Heparan Sulfate

Catalog No.S5992 Synonyms: HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan

For research use only.

Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.

Heparan Sulfate Chemical Structure

CAS No. 9050-30-0

Purity & Quality Control

Choose Selective 3C-Like Protease Inhibitors

Biological Activity

Description Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
Targets
Wnt [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

Water 100 mg/mL
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight
Formula

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CAS No. 9050-30-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04939311 Not yet recruiting Drug: VB-201|Drug: Placebo Inflammation|HIV Infection|Cardiovascular Disease Priscilla Hsue MD|University of California Los Angeles|University of Utah|University of California San Francisco July 1 2022 Phase 1|Phase 2
NCT04573023 Not yet recruiting Drug: JR-141|Drug: Idursulfase|Drug: JR-141 or Idursulfase Mucopolysaccharidosis II JCR Pharmaceuticals Co. Ltd. February 28 2022 Phase 3
NCT05179148 Not yet recruiting Behavioral: Motivational Interviewing Motivational Interviewing University of Manitoba January 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

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