TVB-2640

For research use only.

Catalog No.S9714 Synonyms: ASC-40, FASN-IN-2

3 publications

TVB-2640 Chemical Structure

CAS No. 1399177-37-7

TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.

Selleck's TVB-2640 has been cited by 3 publications

Purity & Quality Control

Choose Selective Fatty Acid Synthase Inhibitors

Biological Activity

Description TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Targets
FAS [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 88 mg/mL (200.2 mM)
Ethanol 88 mg/mL (200.2 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 439.55
Formula

C27H29N5O

CAS No. 1399177-37-7
Storage powder
in solvent
Synonyms ASC-40, FASN-IN-2

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04906421 Recruiting Drug: TVB-2640|Other: Placebo Nonalcoholic Fatty Liver Disease Sagimet Biosciences Inc. May 30 2021 Phase 2
NCT04843449 Completed Drug: ASC40|Drug: Itraconazole|Drug: rifampicin Healthy Ascletis Pharmaceuticals Co. Ltd. April 4 2021 Phase 1
NCT04352361 Completed Drug: TVB-2640|Drug: Placebo Healthy Ascletis Pharmaceuticals Co. Ltd. April 2 2020 Phase 1
NCT03808558 Recruiting Drug: TVB-2640 KRAS Gene Mutation David E Gerber|Sagimet Biosciences Inc.|Cancer Prevention Research Institute of Texas|University of Texas Southwestern Medical Center September 11 2019 Phase 2
NCT03938246 Recruiting Drug: TVB-2640|Other: Placebo Non-Alcoholic Fatty Liver Disease Sagimet Biosciences Inc. March 22 2019 Phase 2
NCT02980029 Recruiting Drug: TVB-2640|Other: Placebo Colon Cancer Mark Evers|University of Kentucky October 6 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID