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L-NMMA acetate NOS inhibitor

Cat.No.S7920

L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS.
L-NMMA acetate NOS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 248.28

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Quality Control

Batch: S792001 Water]50 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

Chemical Information, Storage & Stability

Molecular Weight 248.28 Formula

C9H20N4O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 53308-83-1 -- Storage of Stock Solutions

Synonyms Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate, Smiles CNC(=N)NCCCC(N)C(O)=O.CC(O)=O

Solubility

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
nNOS [2]
(Cell-free assay)
4.1 μM
In vitro

As a nitric oxide synthase inhibitor, L-NMMA acetate has the Ki values for nNOS (rat) and iNOS (rat) are approximately 0.18 and 6 µM, respectively.[3]
In vivo

Following L-NMMA acetate administration, skeletal muscle contractile function is dose-dependently decreased with the administration of drug during ischemia/reperfusion (I/R) in vivo.[1]
References

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