Home Transmembrane Transporters TRP Channel antagonist HC-067047 For research use only.

HC-067047

HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.

HC-067047 Chemical Structure

HC-067047 Chemical Structure

CAS: 883031-03-6

Selleck's HC-067047 has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.91%
99.91

HC-067047 Related Products

Choose Selective TRP Channel Inhibitors

Biological Activity

Description HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.
Targets
mTRPV4 [1]
(Cell-free assay)		 hTRPV4 [1]
(Cell-free assay)		 rTRPV4 [1]
(Cell-free assay)
17 nM 48 nM 133 nM
In Vivo
In vivo

HC-067047 causes a significant increase in functional bladder capacity in mice and rats suffering from cystitis, thus providing proof of principle that pharmacological inhibition of TRPV4 can be used to treat bladder dysfunction.HC-067047 had no effect on the cystometric parameters of Trpv4−/− mice demonstrates that the observed in vivo effects are specific.[1]

Chemical Information & Solubility

Molecular Weight 471.51 Formula

C26H28F3N3O2
CAS No. 883031-03-6 SDF --
Smiles CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 94 mg/mL ( (199.35 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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