L-Arginine HCl (L-Arg)

Catalog No.S3174

For research use only.

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

L-Arginine HCl (L-Arg) Chemical Structure

CAS No. 1119-34-2

Selleck's L-Arginine HCl (L-Arg) has been cited by 3 Publications

Purity & Quality Control

Choose Selective NOS Inhibitors

Biological Activity

Description L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
In vitro

L-Arginine (0.3 mM, 30 minutes) supplementation do not induce any significant increases in the peak NO concentration at low level of native LDL. However, at native LDL concentrations from 60-130 mg cholesterol/dL, NO concentration is 2 times higher than before L-Arginine treatment in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment results in a significant increase of NO production in n-LDL–treated cells as well as in oxidized -LDL–treated cells in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) does not increase O2- concentration at low nativeLDL concentrations but reduce O2- production by 50% when incubate with n-LDL at concentrations >40 mg cholesterol/dL in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment completely abolishes O2- production at every oxidized LDL dosage in bovine aortic endothelial cells. [1]

In vivo L-Arginine (4 mg/kg/min for 1 hour) treatment decreases superoxide generation by cNOS while increasing NO accumulation in rabbit limb during ischemia/reperfusion. L-Arginine (4 mg/kg/min for 1 hour) prevents microvessel constriction in the reperfused muscle despite reduced but still apparent interstitial edema in rabbit limb. L-Arginine (4 mg/kg/min for 1 hour) treatment results in a significant reduction of muscular reperfusion edema in rabbit limb. [2] L-Arginine (0.1 g/kg, oral) supplementation significantly reduces pulmonary artery systolic pressure by a mean of 15.2% after 5 days of therapy in patients with sickle cell disease. Both L-Arginine and ornithine concentrations increased significantly after 5 days of oral L-Arginine (0.1 g/kg) supplementation in patients with sickle cell disease. [3] L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. [4] L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 42 mg/mL
(199.37 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 210.66
Formula

C6H14N4O2.HCl

CAS No. 1119-34-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(C(=O)O)N)CN=C(N)N.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04456491 Recruiting -- Asthma|COPD Ryazan State Medical University September 1 2021 --
NCT04535427 Not yet recruiting Drug: L-arginine|Drug: Placebo Rheumatoid Arthritis RenJi Hospital January 1 2021 Phase 2
NCT04328311 Active not recruiting Other: Watermelon Juice|Other: Water Healthy Aging University of Reading January 8 2020 Not Applicable
NCT04156711 Completed Procedure: Remote Ischemic Preconditioning (RIPC) Acute Cholecystitis|Endothelial Dysfunction Zealand University Hospital September 4 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy L-Arginine HCl (L-Arg) | L-Arginine HCl (L-Arg) ic50 | L-Arginine HCl (L-Arg) price | L-Arginine HCl (L-Arg) cost | L-Arginine HCl (L-Arg) solubility dmso | L-Arginine HCl (L-Arg) purchase | L-Arginine HCl (L-Arg) manufacturer | L-Arginine HCl (L-Arg) research buy | L-Arginine HCl (L-Arg) order | L-Arginine HCl (L-Arg) mouse | L-Arginine HCl (L-Arg) chemical structure | L-Arginine HCl (L-Arg) mw | L-Arginine HCl (L-Arg) molecular weight | L-Arginine HCl (L-Arg) datasheet | L-Arginine HCl (L-Arg) supplier | L-Arginine HCl (L-Arg) in vitro | L-Arginine HCl (L-Arg) cell line | L-Arginine HCl (L-Arg) concentration | L-Arginine HCl (L-Arg) nmr