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RO1138452

Name: RO1138452
Brand: Selleck Chemicals
SKU: S0305
Rating: 5 (1 reviews)

Synonyms: CAY10441

Catalog No.S0305 Purity: 99.66%

RO1138452 (CAY10441) is a potent and selective antagonist of IP (prostacyclin, PGI2) receptor with pKi of 9.3 and 8.7 in human platelets and a recombinant IP receptor system, respectively.

RO1138452 Chemical Structure

CAS: 221529-58-4

Purity & Quality Control

Batch: S030501 DMSO] 62 mg/mL] false] Ethanol] 62 mg/mL] false] Water] Insoluble] false Purity: 99.66%

99.66

RO1138452 Related Products

Related Targets	PGD1 PGD2 PGE2 PGE4 PGF2α PGI2 TXA2 TXB2	Click to Expand
Related Compound Libraries	Kinase Inhibitor Library FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ	Click to Expand

Choose Selective Prostaglandin Receptor Inhibitors

Biological Activity

Description

RO1138452 (CAY10441) is a potent and selective antagonist of IP (prostacyclin, PGI2) receptor with pKi of 9.3 and 8.7 in human platelets and a recombinant IP receptor system, respectively.

Targets

PGI2 ^[1] (in human platelets)	PGI2 ^[1] (in a recombinant IP receptor system)
9.3(pKi)	8.7(pKi)

References

[1] Keith R Bley, et al. Br J Pharmacol. 2006 Feb;147(3):335-45.

Chemical Information & Solubility

Molecular Weight	309.41	Formula	C₁₉H₂₃N₃O
CAS No.	221529-58-4	SDF	--
Smiles	CC(C)OC1=CC=C(C=C1)CC2=CC=C(C=C2)NC3=NCCN3
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 62 mg/mL ( (200.38 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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