TVB-3664

For research use only.

Catalog No.S8563

2 publications

TVB-3664 Chemical Structure

CAS No. 2097262-58-1

TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.

Selleck's TVB-3664 has been cited by 2 publications

Purity & Quality Control

Choose Selective Fatty Acid Synthase Inhibitors

Biological Activity

Description TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.
Targets
FASN [1]
(mouse cell palmitate synthesis)
FASN [1]
(human cell palmitate synthesis)
0.012 μM 0.018 μM
In vitro

TVB-3664 induces FASN inhibition with significantly reduced tubulin palmitoylation and mRNA expression. Disrupted microtubule organization in tumor cells is an additional consequence of FASN inhibition. TVB-3664 combined with taxane treatment enhances inhibition of in vitro tumor cell growth compared to treatmentwith either agent alone.[1]

In vivo

In lung, ovarian, prostate, and pancreatic tumor xenograft studies, TVB-3664 and paclitaxel or docetaxel combine to inhibit xenograft tumor growth with significantly enhanced anti-tumor activity. Tumor regression is observed in 3 of 6 tumor xenograftmodels.[1]

Protocol

Cell Research:

[1]

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  • Cell lines: Calu-6 cells, A549 cells
  • Concentrations: 50 nM
  • Incubation Time: 48 h, 72 h
  • Method:

    Calu-6 cells are treated with 50 nM TVB-3664 for 48 h. Paclitaxel is added to the cell culture media to a final concentration of 6 nM. After the 2 h of incubation with paclitaxel, cells and supernatant are collected for analysis.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: female BALB-c-nude mice
  • Dosages: 10 mg/kg, 2.5 mg/kg
  • Administration: PO, IV
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 94 mg/mL (200.65 mM)
Ethanol 50 mg/mL (106.73 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 468.47
Formula

C25H23F3N4O2

CAS No. 2097262-58-1
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=C(C=C1C2=C(NC(=N2)C(F)(F)F)COC)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N)C

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID