PPARα Selective Inhibitors | Activators | Agonists | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8029 WY-14643 (Pirinixic Acid)

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

Selective PPARα, EC50: 1.5 μM
S4207 Clofibric Acid

Clofibric acid is a PPARα agonist and hypolipidemic agent.

Selective
S1729 Gemfibrozil

Gemfibrozil (Lopid) is a compound used to lower lipid levels.

Selective
S1794 Fenofibrate

Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative.

Selective
S2915 GW9662

GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.

Pan PPARα, IC50: 32 nM
S2871 T0070907

T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM, with a >800-fold selectivity over PPARα and PPARδ.

Pan PPARα, IC50: 0.85 μM