TRPM Selective Inhibitors | Agonists | Antagonists

Catalog No.	Product Name	Information	Selective / Pan	IC50 / Ki
S0174	TRPM8 antagonist 2	TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.	Selective	TRPM8, IC50: 0.2 nM
S6638	AMG-333	AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.	Selective	rat TRPM8, IC50: 30 nM
S2963	WS-12	WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.	Selective	TRPM8, EC50: 39 nM
S6122	Cyclohexanecarboxamide	Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).	Selective	TRPM8, EC50: 3.7 μM
S6070	CBA (TRPM4-IN-5)	CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM.	Selective	TRPM4, IC50: 1.5µM
S3605	Borneol	Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.	Selective	TRPM8, EC50: 65 μM