Home Immunology & Inflammation NOS inhibitor L-NMMA acetate For research use only.

L-NMMA acetate

Synonyms: Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate,

L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS.

L-NMMA acetate Chemical Structure

L-NMMA acetate Chemical Structure

CAS: 53308-83-1

Selleck's L-NMMA acetate has been cited by 1 publication

Purity & Quality Control

Batch: S792001 Water] 50 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

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Biological Activity

Description L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS.
Targets
nNOS [2]
(Cell-free assay)
4.1 μM
In vitro
In vitro

As a nitric oxide synthase inhibitor, L-NMMA acetate has the Ki values for nNOS (rat) and iNOS (rat) are approximately 0.18 and 6 µM, respectively.[3]
In Vivo
In vivo

Following L-NMMA acetate administration, skeletal muscle contractile function is dose-dependently decreased with the administration of drug during ischemia/reperfusion (I/R) in vivo.[1]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 100 nM/min, 10 µM/min
Administration --

Chemical Information & Solubility

Molecular Weight 248.28 Formula

C9H20N4O4
CAS No. 53308-83-1 SDF --
Smiles CNC(=N)NCCCC(N)C(O)=O.CC(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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