjbXHn[UBqdmSrY3H0[YQh[nliUFHSVEBkdGWjdnHn[S=> M2fOc|I{PDl7OEe0
HL-60  MUPDfZRwfG:6aXPpeJkhSXO|YYm= M3vCXlIx|ryPwrC= MnPjNlRp NUfkcIVVemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 MmTPNlM1QTR2OEC=
HA M{LYRWFxd3C2b4Ppd{BCe3OjeR?= Ml2yOVDPxE1? MWeyOIg> NFzuTIR{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? MnPlNlM1PzV7NU[=
C666-1 MVXBdI9xfG:|aYOgRZN{[Xl? M4X1PFUx|ryP NFfGcHczPGh? NEjDSIZ{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? NV7FPWM5OjN2N{W5OVY>
Hepa1-6 NXXVZWhmSXCxcITvd4l{KEG|c3H5 MWO1NO69VQ>? NHO0NJgzcA>? M{jFe4lvcGmkaYTzJIN2emO3bXnuJIFv\CC{ZYP2[ZJifHKxbD3pcoR2[2WmIHHwc5B1d3Orcx?= M2CyZ|I{PDR4N{Wz
PLC/PRF/5c NH\3OpJCeG:ydH;zbZMhSXO|YYm= M2HQRVUx|ryP MkHLNYg> NIPmRolxemW4ZX70d{BieG:ydH;zbZMhfHKrZ3fldoVlKGK7IFPJUi=> M3fKVlI{PDN6OEK0
HCT116 M2DIdGFxd3C2b4Ppd{BCe3OjeR?= NH7XS4QyODEQvF2= NELuemIyNjWq NVSwdoczcW6qaXLpeJMhV3NvaX7keYNm\CClZXzsJIRm[XSq NEKxTFMzOzd2NEO1Ny=>
HCEC NFP0Z|ZHfW6ldHnvckBCe3OjeR?= Ml\QOVDPxE1? NYXJc4JoPzKq NU\Be5JETE2VTx?= NWLaRodCemW|dH;y[ZMhd2ZidHjlJI5wem2jbDDIR2VEKHCqZX7veJlx\Q>? MXeyN|c1OjBzMR?=
Primary rat cerebral cortical neurons M4\vTmFxd3C2b4Ppd{BCe3OjeR?= MYSxNFDPxE1? M{nocVFp NHXsNZpxemW4ZX70d{BE\C2rbnT1Z4VlKGGyb4D0c5NqeyCjbnSgZ4VtdCCmZXH0bC=> MmDzNlM4PDF|MUe=
MDA-MB-231  NVe1WlA1SXCxcITvd4l{KEG|c3H5 NWnTRZp1OjYQvF2= NV3RVYNTOjSq M4TJcYFjem:pYYTld{BkgXSxdH;4bYNqfHliYX7kJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCrbnT1Z4VlKGK7IGLnNy=> MVWyOVM{PzV2NB?=
NLRP3-Tet-on-MC/9  M2XXS2Fxd3C2b4Ppd{BCe3OjeR?= M4L1NVExNTRyzszN NX[3dFhnOTKq MW\heJRmdnWjdHXzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDDRXBUNWG|c3;jbYF1\WRiTlzSVFMhdXW2YX70d{BqdiC2aHWgWIV1NW:wIIP5d5RmdQ>? NHXkSYMzOzdyM{O4PS=>
KNS42  MU\BdI9xfG:|aYOgRZN{[Xl? NEHtRoM2OM7:TR?= M3j0UlFp M2PVeZJm\HWlZYOgZ4VtdCCmZXH0bEBidmRiY3;tdIxmfGWueTDhZo9tcXOqZXSgZ4F{eGG|ZTCzM|ch[WO2aY\peJkhcW5icnXzdI9ve2VidH:gRWJVNTJ4Mz:ySGcwdWW2Zn;ycYlvKGOxbXLpcoF1cW:w MX6yN|Y6OTF2NR?=
MCF-7  MUPBdI9xfG:|aYOgRZN{[Xl? M1;rNlIx|ryPwrC= MWW3Nog> NV24SW5HcW6qaXLpeJMh\XG3b3ytJIFv\CB2LV;IWE1u\WSrYYTl[EBieG:ydH;zbZM> MmnYNlM3PzV4NEO=
hCMEC/D3  MUjBdI9xfG:|aYOgRZN{[Xl? NX\oXottOjYQvF2= MVm3Nog> MnLudoVlfWOnczDMeJhCKGmwZIXj[YQh[XCxcITvd4l{ NHu5Z3QzOzZ4NUG5PC=>
Jurkat MWrBdI9xfG:|aYOgRZN{[Xl? Mo[2NVIvPS13MN88US=> M4S3WVFp NVTNN2xM\G:|ZTDk[ZBmdmSnboTsfUB{fXCycnXzd4V{KFOSSD3pcoR2[2WmIGDhdk01KGOuZXH2ZYdmNCCSQWLQJINt\WG4YXflMEBFVkFiZoLh[41mdnSjdHnvckwh[W6mIHzvd5Mhd2ZidnnhZoltcXS7 M2qzZlI{PDR{OUe2
CNE-1 M{\EfGFxd3C2b4Ppd{BCe3OjeR?= M1\ScVIx|ryPwrC= NGrvZmkzPGh? NWXmbFBHcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NV;E[ZZ6OjN2Mk[4OVA>
HONE-1 M3HCc2Fxd3C2b4Ppd{BCe3OjeR?= MnjMNlDPxE4EoB?= M3fyXVI1cA>? NUfsZ4xMcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MX6yN|QzPjh3MB?=
astrocytes cell M3;ZSmFxd3C2b4Ppd{BCe3OjeR?= Mn\ROFDPxE1? Ml63Oog> NHjFUnNz\WS3Y3XzJIViemy7IHHwc5B1d3OrczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmV? NH\kSlgzOzRzMUe3PC=>
U-937 Mmr4RZBweHSxc3nzJGF{e2G7 MU[xNO69VQ>? M2jab|MxdWmw MVnwdoV3\W62czDUUmYucW6mdXPl[EBv\WO{b4D0c5Nqew>? MVmyN|QyODd2OB?=
MDA-MB-231 M1qyc2Fxd3C2b4Ppd{BCe3OjeR?= NIC0ZpMyODEQvF2= M4Ts[lFp MmLVbY5pcWKrdIOgd4Vve2m2aYrheIlwdiC2bzDUVmFKVCC3cH;uJG1VTEhiZH;3ck1z\We3bHH0bY9v NWTRUY9rOjN2MEi0Nlk>
HeLa  NUHzcXFHSXCxcITvd4l{KEG|c3H5 MUmxNFDPxE1? NEXFfIwzcA>? MnXsZoxw[2u|IFrSV{0yPSCLbnT1Z4V{KEGyb4D0c5Rq[yCFZXzsJGRm[XSq M1ryWVI{OzR2MES1
Ec109 NYTuOGFFSXCxcITvd4l{KEG|c3H5 MWqxNO69VQ>? NFe3cGY3cA>? MYPicI9kc3NiYYDvdJRwfGmlIHPvcYJqdmG2aX;uJI9nKFSjdD3TcYFkVjdiYX7kJJJi\GmjdHnvci=> M4Lve|I{OzN6NU[4
H460  NEj0XmlCeG:ydH;zbZMhSXO|YYm= M3fZ[lEx|ryP M2HY[VZp M2fnToJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v M{TMXFI{OzN6NU[4
HeLa  NETZO4JCeG:ydH;zbZMhSXO|YYm= M3SzVFUx|ryP NHXXOZcyNjWq MXnhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> M{jaWVI{OzB|OEC0
SK-HEP1 M2rUbWFxd3C2b4Ppd{BCe3OjeR?= M4LkT|ExOM7:TR?= NXnQcoE3OWh? NUO0[4NvcW6qaXLpeJMhS3KWMTDhZ5RqfmG2ZXSgZ4F{eGG|ZT2zMEAuPyxiLUisJE06NCCjbnSgdI9tgSiDRGCtdoljd3OnKTDwc4x6dWW{YYPl NFrJVlMzOzNyMk[1NC=>
QGY7701 NYf6XHJYSXCxcITvd4l{KEG|c3H5 Ml7aNlXPxE1? MUmxMlVp M2r5dolvcGmkaYTzJIFk[3WvdXzheIlwdiCxZjDzeYIuTzFicHjhd4UhcW6mdXPl[EBjgSCGT2igL{ByfWW{Y3X0bY4> MX:yN|I1ODB4MR?=
HepG2 MkXkRZBweHSxc3nzJGF{e2G7 M1;DSFIx|ryP NY\2R49OOzCvaX6= MUnpcohq[mm2czD0bIUh\W6qYX7j[YQh[2WubDDk[YF1cCCkeTDjc41jcW6nZDD0doVifG2nboSgc4Yh[XCrZ3XubY4h[W6mIGTSRWlN MYCyN|IzPDJ|OR?=
U87  MXXBdI9xfG:|aYOgRZN{[Xl? NH\qbYIzPc7:TR?= MX6ybC=> MYHk[YNz\WG|ZYOgbZNwdGmzdXnybZRq\2WwaX6gLGlUVClvaX7keYNm\CCjcH;weI91cWNiY3XscEBl\WG2aDygZpV1KG6xdDDu[YNzd3SrYzDj[YxtKGSnYYTo NVz2XFNbOjN{Mkm2NlY>
HSC-2 M3Ts[WFxd3C2b4Ppd{BCe3OjeR?= NVftSmJEOjVxNUFOwG0> M2nLRlFp NYTZVXFvcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> M{nESlI{OTV3MkS4
HSC-4 MVTBdI9xfG:|aYOgRZN{[Xl? M3\vNlI2NzVyzszN MmPUNYg> MVHpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= M1TBZ|I{OTV3MkS4
CL-1 M{XMS2Fxd3C2b4Ppd{BCe3OjeR?= NHW0fFczOM7:TR?= M2Wxd|Fp NF:1WI9jdG:la4OgU3A1PDliaX7keYNm\CClZXzsJIRm[XSq MYCyN|E{OTd6Mh?=
MEL MU\BdI9xfG:|aYOgRZN{[Xl? M3TtWVIx|ryP M125b|I1cA>? MnH1SG1UVw>? MX3pcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ NITxZWYzOzBzNEi4Oy=>
Bel-7402  MWnDZZNx[XOnIFHjeIl3[XSrb36gRZN{[Xl? MmnUOVDPxE1? MnvINog> MonGbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> MmPGNlMxODh5NEK=
Eca-109 MWHBdI9xfG:|aYOgRZN{[Xl? MlTuNlXPxE1? NGm4blk{OG2rbh?= MX7pcohq[mm2czDCTk1DOTFvaX7keYNm\CClZXzsJIRm[XSq Ml3tNlMxPzZ7Nke=
MEL MV\BdI9xfG:|aYOgRZN{[Xl? MU[yNO69VQ>? NVvTfVk4OWh? NXOzNYpSTE2VTx?= NVrjN242cW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= NHzCXlEzOzBzNEi4Oy=>
Bel-7402  NX3qSppwSXCxcITvd4l{KEG|c3H5 MWe1NO69VQ>? NW[xbVRvOmh? NWHZO2I3cW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? NYnjSlJuOjNyMEi3OFI>
L929 NF\Fdm9HfW6ldHnvckBCe3OjeR?= M{LnNlIvPc7:TR?= Moi4NYg> M1XBW4lv[3KnYYPld{BTUVBzIHX4dJJme3Orb36gZY5lKGW6YXPldoJifGWmIGTOSu6yNWmwZIXj[YQhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBidmRiUl;TJJBzd2S3Y4Tpc44> MXOyN|AxODVzOB?=
RCC  Ml7rR4VtdCCYaXHibYxqfHliQYPzZZk> MoXINVAx|ryP M{fBUVI1cA>? MoXxdoVkd3[ncnXzJJRp\SC4aXHibYxqfHlib3[gZ4VtdHNiZYjwc5Nm\CC2bzCxOYQuWEeMMh?= MXKyNlk6OTR7NB?=
NB2a/d1 M{fhV2Fxd3C2b4Ppd{BCe3OjeR?= M1;tZ|ExOM7:TR?= NYPIS4xYPzKq MmXiZZR1\W63YYTld{B{fGG3cn;zdI9zcW6nLXnu[JVk\WRiY3HzdIF{\SCjY4Tpeol1gSxiUFHSVEwh[W6mIITheUBkdGWjdnHn[S=> MX[yNlk5QDV2MR?=
T cell NHG0b|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUntfIxMOjVvMUCw{txO NG\QcIgzPGh? M3XVZYRwe2VvZHXw[Y5l\W62bImgbY5pcWKrdHXkJHQh[2WubDDwdo9tcW[ncnH0bY9vKG2nZHnheIVlKHSqcn;1[4ghfGinIHPvMZN1cW23bHH0bY9vKHerdHigZY51cS2FREOgZY5lKGGwdHmtR2QzQA>? MlvzNlI6QDJ3M{i=
K562 M1PBOWFxd3C2b4Ppd{BCe3OjeR?= M2q2eFExOM7:TR?= NVHZTWZVOWh? M4nzNYJtd2OtczDBZo5w[mG4aYPjeY3DqEZvaX7keYNm\CCjcH;weI9{cXN? NF62b48zOjl5MkO3Ni=>
Jurkat  MlPwRZBweHSxc3nzJGF{e2G7 MYG0NO69VQ>? NGLqO4gycA>? MXzhZo9tcXOqZYOgSoF{VC2rbnT1Z4VlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=> NV:0b|ZkOjJ7NEK3N|g>
BGC-823 M2r0OWFxd3C2b4Ppd{BCe3OjeR?= MW[xNFDPxE1? NXm4XIdEOWh? NYHCXppleGG{dHnhcIx6KHKnc3P1[ZMh[2WubIOgZYdicW6|dDDkZY1i\2Vib3[g[IFq\HqnaX6= NF\lfWYzOjl{NkW0OS=>
Hep3B M2niNWFxd3C2b4Ppd{BCe3OjeR?= Mk\SOVDPxE1? NXrUeFdmOWh? Ml;aZoxw[2u|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGhGT0O| MYeyNlkzOzF3NB?=
LLC-PK1 MWnBdI9xfG:|aYOgRZN{[Xl? M4XNXVIx|ryP Ml\ZNYg> Mkf2dJJmfmWwdIOgZ4l{eGyjdHnuMYlv\HWlZXSg[IVoemGmYYTpc44hd2ZiQYTnOUwh[mWlbHnuMVEtKGGwZDDBeIcyOiCycn;0[Ylvew>? M3q0VFIzQDl4MEO3
A549 MYHBdI9xfG:|aYOgRZN{[Xl? M3HtbVUx|ryP Mm\hNYg> MmS2Zoxw[2u|IITo[UBDSUlvaX7keYNm\CCjcH;weI9{cXQEoB?= M4i3R|IzQDh5MkG1
SGC-7901  MmC5RZBweHSxc3nzJGF{e2G7 NYjPNZBiOTEQvF2= Mmi5NlRp NGfsTWNqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? M3G5VVIzQDR6NUm3
DM6 NFzadZhCeG:ydH;zbZMhSXO|YYm= M{DRd|ExOM7:TR?= NIPvTI84Omh? NXPmZVBm[myxY3vzJIJwfGhiRULGMVEh[W6mIFWySpRzNW2nZHnheIVlKGO7dH;0c5hq[2m2eR?= NYS4[ox7OjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLKPG4zPTEQvF2= NYP0WIoyPDiq NF7jU2RqdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBqdmS3Y3XkJIJ6KHOjcH;ubY4> MlPZNlI5ODB7Nki=
A2750  MkHzRZBweHSxc3nzJGF{e2G7 MnXpNlDPxE1? MVOybC=> MnXESG1UVw>? MUficI9kc3NiY3HzdIF{\SClbHXheoFo\SCmdYLpcochcGWuZX7hcIlvKHS{ZXH0cYVvfCCjbnSgdoVlfWOnczDheZRweGijZ3njJINmdGxiZHXheIg> NWnEdollOjJ5OESzOlM>
U87  NVyyTJdLSXCxcITvd4l{KEG|c3H5 M3;D[FIx|ryP MYKyOIg> MkDDdoVlfWOnczD0bIUh[XCxcITvd4l{KHKjdHWgbY5lfWOnZDDifUBRVEGE NVq4eGRGOjJ5N{i3PFA>
HT1080 NWDZWJRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV[1NO69VQ>? NX\1dHd1P2R? NYfpenp3cW6qaXLpeJMhfGinIHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[2G3c3XkJIJ6KGOxbXLpcoVlKHS{ZXH0cYVvfCCxZjDER2Eh[W6mIF;NVC=> NHzxZ3AzOjd2MEm4OC=>
A549  NFyxdXRCeG:ydH;zbZMhSXO|YYm= NUD5OmxmPTEQvF2= MVGybC=> NVnycHVjeGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> MViyNlczOThyNB?=
Primary OPC MUnBdI9xfG:|aYOgRZN{[Xl? M4X1b|HPxE1? MmPtOogwOjSq NVrtN2RTemWmdXPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBm[XKueT2gZY5lKGyjdHWtZZBweHSxc3nzM45m[3Kxc3nz M4nJ[|IzPzB5M{i1
PMNs M3XS[GFxd3C2b4Ppd{BCe3OjeR?= MYS0NO69VQ>? NHfoNGE3cA>? MmfzSG1UVw>? M33ONpJmfmW{c3XkJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CClYYPwZZNmNTNidH:gcoVieiC4ZXjpZ4xmKGyndnXsdy=> NH[4fW8zOjZ7MkW3Oy=>
A549  M4e2VmFxd3C2b4Ppd{BCe3OjeR?= NUHle|MzPTEQvF2= M4TrRlFp Ml\JdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSmGxaIXvd4ll\SCL M3na[VIzPjh5NkO1
AGS M3HWOmFxd3C2b4Ppd{BCe3OjeR?= MljnNlDPxE1? MlHnNVJp M4TxUolvcGmkaYTzJJRp\SCjY4TpeoF1cW:wIH;mJJBzdy2lYYPwZZNmNTNiaX6gdoV{eG:wc3WgeI8hfGinIFX0U2FkKG[{YXP0bY9v NX;yNYlXOjJ4OEezPVg>
shC9  NGfNWo9CeG:ydH;zbZMhSXO|YYm= NEmyTIEyOM7:TR?= NXLzc5FZOT[q MnfjZox2dnS|IGPITEBmgHC{ZYPzbY9vKGmwIIPoR|kh[2WubIOg[Zhxd3OnZDD0c{BmcXSqZYKgVGEhd3JiTGDD NIjzN3AzOjZ2MUC5OC=>
primary MEFs MlnvSpVv[3Srb36gRZN{[Xl? NVi1dpRYOTKq MXtCpIlv[3KnYYPld{BmfG:yb4Pp[IUucW6mdXPl[EBucXSxY3jvcoRzcWGuIH3lcYJz[W6nIHTldI9t[XKrenH0bY9v M3;2e|IzPjF|N{[3
3T9 MEFs NWLXWlNxTnWwY4Tpc44hSXO|YYm= M2LEPVE3cA>? MnjObY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> NFX1bW8zOjZzM{e2Oy=>
3T9 MEFs NVnPcYR2TnWwY4Tpc44hSXO|YYm= MUCxPIg> MUf1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> MmfpNlI3OTN5Nke=
MDA-MB-231  NIf1N3BCeG:ydH;zbZMhSXO|YYm= NGLPb5EzOM7:TR?= M4n0fVRl MVXy[YR2[2W|IITo[UBk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JI1mfG[xcn3pckB1emWjdH3lcpQhf2G|IIPp[45q\mmlYX70cJk> MUOyNlU6OzR2MR?=
C6  MlvuRZBweHSxc3nzJGF{e2G7 MnLiNVDPxE1? M4LHW|I1cA>? M3:4SoJtd2OtczD0bIUhe3WycILld5NqfmViZX\m[YN1KG:oIITo[UBx\XC2aXTlJI9vKH[rYXLpcIl1gQ>? Ml7pNlI2QDh7OEC=
HL-60  NIroR4RCeG:ydH;zbZMhSXO|YYm= MYSxNFDPxE1? MVqyOIg> NV35NmVtcW6qaXLpeJMhfGinIHPlcIwh[XCxcITvd4l{KHOnbHXjeIVlKChtKT3t[Y51cHmuIN8yMUgy6obUNjmt[IlodHWlb4D5doFvd3OrZHZCpFU> NHvMR28zOjV2Nk[2PS=>
HL-60 Mlq2RZBweHSxc3nzJGF{e2G7 NYfNT5BDOTBvOEFOwG0> NEK3O3g1cA>? M3HzdIlvcGmkaYTzJHRIUFFvaX7keYNm\CClZXzsJIFxd3C2b4Ppd:Kh NXK4bnZxOjJ3MkOyNlk>
BCC M33qRWFxd3C2b4Ppd{BCe3OjeR?= NXmyTmZYPTEQvF2= MVSxbC=> M4rPPYlvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? NI\LUWEzOjVzOUSzOi=>
RAW 264.7 M2G5SWFxd3C2b4Ppd{BCe3OjeR?= M3vEUFUxNzFyMN88US=> Ml7SNYg> M2jVOoNwdmOnboTyZZRqd25vZHXw[Y5l\W62IHnubIljcXS|IFTPUk1qdmS3Y3XkJJJTVkFiY3zlZZZi\2V? M3\ZZlIzPDlzNEK2
K562 NX\6cFhISXCxcITvd4l{KEG|c3H5 Ml;FNlXPxE1? M4XSUlJp MUfwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkdy22cnXheI1mdnRid3n0bEBidXW{ZX7zbY4hTyCjbnSgWHJCUUx? MXGyNlQ5Ozd5Nx?=
SGC-7901 M1v2OWFxd3C2b4Ppd{BCe3OjeR?= MXOyNEDPxE4EoB?= M1K3eFJp NXjEfIVT[XS2ZX71ZZRmeyCKMl:yxsBweiCWTl[g{tEucW6mdXPl[EBk\WyuIHHwc5B1d3OrczDhd{B4\WyuIHHzJINie3Cjc3WtN{Bi[3Srdnn0feKh NH;FfWgzOjR5MUW4PS=>
PC3 NYPoVYtHSXCxcITvd4l{KEG|c3H5 MmnkNVDPxE1? NUi2WZdVPGh? NEjaZYhkd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> NFzZdpYzOjR5MUm3OC=>
SMMC-7721 NGfGUoFCeG:ydH;zbZMhSXO|YYm= MXq1NO69VQ>? MmezOFhp NWjxU2lb[XS2ZX71ZZRmeyCxVGKtbY5lfWOnZDDhdI9xfG:|aYO= MWWyNlQ3PTh|Mx?=
HeLa  NWCyPJhUSXCxcITvd4l{KEG|c3H5 MVq1NOKh|ryP MWm0M|hp MnnIbY5pcWKrdIOgV3RUNWmwZIXj[YQhdGG2ZT3wbIF{\SCjcH;weI91cWNiZY\lcpR{ M3Gy[|IzPDZyNUC0
HeLa  NYTBeZlHSXCxcITvd4l{KEG|c3H5 MXu1NOKh|ryP M4XyN|Fp M3jkd5N2eHC{ZYPz[ZMhfGinIF\SRXAucW6mdXPl[EBi[2O3bYXsZZRqd25ib3[gZY5v\XirbjDWJJBwe2m2aY\lJINmdGy| NGXFSFMzOjR2OUS0NC=>
T47D  M{L2RWFxd3C2b4Ppd{BCe3OjeR?= MkD2NVAx|ryP Ml7HNYg> M3u3XYJtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NVTW[G1IOjJ2MEGxOlg>
HeLa  NUHmTnl3SXCxcITvd4l{KEG|c3H5 M3;UdlMx|ryP MojkOIg> NUHZVlBOyqCrbnPy[YF{\XNidHjlJIdmdmW{YXygZ4VtdCC4aXHibYxqfHliNEigbEBi\nSncjDwbI91d2S7bnHtbYMhfHKnYYTt[Y51yqB? NXjNTJBjOjJ|OUSyOFg>
HCC MmrORZBweHSxc3nzJGF{e2G7 NHjHO4ozOCEQvF5CpC=> NGTyclEzcA>? M1vZfYF1fGWwdXH0[ZMhfGinIFTIRUBqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiUFHSVC=> M1P0XFIzOzR{N{Oy
mESCs MXTBdI9xfG:|aYOgRZN{[Xl? MnLWNk42|ryP NXTrPYZwOmh? MXfpcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= MWeyNlI5PTJ5NB?=
EMT-6  NFHETmxEgXSxdH;4bYNqfHliQYPzZZk> MXqxNFDPxE1? MYSxbC=> MljzdIFzfGmjbHz5JIJtd2OtZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KHOrcnHt[ZNqdmV? MW[yNlI2OTl{MR?=
MCF7 MYnBdI9xfG:|aYOgRZN{[Xl? NFOxSHA2OMLizszN NYHxPVl6OWh? MnLabY5pcWKrdIOgVGEh[WO2aY\heIVlKGOjc4Dhd4UuOyxiLUmsJIFv\CCyb3z5LGFFWC2{aXLvd4UqKHCxbInt[ZJie2V? M2DhPFIzOjJ|M{S1
K562 NWjy[IxCSXCxcITvd4l{KEG|c3H5 M1vqNFIxKM7:TdMg MWS0PIg> MlnnSG1UVw>? NFLkd3BjdG:la4OgcIFx[XSrbnniMYlv\HWlZXSgbY5pcWKrdHnvckBw\iC4aXHibYxqfHliYX7kJIFxd3C2b4Ppd{BqdmS3Y4Tpc44> Mke3NlIzOTZzNUi=
Molt4-hyg M3nzSmFxd3C2b4Ppd{BCe3OjeR?= MXuxNO69VQ>? NY\JVHNjOC53aB?= M{jkeYJtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 M3f0VlI3Ojd3OEGx
HeLa M1vH[mFxd3C2b4Ppd{BCe3OjeR?= M2[3PVEx|ryP NYfXZ|dqOC53aB?= MWrpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1cGViY3;tZolv\WRidILlZZRu\W62IIfpeIgh\2:vaYPpckBPKGGwZDDUVmFKVA>? NHzkb3ozOjF5OU[2NS=>
Jurkat T M4TJSmFxd3C2b4Ppd{BCe3OjeR?= NFfl[VU{OM7:TR?= M4\F[lAvPWh? NIr5UpRFVVOR M2DPOoJtd2OtczD0bIUhgmm{YX2tbY5lfWOnZDDhdI9xfG:|aYO= MnjtNlIyPTl6OUi=
Neutrophil NWLtSXRHSXCxcITvd4l{KEG|c3H5 NWXpfZROOjEQvF2= M1vQN|AvPWh? MkjXZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= NUPweXd2OjZzOU[4OFQ>
HCT116 M2HuOWFxd3C2b4Ppd{BCe3OjeR?= Mk\FOVDDqM7:TR?= NWTPR4R1Omh? MXzy[ZZmenOnczDzfY5memerc4TpZ{BieG:ydH;zbZMh\W[oZXP0d{Bw\iClZXzlZ495cWJiYX7kJG5RSy1zNtMg M4Tq[VIzOTV7N{Wy
MDA-MB-231  Mn;pRZBweHSxc3nzJGF{e2G7 M33BU|IvPS15LkZOwG0> NWrydZBzOmh? M1fyWIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? Mm\pNlIyOTV3Mk[=
LNCaP NXy4cIJHSXCxcITvd4l{KEG|c3H5 MnrTOFDPxE1? NV2zVYY{Omh? MV7pcohq[mm2czDieZRmcW5iaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> MmWzNlIyOTR5NkS=
MB231 NFLpdnNCeG:ydH;zbZMhSXO|YYm= M{nPTlExOM7:TR?= MWmxbC=> M3TkWGROW09? MXLhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v MXSyNlEyOjl2MB?=
HCC38  NXXsT4trSXCxcITvd4l{KEG|c3H5 MVSxNFDPxE1? MmjuNYg> NUe1b5JLTE2VTx?= MWfhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v M4[0[FIzOTF{OUSw
MDA-MB231 MX7BdI9xfG:|aYOgRZN{[Xl? NYHuSJRCPTEEoN88US=> Mn3iNlRp MVzEUXNQ MX;hZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M2r3VVIzOTBzM{O1
LNCaP NVPpSmsxSXCxcITvd4l{KEG|c3H5 NHywN4Q2OMLizszN M4XIelI1cA>? M1jNdWROW09? NETGfWRi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp NFzEe4gzOjFyMUOzOS=>
HCT116 M1\Uc2Fxd3C2b4Ppd{BCe3OjeR?= MlfTOVDDqM7:TR?= NUTxZYJIOjSq M{i1e2ROW09? NGHwdlNi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MV6yNlExOTN|NR?=
Ishikawa  NEftUXJCeG:ydH;zbZMhSXO|YYm= NEG2WGQzPc7:TR?= MWWyOIg> MUfy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFLh[kBCOQ>? NITodmMzOjB6OEmxPC=>
 YD-8  NILm[VhCeG:ydH;zbZMhSXO|YYm= NInEUY0yODEQvF2= MWixbC=> NVTUXlFycW6qaXLpeJMhWEyHTz3pcoR2[2WmIHHwc5B1d3Orcx?= MYCyNlA5PjF6Mx?=
eosinophil  MWPBdI9xfG:|aYOgRZN{[Xl? NHfFVpM6OM7:TR?= M4e5N|I1cA>? NWSwdlVpcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliRnHzJIFvfGmkb3T5xsA> NX\UVFM6OjJyN{mzN|Q>
L929 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvnNk42|ryP M{DXelI1cA>? NFW4N5JqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBxNXB|ODDhcoQhVkZvzsrCJJRwKGG3Z33lcpQhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 M3HZW|IzODJ5MEm3
YD-8  MoTORZBweHSxc3nzJGF{e2G7 M13yblExOM7:TR?= NVjPTldDOWh? MUficI9kc3NidHjlJGdUNUiFbD3pcoR2[2WmIHHwc5B1d3Orcx?= NHGwR|EzOjB{MEC3PC=>
HBx MWPBdI9xfG:|aYOgRZN{[Xl? Ml;zNlXPxE1? MnvyOFhp MXjEUXNQ M2nTO5Jm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= MWiyNlAzODB5OB?=
U937  MVrBdI9xfG:|aYOgRZN{[Xl? MV:1NOKh|ryP NVm3ZYVpOWh? MV;pcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NX;nb5R2OjF7OUi3N|E>
HL60 NH3L[GFCeG:ydH;zbZMhSXO|YYm= MUO0NO69VQ>? MkfYOFBucW5? NWe5UlFITE2VTx?= MV\icI9kc3NiQl7ER{Bkd22yb4Xu[JMhcW6mdXPlJIV5eG:|dYLlJI9nKHCqb4PwbIF1cWS7bIPldolv\SCjbnSgSG5CKG[{YXft[Y51[XSrb36= M4jZcFIyQTh|Mkm2
M-14 NYOxWYZNSXCxcITvd4l{KEG|c3H5 MkHyNlXPxE1? MoW5NE42cA>? NHW2U2/DqGmwaHnibZR{KGKxdHigeIhmKGO{dXTlJIV5fHKjY4StJIFv\CClb33wc5Vv\C2rbnT1Z4VlKGGyb4D0c5Nqew>? MUCyNVk2PDl3OR?=
SK-BR-3 NHTCTpNCeG:ydH;zbZMhSXO|YYm= M4DQTlUxyqEQvF2= MlnYNog> MmTIZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u M1TFelIyQTBzM{i2
MDA-MB-468 MojJRZBweHSxc3nzJGF{e2G7 NYrZdGMxPTEEoN88US=> M3jBS|Jp MXLicI9kc3NiYYDvdJRwfGmlIFTORUBnemGpbXXueIF1cW:wIHnu[JVk\WRiYomgZ49u[mmwYYTpc44hd2ZiU12tNVY1KGGwZDDyZYRq[XSrb36= MVqyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Caspase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID