Home GPCR & G Protein Prostaglandin Receptor chemical Ethamsylate For research use only.

Ethamsylate

Synonyms: Etamsylate

Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

Ethamsylate Chemical Structure

Ethamsylate Chemical Structure

CAS: 2624-44-4

Purity & Quality Control

Batch: S415201 DMSO] 53 mg/mL] false] Water] 53 mg/mL] false] Ethanol] Insoluble] false Purity: 99.91%
99.91

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Biological Activity

Description Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Targets
prostaglandins [1]
In vitro
In vitro Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM. [1] Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187. [2]
In Vivo
In vivo Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema. [2]

Chemical Information & Solubility

Molecular Weight 263.31 Formula

C6H6O5S.C4H11N
CAS No. 2624-44-4 SDF Download Ethamsylate SDF
Smiles CCNCC.C1=CC(=C(C=C1O)S(=O)(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (201.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 53 mg/mL

Ethanol : Insoluble


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In vivo
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