Home Metabolism Fatty Acid Synthase inhibitor Fasnall For research use only.

Fasnall

Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.

Fasnall Chemical Structure

Fasnall Chemical Structure

CAS: 929978-58-5

Purity & Quality Control

Batch: S624801 Ethanol] 25 mg/mL] false] DMSO] 13 mg/mL] false] Water] Insoluble] false Purity: 99.32%
99.32

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Biological Activity

Description Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
Targets
FASN [1]
In vitro
In vitro

Fasnall and IU1 have different modes of metabolic variability in cancer cells.[2]
Cell Research Cell lines HEK293T cells, LNCaP cells, MCF7 cells, and A549 cells
Concentrations 10 μM
Incubation Time 48 h
Method

LNCaP cells were seeded at a density of 1 × 104 cells/well in a 96-well plate. Cells were transfected with USP14i or FASNi alone or together both for 72 h, or treated with IU1 or Fasnall alone or together both for 48 h. To measure cell viability, a WST-1 assay was performed using EZ-Cytox following the manufacturer’s instructions. The absorbance was measured on a microplate spectrophotometer at a wavelength of 450 nm.

Chemical Information & Solubility

Molecular Weight 338.47 Formula

C19H22N4S
CAS No. 929978-58-5 SDF --
Smiles CC1=C(C)C2=C(NC3CCN(C3)CC4=CC=CC=C4)N=CN=C2S1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Ethanol : 25 mg/mL

DMSO : 13 mg/mL ( (38.4 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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