Cinacalcet

Catalog No.S5191 Batch:S519101

Technical Data

Formula	C₂₂H₂₂F₃N
Molecular Weight	357.41	CAS No.	226256-56-0
Solubility (25°C)*	In vitro


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Targets

CaR ^[1]

In vitro

Cinacalcet can activate CaSR and elicit an increase of atg7, becn and lc3a mRNA transcripts.^[2]

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines human AT-derived (primary) preadipocytes Concentrations 2 μM Incubation Time 6 h Method Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator. (Data sourced from selleck products)

Cell Assay:^{^[2]}

Cell lines
human AT-derived (primary) preadipocytes
Concentrations
2 μM
Incubation Time
6 h
Method
Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator.

(Data sourced from selleck products)

References

Selleck's Cinacalcet has been cited by 1 publication

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia [ Int J Mol Sci, 2022, 23(8)4323]	PubMed: 35457141

AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia [ Int J Mol Sci, 2022, 23(8)4323]

PubMed: 35457141

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SHIPPING AND STORAGE
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