For research use only. Not for use in humans.

Crenezumab (Anti-Amyloid Beta)

Synonyms: MABT 5102A; RG 7412 Cat.No.A2764 Purity:99%

Crenezumab (Anti-Amyloid Beta) is a fully humanized immunoglobulin (Ig) G4 monoclonal antibody that targets amyloid beta (Abeta) with potential for use in Alzheimer's disease research. MW: 143.58 kD.

Crenezumab (Anti-Amyloid Beta)

Quality Control

Batch: A276401 Purity: 99% Protein concentration: 14.9mg/ml Endotoxin Level: ＜1EU/mg

99

Specificity

Name	Citation	Beta Amyloid	Others
DAPT	398	+++	Notch
RO4929097 (RG-4733)	123	+++	γ secretase,Notch
Semagacestat (LY450139)	22	+++	Notch
MK-0752	23	++++
Avagacestat (BMS-708163)	22	++++
LY2811376	19	++	BACE1
CRANAD-2	0	++
Hoechst 34580	1	+
Frentizole	0	+
Simufilam	0	✔
Ginsenoside Rg1	5	✔	NF-κB
Ginsenoside Re	1	✔	NF-κB,JNK
Tabersonine hydrochloride	0	✔
EUK 134	6	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Crenezumab (Anti-Amyloid Beta) is a fully humanized immunoglobulin (Ig) G4 monoclonal antibody that targets amyloid beta (Abeta) with potential for use in Alzheimer's disease research. MW: 143.58 kD.
References	https://pubmed.ncbi.nlm.nih.gov/32497293/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1095207-05-8
Molecular Weight	143.58
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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