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Technical Data
| Formula | C16H17NO2 . HCl |
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| Molecular Weight | 291.77 | CAS No. | 62717-42-4 | |
| Solubility (25°C)* | In vitro | DMSO | 58 mg/mL (198.78 mM) | |
| Ethanol | 6 mg/mL (20.56 mM) | |||
| Water | 5 mg/mL (17.13 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. | ||
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| Targets |
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| In vitro | SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4] | ||
| In vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5] |
Protocol (from reference)
| Animal Study:[3] |
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References
Selleck's SKF38393 HCl has been cited by 2 publications
| Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] | PubMed: 37606043 |
| Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling [ JCI Insight, 2023, 8(16)e170434] | PubMed: 37606043 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.