Z-VAD-FMK

Catalog No.S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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4 Customer Reviews

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a MmCwRZBweHSxc3nzJGF{e2G7 MVW1NO69VQ>? NF;4XlMzPGh? NIj4bGdqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? M{Lq[FI3OTZ7MEe1
HGL5 MWfBdI9xfG:|aYOgRZN{[Xl? MXu1NO69VQ>? MlfjNlRp MnH4bY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> MnTtNlYyPjlyN{W=
HepG2 Ml3TRZBweHSxc3nzJGF{e2G7 MYOyNO69VQ>? MW[xbC=> M{XleYF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> NVn1bGhbOjZzNkS3PVU>
BEL-7402 NULNR4doSXCxcITvd4l{KEG|c3H5 NFTJVmMzOM7:TR?= NXzHSXBzOWh? MnHDZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> M{PlSFI3OTZ2N{m1
CEF NXvOOXBpU2mwYYPlJGF{e2G7 NEHhem4xNDN|LE[3MFExOM7:TR?= NYD5NHltOTWvaX6= MXjkc5dvNXKnZ4XsZZRmeyCSUjDlcpp6dWViYXP0bZZqfHlidH:gOFDwxIViYYSgNVAx|ryP MnK3NlYyODJ|M{m=
SP2/0 M3G2R2Fxd3C2b4Ppd{BCe3OjeR?= MVKxNFDPxE1? M4HZPVFp M3vxdGROW09? NV;McXp7[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> NGLqS4kzPjB5NEezNi=>
HUVEC-2c Mom1RZBweHSxc3nzJGF{e2G7 MYC1NO69VQ>? MXG2bC=> NGe2cmhl\WO{ZXHz[YQhfGinIH;4MWxFVC2rbnT1Z4VlKGG3dH;wbIFogQ>? NHXz[4wzPjB{MUeyPS=>
U1 NW[zO216SXCxcITvd4l{KEG|c3H5 NEG0V|YxNTFyMN88US=> MX:ybC=> NFz3[G5z\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NYeze3VtOjV7OEC5OFI>
ACH-2 M{W1cWFxd3C2b4Ppd{BCe3OjeR?= MlO2NE0zODEQvF2= NYnuUpVkOmh? MlH4doVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NVTaWHRkOjV7OEC5OFI>
U1 NYjFbIMzU2mwYYPlJGF{e2G7 M{TYeFExOM7:TR?= MkjqNog> M2DSVIlvcGmkaYTzJINie3Cjc3WtNy=> MoDtNlU6QDB7NEK=
A549/V16 NUPLTm9ISXCxcITvd4l{KEG|c3H5 NFexXno2OM7:TR?= MlixNYg> MkLkdoVxemW|c3XzJHRIN1SPLXnu[JVk\WRiYYDvdJRwe2m| MmjhNlU6PDZyM{O=
SGN MmO0RZBweHSxc3nzJGF{e2G7 NFfq[pUzOG2P M2fQdVQ5cA>? M2LVV4hieyCwbzDpcoZtfWWwY3Wgc44hSUmILDDjZYxx[WmwIHX4dJJme3Orb36gc5Ih[2WubDDhdI9xfG:|aYO= M4nic|I2QDd2NkOz
HCT116  NEHLdpNCeG:ydH;zbZMhSXO|YYm= M2HkTVUx|ryP M1\4cFJp NXLVNlBQcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBFTF[S NIGz[FQzPTh4OEixPC=>
DTK-SME M37hWGFxd3C2b4Ppd{BCe3OjeR?= M3:3R|Ux|ryP NUjoU4puOmh? NIfufZVFVVOR NYPzcFF7eGG{dHnhcIx6KGmwaHnibZR{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBjfXCrdnHjZYlv\Q>? NXG5NGpvOjV6NEO4PVc>
HL-60 M4LnNWFxd3C2b4Ppd{BCe3OjeR?= MkHrOVDPxE1? NWr3WGtDPDiq NUXVV5R2emWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? MnnNNlU5OjRyNEO=
U937 MX;BdI9xfG:|aYOgRZN{[Xl? Mmi2OVDPxE1? MYG0PIg> M2qzS5Jm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh NELwbG4zPTh{NEC0Ny=>
A549 MUnBdI9xfG:|aYOgRZN{[Xl? MXuyNEDPxE1? NHrBeFYzPGh? MWXy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JGhHS1BidILlZZRu\W62 M3TZUVI2Pzl2MUS5
HeLa M4i2OmFxd3C2b4Ppd{BCe3OjeR?= NXfJSGhPOTEQvF2= M3PnN|Q5cA>? MV3k[YNtcW6nczD0bIUhemG2ZTDv[kBieG:ydH;zbZMh\HKjbXH0bYNidGy7 M{\OcVI2Pzd{NUS1
SGC-7901 M2CzfWFxd3C2b4Ppd{BCe3OjeR?= MXmyNOKh|ryP MkjKNYg> NWTXOmVncW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBwgGGuaYDsZZRqdg>? NEf2SlEzPTd4N{C3Oi=>
MCF-7 NVyxPHpqSXCxcITvd4l{KEG|c3H5 MmnCNVDPxE1? M17wNlJp M2WyXIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgN2I> MWGyOVczOjFzNB?=
A549 MXvBdI9xfG:|aYOgRZN{[Xl? NUG1ZZhNOTBizszN NWLSWJNHOjSq NIDFNI5FVVOR NH;LS2Jxem:vb4Tld{BJSkNvdILlZZRm\CCDNUS5JINmdGxic4Xyeol3[WxiJjDheJRmdnWjdHXzJJRp\SClbHXheoVlKFCDUmCg[ZhxemW|c3nvci=> MYiyOVY5OzV4OB?=
U87 NETmdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS0S5Y2OM7:TR?= NIXON|AycA>? NGm1VpBz\WOxdnXyd{Bk\WyuIHfyc5d1cCCocn;tJHROYiC2cnXheI1mdnR? MV2yOVY5OTZ4OB?=
Neocortical Neuron MXPO[ZVzd3SxeHnjbZR6KEG|c3H5 Mn3mNVAx|ryP M{G4SVFp M{HDXIFvfGGpb37pfoV{KEixaXHtbYRmKEFvSX7keYNm\CCQZYXyc5RwgGmlaYT5 M{fCUVI2Pjd3MECx
Primary human placental cytotrophoblasts NY\3OWxnSXCxcITvd4l{KEG|c3H5 NXWxOHNrOzEQvF2= MXWyOIg> MVrEUXNQ M1;xR5JmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= MXWyOVY1OjV7Mh?=
MM NIPEenBCeG:ydH;zbZMhSXO|YYm= NGTYXGw2OM7:TR?= MVuyNI1qdg>? M4jtXpBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? NIDSe5czPTV|MEC5PC=>
DLD1 MX7BdI9xfG:|aYOgRZN{[Xl? MkXTNlDDqM7:TR?= MkHaNYg> MlXJdIFzfGy7IILleoVze2W|IHPlcIwh[XCxcITvd4l{KGOjdYPl[EBjgSCZU2Cx M4\tTVI2PTJ2MkS2
MDA-MB-231 MVzDfZRwfG:6aXPpeJkhSXO|YYm= Mk\xNVDPxE1? M4C1elFp M2r0[IF2\22nboTzJINmdGxiZHXheIgh[W[2ZYKgR2hWSSC2cnXheI1mdnR? MnnDNlU2OjF3MEG=
MKN28 NGLJe5hCeG:ydH;zbZMhSXO|YYm= M3vGZVEx|ryP Mnr1N|BucW5? NWPqXlhTTE2VTx?= MoLXbY5pcWKrdIOgWG5HNc7zIIDseZMhS0i[LXnu[JVk\WRiYYDvdJRwe2m| NVfhS4s{OjV3MUO5OlA>
HL-60 Ml\3R5l1d3SxeHnjbZR6KEG|c3H5 MlzoNVAx|ryP NWS2cYI1OWh? M2O2fmROW09? NYr3dFFuyqCrbYDyc5ZmeyC4aXHibYxqfHlib3[gWGNPSXNvdILlZZRm\CClZXzsdy=> Mn\GNlU2ODJ7M{K=
AGS MVrBdI9xfG:|aYOgRZN{[Xl? NWS1PHFqOTEQvF2= NXLtVGt3OWh? MkPadJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? NUf4VVlJOjV2OUKyNVQ>
A549  MUTBdI9xfG:|aYOgRZN{[Xl? NESx[JQyOM7:TR?= MmOxNlRp MVLicI9kc3NiRF3BV{1qdmS3Y3XkJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCjbnSgVGFTWCCjbnSgZZBweHSxdHnjJINmdGxiZHXheIg> NIfGU3czPTR|NEm4PS=>
INS-1 MmTlRZBweHSxc3nzJGF{e2G7 NVPRXoI4PTEQvF2= Mm[yOog> NHfk[GJFVVOR M4LFV4Rm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= NYrFcnJNOjV2M{C4PVc>
Primary hepatocytes  M4\Gb2Fxd3C2b4Ppd{BCe3OjeR?= M3TLN|Ux|ryP Mn24NVhp NEflTYdqdmirYnn0d{BieG:ydH;zbZMhd2ZiaHXwZZRw[3m2ZYOgbY5lfWOnZDDifUBC[3RiRDDhcoQhXE6ILd8x MVqyOVQxPzV|OB?=
L929-A  M{e4NmN6fG:2b4jpZ4l1gSCDc4PhfS=> MkPjNlDDqM7:TR?= NFfEOlEzPGh? M3i1eYlvcGmkaYTzJHRPTs7zLXnu[JVk\WRiY3XscEBl\WG2aB?= MkXFNlU{QTh3NEC=
L929-N NFjySYVEgXSxdH;4bYNqfHliQYPzZZk> MonQNlDDqM7:TR?= MUKyOIg> NWGyZ5RQ\W6qYX7j[ZMh\GWjdHigeoliKGG3dH;jdolv\SCWTldOtUBxem:mdXP0bY9v NILzZZozPTN7OEW0NC=>
Cytotoxicity Assay MnzuR4VtdCCYaXHibYxqfHliQYPzZZk> MmOxNlDPxE1? NHTwVIU1QGh? M4DpV5Bz\X[nboSgUWhOTC2rbnT1Z4VlKGOnbHyg[IVifGh? M4K0flI2Ozl{MUG2
COS7 MVTLbY5ie2ViQYPzZZk> M3fkd|Ex|ryP M{iwclI1cA>? MYPpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? NHH1XHEzPTN6NECyOS=>
COS7 NH3OSFlCeG:ydH;zbZMhSXO|YYm= MVixNO69VQ>? NV3PTGdlPDiq MkTIdIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= MoqxNlU{QDRyMkW=
A375 MofTRZBweHSxc3nzJGF{e2G7 MUSzNO69VQ>? M4HFfVJp MWrwdoV3\W62czD0bIUh\HK3Zz3pcoR2[2WmIGDBVnAh[2ynYY\h[4U> MUeyOVM4PjFzNR?=
A549 NI\uTZlCeG:ydH;zbZMhSXO|YYm= NVzWWVN6PTEQvF2= NW[2PHNJOjSq NVvMZ5UxemW4ZYLz[ZMhemmkb4PvcYUh[mmxZ3Xu[ZNqeyCjbnSgZZBweHSxc3nzJINifXOnZDDifUAhS2iran;u[4Ridg>? MmDxNlU{PDl5OEG=
A549 M3rEU2Fxd3C2b4Ppd{BCe3OjeR?= MV6yMlUuOjYQvF2= NGHCemMycA>? NWTUbIJx\GWlcnXhd4V{KHSqZTDwc5B2dGG2aX;uJI9nKGGyb4D0c5Rq[yClZXzsd{Bl\XCnbnSgc44h[2:wY3XueJJifGmxboO= MXKyOVM1OjR{Nx?=
 NBL-W-S  MoLSRZBweHSxc3nzJGF{e2G7 M{\LUFUx|ryP NEXYfHAycA>? MXnmeYxtgSC{ZYPjeYV{KGOnbHygeoli[mmuaYT5JIFnfGW{IFfBUnQuPjFidILlZZRu\W62 NXewXIRoOjV|MkOyNlI>
Caki-1  MV\BdI9xfG:|aYOgRZN{[Xl? Mmi3OFDPxE1? M1foTFQ5cA>? MlHadoVlfWOnczD0bIUhdnWvYnXyJI9nKEGwbnX4bY4hXi2yb4PpeIl3\SClZXzsdy=> NWLCOpVEOjV{N{mxPVE>
769-P MWjBdI9xfG:|aYOgRZN{[Xl? Mkf2OFDPxE1? NYDNeYp{PDiq NXmxW|lbemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? MX:yOVI4QTF7MR?=
H9c2 MkfuRZBweHSxc3nzJGF{e2G7 MUW1NO69VQ>? M1e1RVFp NH3TN|hqdmirYnn0d{BFV1hvaX7keYNm\CClYYPwZZNmKDNiYXP0bZZifGmxbjDieZQhdm:2IITo[UBtd3O|IH;mJINmdGy| MlfINlUzQDN6MUm=
K562 Mn3FRZBweHSxc3nzJGF{e2G7 MkjFOVDPxE1? M3XPSFRp M1y4ZYlvcGmkaYTzJGpi[y2DLXnu[JVk\WRiY3XscEBieG:ydH;zbZM> NUL6OmRsOjV{NEG2NVk>
L929 M3TwcWFxd3C2b4Ppd{BCe3OjeR?= MYexNO69VQ>? MnPmOog> NHy5c2lqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H MlHHNlUyQTV4NkC=
A549 MXjBdI9xfG:|aYOgRZN{[Xl? Mm\yNVDPxE1? NVHMZmpEO2h? MnHMdoVlfWOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliUGHR NGjVNpYzPTF4MU[5PS=>
MCF-7 M4DPTmFxd3C2b4Ppd{BCe3OjeR?= Mki2NlDPxE1? NFr2OXMzcA>? MYTk[YNz\WG|ZYOgT2RTNXOrUl7BMYlv\HWlZXSgZZBweHSxc3nz NH[yR5QzPTF6MkK0NC=>
OS NHro[YxCeG:ydH;zbZMhSXO|YYm= M1jmTVIxNzRyzszN MYS3Nog> NWC5UmF5cW6qaXLpeJMhV1NiY3XscEB3cWGkaXzpeJkhemWmdXP0bY9vKGK7IFO2JINmemGvaXTl NGjrdHozPTF3MkO5PS=>
HUVECs NWDqdmFXSXCxcITvd4l{KEG|c3H5 NE\lOZAyOM7:TR?= NFTjOYUzcA>? MVxCpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGhWXkWFcx?= NH:0dFczPTF|OEewNy=>
EA.hy926 MXnBdI9xfG:|aYOgRZN{[Xl? MX6xNO69VQ>? MmnwNog> MnLhxsBqdmirYnn0d{BieG:ydH;zbZMh[W6mIH\hZ4ltcXSjdHXzJIF2fG:yaHHnfUBqdiCGRV7WNk1qdm[nY4Tl[EBGSS6qeUmyOi=> NFXwZWYzPTF|OEewNy=>
Ebs NIHrOJBCeG:ydH;zbZMhSXO|YYm= NFTSVlcyOC1zMEFOwG0> MkTxNlRp MV9CpG1OXFNiZ3Xu[ZJifGmxbjDyZZRmKGSnY4LlZZNm\CCjczD0bIUh[2:wY3XueJJifGmxbjDv[kB7NV[DRD7mcYshcW6lcnXhd4Vl NXrTcHNXOjVzM{S4NVc>
Jurkat NHLMW4dCeG:ydH;zbZMhSXO|YYm= M3jBc|Ix|ryP MmfNNlRp NYrISGZ2TE2VTx?= NUftTZNTeGG{dHnhcIx6KGmwaHnibZQh[2WubDDk[YF1cCCxZjDKeZJs[XRiY3XscJMhcW6mdXPl[EBjgSBzMEC1PE1HPCClb33ibY5m\CC5aYToJHZRScLi Ml3XNlUyOjB5MkO=
K562 NWW5VINGSXCxcITvd4l{KEG|c3H5 Mnr1NE4yNTIQvF2= MlSwNYg> MlvKbY5pcWKrdIOgZ4xm[X[jZ3Wgc4YhUFOSOUCgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= NEL1PXYzPTFzOUG4PC=>
IMR-32 NF;yd4ZCeG:ydH;zbZMhSXO|YYm= NXfxbodDPDEEoN88UeKh MUSybC=> M2jiOoRm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? Mn3kNlUxQDR5NUW=
RPMI 8226 MVzBdI9xfG:|aYOgRZN{[Xl? NFi2fIYyODEQvF2= NWnkb3NsOWh? MlnPZYxud3O2IHPvcZBt\XSnbImgZoxw[2u|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JI5m[3Kxc4TheIlvNTF? MX6yOVA{Pzh3MR?=
U266  NXq2UFlNSXCxcITvd4l{KEG|c3H5 NWr2PVZuOTByzszN NITlN|MycA>? MnT2dIFzfGmjbHz5JIJtd2OtczDj[YxtKGSnYYToJINifXOnZDDifUBv\WO{b4P0ZZRqdi1z NGfSSVAzPTB|N{i1NS=>
H929  NV3ZS5hySXCxcITvd4l{KEG|c3H5 NX\sfY1EOTByzszN M4\TU|Fp NXnhcVZ4eGG{dHnhcIx6KGKub3Prd{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCwZXPyc5N1[XSrbj2x M1vzdFI2ODN5OEWx
MM.1S  MnrTRZBweHSxc3nzJGF{e2G7 M{XZfFExOM7:TR?= NV\yWld1OWh? Mmfp[YZncWOrZX70cJkheHKndnXueJMhe2:{YX\lcoljNWmwZIXj[YQh[2WubDDk[YF1cCClb33ibY5mKHerdHigcoVkem:|dHH0bY4uOQ>? MlPBNlUxOzd6NUG=
C6 NHrtOmlCeG:ydH;zbZMhSXO|YYm= M{\mN|Ux|ryP NHGxSWE1QGh? MnuxdJJmfmWwdIOgeIhmKGyxc4Ogc4Yh[2WubDD2bYFjcWyrdImgZ4F2e2WmIHL5JJBz\WewZX7vcI9v\Q>? MXeyOVAyOzR5OR?=
AGS MmK2RZBweHSxc3nzJGF{e2G7 Mn\nOVDPxE1? NWXLRnBQOjSq NHi0cHli[m:uaYPod{DPui2uYYDhZ4hwdmVvaX7keYNm\CClZXzsJIRm[XSqIHHu[EBqdmirYnn0[YQh\3Kxd4To M1LIOlI2ODB7Nkm4
HeLa  MYLBdI9xfG:|aYOgRZN{[Xl? NYHoU4JzPDEQvF2= MX[yOIg> MmTubY5pcWKrdIOgeIhmKGmwY4LlZZNm\CCjcH;weI9{cXNiaX7keYNm\CCkeTDzbXJPTjF{MR?= MnfzNlQ6Ojh4OEW=
THP-1  NWC2foRQSXCxcITvd4l{KEG|c3H5 MX[xNO69VQ>? M3fSNlFp NWr3fJZ5emWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCDTFGtV2RVyqB? MnjmNlQ6OjN4NUO=
P815  MlK3RZBweHSxc3nzJGF{e2G7 NFf5OnYyODBiwsXN NYLqO4VTOTKq NGHXNWpFVVOR M3S0TIlvcGmkaYTzJJZqenW|LXnu[JVk\WRiYYDvdJRwe2m| MmXjNlQ6OjN{N{O=
HCT116 M2m3NmFxd3C2b4Ppd{BCe3OjeR?= M{P0XFIx|ryP M2HqfVI1cA>? NW\VSZps[WK{b3fheIV{KG:oIGTRMYlv\HWlZXSgZZBweHSxc3m= MlO5NlQ5QTB2NEm=
SW1116  NHTGfmJCeG:ydH;zbZMhSXO|YYm= NWfzcVFQOTBiwsXN MmD5NYg> NWrxOFJKTE2VTx?= MXPy[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n MXKyOFg4PDJ6Nh?=
LOVO NH\VbYJCeG:ydH;zbZMhSXO|YYm= NHLYdIEyOCEEtV2= Ml\HNYg> NFLGRnBFVVOR NGTQXGJz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l M4XFXFI1QDd2Mki2
SNU449  MkjGRZBweHSxc3nzJGF{e2G7 M{\EPFIx|ryP M{LOdFQ5cA>? MoqzSG1UVw>? NXjFcngx\GWlcnXhd4V{KG2rUj20OVEucW6mdXPl[EBieG:ydH;0bYM> M4S3WFI1QDRzNkO4
Caco-2 NIG1c5RCeG:ydH;zbZMhSXO|YYm= MkO0OFDjiIoQvF2= MYq0bC=> Ml7YdJJmfmWwdIOgV3QuPy2rbnT1Z4VlKFqRLUGgZ4hidmenczDhcoQhXEWUIHTyc5A> MoiwNlQ5OjJzOEO=
macrophage NGn2OoVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M36yT|AuOjByzszN MlfoNlRp NWnBendDcW6mdXPld{BVVkZvIHHu[EBTcXB|LXTldIVv\GWwdDDu[YNzd3C2b4Ppd{BqdiCvYXPyc5Bp[Wen NV\aPFlMOjR5OUm1OlU>
AGS  NFnZVHVCeG:ydH;zbZMhSXO|YYm= MXSyNO69VQ>? NVvL[VJWOTKq MYfEUXNQ MV;y[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NY\0eW9zOjR5OEm3NFM>
LCC9  NGXIe5dE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NH;hcpoyODEQvF2= MorhOYQ> NUDPepZz[myxY3vzJINmdGxiZHXheIghcW6mdXPl[EBjgSClb33ibY5ifGmxbjDMNVch[W6mIHPocI9zd3G3aX7l MUSyOFc5PTJ3Nh?=
U937  M4mwXo5m[3KxcITvd4l{KEG|c3H5 MYSxNOKh|ryP NFj4XlE{OMLibXnu MWjpcoR2[2W|IH7lZ5JweHSxc3nzJINwdWKrbnWge4l1cCCWTl[= NGXaXlMzPDd5M{e1Oi=>
T cell MYXD[YxtKHC{b3zp[oVz[XSrb36gZZN{[Xl? M2nXfFAuOTByzszN MlLIO|Jp NHjicYFKSzVyPUewJO69VSxiaX7obYJqfHNiYX70bU1ETDNvaX7keYNm\CCWIHPlcIwheHKxbHnm[ZJifGmxbjDpckBRSk2Fcx?= MYeyOFc3QDdyNx?=
HeLa  MYrBdI9xfG:|aYOgRZN{[Xl? M3TTblUx|ryP MmHpO|Jp NEXLW2VFVVOR MV;wdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkd22yb4Xu[JPDqDIkgKO1 NGmwdIwzPDd3NEe4Oi=>
HeLa  NVjKOotuSXCxcITvd4l{KEG|c3H5 Mo\2NVAx|ryP M{jaclI1cA>? M4LtdZN2eHC{ZYPz[ZMhemG2ZTDv[kBk\WyuIHTlZZRpKGmwZIXj[YQh[nlib4\ldoV5eHKnc4Ppc44hd2ZiR{W5V{BweiCJN{HSJJAyPTCpbIXl[OKh MmfNNlQ4OjJ2Nki=
IEC-6  MnnORZBweHSxc3nzJGF{e2G7 NHjkO44yOM7:TR?= MWiyOIg> NIm2SldxemW4ZX70d{BV[2SDLXnu[JVk\WRiY3HzdIF{\S1|IHPs[YF3[WenIHHu[EDPui2lYYTlcolvKGSnZ4Lh[IF1cW:w MYqyOFcyOTV5MR?=
HCT116 Mnr5RZBweHSxc3nzJGF{e2G7 NW\vfJJrOjEQvF2= M1S2VFI1cA>? MYrpcohq[mm2czD0bIUh[2WubDDhdI9xfG:2aXOgbY5lfWOnZDDifUB[VFR{MEW= MYiyOFcyOzhzMh?=
L02 NVTT[JFvSXCxcITvd4l{KEG|c3H5 NIrLXHgzOM7:TR?= NYHpT2N1OWh? MVjwdoV3\W62czD0bIUh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBOTUiS M2LIR|I1PzB4NE[x
A375 MkfFRZBweHSxc3nzJGF{e2G7 NILwWIEzOM7:TR?= M33peVI1cA>? M{nwRZJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? MYiyOFY6QTFzMR?=
HDPC NFvaVphCeG:ydH;zbZMhSXO|YYm= NHy2dVY2OML3TR?= NIjmT2EzPGh? MmPmbY5pcWKrdIOgUm8ucW6mdXPl[EBieG:ydH;zbZM> MonINlQ3OzR3OUO=
A549 M1vqeGFxd3C2b4Ppd{BCe3OjeR?= NHfLOos2OML3TR?= M2Da[VJp MlnZSG1UVw>? NHG5ZVBxemW4ZX70d{B1cGViaInwc4RqeGyxaXSgSG5CKGOxboTlcpQheGijc3WgbY5lfWOnZDDifUBk\XCqYXzvZ4hzd22rbh?= M4fzc|I1PTh6MUO1
 BV-2 M13qVWFxd3C2b4Ppd{BCe3OjeR?= NV3k[YV2OjEQvF2= M2DEWlJp NYHBZ2Fye3WycILld5NmeyCXVj3pcoR2[2WmIHPodo9u[XSrbjDlfJRzfXOrb36gZY5lKGSrbHH0bY9vKG:oIITo[UBvfWOuZXHyJIVvfmWub4Dl NUDaRZFwOjR3NUixNVg>
HT-29  MU\BdI9xfG:|aYOgRZN{[Xl? NHXkSZM2OM7:TR?= MXi0PIg> M4fIPIJtd2OtczD0bIUh[XCxcITvd4l{KGmwZIXj[YQh[nlia3HlcZBn\XKxbB?= MXyyOFU1QTF5NR?=
A549 MVnBdI9xfG:|aYOgRZN{[Xl? MYG1{txO MoLyNlRp M{XxSpN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg M4rnclI1PTJ7OEex
MIA-PaCa-2 MnT2RZBweHSxc3nzJGF{e2G7 NWHkb3djOjSq MVricI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? NXX0WphmOjR3MUC5PVI>
Caki-1 MoraRZBweHSxc3nzJGF{e2G7 MkfjNlDPxE1? MXGxbC=> NV\wOoxFcW6qaXLpeJMhW0OSLXnu[JVk\WRiYYDvdJRwe2m| NFnWSFEzPDVyNE[4NS=>
CLL NYDuc3FVSXCxcITvd4l{KEG|c3H5 M{TpfVI2|ryP MYixbC=> MofUdIFzfGmjbHz5JIJtd2OtczDNUG4zOjN6LXnu[JVk\WRiY3XscEBieG:ydH;zbZM> NUPtbm4yOjR2Nke2N|Q>
SGC-7901 M3jEc2Fxd3C2b4Ppd{BCe3OjeR?= MUKxNO69VQ>? NFezfmYzPGh? NGfZdJJxem:vb4Tld{B1cGViQ1fJTU1qdmirYnn0[YQh[2WubDDndo94fGhiaX6gV2dENTd7MEGgZ4VtdHN? Mn;5NlQ1PTR2OEi=
k1735 NWrzVndsSXCxcITvd4l{KEG|c3H5 NFy1elkzOOLCid88cS=> NH:0SFc1cA>? NYDEOWo2cW6qaXLpeJPDqFOjbH3vcoVtdGFvaX7keYNm\CCjcH;weI9{cXN? MknJNlQ1PTFzMU[=
HaCaT  Ml70RZBweHSxc3nzJGF{e2G7 NGe2UIcyODEQvF2= M1LKXFFp MXPicJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| MVWyOFM2Pjl7Nx?=
podocytes NFf0fYpCeG:ydH;zbZMhSXO|YYm= NH:1e5gzODEQvF2= MVW2bC=> MXzpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA{NDRvRFfF NXzPbXRVOjR|M{e3O|c>
 KB M2Lme2Fxd3C2b4Ppd{BCe3OjeR?= MofaOVDPxE1? NIjBfVAzPGh? NUXNUYVGcW6qaXLpeJMhVGmlbz3BMYlv\HWlZXSgZ4F{eGG|ZT2zJIFv\CCSQWLQJIFkfGm4YYTpc44> NEC1R|YzPDN|N{S5Ni=>
 HepG2  NH:4[FRCeG:ydH;zbZMhSXO|YYm= M1zKS|Ex|ryP NGr1e3MzPGh? M4n3ZpJm\HWlZYOgeolu\W62aX6gZ4xm[X[jZ3WgZ4F2e2WmIHL5JGxRWw>? MojpNlQ{OjV6MU[=
fetal rat lung fibroblasts  MXnLbY5ie2ViQYPzZZk> M4Di[lgx|ryPwrC= MWGxbC=> MYTpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> MWiyOFMyPDF|NR?=
PDL fibroblasts NWXYOIF4U2mwYYPlJGF{e2G7 M2j1dFgx|ryPwrC= NYm2bFFpOWh? MVfpcohq[mm2czDDZZNx[XOnLUOgZYN1cX[rdIpCpC=> MWiyOFMyPDF|NR?=
MB49 MVvBdI9xfG:|aYOgRZN{[Xl? MWiyNO69VQ>? Mk\qNYg> NVfifZVKemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq MVOyOFI5OjR|Mx?=
5637 MnOyRZBweHSxc3nzJGF{e2G7 MXOyNO69VQ>? MoHUNYg> NVmzU5dWemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq NF22cnQzPDJ6MkSzNy=>
A549  MlnZRZBweHSxc3nzJGF{e2G7 NWHnT4tIOTByzszN NXvqNGJiPDiq MlrSd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg MV[yOFI4OjJyMR?=
MCC-2 MX\BdI9xfG:|aYOgRZN{[Xl? MYeyNEDPxE1? NYnGXXE{Pmh? M1vKNGROW09? MUficI9kc3NiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5mKGGyb4D0c5NqeyClZXzsJIRm[XSq M173SlI1OjZ{NkW4
ADF MVXBdI9xfG:|aYOgRZN{[Xl? NH3YNFQ1OM7:TR?= Mn22Oog> MoXRbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= NULwfINEOjR{MkiyN|I>
 U373  NVrHeo84SXCxcITvd4l{KEG|c3H5 Ml76OFDPxE1? NVjOWFhiPmh? MXrpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= M3zqUFI1OjJ6MkOy
RKO-HIPK2i NEHVPVZCeG:ydH;zbZMhSXO|YYm= NHT5UY01OM7:TR?= MmrUOog> NUXBOXVZcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> NVrNWIp4OjR{MkiyN|I>
HEC-1B MnvKRZBweHSxc3nzJGF{e2G7 NE\HTZMzOM7:TR?= MVOxbC=> NUTNVmlOemWmdXPld{BVWC2rbnT1Z4VlKGGyb4D0c5Nqe8LiY3HzdIF{\S1|IHHu[EBk[XOyYYPlMVk> NX3YbXZHOjR{MUOzOVg>
4T1 MWfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NUDsT4s3Oi53LUGw{txO NEn6fnc1cA>? MUfEUXNQ NFnCXWtz\XOldXXzJJRp\SCleYTveI95cWOrdImgc4YhPFRzIHPlcIx{KGmwZIXj[YQh[nliU2DEWEBqdiCjIHPvcoNmdnS{YYTpc44h\GWyZX7k[Y51KG2jbn7ldi=> MnnuNlQzODZzNkG=
OS  NX\1d2F6SXCxcITvd4l{KEG|c3H5 MX6yNO69VQ>? M1HOfVRp MXXpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliUFTU MknONlQzODR7M{e=
RPE NFXF[olCeG:ydH;zbZMhSXO|YYm= NWTQclZYOTByzszN M2TIVVQ5cA>? NWHSclRQeGG{dHnhcIx6KGmwaHnibZR{KHSqZTDjZYxx[WmwLUGgZY5lKC1{IHHjeIl3[XSrb36gZZMhf2WubDDhd{B1cGViY3HzdIF{\SCjY4TpeoF1cW:w M4G0SlI1OjB{MEWy
UD29a MYfBdI9xfG:|aYOgRZN{[Xl? NFLreY02OM7:TR?= M4rRRVI1cA>? NXfQUGdZcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JG5WXDN? NUHzfoh2OjRzOUC1O|Q>
SH-SY5Y  NVrZTFdbSXCxcITvd4l{KEG|c3H5 NWfpZ|hyOTEQvF2= M4nrZVI1cA>? M4r0SoF1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> M4mxS|I1OTR3NE[z
HeLa  MlG4RZBweHSxc3nzJGF{e2G7 NEPxbGQyOC9{MN88US=> MUiyOIg> MXLpcohq[mm2czD0bIUh[WO2aY\peJkhd2ZidHjlJI1icm:{aYT5JI9nKHSqZTDt[Y1j\XK|IH;mJJRp\SClYYPwZZNmNW[jbXnsfS=> MWCyOFE{PzJ4Nh?=
SCCVII  NYjWcnlKSXCxcITvd4l{KEG|c3H5 M3nLTlI2|ryP MkXwNYg> NU\JS2dmcW6qaXLpeJMhfGinIHPlcIwhc2mubHnu[{Bi\nSncjDkZZNifGmwaXK= NVzIS49GOjRzMk[0OlQ>
RAW 264.7 NVLpemo3SXCxcITvd4l{KEG|c3H5 NYDvSIo3OjEQvF2= NF;2VGMyQGh? MVPpcoNz\WG|ZYOgUGM{NUmLL98yMYFkfGmwIILheIlwKGOxbYDhdoVlKHSxIFXDWHYuVU:VIITy[YF1dWWwdDDvcox6 NXnk[5psOjRzMU[3NFc>
A549  MlXHRZBweHSxc3nzJGF{e2G7 NY[5NllqOi53zszN NEm1VpEzPGh? NH7ocpNl\WO{ZXHz[ZMhd3KrZH;ubY4ucW6mdXPl[EBifXSxcHjh[5kh[XNid3XscEBidmRiTH;zd{Bw\iEQlN-IcUBidHOxIH;jZ5VzemWmIHT1dolv\yCjdYTvdIhi\2mlIIDyc4Nme3N? MVqyOFExOjV{Mh?=
UM-SCC-10A  NWfDbmdSSXCxcITvd4l{KEG|c3H5 NUP0cFVpPTEEtV2= M4D0OFJp NXfPVVl7emWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCqaXfoMYRwe2ViaYPvZYxidnSxbHHjeI9v\Q>? NWS2cIdsOjRyOUi3OVM>
BGC-823 MU\BdI9xfG:|aYOgRZN{[Xl? M3:wXVExKM7:TR?= MX2yOIg> MmT2doVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NIf0O2ozPDB7OEWxNS=>
Nalm-6  MonwRZBweHSxc3nzJGF{e2G7 NHfIelIzOM7:TR?= MnHTOIg> NFjiTJdqdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> M3e1NlI1ODN7OU[3
KHOS  NY\XfJU6SXCxcITvd4l{KEG|c3H5 MY[0NO69VQ>? NGXCWnQzPGh? NUf2SZZt[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> M4HXSFI1ODJ3M{[x
G292 MUDBdI9xfG:|aYOgRZN{[Xl? NWP2WXhtPDEQvF2= NUnvTFFuOjSq NXPXe3Nr[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NIKxcZUzPDB{NUO2NS=>
MG-63 MVrBdI9xfG:|aYOgRZN{[Xl? M4P4eFQx|ryP MoC5NlRp NIfCOmZjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg Mke2NlQxOjV|NkG=
EBV-transformed B cells MnXXRZBweHSxc3nzJGF{e2G7 NFrOWVMzOM7:TR?= MlSxNog> NV3R[3BmTE2VTx?= MkLXZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ NV3ZcIJxOjRyMEi2Nlg>
IM-9 B Mm[3RZBweHSxc3nzJGF{e2G7 NWnXTlVxOjEQvF2= NWj2SZUyOmh? MknQSG1UVw>? M2KxXoJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? NVjQXVd4OjRyMEi2Nlg>
CNE1 NU\Gem5MSXCxcITvd4l{KEG|c3H5 MVGyNO69VQ>? M2HRWlQ5cA>? MUHicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> M37MRVI{QTh3MEK5
CNE2 MkXVRZBweHSxc3nzJGF{e2G7 NWnTTGpiOjEQvF2= NVnCb5lpPDiq M4i5VoJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ MknINlM6QDVyMkm=
HL-60 M2TBTmFxd3C2b4Ppd{BCe3OjeR?= M1fre|UxyrWP NI[zN3cycA>? MWrEUXNQ NEixTm1qdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCEQUG0OS=> M3mzRVI{QTR6N{Wx
L929 MVrBdI9xfG:|aYOgRZN{[Xl? NE\4e5YyNjJ34pETOeKh|ryPwrC= NVfFV3JtOjSq M{OxUoF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? M1HyZlI{QTRzN{[5
Jurkat NX3CUmdNS2WubDDWbYFjcWyrdImgRZN{[Xl? M3zFZ|LPxE1? M3zWdlRp MnjwdoV3\XK|ZYOg[5Jwf3SqIHnubIljcXSrb36gZY5lKM7{LXPheIVvcW5iZHXjdoVie2ViYomgTHMuSVOD NI[ybFUzOzh7NkC2NS=>
RAW264.7  Mnu0RZBweHSxc3nzJGF{e2G7 MXyxNEDPxE1? MWKyOIg> M4\DSIRm[3KnYYPld{B1cGViYYDvdJRwe2m|IHnu[JVk\WRiYomgS2E> MlP3NlM5OjB{MEO=
A431  MYfLbY5ie2ViQYPzZZk> NUPwOoNJPDEQvF2= NW\qSGZWOmh? M1r1RYJtd2OtczDmbZNmfGmwLXnu[JVk\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZYOgZY5lKFCDUmC= MnPINlM5ODByNUi=
Jurkat M3;oRWNmdGxiVnnhZoltcXS7IFHzd4F6 MlnVNlUuOTByzszN MkO2Oog> M3LtNIlvcGmkaYTzJJouTkFvQ13LMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M2jiTFI{QTN|NUOy
COS-7  Mn7uSpVv[3Srb36gRZN{[Xl? M1zM[|UxyrWP MXKyOIg> NX3GdWpu[W[oZXP0d{B1cGVicILvZ4V{e2mwZzDv[kBCXE5zczD3bZRpKHCxbInRJJRz[WO2cx?= NHL6VI4zOzl|M{KwPC=>
CAL27 Mnj3RZBweHSxc3nzJGF{e2G7 NGDpXmgyOCEQvF2= MoHyNog> NV3icmtwe3WycILld5NmeyCFdYKtUnB{NXKnZIXj[YQhfmmjYnnsbZR6KGK7IIXwJJRwKDlyJR?= NWrQXpplOjN7MUezPVY>
THP-1  MWDBdI9xfG:|aYOgRZN{[Xl? M4e4V|ExNTVyzszN MlHLNog> MXTpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUB1emmydH;sbYRm NUHXU5NoOjN7MECyPVk>
K562 NGH3TYNCeG:ydH;zbZMhSXO|YYm= M3XUd|Ix|ryP M1jjdFQ5cA>? MXvpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUA1NU2X MYmyN|g4Pjh{Nh?=
HL-60 NHfzRXVCeG:ydH;zbZMhSXO|YYm= M4C2XlExOM7:TR?= NFrORoozPGh? NHizfmtqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= MU[yN|g3PTd5OB?=
HeLa  NHTzemZCeG:ydH;zbZMhSXO|YYm= MYqyNO69VQ>? NFy5SW4zcA>? MVfpcohq[mm2czDEUW1RKGmwZIXj[YQh[XCxcITvd4l{ NUDydmlGOjN6NkO5OlY>
U251 M2ftSWFxd3C2b4Ppd{BCe3OjeR?= M2K5TlIx|ryP MYqyOIg> NXz5NWhbcW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| MoLqNlM5OTZ6MU[=
HL-60 M4TqWmFxd3C2b4Ppd{BCe3OjeR?= MYK1NOK2VQ>? NF[yemw1cA>? NUPxNplp[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z M1LhSlI{QDB2N{C2
Ec-109 NETBOJZCeG:ydH;zbZMhSXO|YYm= Ml\PNVAh|ryP M4G1VVQ5cA>? NFvnRZBz\XC{ZYPz[ZMhWEVvbXXkbYF1\WRiRXOtNVA6KGOnbHygZZBweHSxc3nz NF\OWWYzOzd6Mk[0NS=>
RKO M4TIVGNmdGxiVnnhZoltcXS7IFHzd4F6 MnLYNVAh|ryP Mn7jNlRp MWfpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= NVrpd3QzOjN5NUiwOlQ>
T98G M2r1W2NmdGxiVnnhZoltcXS7IFHzd4F6 MX6xMVExOM7:TR?= NIrqe5UzPGh? MYDpcZBzd3[nczDj[YxtKH[rYXLpcIl1gSClb4Ty[YF1dWWwdDD3bZRpKFSV NGftdpAzOzd4OUK3OS=>
Jurkat NVzkSpUyS2WubDDWbYFjcWyrdImgRZN{[Xl? MXGxNFAuOjByzszN MojtNlRp NUfFV5gycW6qaXLpeJMhUGGDNDDpcoR2[2W|IHHwc5B1d3OrczDk[ZBmdmSnboSgc4Yh[2:wY3XueJJifGmxbtMg NXXCZplmOjN5M{K0PFE>
Molt-3  NULQc5FGSXCxcITvd4l{KEG|c3H5 M33HblUx|ryP MmntNog> NWHvUFZwemWmdXPld{Bu\WyjdH;ubY4ucW6mdXPl[EBieG:ydH;zbZM> MUWyN|czPTBzMx?=
hMSC12 NHrOVHJCeG:ydH;zbZMhSXO|YYm= NHHiUYMyODEQvF2= NET4ZmM1\A>? MUHpcohq[mm2czDvd5Rmd2enbnnjJIN2dHS3cnWtbY5lfWOnZDDj[YxtKGSnYYToJIFv\CClYXzjbYZq[2G2aX;u NYLxPWl2OjN4NUe4NlI>
HM7  M1u3VWFxd3C2b4Ppd{BCe3OjeR?= M1XHVFIx|ryPwrC= NVzFbolHOWh? M2LBToJtd2OtczDhdIlkfWyjcnXuJGEh[WOndHH0[U1qdmS3Y3XkJINie3Cjc3WtN{Bi[3SrdnH0bY9vKGGwZDDQRXJRKGOuZXH2ZYdm MYeyN|U5OzRzMh?=
Hep-2  M3nzeGFxd3C2b4Ppd{BCe3OjeR?= M3LqblIx|ryPwrC= MXmyOIg> M2n5fGROW09? MnT5ZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= NXvnUHVHOjN3OECwN|I>
HSCs NW\uNHVLSXCxcITvd4l{KEG|c3H5 NFHp[Jk2OM7:TR?= NXjrU2RpOjSq NIHGWXVFVVOR MY\pcohq[mm2czDubYxwfGmwaXKtbY5lfWOnZDDEUmEh\GGvYXflJIlv\GmlYYTl[EBjgSCSQWLQJINt\WG4YXfl NHi0e2czOzR7OUi3OC=>
HL-60  NIr2ZmREgXSxdH;4bYNqfHliQYPzZZk> MXiyNO69VcLi NIr3U2gzPGh? NUnpUHlyemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 MmLCNlM1QTR2OEC=
HA MYPBdI9xfG:|aYOgRZN{[Xl? NFjlSm02OM7:TR?= MlTJNlRp MXXzeZBxemW|c3XzJJRp\SClbHXheoFo\SCxZjDQRXJRKGGwZDDjZZNx[XOnLUOsJE04NCCjbnSgMVkhcW6mdXPl[EBjgSCkb4L0[ZpwdWmkL2PBTGE> NHTWOpIzOzR5NUm1Oi=>
C666-1 NH;n[oVCeG:ydH;zbZMhSXO|YYm= Ml71OVDPxE1? M{HQN|I1cA>? MoXyd5VxeHKnc4Pld{B1cGViY3zlZZZi\2Vib3[gVGFTWCCjbnSgZ4F{eGG|ZT2zMEAuPyxiYX7kJE06KGmwZIXj[YQh[nliYn;yeIV7d22rYj;TRWhC NVHMOJdtOjN2N{W5OVY>
Hepa1-6 NELq[ZhCeG:ydH;zbZMhSXO|YYm= NX3uOHBbPTEQvF2= NYj4dWxzOmh? Mn3XbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| NX;COlRyOjN2NE[3OVM>
PLC/PRF/5c MVHBdI9xfG:|aYOgRZN{[Xl? M{G2WlUx|ryP MVixbC=> NVfWfYN[eHKndnXueJMh[XCxcITvd4l{KHS{aXfn[ZJm\CCkeTDDTW4> NYPqfI11OjN2M{i4NlQ>
HCT116 M4XXVWFxd3C2b4Ppd{BCe3OjeR?= MorNNVAx|ryP M3T4T|EvPWh? M1nGVIlvcGmkaYTzJG9{NWmwZIXj[YQh[2WubDDk[YF1cA>? NUeycXRXOjN5NESzOVM>
HCEC NYTYc3ZITnWwY4Tpc44hSXO|YYm= NXfvUZpiPTEQvF2= M4PaNlczcA>? MoS1SG1UVw>? MmWwdoV{fG:{ZYOgc4YhfGinIH7vdo1idCCKQ1XDJJBp\W6xdInw[S=> MXuyN|c1OjBzMR?=
Primary rat cerebral cortical neurons NV7xcmlUSXCxcITvd4l{KEG|c3H5 MlP5NVAx|ryP M3O4R|Fp MUnwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= NH;XXYMzOzd2MUOxOy=>
MDA-MB-231  Mlz0RZBweHSxc3nzJGF{e2G7 NXLt[lB5OjYQvF2= MX[yOIg> MVXhZpJw\2G2ZYOgZ5l1d3SxeHnjbZR6KGGwZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMh[W6mIGDBVnAhcW6mdXPl[EBjgSCUZ{O= M3[0RVI2OzN5NUS0
NLRP3-Tet-on-MC/9  NU\R[WFuSXCxcITvd4l{KEG|c3H5 M4nJdVExNTRyzszN MkG0NVJp MlfiZZR1\W63YYTld{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgR2FRWy2jc4PvZ4lifGWmIF7MVnA{KG23dHHueJMhcW5idHjlJHRmfC2xbjDzfZN1\W1? NETaT5kzOzdyM{O4PS=>
KNS42  NFnLWlFCeG:ydH;zbZMhSXO|YYm= MljYOVDPxE1? MUexbC=> MYjy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGOxbYDs[ZRmdHliYXLvcIl{cGWmIHPhd5Bie2ViMz:3JIFkfGm4aYT5JIlvKHKnc4DvcpNmKHSxIFHCWE0zPjNxMlTHM41mfG[xcn3pckBkd22kaX7heIlwdg>? NF\YNIUzOzZ7MUG0OS=>
MCF-7  MkfGRZBweHSxc3nzJGF{e2G7 MYeyNO69VcLi MUW3Nog> MmjrbY5pcWKrdIOg[ZF2d2xvIHHu[EA1NU:KVD3t[YRq[XSnZDDhdI9xfG:|aYO= NXPGempCOjN4N{W2OFM>
hCMEC/D3  Ml31RZBweHSxc3nzJGF{e2G7 MWSyOe69VQ>? NXHSTHNqPzKq MoX6doVlfWOnczDMeJhCKGmwZIXj[YQh[XCxcITvd4l{ MoPLNlM3PjVzOUi=
Jurkat M1TE[WFxd3C2b4Ppd{BCe3OjeR?= MmPSNVIvPS13MN88US=> NU\GWmU3OWh? NUX4SlNW\G:|ZTDk[ZBmdmSnboTsfUB{fXCycnXzd4V{KFOSSD3pcoR2[2WmIGDhdk01KGOuZXH2ZYdmNCCSQWLQJINt\WG4YXflMEBFVkFiZoLh[41mdnSjdHnvckwh[W6mIHzvd5Mhd2ZidnnhZoltcXS7 MXuyN|Q1Ojl5Nh?=
CNE-1 NYLEOJdsSXCxcITvd4l{KEG|c3H5 M4HEOFIx|ryPwrC= NXzkW2VwOjSq NVjOR2dIcW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NFLu[ZYzOzR{Nki1NC=>
HONE-1 NGX0PHRCeG:ydH;zbZMhSXO|YYm= M4rQVlIx|ryPwrC= M{fS[FI1cA>? M3zSfIlvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= MoGzNlM1OjZ6NUC=
astrocytes cell M3rBOmFxd3C2b4Ppd{BCe3OjeR?= MnjGOFDPxE1? NIrubGI3cA>? MmnYdoVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m NVewV4l6OjN2MUG3O|g>
U-937 MYHBdI9xfG:|aYOgRZN{[Xl? NFzKcIUyOM7:TR?= NGnSelM{OG2rbh?= MlntdJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? NEizW|MzOzRzMEe0PC=>
MDA-MB-231 NWnmfYFGSXCxcITvd4l{KEG|c3H5 NYDGboZoOTByzszN MkfaNYg> MX3pcohq[mm2czDz[Y5{cXSrenH0bY9vKHSxIGTSRWlNKHWyb36gUXRFUCCmb4fuMZJm\3WuYYTpc44> MUmyN|QxQDR{OR?=
HeLa  MVvBdI9xfG:|aYOgRZN{[Xl? MmKzNVAx|ryP MoHJNog> M4TNcoJtd2OtczDKVnMuOTViSX7keYNmeyCDcH;weI91cWNiQ3XscEBF\WG2aB?= NX3mdYRiOjN|NESwOFU>
Ec109 NI\re5VCeG:ydH;zbZMhSXO|YYm= NGnpTnEyOM7:TR?= MV:2bC=> M37xboJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v MkS2NlM{Ozh3Nki=
H460  MUXBdI9xfG:|aYOgRZN{[Xl? NHHtd5gyOM7:TR?= M{PDOlZp NYL5eItq[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? M4DoWFI{OzN6NU[4
HeLa  NVy2bIVQSXCxcITvd4l{KEG|c3H5 Mn3OOVDPxE1? M{\UXlEvPWh? NF;vblZi[nKxZ3H0[ZPDqEOqbHHtfYRq[S2rbnT1Z4VlKGGyb4D0c5Nqew>? NWDwR41kOjN|MEO4NFQ>
SK-HEP1 NI\mVoVCeG:ydH;zbZMhSXO|YYm= NUK0UJZFOTByzszN NV;hVXhLOWh? NVzWRllLcW6qaXLpeJMhS3KWMTDhZ5RqfmG2ZXSgZ4F{eGG|ZT2zMEAuPyxiLUisJE06NCCjbnSgdI9tgSiDRGCtdoljd3OnKTDwc4x6dWW{YYPl NFzxVWkzOzNyMk[1NC=>
QGY7701 MnjiRZBweHSxc3nzJGF{e2G7 M3TRPFI2|ryP MWmxMlVp MYDpcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu M3LZV|I{OjRyME[x
HepG2 MVvBdI9xfG:|aYOgRZN{[Xl? NX;PRXhkOjEQvF2= MU[zNI1qdg>? M{jFXIlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? M1TTZ|I{OjJ2MkO5
U87  M4DYb2Fxd3C2b4Ppd{BCe3OjeR?= MXGyOe69VQ>? M3HOVlJp M4PZ[4Rm[3KnYYPld{Bqe2:uaYH1bZJqfGmpZX7pckApUVOOKT3pcoR2[2WmIHHwc5B1d3SrYzDj[YxtKGSnYYToMEBjfXRibn;0JI5m[3KxdHnjJINmdGxiZHXheIg> NWPadpc1OjN{Mkm2NlY>
HSC-2 NYLaNZR1SXCxcITvd4l{KEG|c3H5 MoL0NlUwPTEQvF2= MUSxbC=> MVjpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= MVeyN|E2PTJ2OB?=
HSC-4 M1vEUWFxd3C2b4Ppd{BCe3OjeR?= NXHRSW0xOjVxNUFOwG0> NYS2[oc{OWh? NXX5[VRUcW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> NIrrc3gzOzF3NUK0PC=>
CL-1 MYLBdI9xfG:|aYOgRZN{[Xl? Mlv4NlDPxE1? MmC2NYg> MUDicI9kc3NiT2C0OFkhcW6mdXPl[EBk\WyuIHTlZZRp M2jNPVI{OTNzN{iy
MEL MWrBdI9xfG:|aYOgRZN{[Xl? NF;wPYEzOM7:TR?= NUn2SHlVOjSq M2T5VGROW09? MmXkbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? MWeyN|AyPDh6Nx?=
Bel-7402  MYLDZZNx[XOnIFHjeIl3[XSrb36gRZN{[Xl? NIPB[m42OM7:TR?= NYLoO3BNOmh? MnPTbY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> M4HVclI{ODB6N{Sy
Eca-109 NWrufoFiSXCxcITvd4l{KEG|c3H5 NXPEXVZqOjYQvF2= NV7OcZBoOzCvaX6= MljxbY5pcWKrdIOgRmouSjFzLXnu[JVk\WRiY3XscEBl\WG2aB?= MYWyN|A4Pjl4Nx?=
MEL NVPkVYZzSXCxcITvd4l{KEG|c3H5 MV6yNO69VQ>? NUDh[XRTOWh? NV;yU41oTE2VTx?= NWTaN4t[cW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= NGLBS44zOzBzNEi4Oy=>
Bel-7402  M1jaRWFxd3C2b4Ppd{BCe3OjeR?= M1L5N|Ux|ryP M4DWPFJp M{DDdYlvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NIrGbZEzOzByOEe0Ni=>
L929 NUWzV|Q4TnWwY4Tpc44hSXO|YYm= NXLpZZZ3Oi53zszN MlL1NYg> MojLbY5kemWjc3XzJHJKWDFiZYjwdoV{e2mxbjDhcoQh\XijY3XyZoF1\WRiVF7G{tEucW6mdXPl[EBucXSxY3jvcoRzcWGuIHT5d4Z2dmO2aX;uJIFv\CCUT2OgdJJw\HWldHnvci=> MonjNlMxODB3MUi=
RCC  Mo\NR4VtdCCYaXHibYxqfHliQYPzZZk> NVnDUWc1OTByzszN MV[yOIg> M4fR[5Jm[2:4ZYLld{B1cGVidnnhZoltcXS7IH;mJINmdGy|IHX4dI9{\WRidH:gNVVlNVCJSkK= NGjxTlQzOjl7MUS5OC=>
NB2a/d1 NEfyR5ZCeG:ydH;zbZMhSXO|YYm= MmjrNVAx|ryP NWrZcJZbPzKq M2TyR4F1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> Mn;NNlI6QDh3NEG=
T cell M2K0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGyOU0yODEQvF2= NVjyPJF7OjSq MlTw[I9{\S2mZYDlcoRmdnSueTDpcohq[mm2ZXSgWEBk\WyuIIDyc4xq\mW{YYTpc44hdWWmaXH0[YQhfGi{b4XnbEB1cGViY3:td5RqdXWuYYTpc44hf2m2aDDhcpRqNUOGMzDhcoQh[W62aT3DSFI5 NHO0T5kzOjl6MkWzPC=>
K562 MVzBdI9xfG:|aYOgRZN{[Xl? NEfrTm8yODEQvF2= MoGzNYg> MknjZoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? MYqyNlk4OjN5Mh?=
Jurkat  NEDpO2xCeG:ydH;zbZMhSXO|YYm= NVLTZnlpPDEQvF2= NGDLNIsycA>? MYHhZo9tcXOqZYOgSoF{VC2rbnT1Z4VlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=> M{nnT|IzQTR{N{O4
BGC-823 M1PLTGFxd3C2b4Ppd{BCe3OjeR?= NHHDPHIyODEQvF2= M3rDVFFp NW\TNpU1eGG{dHnhcIx6KHKnc3P1[ZMh[2WubIOgZYdicW6|dDDkZY1i\2Vib3[g[IFq\HqnaX6= MXqyNlkzPjV2NR?=
Hep3B NX3uS45JSXCxcITvd4l{KEG|c3H5 M2LyblUx|ryP MWKxbC=> MXLicI9kc3NiYYDvdJRwe2m|IHnu[JVk\WRiYomgTGVIS3N? MXWyNlkzOzF3NB?=
LLC-PK1 M4m3fmFxd3C2b4Ppd{BCe3OjeR?= MUeyNO69VQ>? NH3tepQycA>? M4fkXZBz\X[nboTzJINqe3CuYYTpck1qdmS3Y3XkJIRm\3KjZHH0bY9vKG:oIFH0[|UtKGKnY3zpck0yNCCjbnSgRZRoOTJicILveIVqdnN? NXnGNYlWOjJ6OU[wN|c>
A549 MnfoRZBweHSxc3nzJGF{e2G7 NH22TJM2OM7:TR?= Mn3oNYg> M1G4VIJtd2OtczD0bIUhSkGLLXnu[JVk\WRiYYDvdJRwe2m|wrC= NX7CcYR5OjJ6OEeyNVU>
SGC-7901  MmHYRZBweHSxc3nzJGF{e2G7 M3nwflEx|ryP MXyyOIg> MmHDbY5pcWKrdIOg{tIt|rJvZHnt[ZRpgWyjY4L5cJNpcWuxbnnuMYlv\HWlZXSgZZBweHSxc3nzxsA> NFXjTokzOjh2OEW5Oy=>
DM6 M2jUc2Fxd3C2b4Ppd{BCe3OjeR?= Mlz1NVAx|ryP MUi3Nog> M2TjcIJtd2OtczDic5RpKEV{Rj2xJIFv\CCHMl\0dk1u\WSrYYTl[EBkgXSxdH;4bYNqfHl? NY\tfGdXOjJ6MkWzNlg>
MCF-7, MDA-MB-468, Caco-2 NFHqO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nleVUx|ryP NYHic5Y4PDiq M2OzUIlvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> M1W0O|IzQDByOU[4
A2750  M1SzWWFxd3C2b4Ppd{BCe3OjeR?= M2HCeFIx|ryP MXmybC=> MlHoSG1UVw>? MmK3Zoxw[2u|IHPhd5Bie2ViY3zlZZZi\2ViZIXybY5oKGinbHXuZYxqdiC2cnXheI1mdnRiYX7kJJJm\HWlZYOgZZV1d3CqYXfpZ{Bk\WyuIHTlZZRp MX2yNlc5PDN4Mx?=
U87  NHfpO4VCeG:ydH;zbZMhSXO|YYm= Mm\ENlDPxE1? NXvXSnNxOjSq MWTy[YR2[2W|IITo[UBieG:ydH;zbZMhemG2ZTDpcoR2[2WmIHL5JHBNSUJ? MlX4NlI4Pzh5OEC=
HT1080 NEmydVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm5[Yg2OM7:TR?= NV;zc4dIP2R? NW\WSHdwcW6qaXLpeJMhfGinIHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[2G3c3XkJIJ6KGOxbXLpcoVlKHS{ZXH0cYVvfCCxZjDER2Eh[W6mIF;NVC=> MV2yNlc1ODl6NB?=
A549  NU\2T25tSXCxcITvd4l{KEG|c3H5 NFfkbmg2OM7:TR?= NWPwTIpvOmh? NVTMRXZmeGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> NIT4PVczOjd{MUiwOC=>
Primary OPC NVrVeFZ6SXCxcITvd4l{KEG|c3H5 NUP6T|JpOc7:TR?= MmfROogwOjSq Mo\ndoVlfWOnczD0bIUheGW{Y3XueIFo\SCxZjDj[YxteyCrbjDlZZJtgS1iYX7kJIxifGVvYYDvdJRwe2m|L37lZ5Jwe2m| NX7yXmdkOjJ5MEezPFU>
PMNs NUXRcXc1SXCxcITvd4l{KEG|c3H5 NWnSd4hkPDEQvF2= MkjOOog> MkDQSG1UVw>? NHfnZndz\X[ncoPl[EB1cGViYX3veY51KG:oIHPs[YF3\WRiY3HzdIF{\S1|IITvJI5m[XJidnXobYNt\SCuZY\lcJM> MVOyNlY6OjV5Nx?=
A549  MWTBdI9xfG:|aYOgRZN{[Xl? M{WwRVUx|ryP MlvmNYg> NX\1eop4eHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQnHvbJVwe2mmZTDJ M4P2UVIzPjh5NkO1
AGS NHLxO2JCeG:ydH;zbZMhSXO|YYm= MV2yNO69VQ>? MXixNog> MV3pcohq[mm2czD0bIUh[WO2aY\heIlwdiCxZjDwdo8u[2G|cHHz[U0{KGmwIILld5BwdnOnIITvJJRp\SCHdF;BZ{BnemGldHnvci=> MlTZNlI3QDd|OUi=
shC9  NIjLeoFCeG:ydH;zbZMhSXO|YYm= MkjSNVDPxE1? MoH6NVZp Mn7VZox2dnS|IGPITEBmgHC{ZYPzbY9vKGmwIIPoR|kh[2WubIOg[Zhxd3OnZDD0c{BmcXSqZYKgVGEhd3JiTGDD M3f0N|IzPjRzMEm0
primary MEFs NW\KV2xZTnWwY4Tpc44hSXO|YYm= NUC5ZlNmOTKq NUHiUo4yyqCrbnPy[YF{\XNiZYTvdI9{cWSnLXnu[JVk\WRibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBl\XCxbHHybZpifGmxbh?= MoDUNlI3OTN5Nke=
3T9 MEFs NU\CO4ExTnWwY4Tpc44hSXO|YYm= NEHpNmEyPmh? Mm\nbY5kemWjc3XzJIN6fG:laILvcYUh[yC{ZXzlZZNmKGGodHXyJIV1d3Cxc3nk[U11emWjdH3lcpQ> MkPRNlI3OTN5Nke=
3T9 MEFs M3\j[WZ2dmO2aX;uJGF{e2G7 NWrIRVFsOTiq MVj1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> NX7lUHByOjJ4MUO3Olc>
MDA-MB-231  MYPBdI9xfG:|aYOgRZN{[Xl? NGfxcokzOM7:TR?= M3nOXVRl NW\nSW1CemWmdXPld{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCvZYTmc5JucW5idILlZZRu\W62IIfhd{B{cWewaX\pZ4FvfGy7 MYOyNlU6OzR2MR?=
C6  MnzLRZBweHSxc3nzJGF{e2G7 MUixNO69VQ>? MYCyOIg> MmDqZoxw[2u|IITo[UB{fXCycnXzd4l3\SCnZn\lZ5Qhd2ZidHjlJJBmeHSrZHWgc44hfmmjYnnsbZR6 NGLEOHYzOjV6OEm4NC=>
HL-60  MlTWRZBweHSxc3nzJGF{e2G7 NIj6NVYyODEQvF2= NGTRZWczPGh? MV3pcohq[mm2czD0bIUh[2WubDDhdI9xfG:|aYOgd4Vt\WO2ZXSgLEsqNW2nboTofYwh|rJvKEJiirI3MS2maXfseYNweHm{YX7vd4ll\cLiNR?= Mne4NlI2PDZ4Nkm=
HL-60 NFTM[GZCeG:ydH;zbZMhSXO|YYm= NX;KS2lLOTBvOEFOwG0> M2nlS|Rp M{TCWYlvcGmkaYTzJHRIUFFvaX7keYNm\CClZXzsJIFxd3C2b4Ppd:Kh NXq2NpVnOjJ3MkOyNlk>
BCC NUPZTINXSXCxcITvd4l{KEG|c3H5 Mm\rOVDPxE1? NF3IO|EycA>? MV3pcohq[mm2czDERXRUNW2nZHnheIVlKGe{b4f0bEBqdmirYnn0bY9v M1jnRlIzPTF7NEO2
RAW 264.7 NV3LdGE5SXCxcITvd4l{KEG|c3H5 Mnj4OVAwOTByzszN MlzoNYg> M2X1XYNwdmOnboTyZZRqd25vZHXw[Y5l\W62IHnubIljcXS|IFTPUk1qdmS3Y3XkJJJTVkFiY3zlZZZi\2V? M4DZNFIzPDlzNEK2
K562 Mnz3RZBweHSxc3nzJGF{e2G7 MlS4NlXPxE1? MoHKNog> M3zvW5Bz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOxLYTy[YF1dWWwdDD3bZRpKGGvdYLlcpNqdiCJIHHu[EBVWkGLTB?= NFXzdoQzOjR6M{e3Oy=>
SGC-7901 MXTBdI9xfG:|aYOgRZN{[Xl? M{XjTlIxKM7:TdMg MlPXNog> NED3SZpifHSnboXheIV{KEh{T{NCpI9zKFSQRjFOtU1qdmS3Y3XkJINmdGxiYYDvdJRwe2m|IHHzJJdmdGxiYYOgZ4F{eGG|ZT2zJIFkfGm4aYT5xsA> NW\abnAyOjJ2N{G1PFk>
PC3 NF3kfHdCeG:ydH;zbZMhSXO|YYm= M1j2[VEx|ryP MoLsOIg> MVXjc5VvfGW{czDmcIF3d2OxeHnkMYlv\HWlZXSgZ4F{eGG|ZT3y[YxifGWmIHHwc5B1d3Orcx?= MoC1NlI1PzF7N{S=
SMMC-7721 NYHxe5F2SXCxcITvd4l{KEG|c3H5 M1;zVlUx|ryP MmHjOFhp M1rsToF1fGWwdXH0[ZMhd1SULXnu[JVk\WRiYYDvdJRwe2m| MX2yNlQ3PTh|Mx?=
HeLa  M1z4[mFxd3C2b4Ppd{BCe3OjeR?= Mk\mOVDDqM7:TR?= M{\LdVQwQGh? M3\BRolvcGmkaYTzJHNVWy2rbnT1Z4VlKGyjdHWtdIhie2ViYYDvdJRwfGmlIHX2[Y51ew>? NI\ueWUzOjR4MEWwOC=>
HeLa  NHXxcVJCeG:ydH;zbZMhSXO|YYm= M{jmcFUxyqEQvF2= NWHhdW5tOWh? NXfBW3Rwe3WycILld5NmeyC2aHWgSnJCWC2rbnT1Z4VlKGGlY4XteYxifGmxbjDv[kBidm6neHnuJHYheG:|aYTpeoUh[2WubIO= NWH3UGh7OjJ2NEm0OFA>
T47D  NYnzdYs3SXCxcITvd4l{KEG|c3H5 NIqydWcyODEQvF2= MW[xbC=> MYricI9kc3NidHjlJIdmdmW{YYTpc44hd2ZiRT3jZYQwS1SIMjDifUBUXFN? M12xc|IzPDBzMU[4
HeLa  MWDBdI9xfG:|aYOgRZN{[Xl? Mme5N|DPxE1? MonQOIg> MoDUxsBqdmO{ZXHz[ZMhfGinIHflcoVz[WxiY3XscEB3cWGkaXzpeJkhPDhiaDDh[pRmeiCyaH;0c4R6dmGvaXOgeJJm[XSvZX70xsA> M{Ho[FIzOzl2MkS4
HCC M4HlTmFxd3C2b4Ppd{BCe3OjeR?= Mn7ENlAh|ryPwrC= MVGybC=> NGfPR2VifHSnboXheIV{KHSqZTDETGEhcW6mdXPl[EBi[3SrdnH0bY9vKG:oIGDBVnA> Ml:0NlI{PDJ5M{K=
mESCs NV\mUWtrSXCxcITvd4l{KEG|c3H5 NWX5OHpKOi53zszN NWLXbVJzOmh? MVnpcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= NUjiZZR2OjJ{OEWyO|Q>
EMT-6  NWfGeZVyS3m2b4TvfIlkcXS7IFHzd4F6 NHq0XGkyODEQvF2= MnXkNYg> NFuzZ2Vx[XK2aXHscJkh[myxY3vl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nlic3nyZY1me2mwZR?= M{[5WVIzOjVzOUKx
MCF7 NEPBTIFCeG:ydH;zbZMhSXO|YYm= M2Tw[VUxyqEQvF2= NWn0V4JROWh? NGDaSVVqdmirYnn0d{BRSSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtPUwh[W6mIIDvcJkpSUSSLYLpZo9{\SlicH;sfY1memG|ZR?= MYSyNlIzOzN2NR?=
K562 NGL2cnJCeG:ydH;zbZMhSXO|YYm= MorRNlAh|ryPwrC= NXm3NXBuPDiq M1T3d2ROW09? MVzicI9kc3NibHHwZZRqdmmkLXnu[JVk\WRiaX7obYJqfGmxbjDv[kB3cWGkaXzpeJkh[W6mIHHwc5B1d3OrczDpcoR2[3Srb36= NVTHU5o5OjJ{MU[xOVg>
Molt4-hyg NUX0RVdvSXCxcITvd4l{KEG|c3H5 NXq0c3p3OTEQvF2= MXywMlVp M3HYWYJtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 NEHnN4MzPjJ5NUixNS=>
HeLa NGLD[2lCeG:ydH;zbZMhSXO|YYm= NHLnZWcyOM7:TR?= NGXNOIUxNjWq MoWwbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfGinIHPvcYJqdmWmIITy[YF1dWWwdDD3bZRpKGexbXnzbY4hViCjbnSgWHJCUUx? NHXydpIzOjF5OU[2NS=>
Jurkat T MWjBdI9xfG:|aYOgRZN{[Xl? NYLNS5pwOzEQvF2= M{Dib|AvPWh? MWfEUXNQ M1;0XoJtd2OtczD0bIUhgmm{YX2tbY5lfWOnZDDhdI9xfG:|aYO= M17EWlIzOTV7OEm4
Neutrophil MYXBdI9xfG:|aYOgRZN{[Xl? NG\mPZkzOM7:TR?= MkH2NE42cA>? MoG4ZZR1\W63YYTld{B1cGVicILvMYFxd3C2b4TpZ{Bm\m[nY4Sgc4YhVWGUMR?= M2TC[|I3OTl4OES0
HCT116 M4TEfWFxd3C2b4Ppd{BCe3OjeR?= MmDUOVDDqM7:TR?= MWqybC=> NIfpfoxz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh NH\kXXczOjF3OUe1Ni=>
MDA-MB-231  MkP0RZBweHSxc3nzJGF{e2G7 NWf1WnlxOi53LUeuOe69VQ>? NYr6dW15Omh? M{jwU4lvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? M3;Zc|IzOTF3NUK2
LNCaP NH7xdXRCeG:ydH;zbZMhSXO|YYm= NH7US4Y1OM7:TR?= NUTwZlBkOmh? Mlf0bY5pcWKrdIOgZpV1\WmwIHnu[JVk\WRiY3XscEBieG:ydH;zbZM> NEK1[mYzOjFzNEe2OC=>
MB231 NH7MbYZCeG:ydH;zbZMhSXO|YYm= MnLsNVAx|ryP MYKxbC=> M3:3VGROW09? MYnhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v MnLlNlIyOTJ7NEC=
HCC38  MkW1RZBweHSxc3nzJGF{e2G7 M331TFExOM7:TR?= NVHFeWZsOWh? M2XrNWROW09? MkjOZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? NVfs[HBbOjJzMUK5OFA>
MDA-MB231 NUfnTFNCSXCxcITvd4l{KEG|c3H5 M3\UXlUxyqEQvF2= NWP2eIRQOjSq MojJSG1UVw>? MVrhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NFTST4gzOjFyMUOzOS=>
LNCaP M4jSUmFxd3C2b4Ppd{BCe3OjeR?= MUK1NOKh|ryP NF:yZ3MzPGh? NVfvNoFXTE2VTx?= NUTaZWNy[WK{b3fheIV{KGO3cnP1cYlvNWmwZIXj[YQh[2WubDDk[YF1cA>? NG\RSHgzOjFyMUOzOS=>
HCT116 MlLhRZBweHSxc3nzJGF{e2G7 MXi1NOKh|ryP MV:yOIg> Mn3FSG1UVw>? M4PXOoFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> NVTOU4Y4OjJzMEGzN|U>
Ishikawa  NFy0N41CeG:ydH;zbZMhSXO|YYm= NHWzblEzPc7:TR?= MlvxNlRp NYnuUnRjemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[WZiQUG= NYXzNmJKOjJyOEi5NVg>
 YD-8  M2foWmFxd3C2b4Ppd{BCe3OjeR?= NH25TXoyODEQvF2= M3TwN|Fp M1jaRolvcGmkaYTzJHBNTU9vaX7keYNm\CCjcH;weI9{cXN? MoDYNlIxQDZzOEO=
eosinophil  M1;xXmFxd3C2b4Ppd{BCe3OjeR?= Mnn3PVDPxE1? M{[yZVI1cA>? MmDjbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhTmG|IHHueIljd2S7wrC= M{X5UFIzODd7M{O0
L929 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nXS|IvPc7:TR?= NUnKTI91OjSq NGXE[3VqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBxNXB|ODDhcoQhVkZvzsrCJJRwKGG3Z33lcpQhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 M4TpW|IzODJ5MEm3
YD-8  MWLBdI9xfG:|aYOgRZN{[Xl? NELkTJcyODEQvF2= NGPiRmwycA>? Mo\HZoxw[2u|IITo[UBIWy2KQ3ytbY5lfWOnZDDhdI9xfG:|aYO= MUeyNlAzODB5OB?=
HBx NWSzVGhiSXCxcITvd4l{KEG|c3H5 NFvRVGUzPc7:TR?= MnXDOFhp Ml7QSG1UVw>? NH7KbnNz\WS3Y3XkJINmdGxiZHXheIghcW6mdXPl[EBjgSB|LV3B MnzpNlIxOjByN{i=
U937  NFriT5lCeG:ydH;zbZMhSXO|YYm= NIHtVYI2OMLizszN NGLROHgycA>? MX\pcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh MYGyNVk6QDd|MR?=
HL60 NHTBeFJCeG:ydH;zbZMhSXO|YYm= Mn7qOFDPxE1? NX31XpVjPDCvaX6= MVHEUXNQ NFrMcYpjdG:la4OgRm5FSyClb33wc5Vv\HNiaX7keYNmKGW6cH;zeZJmKG:oIIDoc5NxcGG2aXT5cJNmemmwZTDhcoQhTE6DIH\yZYdu\W62YYTpc44> NGfSRXEzOTl6M{K5Oi=>
M-14 MknSRZBweHSxc3nzJGF{e2G7 M{G3OlI2|ryP MnHtNE42cA>? MoG2xsBqdmirYnn0d{Bjd3SqIITo[UBkenWmZTDlfJRz[WO2LTDhcoQh[2:vcH;1coQucW6mdXPl[EBieG:ydH;zbZM> NEG5dVczOTl3NEm1PS=>
SK-BR-3 MVfBdI9xfG:|aYOgRZN{[Xl? NUW0WoRvPTEEoN88US=> NUmxOFZyOmh? MlvSZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u Mn7MNlE6ODF|OE[=
MDA-MB-468 Mlf6RZBweHSxc3nzJGF{e2G7 MVy1NOKh|ryP M3rhNVJp M4XxVYJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> MWmyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

+ Expand
  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: CD1 mice
  • Formulation: dissolved in DMSO, diluted in PBS (final concentration of DMSO < 1%)
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

DMF 84mg/ml

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
Synonyms N/A

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • Answer:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • Question 2:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID