TRPA Selective Inhibitors | Activators | Agonists | Antagonists

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S4787	Methyl syringate	Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.	Selective
S3763	Cinnamaldehyde	Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.	Selective
S3942	Cardamonin	Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.	Selective	hTRPA1, IC50: 454 nM
S3867	(E)-Cardamonin	(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.	Selective	TRPA1, IC50: 454 nM
S8073	Optovin	Optovin is a reversible photoactivated TRPA1 activator.	Selective
S2918	HC-030031	HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.	Selective
S7848	QX-314 chloride	QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.	Pan
S3756	Methyl salicylate	Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.	Pan