Home Immunology & Inflammation NOS agonist - Guanylate Cyclase activator Isosorbide dinitrate

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Isosorbide dinitrate NOS agonist

Cat.No.S5229

Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
Isosorbide dinitrate NOS agonist Chemical Structure

Chemical Structure

Molecular Weight: 236.14

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Quality Control

Batch: S522901 DMSO]47 mg/mL]false]]]false]]]false Purity: 99.62%
99.62

Chemical Information, Storage & Stability

Molecular Weight 236.14 Formula

C6H8N2O8

 Storage (From the date of receipt)
CAS No. 87-33-2 -- Storage of Stock Solutions

Synonyms Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide Smiles C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (199.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05954689 Not yet recruiting
Tourniquets|Anesthesia Conduction|Anesthetics Local|Hypertension
Hospital da Luz Portugal
 July 10 2023 Not Applicable
NCT04297241 Completed
Fontan
Children''s Hospital Medical Center Cincinnati
 December 12 2019 Phase 2
NCT02488642 Completed
Cervical Pregnancy|Maternal Care for Late Fetal Death
National Institute of Perinatology|National Council of Science and Technology Mexico
 May 2008 Phase 4

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