|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C26H31N5O3 |
|||
| Molecular Weight | 461.56 | CAS No. | 1821428-35-6 | |
| Solubility (25°C)* | In vitro | Ethanol | 2 mg/mL (4.33 mM) | |
| DMSO | 0.3 mg/mL (0.64 mM) | |||
| Water | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. This compound prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. | |
|---|---|---|
| Targets |
|
|
| In vitro | AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes[1]. | |
| In vivo | AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. This compound shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. It is currently undergoing early clinical assessment[1]. |
Protocol (from reference)
References
|
Selleck's AZD0156 Has Been Cited by 48 Publications
| KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer [ Cancer Cell, 2025, 43(8):1530-1548.e9] | PubMed: 40645185 |
| ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders [ J Clin Invest, 2025, 135(8)e181659] | PubMed: 40179146 |
| USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance [ Nucleic Acids Res, 2025, 53(12)gkaf544] | PubMed: 40548939 |
| SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells [ Br J Cancer, 2025, 132(8):690-702] | PubMed: 39994444 |
| Inhibiting the DNA damage repair of HNSCC cells in combination with normo-fractionated radiotherapy influences clonogenicity, senescence and expression of NK cell activation markers [ Sci Rep, 2025, 15(1):31827] | PubMed: 40883442 |
| Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage [ Res Sq, 2025, rs.3.rs-7303237] | PubMed: 40831504 |
| In vivo DNA replication dynamics unveil aging-dependent replication stress [ Cell, 2024, S0092-8674(24)00963-2] | PubMed: 39293447 |
| Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors [ Mol Cancer, 2024, 23(1):242] | PubMed: 39478560 |
| Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress [ Nat Commun, 2024, 15(1):7404] | PubMed: 39191776 |
| Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity [ J Adv Res, 2024, S2090-1232(24)00601-5] | PubMed: 39708961 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.