Prostaglandin E2 (PGE2)

Catalog No.S3003 Synonyms: Dinoprostone

For research use only.

Prostaglandin E2 (PGE2, Dinoprostone) palys important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.

Prostaglandin E2 (PGE2) Chemical Structure

CAS No. 363-24-6

Selleck's Prostaglandin E2 (PGE2) has been cited by 10 Publications

Purity & Quality Control

Choose Selective PGES Inhibitors

Biological Activity

Description Prostaglandin E2 (PGE2, Dinoprostone) palys important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NH3mNnpHfW6ldHnvckBie3OjeR?= NIXUe3dVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJHBIXC2neIDy[ZN{cW6pIFjlUIEh[2WubIOsJGtuKD1iMD6wPVQh|ryPLh?= M1nsb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd5NUSzOlkoRjd5NUSzOlk9N2F-
HeLa NXTheWNyTnWwY4Tpc44h[XO|YYm= MYXUVH9VWkGQU2DPVnRGWjpidYD0ZYtmKGmwIGDHWE1mgHC{ZYPzbY5oKEinTHGgZ4VtdHNuIFuxM|IhRSByLkGg{txONg>? NIr5XlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96N{i3Olc4Lz56N{i3Olc4RC:jPh?=
S2 NXHLRo53TnWwY4Tpc44h[XO|YYm= NHf5[YJVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJG9EXDJvZYjwdoV{e2mwZzDTNkBk\WyuczygT40hRSByLkCyPFkh|ryPLh?= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTlyN{G4Okc,OTF7MEexPFY9N2F-
S2 Ml31SpVv[3Srb36gZZN{[Xl? NIfqWWFVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJG9CXDRvZYjwdoV{e2mwZzDTNkBk\WyuczygT40hRSByLkG1OEDPxE1w NYHSblBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG5NFcyQDZpPkGxPVA4OTh4PD;hQi=>
S2 MV;GeY5kfGmxbjDhd5NigQ>? NGXXW4FVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJG9CXDNvZYjwdoV{e2mwZzDTNkBk\WyuczygT40hRSByLkO0OUDPxE1w Mo[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF7MEexPFYoRjFzOUC3NVg3RC:jPh?=
S2 NYfwV3FKTnWwY4Tpc44h[XO|YYm= NInoXZJVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJG9EXDFvZYjwdoV{e2mwZzDTNkBk\WyuczygT40hRSByLk[1O{DPxE1w NUDxW4xZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG5NFcyQDZpPkGxPVA4OTh4PD;hQi=>
S2 MlS2SpVv[3Srb36gZZN{[Xl? MnfVWHBgXFKDTmPQU3JVTVJ8IIXweIFs\SCrbjDPRXQzNWW6cILld5NqdmdiU{KgZ4VtdHNuIFvtJF0hOC55MUOg{txONg>? Ml;QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF7MEexPFYoRjFzOUC3NVg3RC:jPh?=
S2 NFrSVlVHfW6ldHnvckBie3OjeR?= NIr5RZRVWF:WUlHOV3BQWlSHUkqgeZB1[WunIHnuJG9CXDFvZYjwdoV{e2mwZzDTNkBk\WyuczygT40hRSByLkm3JO69VS5? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTlyN{G4Okc,OTF7MEexPFY9N2F-
HEK293 MYrGeY5kfGmxbjDhd5NigQ>? NX\SUYszUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGVRPCC{ZXPldJRweiCneIDy[ZN{\WRiaX6gTGVMOjl|IHXicoEh[2WubIOsJGlEPTBiPTCwMlAxODdizszNMi=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ2M{myO{c,OTJ4NEO5Nlc9N2F-
HEK293 MoKzSpVv[3Srb36gZZN{[Xl? MkLnSXA1KGGpb37pd5QheG:2ZX7jfUB2fGmuaYrpcoch[SC|dHHicIUh[2yxbnWgc4YheFOYNECtSXA1KHS{YX7z[oVkfGWmIHnueI8hUEWNMkmzJINmdGy|IHX4dJJme3OrbnegSXA1KHKnY3XweI9zNCCHQ{WwJF0hOC5yMEOg{txONg>? MoDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEO5NlcoRjF{NkSzPVI4RC:jPh?=
Sf9 Ml;QSpVv[3Srb36gZZN{[Xl? NFn5OXJVWF:WUlHOV3BQWlSHUkqgeZB1[WunIDj2[ZNq[2ynKTDpckBu\W2kcnHu[UB3\XOrY3zld{Bnem:vIF3SVFQu\XiycnXzd4lv\yCVZkmgZ4VtdHNuIFvtJF0hOy52IN88UU4> M1PhfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEO1OFEzLz5zMkizOVQyOjxxYU6=
HEK293 M1;icmZ2dmO2aX;uJIF{e2G7 NX7wTI9LTGm|cHzhZ4Vu\W62IH;mJHs{UF2SR1WyJIZzd21iaIXtZY4hTVB|IILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpJF0hOC5yMECzN{DPxE1w NF:3TZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WzNVQ5QCd-MUe1N|E1QDh:L3G+
HEK293 NV3tXW1yTnWwY4Tpc44h[XO|YYm= MlXqSIl{eGyjY3Xt[Y51KG:oIGuzTH1RT0V{IH\yc40hcHWvYX6gSXA1KHKnY3XweI9zKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMtKEurIE2gNE4xODB5OTFOwG0v M4e5SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUOxOFg5Lz5zN{WzNVQ5QDxxYU6=
HEK293 NIflN3VHfW6ldHnvckBie3OjeR?= MX;EbZNxdGGlZX3lcpQhd2ZiW{PIYXBITTJiZoLvcUBpfW2jbjDFVFIhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{whU2liPTCwMlAxPDlizszNMi=> NF\GOVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WzNVQ5QCd-MUe1N|E1QDh:L3G+
HEK293 MlLJSpVv[3Srb36gZZN{[Xl? NWnnRZFjTGm|cHzhZ4Vu\W62IH;mJHs{UF2SR1WyJIZzd21iaIXtZY4hTVBzIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpJF0hOC5yMEmxJO69VS5? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV|MUS4PEc,OTd3M{G0PFg9N2F-
HEK293 MmmzSpVv[3Srb36gZZN{[Xl? NIfBWGxC\2:waYP0JIFkfGm4aYT5JIFo[Wmwc4SgdoF1KEWSMjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHPBUXAhemWuZXHz[UwhTUN3MDC9JFAvODByMjFOwG0v NXO4PYZ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOVA5OjNpPkG5NlUxQDJ|PD;hQi=>
HEK293 NU\FRllyTnWwY4Tpc44h[XO|YYm= MmXtRYdwdmm|dDDhZ5Rqfmm2eTDh[4FqdnO2IILheEBGWDRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDzeIlufWyjdHnvckBw\iClQV3QJJJmdGWjc3WsJGVEPTBiPTCwMlAxODdizszNMi=> MorMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{NUC4NlMoRjF7MkWwPFI{RC:jPh?=
HEK293 NFy2e2hHfW6ldHnvckBie3OjeR?= NEnRWHdKdmirYnn0bY9vKG:oIILheEBGWDRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyxiSVO1NEA:KDBwMECyNUDPxE1w MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ3MEiyN{c,OTl{NUC4NlM9N2F-
HEK293 Mn3qSpVv[3Srb36gZZN{[Xl? NWjqZWp5UW6qaXLpeIlwdiCxZjDyZZQhTVB{IILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFnDOVAhRSByLkCwOVIh|ryPLh?= MoDvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{NUC4NlMoRjF7MkWwPFI{RC:jPh?=
CHO MnrBSpVv[3Srb36gZZN{[Xl? Ml7sOlAhdWmwcx?= M4\OemRqe3CuYXPlcYVvfCCxZjDbN2heNVCJRUKg[pJwdSCvb4Xz[UBGWDRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{Bi\nSncjC2NEBucW6|IHL5JIxqeXWrZDDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNaTC9JFAvODB|MTFOwG0v NHTI[HM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVQ4OSd-MkKxNVk1PzF:L3G+
CHO NIjEcJdHfW6ldHnvckBie3OjeR?= NVzmSmlVPjBibXnudy=> M2\MOGRqe3CuYXPlcYVvfCCxZjDbN2heNVCJRUKg[pJwdSCvb4Xz[UBGWDNicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{Bi\nSncjC2NEBucW6|IHL5JIxqeXWrZDDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNaTC9JFAvODB3IN88UU4> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzOUS3NUc,OjJzMUm0O|E9N2F-
CHO M1\WcGZ2dmO2aX;uJIF{e2G7 Mnf3NlAhdWmwcx?= MXfEbZNxdGGlZX3lcpQhd2ZiW{PIYU1RT0V{IH\yc40hdW:3c3WgSXAyKHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZYZ1\XJiMkCgcYlveyCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{whU2liPTCwMlAxPiEQvF2u NGC0R2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxPVQ4OSd-MkKxNVk1PzF:L3G+
CHO MYrGeY5kfGmxbjDhd5NigQ>? NW\4V3A{PjBibXnudy=> M1e0UmRqe3CuYXPlcYVvfCCxZjDbN2heNVCJRUKg[pJwdSCvb4Xz[UBGWDJicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{Bi\nSncjC2NEBucW6|IHL5JIxqeXWrZDDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNaTC9JFAvODJ{IN88UU4> NYXVNnhJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVk1PzFpPkKyNVE6PDdzPD;hQi=>
CHO MnXhSpVv[3Srb36gZZN{[Xl? M4HP[VYxKG2rboO= MojVSIl{eGyjY3Xt[Y51KG:oIGuzTH0uWEeHMjDmdo9uKG2xdYPlJGVRPCC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIFnfGW{IE[wJI1qdnNiYomgd4NqdnSrbHzheIlwdiClb4XueIlv\yxiS3mgQUAxNjByM{Gg{txONg>? MofyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|OE[5O|koRjJ{M{i2PVc6RC:jPh?=
CHO NGDFRYhHfW6ldHnvckBie3OjeR?= MnT6OlAhdWmwcx?= MWnEbZNxdGGlZX3lcpQhd2ZiW{PIYU1RT0V{IH\yc40hdW:3c3WgSXA{KHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZYZ1\XJiNkCgcYlveyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCNaTC9JFAvODB3IN88UU4> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN6Nkm3PUc,OjJ|OE[5O|k9N2F-
CHO NYixelJXTnWwY4Tpc44h[XO|YYm= MoriOlAhdWmwcx?= NIPCXIVFcXOybHHj[Y1mdnRib3[gX|NJZS2SR1WyJIZzd21ibX;1d4UhTVBzIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[W[2ZYKgOlAhdWmwczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pLDDLbUA:KDBwMEC2JO69VS5? NHTVSo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO4Olk4QSd-MkKzPFY6Pzl:L3G+
CHO MkfsSpVv[3Srb36gZZN{[Xl? NITJfmM3OCCvaX7z NGD1NmVFcXOybHHj[Y1mdnRib3[gX|NJZS2SR1WyJIZzd21ibX;1d4UhTVB{IILlZ4VxfG:{IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[W[2ZYKgOlAhdWmwczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pLDDLbUA:KDBwMEKyJO69VS5? NV;DZ3JpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzPFY6PzlpPkKyN|g3QTd7PD;hQi=>
CHEM1 Mk[xSpVv[3Srb36gZZN{[Xl? M4KxbFIhcHK| M3n1eWRqe3CuYXPlcYVvfCCxZjDbN2heWEeHMjDmdo9uKGi3bXHuJJJm[2:vYnnuZY51KHC{b4P0ZY5wcWRiRWC0JJJm[2WydH;yJIlvKEOKRV2xJINmdGy|IHHmeIVzKDJiaILzMEBMcSB;IECuNFAxPDVizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyM{C4Nkc,OjN2MEOwPFI9N2F-
CHEM1 NFjBSGdHfW6ldHnvckBie3OjeR?= MVeyJIhzew>? MXvEbZNxdGGlZX3lcpQhd2ZiW{PIYXBITTJiZoLvcUBpfW2jbjDy[YNwdWKrbnHueEBxem:|dHHuc4llKEWSNDDy[YNmeHSxcjDpckBEUEWPMTDj[YxteyCjZoTldkAzKGi{czygTWM2OCB;IECuNFAyOSEQvF2u NEnmemw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SwN|A5Oid-MkO0NFMxQDJ:L3G+
CHO MX\GeY5kfGmxbjDhd5NigQ>? NFX6R4gyODBibl2= M3S0e2FkfGm4aYT5JIF1KHKnY3;tZolv[W62IFXQNUBz\WOncITvdkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiY3:t[ZhxemW|c3nu[{BIeSCycn;0[YlvKGG2IEGwNEBvVSCkeTDlcIVkfHKrY3HsJINmdGxic4Xid5Rz[XSnIHntdIVl[W6lZTDz[Y5{cW6pIIP5d5RmdQ>? M4DEdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{CxNlU1Lz5{NUewNVI2PDxxYU6=
CHO MUPGeY5kfGmxbjDhd5NigQ>? M4PF[VExOCCwTR?= Ml;CRYN1cX[rdImgZZQhemWlb33ibY5idnRiRWC0JJJm[2WydH;yJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyClbz3lfJBz\XO|aX7nJGd{KHC{b4TlbY4h[XRiMUCwJI5OKGK7IHXs[YN1emmlYXygZ4VtdCC|dXLzeJJifGViaX3w[YRidmOnIIPlcpNqdmdic4nzeIVu MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdyMUK1OEc,OjV5MEGyOVQ9N2F-
CHO NUT6cGpjTnWwY4Tpc44h[XO|YYm= NEj0VVIyODBibl2= NEXTbW1C[3Srdnn0fUBifCC{ZXPvcYJqdmGwdDDFVFMhemWlZYD0c5IhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQ1jPJINmdGy|IHPvMYV5eHKnc4PpcochT2licILveIVqdiCjdDCxNFAhdk1iYomg[Yxm[3S{aXPhcEBk\WyuIIP1ZpN1emG2ZTDpcZBm\GGwY3Wgd4Vve2mwZzDzfZN1\W1? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTdyMUK1OEc,OjV5MEGyOVQ9N2F-
CHO Ml7ESpVv[3Srb36gZZN{[Xl? M1;XR|MxKG2rboO= NXHwZnBKSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBGWDJicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKGODTWCgcIV3\WxiYX\0[ZIhOzBibXnud{BjgSCKVGLGJI1mfGixZDygSWM2OCB;IECuNFAyQSEQvF2u NIPNfWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzOCd-Mk[5PFU{OjB:L3G+
CHO MkTwSpVv[3Srb36gZZN{[Xl? NFvKeI1C\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGVROyC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHnueJJi[2WubIXsZZIh[2GuY3n1cUBt\X[nbDDifUBndHWxcnXzZ4Vv[2ViYnHz[YQh[W6jbInzbZMtKEWFNUCgQUAxNjByMkWg{txONg>? NFnCUmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzOCd-Mk[5PFU{OjB:L3G+
CHO M1zMSGZ2dmO2aX;uJIF{e2G7 MlPsRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDFVFEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJINidGOrdX2gcIV3\WxiYomg[ox2d3Knc3PlcoNmKGKjc3XkJIFv[Wy7c3nzMEBGSzVyIE2gNE4xODN5IN88UU4> MmHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OEWzNlAoRjJ4OUi1N|IxRC:jPh?=
CHO MX\GeY5kfGmxbjDhd5NigQ>? MmTHN|AhdWmwcx?= M{XTUGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gSXA1KHKnY3XweI9zKGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBkSU2SIHzleoVtKGGodHXyJFMxKG2rboOgZpkhUFSURjDt[ZRpd2RuIFXDOVAhRSByLkCwO|Uh|ryPLh?= NYm4[IprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5PFU{OjBpPkK2PVg2OzJyPD;hQi=>
Chem1 MlX2SpVv[3Srb36gZZN{[Xl? MX\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\QJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCqdX3hckBEcGWvMTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHPhcINqfW1ibHX2[Ywh[nliZnz1c5Jme2OnbnPlJIJie2WmIHHuZYx6e2m|LDDFR|UxKD1iMD6yOUDPxE1w NET4R249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzOCd-Mk[5PFU{OjB:L3G+
HEK293 M1nIdWZ2dmO2aX;uJIF{e2G7 M3rSOlkxKG2rboO= NYLKXIJWSWexbnnzeEBi[3Srdnn0fUBifCCSS{KteIFo\2WmIHj1cYFvKEWSMjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCHQT30ZYdo\WRiYnX0ZU1ienKnc4TpckBz\WO{dXn0cYVvfCCrbnP1ZoF1\WRiZn;yJFkxKG2rboOgZpkh[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkO0OkDPxE1w NH;K[JE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nkm4OVMzOCd-Mk[5PFU{OjB:L3G+
CHO M33NPGZ2dmO2aX;uJIF{e2G7 MkT4N|AhdWmwcx?= MXvB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFnQJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXsJIFnfGW{IEOwJI1qdnNiYomgTHRTTiCvZYToc4QtKEWFNUCgQUAxNjN2NzFOwG0v M1zxR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUi1N|IxLz5{Nkm4OVMzODxxYU6=
HEK293 NFLoc3FHfW6ldHnvckBie3OjeR?= MUTEbZNxdGGlZX3lcpQhd2ZiW{PIYXBITTJiZoLvcUBpfW2jbjDy[YNwdWKrbnHueEBxem:|dHHuc4llKEWSMjDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|LDDJR|UxKD1iMD6wNFI3KM7:TT6= MnK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ7OEi4NFEoRjJ4OUi4PFAyRC:jPh?=
HEK293 NHj3NFNHfW6ldHnvckBie3OjeR?= MmS1NVIxKG2rboO= M1TZR2Rqe3CuYXPlcYVvfCCxZjDbN2heWEeHMjDmdo9uKGi3bXHuJJJm[2:vYnnuZY51KEWSNDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IH3lZZN2emWmIHHmeIVzKDF{MDDtbY5{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcochdWW2aH;kMEBKSzVyIE2gNE4xODB3NTFOwG0v MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh5NkK1NEc,Ojd6N{[yOVA9N2F-
HEK293 MkHDSpVv[3Srb36gZZN{[Xl? MnvINVIxKG2rboO= MnnKSIl{eGyjY3Xt[Y51KG:oIGuzTH1RT0V{IH\yc40hcHWvYX6gdoVkd22kaX7hcpQhTVB{IILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhOTJyIH3pcpMh[nlic3PpcpRqdGyjdHnvckBkd3WwdHnu[{Bu\XSqb3SsJGlEPTBiPTCwMlAxOjZizszNMi=> MnW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6N{[yOVAoRjJ5OEe2NlUxRC:jPh?=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 70 mg/mL
(198.59 mM)
Water 40 mg/mL
(113.48 mM)
Ethanol ''70 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 352.47
Formula

C20H32O5

CAS No. 363-24-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04456569 Not yet recruiting Device: Geniculate Artery Embolization Osteo Arthritis Knee|Arthritis|Osteoarthritis|Osteoarthritis Knee University of Minnesota November 1 2021 Not Applicable
NCT04626609 Recruiting Other: Biopsy samples|Other: Blood samples Eosinophilic Esophagitis (EoE) Medical University of Graz July 1 2021 --
NCT04786548 Recruiting Drug: Celecoxib Obsessive-Compulsive Disorder New York State Psychiatric Institute April 1 2021 Phase 2
NCT04694300 Recruiting Drug: Naproxen|Drug: Acetaminophen|Drug: Tramadol Osseointegrated Dental Implantation|Pain Acute Hersh Elliot V. DMD MS PhD|University of Pennsylvania February 7 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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