SB366791

Catalog No.S8238 Batch:S823801

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Technical Data

Formula

C16H14ClNO2
Molecular Weight 287.74 CAS No. 472981-92-3
Solubility (25°C)* In vitro DMSO 57 mg/mL (198.09 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.
Targets
TRPV1 [1]
(Cell-based assay)
5.7 nM
In vitro SB-366791 is a structurally novel and potent TRPV1 antagonist which is capable of inhibiting the capsaicin-, acid- and heat-mediated activation of the receptor but produces little or no effect on a wide range of enzymes, ion channels, GPCRs and other proteins. SB-366791 may prove to be a better tool for unambiguously defining the (patho)physiological role of TRPV1[1].
In vivo the TRPV1 antagonist SB366791 reduces the number of flinches but did not improve ambulation and weight-bearing. A sub-analgesic dose of SB366791 potentiates the effects of morphine at doses of 3.0 and 10.0 mg/kg on flinches and weight-bearing but not ambulation. The combination of morphine and SB366791 has potent analgesic effects on bone cancer pain[2].

Protocol (from reference)

Cell Assay:[3]
  • Cell lines

    Gingival epithelial cells(epi 4)

  • Concentrations

    1 μM

  • Incubation Time

    30 min

  • Method

    Pretreatment with the TRPV1 antagonist, SB-366791 (1 µM), for 30 min inhibited capsaicin-induced cell proliferation at 72 hr.
Animal Study:[2]
  • Animal Models

    Adult male C3H/HeJ mice

  • Dosages

    0.1, 0.3 and 1.0 mg/kg

  • Administration

    i.p.

Selleck's SB366791 has been cited by 1 publication

Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension [Zhang W, et al. Mol Pain, 2018, 14:1744806918816850] PubMed: 30444177

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.