Tegatrabetan (BC-2059)

Synonyms: Tegavivint

Tegatrabetan (BC2059,Tegavivint) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.

Tegatrabetan (BC-2059) Chemical Structure

Tegatrabetan (BC-2059) Chemical Structure

CAS: 1227637-23-1

Selleck's Tegatrabetan (BC-2059) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.86%
99.86

Tegatrabetan (BC-2059) Related Products

Choose Selective Wnt/beta-catenin Inhibitors

Biological Activity

Description Tegatrabetan (BC2059,Tegavivint) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
Targets
β-catenin [1]
In vitro
In vitro

Tegatrabetan (BC2059,Tegavivint) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.

Cell Research Cell lines HL-60, OCI-AML3 and MV4-11 cells
Concentrations 20–100 nM
Incubation Time 120 h
Method

Cells were treated with various concentrations of drug for 120 h.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05797805 Recruiting
Advanced Hepatocellular Carcinoma
Iterion Therapeutics
September 13 2023 Phase 1|Phase 2
NCT03459469 Completed
Desmoid Tumor
Iterion Therapeutics
July 15 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 588.74 Formula

C28H36N4O6S2

CAS No. 1227637-23-1 SDF --
Smiles CC1CC(CN(C1)S(=O)(=O)C2=CC3=C(C=C2)C(=C4C=CC(=CC4=C3N=O)S(=O)(=O)N5CC(CC(C5)C)C)NO)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (169.85 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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