Fenofibric acid

For research use only.

Catalog No.S4527 Synonyms: NSC 281318, Trilipix, FNF acid

1 publication

Fenofibric acid Chemical Structure

CAS No. 42017-89-0

Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

Selleck's Fenofibric acid has been cited by 1 publication

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Biological Activity

Description Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.
Targets
PPARα [1]
In vitro

Fibric acids, active forms of fibrate drugs and activators of peroxisome proliferator-activated receptor-alpha (PPARα), are also known for an HDL-raising effect. Fibric acids enhance fatty acid catabolism and accordingly reduce plasma lipid level, predominantly triglyceride (TG). Fenofibric acid increases the expression of ABCA1 and apoA-I–mediated HDL production. The effect on ABCA1 expression was through the enhancement of the transcription of the ABCA1 gene being dependent on LXR[1].

In vivo Fenofibric acid attenuates aberrant increases of circulating EPC(Endothelial Progenitor Cells) in OIR mice. Inhibitory effect of Fenofibric acid on EPC mobilization in the OIR model is PPARα-dependent.Fenofibric acid Inhibits hypoxia-induced retinal EPC increase in a PPARα-dependent manner. Fenofibric acid decreases CXCR4-positive EPC in the circulation, downregulates the serum SDF-1 level and suppresses HIF-1a and SDF-1 overexpression in the retina[1].

Protocol

Cell Research:

[1]

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  • Cell lines: RAW264 cells; THP-1 cells
  • Concentrations: 0-200 μmol/L
  • Incubation Time: 48 h
  • Method:

    PPAR activators fenofibric acid is dissolved in DMSO and added to the culture medium containing 0.2% BSA. RAW264 cells are washed with PBS and cultured an additional 48 hours in the presence of fenofibric acid in DMEM/F-12(1:1) medium containing 2% TCM and 0.2% BSA. During the last 24 hours of the drug treatment, 300 mol/L of dibutyryl cAMP and apoA-I (10 μg/mL) are added to the medium. THP-1 cells are also treated with the compound and apoA-I in 0.2% BSA-RPMI 1640 medium and 0.1% BSA-MEM. Cholesterol and choline-phospholipid released into the medium by apoA-I are determined enzymatically. Adherent cells are dissolved in 0.1 N NaOH for protein determination by bicinchoninic acid protein assay system.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: C57BL/6J; PPARa-/- mice
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (197.64 mM)
Water 63 mg/mL (197.64 mM)
Ethanol '63 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 318.75
Formula

C17H15ClO4

CAS No. 42017-89-0
Storage powder
in solvent
Synonyms NSC 281318, Trilipix, FNF acid
Smiles CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03382756 Completed Dietary Supplement: High fat diet|Drug: CKD-337 Dyslipidemias Chong Kun Dang Pharmaceutical October 12 2017 Phase 1
NCT02891408 Completed Drug: Firsocostat|Drug: Fenofibrate Nonalcoholic Steatohepatitis (NASH) Gilead Sciences September 23 2016 Phase 1
NCT02651753 Completed Drug: Lipitor + Lipidil supra|Drug: CKD-337 Dyslipidemia Chong Kun Dang Pharmaceutical January 2016 Phase 1
NCT02422030 Completed Drug: Lipitor Tab. 40mg|Drug: Trilipix 135mg Healthy Chong Kun Dang Pharmaceutical March 17 2015 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID