Fenofibric acid

PPAR inhibitor

Synonyms: NSC 281318, Trilipix, FNF acid

Home Metabolism PPAR inhibitor Fenofibric acid

For research use only.

Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

Fenofibric acid Chemical Structure

Fenofibric acid Chemical Structure

Molecular Weight: 318.75

CAS No. 42017-89-0

Purity & Quality Control

Fenofibric acid Related Products

Signaling Pathway

PPAR Signaling Pathways

PPAR Signaling Pathway

Mechanism of Action

Description Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.
Targets
PPARα [1]

In vitro
In vitro Fibric acids, active forms of fibrate drugs and activators of peroxisome proliferator-activated receptor-alpha (PPARα), are also known for an HDL-raising effect. Fibric acids enhance fatty acid catabolism and accordingly reduce plasma lipid level, predominantly triglyceride (TG). Fenofibric acid increases the expression of ABCA1 and apoA-I–mediated HDL production. The effect on ABCA1 expression was through the enhancement of the transcription of the ABCA1 gene being dependent on LXR[1].
Cell Research Cell lines RAW264 cells; THP-1 cells
Concentrations 0-200 μmol/L
Incubation Time 48 h
Method

PPAR activators fenofibric acid is dissolved in DMSO and added to the culture medium containing 0.2% BSA. RAW264 cells are washed with PBS and cultured an additional 48 hours in the presence of fenofibric acid in DMEM/F-12(1:1) medium containing 2% TCM and 0.2% BSA. During the last 24 hours of the drug treatment, 300 mol/L of dibutyryl cAMP and apoA-I (10 μg/mL) are added to the medium. THP-1 cells are also treated with the compound and apoA-I in 0.2% BSA-RPMI 1640 medium and 0.1% BSA-MEM. Cholesterol and choline-phospholipid released into the medium by apoA-I are determined enzymatically. Adherent cells are dissolved in 0.1 N NaOH for protein determination by bicinchoninic acid protein assay system.

In Vivo
In vivo Fenofibric acid attenuates aberrant increases of circulating EPC(Endothelial Progenitor Cells) in OIR mice. Inhibitory effect of Fenofibric acid on EPC mobilization in the OIR model is PPARα-dependent.Fenofibric acid Inhibits hypoxia-induced retinal EPC increase in a PPARα-dependent manner. Fenofibric acid decreases CXCR4-positive EPC in the circulation, downregulates the serum SDF-1 level and suppresses HIF-1a and SDF-1 overexpression in the retina[1].
Animal Research Animal Models C57BL/6J; PPARa-/- mice
Dosages 10 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03382756 Completed
Dyslipidemias
Chong Kun Dang Pharmaceutical
 October 12 2017 Phase 1
NCT03515213 Completed
Huntington Disease
University of California Irvine
 April 27 2017 Phase 2
NCT02891408 Completed
Nonalcoholic Steatohepatitis (NASH)
Gilead Sciences
 September 23 2016 Phase 1
NCT02651753 Completed
Dyslipidemia
Chong Kun Dang Pharmaceutical
 January 2016 Phase 1
NCT02422030 Completed
Healthy
Chong Kun Dang Pharmaceutical
 March 17 2015 Phase 1
  • https://pubmed.ncbi.nlm.nih.gov/15790930/
  • https://pubmed.ncbi.nlm.nih.gov/24845641/

Chemical Information

Molecular Weight 318.75 Formula

C17H15ClO4
CAS No. 42017-89-0 SDF Download Fenofibric acid SDF
Smiles CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 64 mg/mL ( (200.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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