Home GPCR & G Protein -Immunology & Inflammation Prostaglandin Receptor PGE2 Selective Agonists | Antagonists | Modulators

PGE2 Selective Agonists | Antagonists | Modulators

  • PGD1
  • PGD2
  • PGE2
  • PGE4
  • PGF2α
  • PGI2
  • TXA2
  • TXB2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6793 TG4-155 TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with Ki value of 9.9 nM. Selective PTGER2, Ki: 9.9 nM
S0111 Taprenepag Taprenepag(CP-544326) is a potent and selective prostaglandin EP2 agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Selective human EP2, IC50: 10 nM; rat EP2, IC50: 15 nM
S7211 PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. Selective EP₂ receptor, IC50: 16 nM
S0325 Treprostinil sodium Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively. Pan EP2, Ki: 3.6 nM
S6694 Grapiprant (CJ-023,423) Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively. Pan rat EP4 receptor, Ki: 20 nM; human EP4 receptor, Ki: 13 nM
S0541 Dazoxiben hydrochloride Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production. Pan