Home Endocrinology & Hormones Endogenous Metabolite inhibitor Heparan Sulfate

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Heparan Sulfate Linear Polysaccharide

Cat.No.S5992

Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
Heparan Sulfate Endogenous Metabolite inhibitor Chemical Structure
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Quality Control

Batch: Purity: 99%
99

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight Formula

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 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 9050-30-0 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
Wnt
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-08-28)

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Sanfilippo Syndrome Type A
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Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Hansoh BioMedical R&D Company
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Cognitive Decline
University of Castilla-La Mancha
 2024-09-01 Not Applicable
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B-Cell Leukemia|Non-Hodgkin''s Lymphoma|B-cell Acute Lymphoblastic Leukemia|Diffuse Large B Cell Lymphoma|High-grade B-cell Lymphoma|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|Mantle Cell Lymphoma|B-cell Lymphoma
British Columbia Cancer Agency
 2024-07-01 Phase 1
NCT05470322 Not yet recruiting
Hidradenitis Suppurativa|Scarring
Montefiore Medical Center
 2024-06 Not Applicable

Read more about Clinical Trials

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