Home GPCR & G Protein Prostaglandin Receptor agonist Treprostinil sodium For research use only.

Treprostinil sodium

Synonyms: UT-15, Remodulin

Treprostinil sodium is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

Treprostinil sodium Chemical Structure

Treprostinil sodium Chemical Structure

CAS: 289480-64-4

Purity & Quality Control

Batch: S032501 DMSO] 82 mg/mL] false] Water] 82 mg/mL] false] Ethanol] 82 mg/mL] false Purity: 99.52%
99.52

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Biological Activity

Description Treprostinil sodium is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.
Targets
EP2 [1]
(Cell-free assay)		 DP1 [1]
(Cell-free assay)		 IP [1]
(Cell-free assay)
3.6 nM(Ki) 4.4 nM(Ki) 32 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05060315 Active not recruiting
Pulmonary Arterial Hypertension
United Therapeutics
 July 5 2023 --
NCT05649722 Recruiting
Pulmonary Hypertension|Interstitial Lung Disease
Insmed Incorporated
 May 11 2023 Phase 2|Phase 3
NCT04882774 Withdrawn
Pulmonary Hypertension Due to Left Heart Disease
Mardi Gomberg -Maitland MD MSc|Ohio State University|Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)|George Washington University
 April 2023 Phase 2
NCT05649748 Recruiting
Pulmonary Arterial Hypertension
Insmed Incorporated
 March 7 2023 Phase 2|Phase 3
NCT05176951 Active not recruiting
Pulmonary Hypertension
Insmed Incorporated
 December 22 2022 Phase 2

Chemical Information & Solubility

Molecular Weight 412.49 Formula

C23H33NaO5
CAS No. 289480-64-4 SDF --
Smiles CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+]
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 82 mg/mL ( (198.79 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 82 mg/mL

Ethanol : 82 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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