For research use only.
CAS No. 81065-76-1
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
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|Description||EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.|
EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase.  EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro.  In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene.  EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). 
|In vivo||EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth.  EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). |
-  Baker K, et al. J Pharmacol Exp Ther. 1998, 284(1), 215-221.
-  Jekabsone A, et al. J Neuroinflammation. 2006, 3, 24.
-  Mohammadi M, et al. Basic Clin Pharmacol Toxicol. 2011, 108(6), 378-384.
|In vitro||DMSO||83 mg/mL (199.16 mM)|
|Water||13 mg/mL (31.19 mM)|
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