Genz-123346 free base

Catalog No.S6496

For research use only.

Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.

Genz-123346 free base Chemical Structure

CAS No. 491833-30-8

Purity & Quality Control

Choose Selective Prostaglandin Receptor Inhibitors

Biological Activity

Description Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
Targets
GL1 synthase [1]
In vivo

In Zucker diabetic fatty rats, treatment with Genz-123346 significantly lowers blood glucose levels and consequently partially prevents the normal deterioration of pancreatic β-cell function over time and preserves the ability of the islets to secrete insulin. In the high-fat-fed diet-induced obese mice, Genz-123346 essentially normalizes A1C levels to that of the lean animals. The improvement in A1C levels is quite persistent, extending >4 months in the diet-induced obese mice[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Zucker diabetic fatty rat
  • Dosages: 75, 85 and 125 mg/kg
  • Administration: oral

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 418.57
Formula

C24H38N2O4

CAS No. 491833-30-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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