PGE2 Selective Agonists | Antagonists | Modulators

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S6793	TG4-155	TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with K_i value of 9.9 nM.	Selective	PTGER2, Ki: 9.9 nM
S0111	Taprenepag	Taprenepag(CP-544326) is a potent and selective prostaglandin EP2 agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively.	Selective	human EP2, IC50: 10 nM; rat EP2, IC50: 15 nM
S7211	PF-04418948	PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.	Selective	EP₂ receptor, IC50: 16 nM
S0325	Treprostinil sodium	Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.	Pan	EP2, Ki: 3.6 nM
S6694	Grapiprant (CJ-023,423)	Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively.	Pan	rat EP4 receptor, Ki: 20 nM; human EP4 receptor, Ki: 13 nM
S0541	Dazoxiben hydrochloride	Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production.	Pan