Home Microbiology HIV Protease inhibitor GS-6207 (Lenacapavir)

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GS-6207 (Lenacapavir) HIV-1 Capsid Inhibitor

Cat.No.S9633

GS-6207 (Lenacapavir) is a HIV-1 capsid inhibitor. It shows anti-HIV activity with an EC50 of 0.1 nM in MT-4 cells.
GS-6207 (Lenacapavir) HIV Protease inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 968.29

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Quality Control

Batch: S963301 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.75%
99.75

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (103.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 968.29 Formula

C39H32ClF10N7O5S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2189684-44-2 -- Storage of Stock Solutions

Synonyms Lenacapavir SMILES CC(C)(C#CC1=NC(=C(C=C1)C2=C3C(=C(C=C2)Cl)C(=NN3CC(F)(F)F)NS(=O)(=O)C)C(CC4=CC(=CC(=C4)F)F)NC(=O)CN5C6=C(C7CC7C6(F)F)C(=N5)C(F)(F)F)S(=O)(=O)C

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Mechanism of Action

Targets/IC50/Ki
HIV-1 capsid
0.1 nM(EC50)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-01-27)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04811040 COMPLETED
HIV-1 Infection
Gilead Sciences
 2021-04-08 PHASE1
NCT04143594 COMPLETED
HIV-1-infection
Gilead Sciences
 2019-11-22 PHASE2
NCT05052996 Active not recruiting
HIV-1 Infection
Gilead Sciences|Merck Sharp & Dohme LLC
 2021-10-05 Phase 2
NCT04150068 ACTIVE_NOT_RECRUITING
HIV-1-infection
Gilead Sciences
 2019-11-21 PHASE2; PHASE3
NCT03739866 COMPLETED
HIV-1 Infection
Gilead Sciences
 2018-11-26 PHASE1
NCT03739866 Completed
HIV-1 Infection
Gilead Sciences
 2018-11-26 Phase 1

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