Treprostinil sodium

For research use only.

Catalog No.S0325 Synonyms: UT-15, Remodulin, Orenitram, Tyvaso, Trevyent

Treprostinil sodium Chemical Structure

CAS No. 289480-64-4

Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

Purity & Quality Control

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Biological Activity

Description Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.
Targets
EP2 [1]
(Cell-free assay)
DP1 [1]
(Cell-free assay)
IP [1]
(Cell-free assay)
3.6 nM(Ki) 4.4 nM(Ki) 32 nM(Ki)

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (198.79 mM)
Water 82 mg/mL (198.79 mM)
Ethanol 82 mg/mL (198.79 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 412.49
Formula

C23H33NaO5

CAS No. 289480-64-4
Storage powder
in solvent
Synonyms UT-15, Remodulin, Orenitram, Tyvaso, Trevyent
Smiles CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+]

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04882774 Not yet recruiting Drug: Treprostinil Diolamine Pulmonary Hypertension Due to Left Heart Disease Mardi Gomberg -Maitland|Ohio State University|Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)|George Washington University April 2022 Phase 2
NCT04691154 Not yet recruiting Combination Product: L606 inhalation suspension Pulmonary Arterial Hypertension Pharmosa Biopharm Inc.|PPD August 1 2021 Phase 3
NCT04791514 Recruiting Drug: Treprostinil Palmitil Pulmonary Arterial Hypertension Insmed Incorporated May 31 2021 Phase 2
NCT03950739 Active not recruiting Drug: Treprostinil Inhalation Powder Pulmonary Arterial Hypertension United Therapeutics September 17 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID