research use only

Treprostinil sodium Prostaglandin Receptor agonist

Name: Treprostinil sodium
Brand: Selleck Chemicals
SKU: S0325
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0325

Treprostinil sodium is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

Chemical Structure

Molecular Weight: 412.49

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S032501 DMSO]82 mg/mL]false]Water]82 mg/mL]false]Ethanol]82 mg/mL]false Purity: 99.52%

99.52

Related Targets	Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras GPR GluR CXCR Adenosine Receptor P2 Receptor CCR Angiotensin Receptor Hedgehog/Smoothened S1P Receptor PKA Cannabinoid Receptor cAMP Glucagon Receptor SGLT Opioid Receptor Sigma Receptor PAR Endothelin Receptor LTR Neurokinin Receptor Guanylate Cyclase PKG LPA Receptor OX Receptor
Related Products	PF-04418948 TG4-155 E7046 (ER-886406) Grapiprant (CJ-023,423)

Chemical Information, Storage & Stability

Molecular Weight	412.49	Formula	C₂₃H₃₃NaO₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	289480-64-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	UT-15, Remodulin			Smiles	CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+]

Solubility

In vitro
Batch:

DMSO : 82 mg/mL ( (198.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 82 mg/mL

Ethanol : 82 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.1mg/ml (9.94mM)	Taking the 1 mL working solution as an example, add 50 μL of 82 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.58mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 11.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	EP2 ^[1] (Cell-free assay) 3.6 nM(Ki) DP1 ^[1] (Cell-free assay) 4.4 nM(Ki) IP ^[1] (Cell-free assay) 32 nM(Ki)
References	https://pubmed.ncbi.nlm.nih.gov/22480736/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05060315	Active not recruiting	Pulmonary Arterial Hypertension	United Therapeutics	July 5 2023	--
NCT05649722	Recruiting	Pulmonary Hypertension\|Interstitial Lung Disease	Insmed Incorporated	May 11 2023	Phase 2\|Phase 3
NCT04882774	Withdrawn	Pulmonary Hypertension Due to Left Heart Disease	Mardi Gomberg -Maitland MD MSc\|Ohio State University\|Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)\|George Washington University	April 2023	Phase 2
NCT05649748	Recruiting	Pulmonary Arterial Hypertension	Insmed Incorporated	March 7 2023	Phase 2\|Phase 3
NCT05176951	Completed	Pulmonary Hypertension	Insmed Incorporated	December 22 2022	Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):