Home GPCR & G Protein Prostaglandin Receptor agonist Tafluprost

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Tafluprost Prostaglandin Receptor agonist

Cat.No.S4851

Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.
Tafluprost Prostaglandin Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 452.53

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Quality Control

Batch: S485101 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.02%
99.02

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (220.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 452.53 Formula

C25H34F2O5

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 209860-87-7 --
Synonyms AFP-168,MK2452 SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
PGF2α
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2023-07-14)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03822559 COMPLETED
Open-angle Glaucoma, Ocular Hypertension
Santen Pharmaceutical Co., Ltd.
 2019-01-20 PHASE3
NCT05299593 UNKNOWN
Glaucoma, Open-Angle; Ocular Hypertension
Fondazione G.B. Bietti, IRCCS
 2020-06-04 PHASE4
NCT04828057 Completed
Ocular Surface Disease|Primary Open Angle Glaucoma
Santen Pharmaceutical (Taiwan) Co. LTD
 2021-09-01 --
NCT04654611 COMPLETED
Glaucoma; Primary Open Angle Glaucoma; Ocular Hypertension
Tun Hussein Onn National Eye Hospital
 2019-02-01 PHASE4
NCT03595865 UNKNOWN
Glaucoma; Drugs
wangdabo
 2018-08-01
NCT04737928 COMPLETED
Glaucoma, Primary Open Angle
Santen Pharmaceutical (Taiwan) Co., LTD
 2018-04-02

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