Name: Darunavir
Brand: Selleck Chemicals
SKU: S5250
Availability: InStock
Rating: 5 (16 reviews)

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Quality Control

Batch: S525001 DMSO]100 mg/mL]false]Ethanol]11 mg/mL]false]Water]Insoluble]false Purity: 99.89%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS/MSDS
Datasheet

99.89

Related Targets	HDAC Caspase Proteasome Secretase MMP HCV Protease Cysteine Protease Tyrosinase DPP Serine Protease
Other HIV Protease Inhibitors	Pepstatin A Limonin Temsavir (BMS-626529) Dextran sulfate sodium (DSS) Bevirimat Rosamultin Mericitabine NBD-556 GS-6207 (Lenacapavir) Azvudine

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (182.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 11 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (9.13mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (1.30mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	547.66	Formula	C₂₇H₃₇N₃O₇S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	206361-99-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	TMC114,DRV			SMILES	CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-28)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07792096	NOT_YET_RECRUITING	HIV Infection	University College, London	2026-11	PHASE3
NCT06338826	NOT_YET_RECRUITING	HIV Infections; HBV Coinfection	ANRS, Emerging Infectious Diseases	2025-02-01	PHASE2
NCT06747507	RECRUITING	HIV-1-infection	University of Nairobi	2025-09-01	PHASE3
NCT07678268	RECRUITING	HIV Infection; Antiretroviral Therapy; Lentivirus Infections	Instituto Mexicano del Seguro Social	2025-07-10	PHASE4
NCT06907056	RECRUITING	HIV Infection	José Antonio Mata Marín	2023-11-09	PHASE4
NCT06787976	UNKNOWN	HIV; Insomnia; Anxiety	Instituto Mexicano del Seguro Social	2025-06-19	PHASE4

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Handling Instructions

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Darunavir HIV Protease inhibitor

Chemical Structure

Molecular Weight: 547.66