Genz-123346 free base

Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.

Genz-123346 free base Chemical Structure

Genz-123346 free base Chemical Structure

CAS No. 491833-30-8

Purity & Quality Control

Genz-123346 free base Related Products

Biological Activity

Description Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
Targets
GL1 synthase [1]
In Vivo
In vivo

In Zucker diabetic fatty rats, treatment with Genz-123346 significantly lowers blood glucose levels and consequently partially prevents the normal deterioration of pancreatic β-cell function over time and preserves the ability of the islets to secrete insulin. In the high-fat-fed diet-induced obese mice, Genz-123346 essentially normalizes A1C levels to that of the lean animals. The improvement in A1C levels is quite persistent, extending >4 months in the diet-induced obese mice[1].

Animal Research Animal Models Zucker diabetic fatty rat
Dosages 75, 85 and 125 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 418.57 Formula

C24H38N2O4

CAS No. 491833-30-8 SDF --
Smiles CCCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 84 mg/mL ( (200.68 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 84 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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