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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C26H31N5O3 |
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| Molecular Weight | 461.56 | CAS No. | 1821428-35-6 | |
| Solubility (25°C)* | In vitro | Ethanol | 2 mg/mL (4.33 mM) | |
| DMSO | 0.3 mg/mL (0.64 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. | |
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| In vitro | AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes. | |
| In vivo | AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. This compound shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. It is currently undergoing early clinical assessment. |
Protocol (from reference)
References
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Selleck's AZD0156 Has Been Cited by 52 Publications
| Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells [ Science Translational Medicine, March 30, 2022, eabc7480] | PubMed: 35353542 |
| Targeting the DNA Damage Response to Increase Anthracycline-Based Chemotherapy Cytotoxicity in T-Cell Lymphoma [ International Journal of Molecular Sciences, March 30, 2022, 3834] | PubMed: 35409194 |
| USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance [ Nucleic Acids Research, June 20, 2025, gkaf544] | PubMed: 40548939 |
| Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis [ Journal of Cell Science, January 1, 2023, jcs260027] | PubMed: 36606487 |
| Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks [ NAR Cancer, February 6, 2023, zcad003] | PubMed: 36755959 |
| RPA-independent activation of the ATR/CHK1 pathway [ Proceedings of the National Academy of Sciences, February 10, 2026, e2524246123] | PubMed: 41628322 |
| KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer [ Cancer Cell, 2025, 43(8):1530-1548.e9] | PubMed: 40645185 |
| ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders [ J Clin Invest, 2025, 135(8)e181659] | PubMed: 40179146 |
| USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance [ Nucleic Acids Res, 2025, 53(12)gkaf544] | PubMed: 40548939 |
| SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells [ Br J Cancer, 2025, 132(8):690-702] | PubMed: 39994444 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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