Decursinol angelate

Catalog No.S3819 Batch:S381901

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Technical Data

Formula

C19H20O5
Molecular Weight 328.36 CAS No. 130848-06-5
Solubility (25°C)* In vitro DMSO 65 mg/mL (197.95 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
Targets
PKC [2]
In vitro Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].
In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].

Protocol (from reference)

Cell Assay:

[4]
  • Cell lines

    MCF-7 cells

  • Concentrations

    10 μM, 20 μM, 50 μM

  • Incubation Time

    24 hours

  • Method

    Cells are treated with decursinol angelate at different exposure concentrations (10 μM, 20 μM, 50 μM) for 24 hours in complete medium.
Animal Study:

[3]
  • Animal Models

    Jugular vein cannulated CD male rats

  • Dosages

    50 mg/kg

  • Administration

    oral

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.